CN114945565A - 一种吡咯烷基脲衍生物的晶型及其应用 - Google Patents
一种吡咯烷基脲衍生物的晶型及其应用 Download PDFInfo
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Abstract
本发明公开了一种TrkA抑制剂的晶型及其制备方法，并公开了其在制备治疗与疼痛、癌症、炎症、神经变性疾病以及某些感染性疾病等相关疾病的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (16)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410626119.3A CN118515652A (zh) | 2020-01-10 | 2021-01-08 | 一种吡咯烷基脲衍生物的晶型及其应用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010027389 | 2020-01-10 | ||
| CN2020100273894 | 2020-01-10 | ||
| PCT/CN2021/070956 WO2021139794A1 (zh) | 2020-01-10 | 2021-01-08 | 一种吡咯烷基脲衍生物的晶型及其应用 |
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| CN202410626119.3A Division CN118515652A (zh) | 2020-01-10 | 2021-01-08 | 一种吡咯烷基脲衍生物的晶型及其应用 |
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| Publication Number | Publication Date |
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| CN114945565A true CN114945565A (zh) | 2022-08-26 |
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| CN202180008898.5A Pending CN114945565A (zh) | 2020-01-10 | 2021-01-08 | 一种吡咯烷基脲衍生物的晶型及其应用 |
| CN202410626119.3A Pending CN118515652A (zh) | 2020-01-10 | 2021-01-08 | 一种吡咯烷基脲衍生物的晶型及其应用 |
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Country Status (5)
| Country | Link |
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| US (1) | US11708357B2 (zh) |
| EP (1) | EP4089086A4 (zh) |
| JP (1) | JP7289017B2 (zh) |
| CN (2) | CN114945565A (zh) |
| WO (1) | WO2021139794A1 (zh) |
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| KR102001364B1 (ko) * | 2011-05-13 | 2019-07-22 | 어레이 바이오파마 인크. | Trka 키나제 저해제로서의 피롤리디닐 유레아 및 피롤리디닐 티오유레아 화합물 |
| RS59286B1 (sr) | 2014-05-15 | 2019-10-31 | Array Biopharma Inc | 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoksietil)pirolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)urea kao inhibitor trka kinaze |
| US10160727B2 (en) | 2014-08-06 | 2018-12-25 | Shionogi & Co., Ltd. | Heterocycle and carbocycle derivatives having TrkA inhibitory activity |
| CA2974784A1 (en) | 2015-01-23 | 2016-07-28 | Gvk Biosciences Private Limited | Inhibitors of trka kinase |
| JP6812059B2 (ja) | 2015-07-07 | 2021-01-13 | 塩野義製薬株式会社 | ＴｒｋＡ阻害活性を有する複素環誘導体 |
| CN112424189B (zh) | 2018-07-12 | 2023-07-07 | 漳州片仔癀药业股份有限公司 | 吡咯烷基脲衍生物及其在TrkA相关疾病的应用 |
-
2021
- 2021-01-08 US US17/791,694 patent/US11708357B2/en active Active
- 2021-01-08 WO PCT/CN2021/070956 patent/WO2021139794A1/zh unknown
- 2021-01-08 CN CN202180008898.5A patent/CN114945565A/zh active Pending
- 2021-01-08 CN CN202410626119.3A patent/CN118515652A/zh active Pending
- 2021-01-08 JP JP2022542633A patent/JP7289017B2/ja active Active
- 2021-01-08 EP EP21738026.0A patent/EP4089086A4/en active Pending
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| JP7289017B2 (ja) | 2023-06-08 |
| US11708357B2 (en) | 2023-07-25 |
| US20230103409A1 (en) | 2023-04-06 |
| WO2021139794A1 (zh) | 2021-07-15 |
| EP4089086A1 (en) | 2022-11-16 |
| CN118515652A (zh) | 2024-08-20 |
| EP4089086A4 (en) | 2023-07-05 |
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