CN103599391A - Traditional Chinese medicine composition for treating radiation pneumonitis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition for treating radiation pneumonitis. The traditional Chinese medicine science believes that the external reason of the radiation pneumonitis is radioactive rays which are 'fire heat and pathogenic toxin', the basic pathogenesis is deficient root and excessive superficial, and the impairment of yin, the deficiency of vital energy, the blood stasis and the heat toxicity are key points of the pathogenesis. Traditional Chinese medicines which have the effects of nourishing yin to moisten dryness, clearing away heat and toxic materials, activating blood and expelling phlegm and comprise fine-stemmed dendrobium, discolor ludisia herb, woody-rhizomed fimbristylis herb, trichosanthes root, silene conoidea, viola inconspicua, indigo naturalis, scutellaria indica, geranium wilfordii, underleaf pearl, Indian melothria root and spiral shell are decocted with water and the obtain decoction is taken by patients. The clinical tests prove that the total effective rate of the traditional Chinese medicine composition is 96.7%, and the traditional Chinese medicine composition has a good curative effect and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of radiation pneumonia.
Background technology
Radiation pneumonia is thoracic malignant tumors radiotherapy common complication while finishing, radiation pneumonia main manifestations is slight or serious dyspnea, dry cough (approximately 60%), occurring sometimes of short duration low grade fever (< 10%), hemoptysis, may there is respiratory insufficiency and cyanosis in severe patient.Generally see 1-3 month after radiotherapy.The main medicine for the treatment of is adrenocortical hormone at present, and curative effect is undesirable, and side effect is more, should not take for a long time.Therefore, manage to improve clinical efficacy with Chinese medicine, reduce side effect, reduce recurrence, a kind of good method of can yet be regarded as.Clinical practice shows, the treatment of the traditional Chinese medical science is often conceived to whole regulating action, focuses on contacting of local and whole body, payes attention to the disease-resistant potential of performance human body.Its " strengthening the body resistance " Therapeutic Method, improves the imperial condition of disease power of radiation pneumonia patient beyond doubt, improves the important means of body's immunity, in long-term clinical course, uses Chinese medicine radiation pneumonia more and more to demonstrate its advantage.
Summary of the invention
The Chinese medicine composition that the object of this invention is to provide a kind for the treatment of radiation pneumonia.The traditional Chinese medical science thinks that the exopathogenic factor of radiation pneumonia is lonizing radiation, is " burning hot poison is evil ", and in Patients During Radiotherapy, patient is in the cloudy wound of intenseness of heat, the scorehed lung-lobe due to lung-heat state, shows as dry cough expectorant few, dry mouth and throat, and hectic fever night sweat, red tongue tongue is few, the syndrome of the deficiency of lung-YIN such as thready and rapid pulse; Hyperactive fire wasting QI, and cancer patient deficiency of qi and blood originally, can show as weakly, loses heart, the syndrome of the insufficiency of lung-QI such as cough unable; Positive exogenous pathogen enters, and can occur again heating, coughs yellow sputum, xerostomia wish drink, red tongue with yellowish and greasy fur, the symptom of the accumulation of phlegm-heat in the lung such as slippery and rapid pulse; Sick become for a long time the stasis of blood, the impact of above factor in addition, can form again the syndrome of blood stasis.Therefore the basic pathogenesis of radiation pneumonia is deficiency in origin and excess in superficiality, cloudy wound, the deficiency of vital energy, blood stasis, pyretic toxicity are pathogenesis main points, therefore should adopt the method for the treatment of of nourishing YIN to relieve dryness, heat-clearing and toxic substances removing, phlegm reduction of blood circulation promoting clinically.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treating radiation pneumonia is made by the Chinese medicine of following weight portion: Herba Dendrobii 20-25 part, Herba Ludisiae Discoloris 5-15 part, Radix Fimbristylis rigidulae 15-25 part, Radix Trichosanthis 15-20 part, Herba Silenes conoideae 23-27 part, Herba Violae japonicae 15-25 part, Indigo Naturalis 1-3 part, Herba Scutellariae indicae 10-20 part, Herba Erodii 5-9 part, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 18-24 part, Radix Melothriae Heterophyllae 25-45 part, Carapax Bellamyae quadratae 5-15 part.
Preferred: 23 parts of Herba Dendrobii, 10 parts of Herba Ludisiae Discoloriss, 20 parts of Radix Fimbristylis rigidulaes, 17 parts of Radix Trichosanthis, 25 parts of Herba Silenes conoideaes, 20 parts of Herba Violae japonicaes, 2 parts of Indigo Naturaliss, 15 parts of Herba Scutellariae indicae, 7 parts of Herba Erodiis, 21 parts of leaf Miscanthus sacchariflorus (Maxim) Benth et Hook fs, 35 parts of Radix Melothriae Heterophyllaes, 10 parts of Carapax Bellamyae quadrataes.
Preparation method is made decoction by above-mentioned Chinese medicine decocting.
In side: Herba Dendrobii, Herba Ludisiae Discoloris nourishing YIN and clearing away heat; Radix Fimbristylis rigidulae is nourshing Yin and drynsessmoistening prescription, and tonify deficiency benefit is damaged; Radix Trichosanthis pathogenic fire reducing is moisturized; Herba Silenes conoideae yin nourishing, and blood; Herba Violae japonicae, Indigo Naturalis heat-clearing and toxic substances removing, evacuation of pus pain relieving; Herba Scutellariae indicae expelling wind and activating blood circulation, removing toxic substances pain relieving; Herba Erodii expelling wind and activating blood circulation, heat-clearing and toxic substances removing; One leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f relaxing muscles and tendons to promote blood circulation, tonifying speen and tonifying kidney; Radix Melothriae Heterophyllae removing heat-phlegm, dampness removing, mass dissipating and swelling eliminating; Carapax Bellamyae quadratae dissipating phlegm and resolving masses, pain relieving sore.
Clinical data
1. the routine treatment target of physical data 60 is all made a definite diagnosis through pathology, is divided at random two groups, every group of each 30 examples.Treatment group male's 20 examples, women's 10 examples; Age minimum is 46 years old, is 73 years old to the maximum, 61 years old mean age; Pulmonary carcinoma 18 examples, breast carcinoma 3 examples, the esophageal carcinoma 5 examples, malignant lymphoma 2 examples, pulmonary carcinoma thoracic wall transferase 12 example; Matched group male 18 examples, women's 12 examples; Age minimum is 45 years old, is 70 years old to the maximum, 59 years old mean age; Pulmonary carcinoma 20 examples, breast carcinoma 2 examples, the esophageal carcinoma 3 examples, malignant lymphoma 2 examples, pulmonary carcinoma thoracic wall shifts 3 examples; Two groups of radiation treatment minimum dose 4500cgy, maximal dose 6500cgy.The shortest time of occurrence of radiation pneumonia is after radiotherapy 2 weeks, and the longest is radiotherapy later six months.Two groups of Genders, age, the equal not statistically significant of sick species diversity (P > 0.05).
2. 1. diagnostic criteria has breast tumor irradiation treatment medical history; 2. clinical manifestation is mainly zest dry cough, uncomfortable in chest, chest pain etc.; 3. breast CT inspection is shown in that clear-cut diffuse haze shade appears in radiation area lung field; 4. first radiotherapy, without serious hepatic and renal function injure; 5. physical function condition grading (KPS) is more than 60 minutes; 6. expect > 6 months life cycle.
3. Therapeutic Method matched group adopts prednisolone 30-60mg every day, and minutes 4 times are oral, continuous application 2-4 decrement after week, and prevention and Roxithromycin, cephalosporins etc. for infection control, with relieving cough and resolving phlegm such as Radix Glycyrrhizae tabellae, ketelins, oxygen uptake etc. are to anti symptom treatment.Treatment group: add on matched group basis and use Chinese medicine preparation of the present invention, take Herba Dendrobii 23g, Herba Ludisiae Discoloris 10g, Radix Fimbristylis rigidulae 20g, Radix Trichosanthis 17g, Herba Silenes conoideae 25g, Herba Violae japonicae 20g, Indigo Naturalis 2g, Herba Scutellariae indicae 15g, Herba Erodii 7g, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 21g, Radix Melothriae Heterophyllae 35g, Carapax Bellamyae quadratae 10g, decocting becomes decoction, every day potion, dividing and sooner or later take for 2 times, 4 weeks is 1 course for the treatment of.
4. criterion of therapeutical effect is formulated with reference to < < disease clinical diagnosis and criterion of therapeutical effect > >.Recovery from illness: the transference cures such as cough, uncomfortable in chest, chest pain, out of breath, heating; Auscultation of lung is without dry, moist sound; X-ray checks that pulmonary's inflammatory shade dissipates.Effective: symptom, sign disappear or obviously alleviate; X-ray checks the most of dissipation of shade.Take a turn for the better: symptom, sign alleviate; X-ray checks that dash area dissipates.Invalid: sings and symptoms does not alleviate; X-ray inspection is not improved or increases the weight of.
5. therapeutic effect treatment is carried out effect assessment, treatment group 30 examples, 16 examples of fully recovering (53.3%), effective 8 examples (26.7%), 5 examples that take a turn for the better (16.7%), invalid 1 example (3.3%), total effective rate 96.7% after 2 courses for the treatment of.Matched group 30 examples, 5 examples of fully recovering (16.7%), effective 10 examples (33.3%), 7 examples that take a turn for the better (23.3%), invalid 8 examples (26.7%), total effective rate 73.3%.Two groups of comparisons, treatment group cure rate, total effective rate are obviously better than matched group, have comparability.P＜0.05。After treatment group patient treatment, have no the abnormal of the aspects such as the blood, urine, stool routine examination and the liver that cause because taking traditional Chinese medicine, renal function, the no abnormal phenomenon of Ecg also occurs without allergic phenomena.Matched group has 1 routine patients with lung cancer to take medicine to occur back burning sensation in latter about 1 hour at every turn, continues approximately 1 hour, and each all spontaneous remissions, disappear after drug withdrawal; There is nausea and vomiting in 4 routine patients, unprocessed symptom spontaneous remission is followed up a case by regular visits to without abnormal.
The specific embodiment
Embodiment mono-: take Herba Dendrobii 23g, Herba Ludisiae Discoloris 10g, Radix Fimbristylis rigidulae 20g, Radix Trichosanthis 17g, Herba Silenes conoideae 25g, Herba Violae japonicae 20g, Indigo Naturalis 2g, Herba Scutellariae indicae 15g, Herba Erodii 7g, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 21g, Radix Melothriae Heterophyllae 35g, Carapax Bellamyae quadratae 10g, above-mentioned Chinese medicine decocting is become to decoction.
Embodiment bis-: take Herba Dendrobii 25g, Herba Ludisiae Discoloris 5g, Radix Fimbristylis rigidulae 25g, Radix Trichosanthis 15g, Herba Silenes conoideae 27g, Herba Violae japonicae 15g, Indigo Naturalis 3g, Herba Scutellariae indicae 10g, Herba Erodii 9g, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 18g, Radix Melothriae Heterophyllae 45g, Carapax Bellamyae quadratae 5g, above-mentioned Chinese medicine decocting is become to decoction.
Embodiment tri-: take Herba Dendrobii 20g, Herba Ludisiae Discoloris 15g, Radix Fimbristylis rigidulae 15g, Radix Trichosanthis 20g, Herba Silenes conoideae 23g, Herba Violae japonicae 25g, Indigo Naturalis 1g, Herba Scutellariae indicae 20g, Herba Erodii 5g, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 24g, Radix Melothriae Heterophyllae 25g, Carapax Bellamyae quadratae 15g, above-mentioned Chinese medicine decocting is become to decoction.
Claims (2)
1. a Chinese medicine composition for treating radiation pneumonia, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Herba Dendrobii 20-25 part, Herba Ludisiae Discoloris 5-15 part, Radix Fimbristylis rigidulae 15-25 part, Radix Trichosanthis 15-20 part, Herba Silenes conoideae 23-27 part, Herba Violae japonicae 15-25 part, Indigo Naturalis 1-3 part, Herba Scutellariae indicae 10-20 part, Herba Erodii 5-9 part, leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f 18-24 part, Radix Melothriae Heterophyllae 25-45 part, Carapax Bellamyae quadratae 5-15 part.
2. according to the Chinese medicine composition of a kind for the treatment of radiation pneumonia described in claim duty, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 23 parts of Herba Dendrobii, 10 parts of Herba Ludisiae Discoloriss, 20 parts of Radix Fimbristylis rigidulaes, 17 parts of Radix Trichosanthis, 25 parts of Herba Silenes conoideaes, 20 parts of Herba Violae japonicaes, 2 parts of Indigo Naturaliss, 15 parts of Herba Scutellariae indicae, 7 parts of Herba Erodiis, 21 parts of leaf Miscanthus sacchariflorus (Maxim) Benth et Hook fs, 35 parts of Radix Melothriae Heterophyllaes, 10 parts of Carapax Bellamyae quadrataes.
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| CN1552413A (en) * | 2003-06-02 | 2004-12-08 | 范永壮 | Internal medicine for treating SARS, AIDS virus, preparing method and use thereof |
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| CN104274706A (en) * | 2014-09-19 | 2015-01-14 | 魏文君 | Traditional Chinese medicine mixture for treating radioactive stomatitis |
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