CN103223059A - Traditional Chinese medicine for treating recurrent oral ulcer - Google Patents

Abstract

.The invention discloses a traditional Chinese medicine for treating the recurrent oral ulcer. The recurrent oral ulcer belongs to the fields of aphthae, aphthous stomatitis and the like in the traditional Chinese medicinal science, and the clinical manifestations of the recurrent oral ulcer mainly comprise skin and mucosal ulcer impairment. Traditional Chinese medicines comprising Souliea vaginata, nervos brake herb, Meadowrue Root and Rhizome, root of Cynoglossumfurcatum Wall., Entireleaf Neoalsomitra, Vietnamese Sophora Root, Natural Indigo, Pyrethrum tatsienense, Euphorbia humifusa Willd, Bigleaf Beautyberry Leaf, catechu, red halloysite, Rhizoma Panacis Majoris, selenitum and all-grass of Climbing Hedyotis are processed in the preparation department of the hospital in which the inventor of the invention works to prepare a decoction. The result of clinic tests shows that the total effective rate of the composition is 96.9% and is obviously higher than that of a contrast group, so the curative effects of the composition are good.

Description

A kind of Chinese medicine composition for the treatment of recurrent oral ulceration

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of recurrent oral ulceration.

Background technology

Recurrent oral ulceration is one of common disease of the department of stomatology, be to locate the ulcer that single or multiple light yellow or canescence such as bean sizes take place mucosa with oral cavity epipharynx, tongue, cheek and palate etc., pain when local pain or stimulation, have the characteristics of frequent outbreak repeatedly, caused great misery to the patient.At present, though medicine kind and method to recurrent oral ulceration are various,, lack specific Therapeutic Method so far because the cause of disease of recurrent oral ulceration be it be unclear that, doctor trained in Western medicine adopts treatments such as Western medicine antiinflammatory, antiviral and iodine glycerol, the undesirable and easy recurrence of curative effect in treatment.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of recurrent oral ulceration.Primary disease belongs to categories such as the traditional Chinese medical science " aphtha ", " erosion of the oral mucosa ", and clinical manifestation is then decreased based on skin and mucosa ulcer.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment recurrent oral ulceration is made by following parts by weight of Chinese traditional medicine: Rhizoma soulieae vaginatae 5-20 part, Herba Pteridis creticae 3-15 part, Radix et Rhizoma Thalictri 10-15 part, divaricate houndstongue root 1-25 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 5-7 part, Radix Vignae yunnanensis 3-6 part, Indigo Naturalis 6-9 part, Flos Pyrethri tatsienensis 3-15 part, Herba Euphorbiae Humifusae 2-25 part, Folium Callicarpae Formosanae 10-15 part, catechu 5-9 part, Halloysitum Rubrum 1-3 part, Rhizoma Panacis Majoris 6-8 part, Selenitum 9-20 part, Herba Hedyotis scandentis 4-7 part.

Preferably, 13 parts of Rhizoma soulieae vaginataes, 9 parts of Herba Pteridis creticaes, 13 parts of Radix et Rhizoma Thalictri, 13 parts of divaricate houndstongue roots, 6 parts of Neoalsomitra integrifoliola (Cogn.) Hucth.s, 5 parts of Radix Vignae yunnanensis, 6 parts of Indigo Naturaliss, 9 parts of Flos Pyrethri tatsienensis, 12 parts of Herba Euphorbiae Humifusaes, 13 parts of Folium Callicarpae Formosanaes, 7 parts in catechu, 2 parts of Halloysitum Rubrums, 7 parts of Rhizoma Panacis Majoris, 14 parts of Selenitum, 5.5 parts of Herba Hedyotis scandentiss.

Preparation method is by traditional preparation method, and decocting is made decoction.

In the side: Rhizoma soulieae vaginatae, Herba Pteridis creticae, Radix et Rhizoma Thalictri pathogenic fire purging dampness, the relieving restlessness that clears away heart-fire, anti-inflammation, the detoxifcation of dispeling the wind; Divaricate houndstongue root, Neoalsomitra integrifoliola (Cogn.) Hucth., Radix Vignae yunnanensis, Indigo Naturalis heat-clearing and toxic substances removing, reducing swelling and alleviating pain, blood cooling and ecchymoses removing, purging liver-fire, convergence pain relieving; The damp eliminating of invigorating blood circulation of Flos Pyrethri tatsienensis, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae, catechu, anti-inflammatory analgetic, the dissipating blood stasis hemostasis, removing toxic substances and promoting subsidence of swelling, life is held back skin ulcer; Halloysitum Rubrum, Rhizoma Panacis Majoris astringing to arrest bleeding, expelling pus and promoting granulation; Selenitum, Herba Hedyotis scandentis nourishing YIN to lower pathogenic fire, the softening the hard mass antiinflammatory.All medicines share with blood circulation promoting and blood stasis dispelling, and the damp eliminating detoxifcation is main, takes into account clearing away heat and cooling blood, can play the inhibition allergy, promote local blood fortune, microcirculation improvement, thus quicken to get rid of toxin and inflammation absorption, be beneficial to the healing of stomatocace.

Clinical data

What 1, all patients of physical data selected between in December, 2003～2007 year December that my institute's department of stomatology goes to a doctor is the no whole body systemic disease of oral ulcer through clinical diagnosis, no allergies, patient's 130 examples of energy partner treatment, wherein male 43 examples, women 87 examples; 10～75 years old age; Be divided into treatment group 65 example and matched group 65 examples at random.Get rid of object: (1) anemia of pregnant woman; (2) take various antibiotic and Aphthasol thing person in the first quarter moon; (3) take immunostimulant or immunosuppressive drug person in the recent period.

2, include standard (1) in and meet diagnostic criteria in the national state-compiled textbook " oral medicine ".The course of disease＞6 month, outbreak repeatedly, outbreak in every month 1～2 time.(2) get rid of other diseases of oral mucosa, and the patient there is not serious whole body illness.(3) patient does not take the medicine of any treatment oral ulcer in 1 month, and this morbidity is preceding without any treatment to going to a doctor.(4) go to a doctor in 3 days in morbidity.

3, criterion of therapeutical effect is with reference to Chinese stomatology meeting " recurrent oral ulceration therapeutic evaluation tentative standard ".Oral ulcer stopped recurrence more than 1 year, was recovery from illness; Total intermittent time prolongs, and total ulcer number reduces, and is produce effects; Total intermittent time prolongs, but total ulcer number do not reduce, or total intermittent time do not have change, but total ulcer number reduces, for effectively; Total intermittent time and total ulcer number average do not have change, for invalid.

4, Therapeutic Method treatment group is taken Chinese medicine composition of the present invention, promptly get Rhizoma soulieae vaginatae 13g, Herba Pteridis creticae 9g, Radix et Rhizoma Thalictri 13g, divaricate houndstongue root 15g, Neoalsomitra integrifoliola (Cogn.) Hucth. 6g, Radix Vignae yunnanensis 5g, Indigo Naturalis 6g, Flos Pyrethri tatsienensis 9g, Herba Euphorbiae Humifusae 12g, Folium Callicarpae Formosanae 13g, catechu 7g, Halloysitum Rubrum 2g, Rhizoma Panacis Majoris 7g, Selenitum 14g, Herba Hedyotis scandentis 5.5g, decocting is made decoction, 1 dose of every day, early, late sub-service; Matched group gives vitamin B2 10mg, and vitamin C 100mg is oral, two groups equal 4 days be a course of treatment, serve on 2 courses of treatment.

5, curative effect relatively sees Table 1 after two groups of therapeutic outcomes treatment two courses of treatment.

Curative effect relatively after table 1 a liang group was treated two courses of treatment

Compare P＜0.05 with matched group

This shows that treatment group cure rate, total effective rate obviously are better than matched group, have comparability.P＜0.05

6, model case patient Liu, the woman, 45 years old, oral cavity and tongue many places ulcer were shown effect 8 months repeatedly, had a strong impact on diet, sleep.Once with antiinflammatory, antiviral and the treatment of multiple stomatocace medicine, unsatisfactory curative effect was in December in 2005 first visit on the 18th.Look into: tonsil, pharyngeal no abnormal, submandibular lymph nodes enlargement, mild tenderness, WBC: neutral 64%, lymphocyte 34%, blood glucose is normal.Treatment to be taking Chinese medicine composition of the present invention, is decocted in water for oral dose 1 dose of every day, and after 3 doses of the logotypes, pain obviously alleviates, and the most of healing of ulcer surface substantially can normal diet, sleep, continues clothes to 9 doses, and the symptom complete obiteration is followed up a case by regular visits to and do not recurred half a year.

The specific embodiment

Embodiment one: take by weighing Rhizoma soulieae vaginatae 13g, Herba Pteridis creticae 9g, Radix et Rhizoma Thalictri 13g, divaricate houndstongue root 15g, Neoalsomitra integrifoliola (Cogn.) Hucth. 6g, Radix Vignae yunnanensis 5g, Indigo Naturalis 6g, Flos Pyrethri tatsienensis 9g, Herba Euphorbiae Humifusae 12g, Folium Callicarpae Formosanae 13g, catechu 7g, Halloysitum Rubrum 2g, Rhizoma Panacis Majoris 7g, Selenitum 14g, Herba Hedyotis scandentis 5.5g, make decoction by traditional preparation method decocting.

Embodiment two: take by weighing Rhizoma soulieae vaginatae 20g, Herba Pteridis creticae 3g, Radix et Rhizoma Thalictri 10g, divaricate houndstongue root 25g, Neoalsomitra integrifoliola (Cogn.) Hucth. 5g, Radix Vignae yunnanensis 6g, Indigo Naturalis 9g, Flos Pyrethri tatsienensis 3g, Herba Euphorbiae Humifusae 25g, Folium Callicarpae Formosanae 10g, catechu 5g, Halloysitum Rubrum 3g, Rhizoma Panacis Majoris 6g, Selenitum 20g, Herba Hedyotis scandentis 4g, make decoction by traditional preparation method decocting.

Embodiment three: take by weighing Rhizoma soulieae vaginatae 5g, Herba Pteridis creticae 15g, Radix et Rhizoma Thalictri 15g, divaricate houndstongue root 7g, Neoalsomitra integrifoliola (Cogn.) Hucth. 7g, Radix Vignae yunnanensis 3g, Indigo Naturalis 6g, Flos Pyrethri tatsienensis 15g, Herba Euphorbiae Humifusae 2g, Folium Callicarpae Formosanae 15g, catechu 9g, Halloysitum Rubrum 1g, Rhizoma Panacis Majoris 8g, Selenitum 9g, Herba Hedyotis scandentis 7g, make decoction by traditional preparation method decocting.

Claims (2)

1. Chinese medicine composition for the treatment of recurrent oral ulceration is characterized in that this Chinese medicine composition made by following parts by weight of Chinese traditional medicine: Rhizoma soulieae vaginatae 5-20 part, Herba Pteridis creticae 3-15 part, Radix et Rhizoma Thalictri 10-15 part, divaricate houndstongue root 1-25 part, Neoalsomitra integrifoliola (Cogn.) Hucth. 5-7 part, Radix Vignae yunnanensis 3-6 part, Indigo Naturalis 6-9 part, Flos Pyrethri tatsienensis 3-15 part, Herba Euphorbiae Humifusae 2-25 part, Folium Callicarpae Formosanae 10-15 part, catechu 5-9 part, Halloysitum Rubrum 1-3 part, Rhizoma Panacis Majoris 6-8 part, Selenitum 9-20 part, Herba Hedyotis scandentis 4-7 part.

2. a kind of Chinese medicine composition for the treatment of recurrent oral ulceration according to claim 1 is characterized in that this Chinese medicine composition made by following parts by weight of Chinese traditional medicine: 13 parts of Rhizoma soulieae vaginataes, 9 parts of Herba Pteridis creticaes, 13 parts of Radix et Rhizoma Thalictri, 13 parts of divaricate houndstongue roots, 6 parts of Neoalsomitra integrifoliola (Cogn.) Hucth.s, 5 parts of Radix Vignae yunnanensis, 6 parts of Indigo Naturaliss, 9 parts of Flos Pyrethri tatsienensis, 12 parts of Herba Euphorbiae Humifusaes, 13 parts of Folium Callicarpae Formosanaes, 7 parts in catechu, 2 parts of Halloysitum Rubrums, 7 parts of Rhizoma Panacis Majoris, 14 parts of Selenitum, 5.5 parts of Herba Hedyotis scandentiss.