CO4810299A1 - Procedimiento para alquilar sulfonamidas impedidas esteri- camente - Google Patents
Procedimiento para alquilar sulfonamidas impedidas esteri- camenteInfo
- Publication number
- CO4810299A1 CO4810299A1 CO99021411A CO99021411A CO4810299A1 CO 4810299 A1 CO4810299 A1 CO 4810299A1 CO 99021411 A CO99021411 A CO 99021411A CO 99021411 A CO99021411 A CO 99021411A CO 4810299 A1 CO4810299 A1 CO 4810299A1
- Authority
- CO
- Colombia
- Prior art keywords
- sulfonamides
- sterily
- renting
- impaired
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- 150000003456 sulfonamides Chemical class 0.000 title abstract 2
- 230000001771 impaired effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 238000006845 Michael addition reaction Methods 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Abstract
La presente invención se refiere a un procedimiento paraalquilar sulfonamidas impedidas estéricamente, mediante una reacción de adición de Michael, a propiolatos y a nuevos intermedios preparados en el citado procedimiento.El procedimiento comprende hacer reaccionar un compuesto de fórmula en la que R1 es bencilo sustituido opcionalmente y R2 , R3 , R4 y Q son como se han definido anteriormente, con un compuesto de fórmulaen la que Y es alquilo C1 -C6 , en presencia de una base y un disolvente polar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8131098P | 1998-04-10 | 1998-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4810299A1 true CO4810299A1 (es) | 1999-06-30 |
Family
ID=22163376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99021411A CO4810299A1 (es) | 1998-04-10 | 1999-04-12 | Procedimiento para alquilar sulfonamidas impedidas esteri- camente |
Country Status (47)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6458822B2 (en) | 2000-03-13 | 2002-10-01 | Pfizer Inc. | 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases |
| EP1134207A1 (en) * | 2000-03-15 | 2001-09-19 | Pfizer Products Inc. | Process for preparing resorcinol derivatives |
| ATE330601T1 (de) | 2000-04-07 | 2006-07-15 | Samsung Electronics Co Ltd | Sulfonamide als matrix-metalloproteinase inhibitoren |
| US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
| US6844373B2 (en) * | 2002-05-28 | 2005-01-18 | Alcatel | Composition comprising fluorinated, radiation-curable dyes for surface energy control |
| ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
| ITFI20040174A1 (it) * | 2004-08-03 | 2004-11-03 | Protera S R L | Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi |
| ITBO20050005U1 (it) * | 2005-01-31 | 2006-08-01 | Ali Spa | Distributore di bevande ghiacciate e simili |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU523636A3 (ru) * | 1973-06-18 | 1976-07-30 | Стауффер Кемикал Компани (Фирма) | Способ получени сульфоксидных или сульфоновых производных тиокарбаматов |
| ZA794723B (en) | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
| GB9000725D0 (en) | 1990-01-12 | 1990-03-14 | Pfizer Ltd | Therapeutic agents |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5863949A (en) * | 1995-03-08 | 1999-01-26 | Pfizer Inc | Arylsulfonylamino hydroxamic acid derivatives |
| JP2000501423A (ja) * | 1996-08-23 | 2000-02-08 | ファイザー インク． | アリールスルホニルアミノヒドロキサム酸誘導体 |
| ID22799A (id) | 1997-02-03 | 1999-12-09 | Pfizer Prod Inc | Turunan-turunan asam arilsulfonilamino hidroksamat |
| KR100372138B1 (ko) | 1997-08-08 | 2003-02-14 | 화이자 프로덕츠 인코포레이티드 | 아릴옥시아릴설포닐아미노 하이드록삼산 유도체 |
| PT895988E (pt) | 1997-08-08 | 2002-09-30 | Pfizer Prod Inc | Derivados do acido arilsulfonilamino-hidroxamico |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
-
1999
- 1999-03-24 PA PA19998469601A patent/PA8469601A1/es unknown
- 1999-03-25 DE DE69900321T patent/DE69900321T2/de not_active Expired - Fee Related
- 1999-03-25 IL IL12916899A patent/IL129168A/xx not_active IP Right Cessation
- 1999-03-25 ES ES99302287T patent/ES2163316T3/es not_active Expired - Lifetime
- 1999-03-25 PT PT99302287T patent/PT949245E/pt unknown
- 1999-03-25 AT AT99302287T patent/ATE206392T1/de not_active IP Right Cessation
- 1999-03-25 GT GT199900047A patent/GT199900047A/es unknown
- 1999-03-25 DK DK99302287T patent/DK0949245T3/da active
- 1999-03-25 EP EP99302287A patent/EP0949245B1/en not_active Expired - Lifetime
- 1999-04-01 OA OA9900073A patent/OA11030A/en unknown
- 1999-04-05 ID IDP990304D patent/ID23244A/id unknown
- 1999-04-06 PE PE1999000277A patent/PE20000417A1/es not_active Application Discontinuation
- 1999-04-06 IS IS5018A patent/IS5018A/is unknown
- 1999-04-07 DZ DZ990055A patent/DZ2754A1/xx active
- 1999-04-07 TW TW088105541A patent/TW520354B/zh not_active IP Right Cessation
- 1999-04-07 KR KR1019990011957A patent/KR100357660B1/ko not_active Expired - Fee Related
- 1999-04-07 IN IN522DE1999 patent/IN192485B/en unknown
- 1999-04-07 TN TNTNSN99054A patent/TNSN99054A1/fr unknown
- 1999-04-07 MA MA25530A patent/MA24833A1/fr unknown
- 1999-04-07 SK SK453-99A patent/SK45399A3/sk unknown
- 1999-04-08 AR ARP990101601A patent/AR017731A1/es active IP Right Grant
- 1999-04-08 AP APAP/P/1999/001506A patent/AP1095A/en active
- 1999-04-08 SG SG1999001651A patent/SG75167A1/en unknown
- 1999-04-08 YU YU18399A patent/YU18399A/sh unknown
- 1999-04-08 EG EG37499A patent/EG21985A/xx active
- 1999-04-08 TR TR1999/00756A patent/TR199900756A2/xx unknown
- 1999-04-08 CA CA002268684A patent/CA2268684C/en not_active Expired - Fee Related
- 1999-04-09 NO NO991675A patent/NO991675L/no not_active Application Discontinuation
- 1999-04-09 NZ NZ335105A patent/NZ335105A/xx unknown
- 1999-04-09 HU HU0101465A patent/HUP0101465A3/hu unknown
- 1999-04-09 TR TR2000/02950T patent/TR200002950T2/xx unknown
- 1999-04-09 DE DE69922638T patent/DE69922638T2/de not_active Expired - Fee Related
- 1999-04-09 WO PCT/US1999/007858 patent/WO1999052862A1/en active IP Right Grant
- 1999-04-09 IL IL13877899A patent/IL138778A0/xx unknown
- 1999-04-09 AU AU35527/99A patent/AU760213B2/en not_active Ceased
- 1999-04-09 PL PL99332451A patent/PL332451A1/xx unknown
- 1999-04-09 HN HN1999000043A patent/HN1999000043A/es unknown
- 1999-04-09 AU AU23691/99A patent/AU755004B2/en not_active Ceased
- 1999-04-09 ZA ZA9902627A patent/ZA992627B/xx unknown
- 1999-04-09 KR KR10-2000-7011232A patent/KR100377718B1/ko not_active Expired - Fee Related
- 1999-04-09 HR HR990106A patent/HRP990106B1/xx not_active IP Right Cessation
- 1999-04-09 UA UA99042034A patent/UA57039C2/uk unknown
- 1999-04-09 RU RU2000125555/04A patent/RU2197479C2/ru not_active IP Right Cessation
- 1999-04-09 EA EA199900277A patent/EA002277B1/ru not_active IP Right Cessation
- 1999-04-09 AT AT99917394T patent/ATE284864T1/de not_active IP Right Cessation
- 1999-04-09 JP JP2000543425A patent/JP3479511B2/ja not_active Expired - Fee Related
- 1999-04-09 CN CN99104932A patent/CN1234396A/zh active Pending
- 1999-04-09 ID IDW20002031A patent/ID27208A/id unknown
- 1999-04-09 BG BG103320A patent/BG63665B1/bg unknown
- 1999-04-09 CN CN99804961A patent/CN1296474A/zh active Pending
- 1999-04-09 ES ES99917394T patent/ES2234253T3/es not_active Expired - Lifetime
- 1999-04-09 EP EP99917394A patent/EP1068180B1/en not_active Expired - Lifetime
- 1999-04-09 US US09/289,454 patent/US6114568A/en not_active Expired - Fee Related
- 1999-04-09 US US09/290,022 patent/US6229025B1/en not_active Expired - Fee Related
- 1999-04-09 CA CA002327498A patent/CA2327498C/en not_active Expired - Fee Related
- 1999-04-09 BR BR9902219-2A patent/BR9902219A/pt not_active IP Right Cessation
- 1999-04-09 PL PL99343530A patent/PL343530A1/xx unknown
- 1999-04-09 HU HU9901043A patent/HUP9901043A1/hu unknown
- 1999-04-09 BR BR9910110-6A patent/BR9910110A/pt not_active IP Right Cessation
- 1999-04-12 UY UY25469A patent/UY25469A1/es unknown
- 1999-04-12 JP JP10387399A patent/JP3540959B2/ja not_active Expired - Fee Related
- 1999-04-12 CO CO99021411A patent/CO4810299A1/es unknown
- 1999-05-05 SA SA99200089A patent/SA99200089A/ar unknown
-
2000
- 2000-08-25 CN CN00126476A patent/CN1288885A/zh active Pending
- 2000-10-02 ZA ZA200005370A patent/ZA200005370B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR9421A (es) | Compuestos heterociclicos fusionados | |
| ATE533775T1 (de) | Verfahren zur herstellung von 17-vinyl-triflaten als intermediate | |
| BR0313341A (pt) | Método para a preparação de uma oxazinona fundida e método para a preparação de um composto de fórmula iii | |
| SE0200730D0 (sv) | Kristallin bas av citalopram | |
| BRPI0408160B1 (pt) | Processo para o preparo de ésteres do ácido nicotínico substituído e intermediários de enamina para uso nesse processo | |
| CO4810299A1 (es) | Procedimiento para alquilar sulfonamidas impedidas esteri- camente | |
| BR0112530A (pt) | Processo para preparar derivados de 4-tioalquilbromobenzeno | |
| PT1442006E (pt) | Preparacao de anfetaminas a partir de fenilpropanolaminas | |
| CY1111606T1 (el) | Διαδικασια διαχωρισμου για to (r)-(-)-2-yδροξy-2- (2-χλωροφαινυλ) οξικο οξυ | |
| DE69922417D1 (de) | Verfahren zur herstellung von amlodipin-benzolsulfonat | |
| EA200200939A1 (ru) | Способ получения циталопрама | |
| ATE255103T1 (de) | Verfahren zur herstellung von pyridinmethanol- verbindungen | |
| ATE428693T1 (de) | Prostaglandinsynthese | |
| EA200200611A1 (ru) | Новые тетрагидропиридины, способ их получения и содержащие их фармацевтические композиции | |
| EA200800633A1 (ru) | Способ получения производных сартана и промежуточных соединений, пригодных для этого способа | |
| AR004015A1 (es) | Procedimiento para preparar compuestos de quinolina o sales farmaceuticamente aceptables de los mismos, y compuestos intermediarios | |
| DK1105392T3 (da) | Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin | |
| AR008810A1 (es) | Proceso para preparar acidos 2-aril-alcanoicos a partir de arilolefinas y dichos compuestos intermedios. | |
| CO4790134A1 (es) | Compuestos fungicidas a base de piridilaminopirimidinas y el proceso para prepararlas | |
| EA200100723A1 (ru) | Способ получения 1-(аминометил)циклогексилуксусной кислоты | |
| DK0391673T3 (da) | Fremstilling af glutarsyrederivater | |
| CO5050289A1 (es) | Proceso novedoso | |
| ECSP992910A (es) | Procedimiento para alquilar sulfonamidas impedidas estericamente | |
| DE60127979D1 (de) | Verfahren zur herstellung von 3,5-bisalkylphenolen | |
| ATE417043T1 (de) | Verfahren zur herstellung von imiquimod und dessen zwischenverbindungen |