CN103211954B

CN103211954B - Chinese medicinal preparation for treating radiation pneumonitis

Info

Publication number: CN103211954B
Application number: CN201310160622.6A
Authority: CN
Inventors: 张勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-04-15
Filing date: 2013-04-15
Publication date: 2014-09-10
Anticipated expiration: 2033-04-15
Also published as: CN103211954A

Abstract

The invention discloses a Chinese medicinal preparation for treating radiation pneumonitis. The radiation pneumonitis belongs to the categories of 'cough' and 'consumptive lung disease' considered by the traditional Chinese medicine, belongs to the evil of toxic heat burns fluid for the irradiation of the radioactive rays and harms the human body vital Qi and Yin blood; and the pathogenesis is heat toxin, Yin deficiency, Qi deficiency, phlegm dampness and blood stasis. Therefore, peristrophe, rhizoma panacis majoris, lignum dalbergiae odoriferae, chicken with yellow feet, adenophora tetraphylla, Ilex cornuta lindl, tricuspid cudrania bark, Chinese pulsatilla root, cacumen biotae, radix tetrastigme, dandelion, gynostemma pentaphyllum, callicarpa bodinieri, argentina anserine, white atractylodes rhizome and licorice are decocted by using water. Clinical experiments in the hospital prove that the total effective rate is 95.3% and the Chinese medicinal preparation is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of radiation pneumonia

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of radiation pneumonia.

Background technology

The major complications of radiation pneumonia after as breast tumor radiotherapies such as pulmonary carcinoma, breast carcinoma, the esophageal carcinoma, cause difficulty to continuing radiotherapy, and as can not be effectively controlled, may cause the generation of chronic fibrosis of lung, further increase the difficulty for the treatment of, bring very large misery to patient, have a strong impact on patient's life quality, even severe one can cause death.Treatment to radiation pneumonia at present, doctor trained in Western medicine often adopts heavy dose of antibiotic to add hormone, is aided with symptomatic drugs and treats, and obtain certain effect, but side effect is larger.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of radiation pneumonia, Chinese medicine thinks that radiation pneumonia is attributed to the category of " cough ", " dyspnea of heat type ", " lung-QI stagnation syndrome ", " consumptive lung disease ", it is outer because of radiation exposure, belongs to the evil consumption of body fluid by heat of pyretic toxicity, damage human righteousness and cloudy blood; Its pathogenesis is pyretic toxicity, the deficiency of YIN, the deficiency of vital energy, phlegm-damp, blood stasis.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treating radiation pneumonia is made up of the Chinese medicine of following weight portion: Herba Peristrophes 10-35 part, Rhizoma Panacis Majoris 5-15 part, Lignum Dalbergiae Odoriferae 1-7 part, Rhizoma disporopsis pernyi 6-20 part, Radix Adenophorae 8-15 part, Radix Ilicis Cornutae 5-10 part, Cortex Cudraniae tricuspidatae 5-15 part, Radix Pulsatillae 7-20 part, Cacumen Platycladi 3-9 part, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 4-25 part, Herba Taraxaci 10-15 part, Herba Gynostemmatis 2-8 part, Folium Callicarpae Formosanae 5-15 part, Radix potentillae anserinae 8-13 part, Rhizoma Atractylodis Macrocephalae 13-20 part, Radix Glycyrrhizae 4-6 part.

Preferably, 22 parts of Herba Peristrophess, 10 parts of Rhizoma Panacis Majoris, 4 parts of Lignum Dalbergiae Odoriferaes, 13 parts of Rhizoma disporopsis pernyis, 11 parts of Radix Adenophoraes, 7 parts of Radix Ilicis Cornutaes, 10 parts of Cortex Cudraniae tricuspidataes, 12 parts of the Radix Pulsatillaes, 6 parts of Cacumen Platycladis, 14 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 13 parts of Herba Taraxacis, 5 parts of Herba Gynostemmatiss, 10 parts of Folium Callicarpae Formosanaes, 11 parts of Radix potentillae anserinae, 17 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Radix Glycyrrhizae.

Preparation method is by traditional preparation method, and decocting is made decoction.

Rhizoma Panacis Majoris, Herba Peristrophes, Lignum Dalbergiae Odoriferae promoting blood circulation and hemostasis in side, tonifying the lung and stopping cough, expelling wind and clearing away heat, removing stasis to stop bleeding, regulating QI to relieve pain; Rhizoma disporopsis pernyi, Radix Adenophorae, Radix Ilicis Cornutae, Cortex Cudraniae tricuspidatae nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst, the QI invigorating of reducing phlegm, invigorating the liver and kidney, fresh breeze heat; The Radix Pulsatillae, Cacumen Platycladi clearing away heat and cooling blood, subduing swelling and detoxicating, hemostasis, preventing phlegm from forming and stopping coughing; Radix Apioris Fortunei (Radix Lespedezae Buergeri), Herba Taraxaci, Herba Gynostemmatis, Folium Callicarpae Formosanae heat-clearing and toxic substances removing, dispelling pathogenic wind and eliminating phlegm, promoting blood circulation and stopping pain, eliminating carbuncle eliminating stagnation, dampness removing is treating stranguria, eliminating inflammation and expelling toxin, astringing to arrest bleeding; Radix potentillae anserinae, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae invigorating spleen and reinforcing stomach, promoting the production of body fluid to quench thirst, vigorate qi and replenish the blood, air making-up and spleen enlivening, dampness diuretic, expelling phlegm for arresting cough, alleviates pain relieving.

Clinical data

1, the selected case of physical data is from radiotherapy patient 86 examples of accepting for medical treatment between in December, 2007～2008, the court year October, wherein pulmonary carcinoma 36 examples, mammary cancer 18 examples, esophageal carcinoma 23 examples, mediastinal tumor 9 examples; Be divided at random treatment group and matched group, wherein treatment group 43 examples, male 25 examples, female's 18 examples, 40～70 years old age, average 58 years old, the course of disease 4～31 days, average 17 days.Matched group 43 examples, wherein male 27 examples, female's 16 examples, course of disease 5-35 days, average 19 days, 45～75 years old age, average 60 years old, two groups of patient's medical history, symptom, sign and x-ray, CT examination all meet the diagnostic criteria of radiation pneumonia: after radiotherapy, in 3 months, clinical symptoms can show as irritable cough, cough up phlegm, tachypnea, uncomfortable in chest, heating etc.; There is diffusivity lamellar shade or clouded glass shadow in chest films showed lung field, like bronchopneumonia, or auscultation of lung audible and dryness or moist sound, two groups of patient's basic conditions, learn and process by statistics, no significant difference.

2, diagnostic criteria is taking nineteen ninety Henan Department of Public Health " common clinical diagnosis basis and the curative effect determinate standard-radiation pneumonia " of promulgating as foundation: (1) is fallen ill and occurred dry cough 6 weeks-March at radiation treatment, out of breath, breathes hard or the symptom such as chest pain; (2) local percussion of acute stage is voiced sound, auscultation audible and rale; (3) x ray examination: radiation position occurs lamellar shade or net bar fibrosis shade with symmetrical pulmonary.

3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, 1 dose of every day, point morning and evening secondary clothes, the control group infection adrenocortical hormones in treating; Two groups equal 10 days is a course for the treatment of.

3, criterion of therapeutical effect recovery from illness: clinical symptoms, sign disappear, it is normal that X-ray film or CT examination are recovered.Take a turn for the better: clinical symptoms, sign substantially disappear or obviously alleviate, and X-ray film or CT examination focus reduce more than 50%.Invalid: clinical symptoms, sign is unchanged or increase the weight of, X-ray film or CT examination are without obvious change.

4, curative effect comparison after three courses for the treatment of of two groups of therapeutic outcomes treatment, treatment group 43 examples, 30 examples of wherein fully recovering (69.8), 11 examples that take a turn for the better (25.6), invalid 2 examples (4.7), total effective rate 95.3%; Matched group 43 examples, 21 examples of wherein fully recovering (48.8), 14 examples that take a turn for the better (32.6), invalid 8 examples (18.6), total effective rate 81.4%; Two groups are compared treatment group cure rate, total effective rate, are obviously better than matched group, have comparability P < 0.05.

Detailed description of the invention

Embodiment mono-: take Herba Peristrophes 22g, Rhizoma Panacis Majoris 10g, Lignum Dalbergiae Odoriferae 4g, Rhizoma disporopsis pernyi 13g, Radix Adenophorae 11g, Radix Ilicis Cornutae 7g, Cortex Cudraniae tricuspidatae 10g, Radix Pulsatillae 12g, Cacumen Platycladi 6g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 14g, Herba Taraxaci 13g, Herba Gynostemmatis 5g, Folium Callicarpae Formosanae 10g, Radix potentillae anserinae 11g, Rhizoma Atractylodis Macrocephalae 17g, Radix Glycyrrhizae 5g, by traditional preparation method, decocting is made decoction.

Embodiment bis-: take Herba Peristrophes 35g, Rhizoma Panacis Majoris 5g, Lignum Dalbergiae Odoriferae 1g, Rhizoma disporopsis pernyi 20g, Radix Adenophorae 8g, Radix Ilicis Cornutae 5g, Cortex Cudraniae tricuspidatae 15g, Radix Pulsatillae 7g, Cacumen Platycladi 3g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 25g, Herba Taraxaci 10g, Herba Gynostemmatis 2g, Folium Callicarpae Formosanae 15g, Radix potentillae anserinae 8g, Rhizoma Atractylodis Macrocephalae 13g, Radix Glycyrrhizae 4g, by traditional preparation method, decocting is made decoction.

Embodiment tri-: take Herba Peristrophes 10g, Rhizoma Panacis Majoris 15g, Lignum Dalbergiae Odoriferae 7g, Rhizoma disporopsis pernyi 6g, Radix Adenophorae 15g, Radix Ilicis Cornutae 10g, Cortex Cudraniae tricuspidatae 5g, Radix Pulsatillae 20g, Cacumen Platycladi 9g, Radix Apioris Fortunei (Radix Lespedezae Buergeri) 4g, Herba Taraxaci 15g, Herba Gynostemmatis 8g, Folium Callicarpae Formosanae 5g, Radix potentillae anserinae 13g, Rhizoma Atractylodis Macrocephalae 20g, Radix Glycyrrhizae 6g, by traditional preparation method, decocting is made decoction.

Claims

1. the Chinese medicine preparation of a treating radiation pneumonia, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: 10-35 parts of Herba Peristrophess, 5-15 parts of Rhizoma Panacis Majoris, 1-7 parts of Lignum Dalbergiae Odoriferaes, 6-20 parts of Rhizoma disporopsis pernyis, 8-15 parts of Radix Adenophoraes, 5-10 parts of Radix Ilicis Cornutaes, 5-15 parts of Cortex Cudraniae tricuspidataes, 7-20 parts of the Radix Pulsatillaes, 3-9 parts of Cacumen Platycladis, 4-25 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 10-15 parts of Herba Taraxacis, 2-8 parts of Herba Gynostemmatiss, 5-15 parts of Folium Callicarpae Formosanaes, 8-13 parts of Radix potentillae anserinae, 13-20 parts of the Rhizoma Atractylodis Macrocephalaes, 4-6 parts, Radix Glycyrrhizae, by traditional preparation method, decocting is made decoction.

2. the Chinese medicine preparation of a kind for the treatment of radiation pneumonia according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: 22 parts of Herba Peristrophess, 10 parts of Rhizoma Panacis Majoris, 4 parts of Lignum Dalbergiae Odoriferaes, 13 parts of Rhizoma disporopsis pernyis, 11 parts of Radix Adenophoraes, 7 parts of Radix Ilicis Cornutaes, 10 parts of Cortex Cudraniae tricuspidataes, 12 parts of the Radix Pulsatillaes, 6 parts of Cacumen Platycladis, 14 parts of Radix Apioris Fortunei (Radix Lespedezae Buergeri)s, 13 parts of Herba Taraxacis, 5 parts of Herba Gynostemmatiss, 10 parts of Folium Callicarpae Formosanaes, 11 parts of Radix potentillae anserinae, 17 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts, Radix Glycyrrhizae.