CN107029210A - Wood frog's fallopian tube antibacterial peptide oral spray - Google Patents
Wood frog's fallopian tube antibacterial peptide oral spray Download PDFInfo
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- CN107029210A CN107029210A CN201710267898.2A CN201710267898A CN107029210A CN 107029210 A CN107029210 A CN 107029210A CN 201710267898 A CN201710267898 A CN 201710267898A CN 107029210 A CN107029210 A CN 107029210A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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Abstract
The present invention relates to a kind of bactericide, i.e. wood frog's fallopian tube antibacterial peptide oral spray.It is made up of the raw material of following percentage by weight：Wood frog antibiotic peptides stoste 40%, Flos Lonicerae extractive solution 0.2%, licorice extract 0.5%, Momordica grosvenori extract solution 0.5%, steviol glycoside 0.01%, honey 2.5%, nipagin ethylester 0.03%, vitamin B3 0.15%, sucrose essence 0.1%, lychee flavor 0.2%, Tea Polyphenols 0.05%, methyl hydroxybenzoate 0.03%, xylitol 20%, menthol 0.08%, water melon frost 0.6%, purified water 35.05%.Wood frog antibiotic peptides stoste coordinates Flos Lonicerae extractive solution, licorice extract, Momordica grosvenori extract solution to play the effect of sterilization is clearing heat and detoxicating altogether, not only has inhibitory action to oral cavity and pharyngeal bacterium but also notable to treatment pharyngitis, virus flu effect.
Description
Technical field
The present invention relates to a kind of bactericide, i.e. wood frog's fallopian tube antibacterial peptide oral spray.Trade name：The pretty companion oral cavity spray of wood frog's fallopian tube antibacterial peptide
Mist agent.
Background technology
In the prior art, Wood frog antibiotic peptides stoste has a bactericidal action, such as Chinese invention patent CN1216768A,
CN100333789C is recorded.The antibacterial peptide extracted from tree frog skin（Wood frog antibiotic peptides）There is good sterilization to pseudomonas aeruginosa
Bacteriostasis, and also have necessarily to other gram-positive bacterias, Gram-negative bacteria and fungi and clinical multi-drug resistant bacteria
Bactericidal effect.Chinese invention patent CN103073628B discloses the preparation method of Wood frog antibiotic peptides stoste.Middle promulgated by the State Council
Bright patent CN1583166A discloses " Chinese forest frog bactericidal peptide spray agent and preparation method thereof ", its composition Wood frog antibiotic peptides be 5%~
40%；Hydroxyl esters preservative is 0.2%~3%；Polyethylene glycol 400 or propane diols are 1%~5%；Sodium chloride is 0.45%
~0.75%；Surplus is water.Its prescription is single, and effect is general.
The content of the invention
The purpose of the present invention is to provide a kind of wood frog's fallopian tube antibacterial peptide oral spray for above-mentioned not enough, with Wood frog antibiotic peptides
Stoste is primary raw material, is equipped with Chinese medicine, improves bactericidal effect, mouthfeel effect, has auxiliary to control treatment pharyngitis, virus flu
Treat.
The present invention technical solution be：Wood frog's fallopian tube antibacterial peptide oral spray, it is characterised in that it is by following weight hundred
The raw material of ratio is divided to be made：Wood frog antibiotic peptides stoste 40%, Flos Lonicerae extractive solution 0.2%, licorice extract 0.5%, Momordica grosvenori is carried
Take liquid 0.5%, steviol glycoside 0.01%, honey 2.5%, nipagin ethylester 0.03%, vitamin B3 0.15%, sucrose essence
0.1%, lychee flavor 0.2%, Tea Polyphenols 0.05%, methyl hydroxybenzoate 0.03%, xylitol 20%, menthol 0.08%, water melon frost
0.6%, purified water 35.05%.
It is used as treatment pharyngitis ancillary drug.
It is used as treatment virus flu ancillary drug.
Wood frog antibiotic peptides stoste preparation method：Wood frog does → added 6% ultrasonic extraction with acetic acid extraction, 30 minutes → stoste and is concentrated into substance
Long-pending 1/5 → antibacterial peptide concentrate → filtering is produced.Method not limited to this.Wood frog's fallopian tube is wood frog alias.
Licorice extract preparation method：Licorice medicinal materials are selected to be prepared into radix glycyrrhizae through washing, moistening, cut and only expect, plus 8 times of amount water are extracted
Three times 1 hour every time, filtration merged extract solution, and extract solution is concentrated into relative density 1.2（80℃）It is stored in freezer standby.
Radix glycyrrhizae（Scientific name：Glycyrrhiza uralensis Fisch）Alias：State is old, Herba Hedyotis cantonensis, Glycyrrhiza Uralensis, sweet tea root
Son.Pulse family, Glycyrrhiza perennial herb, root are sturdy with root-like stock, are a kind of help Chinese herbal medicines.Swollen for ulcer sores, throat
Pain etc..Radix glycyrrhizae also has anti-inflammatory, and anti-allergic effects can protect the throat and tunica mucosa tracheae of inflammation.Extract of licorice root and glycyrrhizic acid are to certain
A little poisonous substances have the detoxication of similar glucuronic acid.
Flos Lonicerae extractive solution preparation method：Select traditional Chinese medicine honeysuckle, plus 8 times of amount water ultrasonic extractions are secondary, 1.5 is small for the first time
When, second 1 hour, filtration merged extract solution, and extract solution is concentrated into relative density 1.2（80℃）It is stored in freezer standby.
Honeysuckle, also known as honeysuckle（Scientific name：Lonicera japonica）.Medicinal material honeysuckle is Caprifoliaceae woodbine
Honeysuckle and congener dry flower or with the flower just opened.Effect is clearing heat and detoxicating.Antibacterial and the effect for strengthening immunologic function：Examination
Test and show honeysuckle to typhoid bacillus, paratyphosum Bacterium, Escherichia coli, proteus, Pseudomonas aeruginosa, Bordetella pertussis, cholera
Vibrios, staphylococcus, streptococcus, Diplococcus pneumopniae, meningococcus etc. have inhibitory action.Suppress drug-fast bacteria protein to close
Into：Breathing of the Honegsukle flower P.E to staphylococcus aureus resistance plant has notable stimulation, is used for antibody-resistant bacterium and leads
The Medicine and Surgery inflammation of cause, such as respiratory tract infection for the treatment of pulmonary tuberculosis complicated, pneumonia, acute bacillary dysentery, diarrhoea.Also have for dropping
Low bottleneck throat bacterial bearing rate.
Momordica grosvenori extracts liquid and preparation method thereof：Medicinal material after arhat is selected to smash to pieces, plus 8 times of amount water ultrasonic extractions are secondary, for the first time
1.5 hours, second 1 hour, filtration merged extract solution, and extract solution is concentrated into relative density 1.2（80℃）It is stored in freezer standby.
Momordica grosvenori, the fruit of the perennial liana of Curcurbitaceae.Alias LAHANGUO, balloonvine heartseed herb, Semen Momordicae, it is invaluable,
Arhat table, naked tortoise bar.Its leaf is heart-shaped, dioecism, summer-flowering, seed in autumn.Effect is relieving cough and reducing sputum.Modern medicine is demonstrate,proved
Bright, Momordica grosvenori has significant curative effect to diseases such as bronchitis, hypertension, still plays prevention and treatment of coronary heart disease, vascular sclerosis, obesity
Effect.It is of high nutritive value, the effects such as having clearing away summerheat, preventing phlegm from forming and stopping coughing, cool blood easypro bone, clearing lung-heat ease constipation and promote the production of body fluid to quench thirst；It can control
The diseases such as acute and chronic tracheitis, sphagitis, bronchial astehma, pertussis, stomach energy, constipation, acute tonsillitis, diabetic is also
Preferably take.
Wood frog's fallopian tube antibacterial peptide oral spray preparation method：STEVIA REBAUDIANA, honey, licorice extract, nipagin ethylester, vitamin
B3, sucrose essence, lychee flavor, Flos Lonicerae extractive solution, Tea Polyphenols, methyl hydroxybenzoate, xylitol, menthol, water melon frost, arhat
Fruit extract solution, purified water are mixed, and are prepared with Wood frog antibiotic peptides stoste, filling spiral cover, and packaging is remembered to produce.
Wood frog's fallopian tube antibacterial peptide oral spray oral efficacy：This product is to staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans
（Fungi）, Escherichia coli have stronger bacteriostasis.With it is clearing heat and detoxicating the effect of, not only have to oral cavity and pharyngeal bacterium
Inhibitory action and to treatment pharyngitis effect it is notable；Also have simultaneously and repair oral mucosa and analgesic activity；To prevention and treatment disease
Toxicity flu also has significant curative effect.
The scope of application：For the antibacterial of oral surfaces, cleaning and nursing.To pharyngitis, toxicity flu auxiliary treatment.
Application method：This product is taken to be sprayed directly on to the antibacterial place of oral surfaces.Using effect is more preferably after brushing teeth or gargling.
It is an advantage of the invention that：1st, through experiment, the application formula fungistatic effect is substantially better than Wood frog antibiotic peptides stoste.2nd, woods
Frog antibacterial peptide stoste coordinates Flos Lonicerae extractive solution, licorice extract, Momordica grosvenori extract solution to play the effect of sterilization is clearing heat and detoxicating altogether, no
Only there is inhibitory action to oral cavity and pharyngeal bacterium and notable to treatment pharyngitis effect；Also have simultaneously and repair oral mucosa and town
Pain is acted on；Also there is significant curative effect to prevention and treatment virus flu.3rd, this product is to staphylococcus aureus, Pseudomonas aeruginosa, white
Color candida albicans（Fungi）, Escherichia coli have stronger bacteriostasis.
Embodiments of the present invention are described in further detail below in conjunction with embodiment.
Embodiment
Embodiment 1
Wood frog's fallopian tube antibacterial peptide oral spray, is made up of the raw material of following percentage by weight：Wood frog antibiotic peptides stoste 40%, honeysuckle
Extract solution 0.2%, licorice extract 0.5%, Momordica grosvenori extract solution 0.5%, steviol glycoside 0.01%, honey 2.5%, Ni Bo
Golden second fat 0.03%, vitamin B3 0.15%, sucrose essence 0.1%, lychee flavor 0.2%, Tea Polyphenols 0.05%, methyl hydroxybenzoate
0.03%, xylitol 20%, menthol 0.08%, water melon frost 0.6%, purified water 35.05%.
Experimental example 1
The pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide
1st, raw material：
The steviol glycoside 0.01% of Wood frog antibiotic peptides stoste 40%
The licorice extract 0.5% of honey 2.5%
The vitamin B3 0.15% of nipagin ethylester 0.03%
The lychee flavor 0.2% of sucrose essence 0.1%
The Tea Polyphenols 0.05% of Flos Lonicerae extractive solution 0.2%
The xylitol 20% of methyl hydroxybenzoate 0.03%
The water melon frost 0.6% of menthol 0.08%
The purified water 35.05% of Momordica grosvenori extract solution 0.5%.
2nd, inhibition zone test
Experiment below is the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide configured using embodiment 1.
（1）Strain
Pseudomonas aeruginosa Pseudomonas aeruginosa ATCC 27853.
ETEC Escherichia coli ATCC 25922.
Staphylococcus aureus Staphylocouus aureus ATCC 25923.
The pseudomonas aeruginosa of clinical multi-drug resistant（Main resistance title Piperacillin, Ofloxacin, CTX,
Radonil, third generation cephalosporin, piperazine ketone）.
The staphylococcus aureus of clinical multi-drug resistant（Main resistance title penicillin, erythromycin, Ofloxacin, first
Oxygen XiLin）.
（2）Method
By above-mentioned each Spawn incubation to exponential phase, 10 are diluted with hydroponics base5—106CFU/ml, is dipped with sterile cotton
Dilution bacterium solution is uniformly applied on the solid medium in sterilized petri dishes.By sterile Oxford cup（10×7.6×6mm）It is placed in plate
In, four Oxford cups are put in each plate, center Oxford cup is negative control, and surrounding three puts the pretty companion oral cavity spray of wood frog's fallopian tube antibacterial peptide
It is 100 μ l that addition amount of medicament is put in mist agent, each Oxford cup, is covered after potlery tile lid, puts 37 DEG C and cultivates 16-24 hours, uses vernier
Slide calliper rule amount antibacterial circle diameter, each experiment is repeated 3-5 times.
By above-mentioned each Spawn incubation to exponential phase, 10 are diluted with hydroponics base5—106CFU/ml, is dipped in sterile cotton
Dilution bacterium solution is taken uniformly to be applied on the solid medium in sterilized petri dishes.By sterile Oxford cup（10×7.6×6mm）It is placed in plate
In, four Oxford cups are put in each plate, center Oxford cup is negative control, and surrounding three puts Wood frog antibiotic peptides stoste, each
It is 100 μ l that addition amount of medicament is put in Oxford cup, is covered after potlery tile lid, puts 37 DEG C and cultivates 16-24 hours, is pressed down with vernier calliper dipstick metering
Bacterium loop diameter, each experiment is repeated 3-5 times.
（3）As a result
Note：Inhibition zone standard --- there is bacteriostasis more than 8mm；Less than 8mm without bacteriostasis.The application formula fungistatic effect is bright
It is aobvious to be better than Wood frog antibiotic peptides stoste.
Experimental example 2
Stability test：Embodiment 1 is formulated.
The present invention is sequentially placed 3 months, 2 months, 1 month at room temperature, 37 DEG C, 50 DEG C respectively, above-mentioned side is used weekly
Method does bacteriostatic test, and strain is the pseudomonas aeruginosa of clinical multi-drug resistant.
Conclusion is：Prove that patented product of the present invention has stable bacteria resistance function by accelerated test.
Experimental example 3
Clinical trial
Experiment proves that the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide has therapeutic action to treatment pharyngitis.
1st, without Wood frog antibiotic peptides stoste, formula：
Steviol glycoside 0.01%
The licorice extract 0.5% of honey 2.5%
The vitamin B3 0.15% of nipagin ethylester 0.03%
The lychee flavor 0.2% of sucrose essence 0.1%
The Tea Polyphenols 0.05% of Flos Lonicerae extractive solution 0.2%
The xylitol 20% of methyl hydroxybenzoate 0.03%
The water melon frost 0.6% of menthol 0.08%
The purified water 75.05% of Momordica grosvenori extract solution 0.5%.
| Pharyngitis patient clinical case（People） | Effectively | It is effective | It is invalid |
| 50 | 28 | 22 | 0 |
Clinical effectiveness：The pretty companion oral cavity spray of wood frog's fallopian tube antibacterial peptide being made up of Flos Lonicerae extractive solution, licorice extract, Momordica grosvenori extract solution
Mist agent has therapeutic action to pharyngitis.
2nd, Wood frog antibiotic peptides stoste is added：
Wood frog antibiotic peptides stoste 40%, steviol glycoside 0.01%, honey 2.5%, licorice extract 0.5%, nipagin ethylester
0.03%, vitamin B3 0.15%, sucrose essence 0.1%, lychee flavor 0.2%, Flos Lonicerae extractive solution 0.2%, Tea Polyphenols
0.05%, methyl hydroxybenzoate 0.03%, xylitol 20%, menthol 0.08%, water melon frost 0.6%, Momordica grosvenori extract solution 0.5%
, purified water 35.05%.
The people of pharyngitis patient clinical case 50：Effective 14 people, effective 36 people, invalid 0 people.
Clinical effectiveness：The pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide after addition Wood frog antibiotic peptides stoste more has to treatment pharyngitis
Effect.
Experimental example 4
Clinical trial
Experiment proves that the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide has therapeutic action to treatment virus flu.
Found while clinic proves that the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide is effective to treatment pharyngitis, wood frog's fallopian tube antibacterial peptide
Pretty companion's oral spray also has good curative effect to treatment virus flu.
| Toxicity cold patients' clinical case（People） | Effectively | It is effective | It is invalid |
| 52 | 20 | 32 | 0 |
Clinical effectiveness：The pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide also has significant curative effect to prevention and treatment toxicity flu.
Summarize：Wood frog antibiotic peptides stoste coordinates Flos Lonicerae extractive solution, licorice extract, Momordica grosvenori extract solution not only to oral cavity
And pharyngeal bacterium has inhibitory action and notable to treatment pharyngitis effect；Also have simultaneously and repair oral mucosa and analgesic activity；
Also there is significant curative effect to prevention and treatment virus flu.
It is described above, simply the embodiment of the present invention, the substantive content structure of various illustrations not to the present invention
Into limitation.
Claims (3)
1. wood frog's fallopian tube antibacterial peptide oral spray, it is characterised in that it is made up of the raw material of following percentage by weight：Wood frog antibiotic peptides
Stoste 40%, Flos Lonicerae extractive solution 0.2%, licorice extract 0.5%, Momordica grosvenori extract solution 0.5%, steviol glycoside 0.01%,
Honey 2.5%, nipagin ethylester 0.03%, vitamin B3 0.15%, sucrose essence 0.1%, lychee flavor 0.2%, Tea Polyphenols
0.05%, methyl hydroxybenzoate 0.03%, xylitol 20%, menthol 0.08%, water melon frost 0.6%, purified water 35.05%.
2. the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide as claimed in claim 1, it is characterised in that be used as treatment pharyngitis adjuvant
Thing.
3. the pretty companion's oral spray of wood frog's fallopian tube antibacterial peptide as claimed in claim 1, it is characterised in that be used as treatment virus flu
Ancillary drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710267898.2A CN107029210A (en) | 2017-04-22 | 2017-04-22 | Wood frog's fallopian tube antibacterial peptide oral spray |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710267898.2A CN107029210A (en) | 2017-04-22 | 2017-04-22 | Wood frog's fallopian tube antibacterial peptide oral spray |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107029210A true CN107029210A (en) | 2017-08-11 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710267898.2A Pending CN107029210A (en) | 2017-04-22 | 2017-04-22 | Wood frog's fallopian tube antibacterial peptide oral spray |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434438A (en) * | 2018-06-22 | 2018-08-24 | 安徽科技学院 | Purposes and pharmaceutical composition of the antibacterial peptide in the drug for preparing treatment helicobacter pylori disease |
| CN111358747A (en) * | 2020-04-30 | 2020-07-03 | 云南风联科技有限公司 | Plant litchi flavored oral cavity atomized liquid and preparation method thereof |
| CN113713081A (en) * | 2021-10-11 | 2021-11-30 | 通化康元生物科技有限公司 | Application of wood frog antibacterial peptide in preparation of helicobacter pylori resistant medicine |
| CN116077399A (en) * | 2023-03-28 | 2023-05-09 | 江苏晨牌邦德药业有限公司 | Compound chlorhexidine gargle and processing technology |
| CN117158444A (en) * | 2023-09-05 | 2023-12-05 | 通化康元生物科技有限公司 | A wood frog antibacterial peptide preparation, its preparation method and application in external protection product and anti-influenza virus medicine |
| CN117256772A (en) * | 2023-10-10 | 2023-12-22 | 通化康元生物科技有限公司 | Preservation method of oviductus ranae |
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| CN1327854A (en) * | 2000-06-08 | 2001-12-26 | 上海高科生物工程有限公司 | Composite lysostaphin enzyme spray for oral cavity and its preparing process |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108434438A (en) * | 2018-06-22 | 2018-08-24 | 安徽科技学院 | Purposes and pharmaceutical composition of the antibacterial peptide in the drug for preparing treatment helicobacter pylori disease |
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| CN111358747A (en) * | 2020-04-30 | 2020-07-03 | 云南风联科技有限公司 | Plant litchi flavored oral cavity atomized liquid and preparation method thereof |
| CN113713081A (en) * | 2021-10-11 | 2021-11-30 | 通化康元生物科技有限公司 | Application of wood frog antibacterial peptide in preparation of helicobacter pylori resistant medicine |
| CN116077399A (en) * | 2023-03-28 | 2023-05-09 | 江苏晨牌邦德药业有限公司 | Compound chlorhexidine gargle and processing technology |
| CN117158444A (en) * | 2023-09-05 | 2023-12-05 | 通化康元生物科技有限公司 | A wood frog antibacterial peptide preparation, its preparation method and application in external protection product and anti-influenza virus medicine |
| CN117158444B (en) * | 2023-09-05 | 2024-02-27 | 通化康元生物科技有限公司 | A wood frog antibacterial peptide preparation, its preparation method and application in external protection product and anti-influenza virus medicine |
| CN117256772A (en) * | 2023-10-10 | 2023-12-22 | 通化康元生物科技有限公司 | Preservation method of oviductus ranae |
| CN117256772B (en) * | 2023-10-10 | 2024-02-20 | 通化康元生物科技有限公司 | Preservation method of oviductus ranae |
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Application publication date: 20170811 |