CN110638891A

CN110638891A - Cough-relieving oral liquid

Info

Publication number: CN110638891A
Application number: CN201911077845.XA
Authority: CN
Inventors: 杨慧卿; 端木艳荣; 史少静; 刘艳玲
Original assignee: SHAANXI BOSEN BIOLOGICAL PHARMACEUTICAL GROUP CO Ltd
Current assignee: SHAANXI BOSEN BIOLOGICAL PHARMACEUTICAL GROUP CO Ltd
Priority date: 2019-11-06
Filing date: 2019-11-06
Publication date: 2020-01-03

Abstract

The invention discloses an antitussive oral liquid which is prepared from the following raw materials in parts by mass: 20-35 parts of kumquat, 15-30 parts of loquat, 6-12 parts of honeysuckle and 6-12 parts of chrysanthemum; mixing the kumquats and the loquats with water in a colloid mill, grinding and filtering to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; mixing the extractive solution of Fortunella margarita and Eriobotrya japonica with sweetener and antiseptic, and sterilizing. The cumquat and the loquat in the raw materials are purely natural and medicinal and edible raw materials without toxic and side effects, are sweet and warm in nature, relieve cough and reduce sputum, and have the effects of helping produce saliva and slake thirst, and relieving cough and moistening lung by assisting the loquat in slaking thirst and descending qi; meanwhile, honeysuckle flower clears away heat and toxic materials, and chrysanthemum flower dispels wind and clears away heat; pharmacodynamic experiments prove that the traditional Chinese medicine composition has the advantages of small side effect, quick response and obvious curative effect, and simultaneously has the treatment effects of invigorating stomach and spleen, promoting the production of body fluid to quench thirst, relieving cough and moistening lung.

Description

Cough-relieving oral liquid

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to an antitussive oral liquid.

Background

In recent years, the incidence of cough and asthma increases year by year with the change of environment, and the cough and asthma are both fierce due to atmospheric pollution, haze, smoking or smoking with hands, excessive exercise, obesity, indoor and outdoor allergens and the like. Cough is one of the most common symptoms of respiratory disease. Cough is a protective defense function of the human body. By coughing, it is possible to discharge secretions of the respiratory tract or foreign bodies invading the trachea. Most of the existing cough and asthma relieving medicines on the market achieve the cough relieving effect by inhibiting the central nervous system of people, obviously, the inhibition of the central nervous system of people brings inconvenience to daily life of people, the side effects of the cough and asthma relieving medicines for inhibiting the central nervous system are frequent, and most of patients have the side effects of sleepiness, weakness, lassitude and the like, so that the lung moistening and cough relieving oral liquid is very necessary to be invented.

Disclosure of Invention

The invention aims to provide the cough-relieving oral solution which has the advantages of small side effect, quick response and obvious curative effect.

The invention is realized by the following technical scheme:

the invention provides an antitussive oral liquid which is prepared from the following raw materials in parts by mass: 20-35 parts of kumquat, 15-30 parts of loquat, 6-12 parts of honeysuckle and 6-12 parts of chrysanthemum;

mixing the kumquats, the loquats and water in a colloid mill, grinding and filtering to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; mixing the extractive solution of Fortunella margarita and Eriobotrya japonica, flos Lonicerae and flos Chrysanthemi extract, sweetening agent and antiseptic, sterilizing, and making into cough-relieving oral liquid.

Further, the raw materials comprise, by mass, 15-30 parts of amur lilac seed, 6-12 parts of rhizoma pinellinae praeparata, 6-12 parts of liquorice, 5-10 parts of lily, 3-5 parts of tangerine and 3-5 parts of mint.

Further, after the amur lilac seed and the rhizoma pinellinae praeparata, the liquorice, the lily and the kumquat and the mint are respectively combined, ethanol is used for reflux extraction, filtration and concentration to prepare an amur lilac seed extract, a liquorice and lily extract and a kumquat and mint extract;

mixing rhizoma Pinelliae Preparata extract, Glycyrrhrizae radix Bulbus Lilii extract, herba Menthae extract, fructus Fortunellae margaritae extract, flos Lonicerae flos Chrysanthemi extract, sweetening agent, and antiseptic, sterilizing, and making into oral liquid.

Further, the sweetener is one or two of honey and white granulated sugar.

Further, the preservative is one or two of sodium citrate and sodium benzoate.

Further, the cumquat and loquat extracting solution is prepared by adding 6 times of purified water into cumquat and loquat, fully mixing by a colloid mill, grinding into homogenate, mixing and stirring for 1-3 h, and filtering.

Further, the preparation of the extract of the pinellia ternata thunb comprises the following steps: adding 10 times of 75% ethanol into the amur lilac fruit and the rhizoma pinellinae praeparata, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain the extract of rhizoma Pinelliae Preparata.

Further, the preparation of the licorice lily extract comprises the following steps: adding 10 times of 75% ethanol into the liquorice and the lily, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain Glycyrrhrizae radix and Bulbus Lilii extract.

Further, the preparation of the green orange mint extract comprises the following steps: adding 10 times of 75% ethanol into the green oranges and the mint, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain herba Menthae extract.

Further, mixing rhizoma Pinelliae Preparata extract, Glycyrrhrizae radix Bulbus Lilii extract, herba Menthae extract, fructus Fortunellae margaritae extract, flos Lonicerae flos Chrysanthemi extract, sweetener, and antiseptic, and pasteurizing to obtain oral liquid.

Compared with the prior art, the invention has the following beneficial technical effects:

the invention discloses an antitussive oral liquid which is prepared from the following raw materials in parts by mass: 20-35 parts of kumquat, 15-30 parts of loquat, 6-12 parts of honeysuckle and 6-12 parts of chrysanthemum; fully grinding the kumquats, the loquats and water in a colloid mill, uniformly mixing, and filtering to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; mixing the extractive solution of Fortunella margarita and Eriobotrya japonica with sweetener and antiseptic, and sterilizing. The invention is prepared from pure natural raw materials, and contains various traditional Chinese medicine components beneficial to human body; the cumquat and the loquat in the raw materials are purely natural and medicinal and edible raw materials without toxic and side effects, wherein the cumquat is sweet and warm in property, can regulate qi, relieve depression, relieve cough and reduce phlegm, is supplemented with the loquat to quench thirst and lower qi, promote lung qi, stop vomiting and reverse, remove upper-jiao heat and moisten five internal organs, and has the effects of promoting the production of body fluid to quench thirst, relieving cough and moistening lung; meanwhile, the honeysuckle contains the pharmacological active ingredients such as chlorogenic acid and luteolin glycoside, can clear away heat and toxic materials and is mainly used for treating epidemic febrile disease fever, heat toxin and bloody dysentery, carbuncle, cellulitis and furunculosis; the chrysanthemum can dispel wind and clear heat, calm liver and improve vision; pharmacodynamic experiments prove that the traditional Chinese medicine composition has the advantages of small side effect, quick response and obvious curative effect, and simultaneously has the health-care effects of invigorating stomach and spleen, promoting the production of body fluid to quench thirst, relieving cough and moistening lung.

Detailed Description

The present invention will now be described in further detail with reference to the following examples, which are intended to be illustrative, but not limiting, of the invention. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. Any non-essential addition and replacement made by the technical characteristics of the technical scheme of the invention by a person skilled in the art belong to the protection scope of the invention.

Further, the amur lilac seed and rhizoma pinellinae praeparata, the liquorice, the lily, the tangerine and the mint are respectively subjected to ethanol reflux extraction, filtration and concentration to prepare a amur lilac seed and rhizoma pinellinae praeparata extract, a liquorice and lily extract and a tangerine and mint extract;

Further, the sweetener is one or two of honey and white granulated sugar.

Further, the preservative is one or two of sodium citrate and sodium benzoate.

Further, mixing rhizoma Pinelliae Preparata extract, Glycyrrhrizae radix Bulbus Lilii extract, herba Menthae extract, fructus Fortunellae margaritae extract, flos Lonicerae flos Chrysanthemi extract, sweetener, and antiseptic, and pasteurizing to obtain oral liquid. Wherein the mass ratio of the cumquat loquat extract, the honeysuckle flower and chrysanthemum extract, the amur lilium extract, the liquorice root and lily extract to the kumquat and mint extract is 1:1:1: 1.

The kumquat in the raw materials of the invention is sweet and warm in nature, and can regulate qi, relieve depression and reduce phlegm; the cumquat can also prevent pigmentation, enhance skin luster and elasticity, slow aging and avoid skin relaxation and wrinkles; in addition, the cumquat contains various vitamins and has certain effects of maintaining cardiovascular functions and preventing diseases such as angiosclerosis, hypertension and the like. Loquat has the effects of quenching thirst, descending qi, benefiting lung qi, stopping vomiting, relieving upper-jiao heat, moistening five internal organs and the like.

The kumquat and the loquat in the raw materials are matched with other raw materials, so that the traditional Chinese medicine composition has obvious effects of promoting the production of body fluid to quench thirst, relieving cough and moistening lung. Among them, jin Yin Hua clears away heat and toxic material and is indicated for warm disease fever, heat toxin bloody dysentery, carbuncle, deep-rooted carbuncle and furuncle. Modern researches prove that the honeysuckle contains the pharmacological active ingredients such as chlorogenic acid and luteolin glycoside, and has an inhibiting effect on a plurality of pathogenic bacteria such as hemolytic streptococcus and staphylococcus aureus and pathogenic viruses causing upper respiratory tract infection. Chrysanthemum has the functions of dispelling wind and clearing heat, calming liver and improving eyesight, and clearing heat and removing toxicity, and can be used for treating wind-heat type common cold or warm disease, fever, slight aversion to wind-cold, headache, liver yang hyperactivity, headache and vertigo, conjunctival congestion and swelling and pain caused by wind-heat attack or liver fire flaming, and dim eyesight and other symptoms. The raw materials of the invention are purely natural and can be used as both medicine and food, and the invention has the health care efficacies of invigorating stomach and spleen, promoting the production of body fluid to quench thirst, relieving cough and moistening lung.

Example 1

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 20 parts of kumquat, 15 parts of loquat, 6 parts of honeysuckle and 6 parts of chrysanthemum;

fully grinding the kumquats, the loquats and the purified water in a colloid mill, mixing and filtering to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; mixing the extractive solution of Fortunella margarita and Eriobotrya japonica, flos Lonicerae and flos Chrysanthemi extract, sweetening agent and antiseptic, sterilizing, and making into cough-relieving oral liquid. The method comprises the following specific steps:

1) adding 6 times of purified water into Fortunella margarita (lour.) Swingle and Eriobotrya japonica, fully grinding in a colloid mill to homogenate, mixing and stirring for 1h, and filtering to obtain filtrate;

2) adding 10 times of 75% ethanol into flos Lonicerae and flos Chrysanthemi, reflux extracting for 1.5 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to a concentration of 1.1g/mL to obtain flos Lonicerae flos Chrysanthemi extract.

3) Mixing the cumquat and loquat extract and the honeysuckle and chrysanthemum extract according to the mass ratio of 1:1, adding honey and sodium citrate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 1.

Example 2

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 30 parts of kumquat, 25 parts of loquat, 9 parts of honeysuckle and 9 parts of chrysanthemum;

1) adding 6 times of purified water into Fortunella margarita (lour.) Swingle and Eriobotrya japonica, fully grinding in a colloid mill to homogenate, mixing and stirring for 2h, and filtering to obtain filtrate;

2) adding 10 times of 75% ethanol into flos Lonicerae and flos Chrysanthemi, reflux extracting for 2 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1.5 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to a concentration of 1.1g/mL to obtain flos Lonicerae flos Chrysanthemi extract.

3) Mixing the cumquat and loquat extract and the honeysuckle extract according to the mass ratio of 1:1, adding honey, white granulated sugar and sodium benzoate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 2.

Example 3

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 35 parts of kumquat, 30 parts of loquat, 12 parts of honeysuckle and 12 parts of chrysanthemum;

1) adding 6 times of purified water into Fortunella margarita (lour.) Swingle and Eriobotrya japonica, fully grinding in a colloid mill to homogenate, mixing and stirring for 3h, and filtering to obtain filtrate;

2) adding 10 times of 75% ethanol into flos Lonicerae and flos Chrysanthemi, reflux extracting for 2.5 hr, and filtering; adding 8 times of 75% ethanol into the filtrate, reflux extracting for 2 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to a concentration of 1.1g/mL to obtain flos Lonicerae flos Chrysanthemi extract.

3) Mixing the cumquat and loquat extract and the honeysuckle and chrysanthemum extract according to the mass ratio of 1:1, adding honey, white granulated sugar, sodium citrate and sodium benzoate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 3.

Example 4

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 20 parts of kumquat, 15 parts of loquat, 6 parts of honeysuckle, 6 parts of chrysanthemum, 15 parts of amur lilac seed, 6 parts of rhizoma pinellinae praeparata, 6 parts of liquorice, 5 parts of lily, 3 parts of green tangerine and 3 parts of mint;

fully grinding the kumquats, the loquats and the purified water in a colloid mill until the mixture is homogenized and filtering the mixture to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; respectively combining the amur lilac seed and the rhizoma pinellinae praeparata, the liquorice and the lily, and the kumquat and the mint, and performing ethanol reflux extraction, filtration and concentration to obtain an amur lilac seed extract, a liquorice and lily extract and a kumquat and mint extract; mixing rhizoma Pinelliae Preparata extract, Glycyrrhrizae radix Bulbus Lilii extract, herba Menthae extract, fructus Fortunellae margaritae extract, flos Lonicerae flos Chrysanthemi extract, sweetening agent, and antiseptic, sterilizing, and making into oral liquid. The method comprises the following specific steps:

2) adding 10 times of 75% ethanol into flos Lonicerae and flos Chrysanthemi, reflux extracting for 2 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1.5 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to a concentration of 1.1g/mL to obtain flos Lonicerae flos Chrysanthemi extract;

3) adding 10 times of 75% ethanol into cortex Syringae and rhizoma Pinelliae Preparata, reflux extracting for 2 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1.5 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain rhizoma Pinelliae Preparata extract;

4) adding 10 times of 75% ethanol into Glycyrrhrizae radix and Bulbus Lilii, reflux extracting for 2 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1.5 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain Glycyrrhrizae radix and Bulbus Lilii extract;

5) adding 10 times of 75% ethanol into fructus Citri Tangerinae and herba Menthae, reflux extracting for 2 hr, and filtering; adding 8 times of 75% ethanol, reflux extracting for 1.5 hr, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain herba Menthae extract;

6) mixing the cumquat and loquat extract, the honeysuckle and chrysanthemum extract, the amur lilium extract, the licorice and lily extract and the green orange mint extract according to the mass ratio of 1:1:1:1:1, adding honey, white granulated sugar and sodium citrate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 4.

The amur lilac, which is also called lotus clove and white clove in the mixture ratio of the invention, is derived from syringa syringae (blume) Hara var. mandshurica (Maxim.) Hara of the syringaceae, and is used as a medicine by using a trunk and branches, and has bitter and slightly cold properties, and mainly treats the effects of clearing lung and eliminating phlegm, and relieving cough and asthma. Can be used for treating cough, bronchitis, and bronchial asthma. Rhizoma Pinelliae Preparata is also called as rhizoma Pinelliae Preparata, and rhizoma Pinelliae Preparata. Processing crude rhizoma Pinelliae with Alumen, Glycyrrhrizae radix, and calx, and adding into the medicine. Low toxicity and strong phlegm-resolving action. Fa ban Xia has mild dryness, and has the actions of regulating spleen and stomach, besides drying dampness and resolving phlegm, it is indicated for spleen deficiency with damp stagnation and internal retention of phlegm-fluid, and has the actions of clearing phlegm and resolving fluid retention, regulating spleen and stomach. The licorice has the obvious functions of relieving cough and eliminating phlegm, can protect inflamed throats and tracheal mucosa, and can also tonify spleen and stomach, replenish qi and recover pulse. The Bulbus Lilii is a perennial herb bulbous plant of Lilium of Liliaceae, and has effects of clearing heat, nourishing yin, invigorating qi and nourishing. In addition, the green orange and the mint are added into the raw materials, the green orange has the effects of clearing heat, eliminating dampness, enriching blood and nourishing qi, and the mint can meticulously clear vexation, nourish liver, improve eyesight, cool and detoxify, and meanwhile, the taste is improved.

Example 5

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 30 parts of kumquat, 25 parts of loquat, 10 parts of honeysuckle, 10 parts of chrysanthemum, 20 parts of amur lilac seed, 10 parts of rhizoma pinellinae praeparata, 8 parts of liquorice, 6 parts of lily, 4 parts of green tangerine and 4 parts of mint;

fully grinding the kumquats, the loquats and the purified water in a colloid mill, mixing and filtering to prepare a kumquat and loquats extracting solution; extracting flos Lonicerae and flos Chrysanthemi with ethanol under reflux, filtering, and concentrating to obtain flos Lonicerae and flos Chrysanthemi extract; respectively combining the amur lilac seed and the rhizoma pinellinae praeparata, the liquorice and the lily, and the kumquat and the mint, and performing ethanol reflux extraction, filtration and concentration to obtain an amur lilac seed extract, a liquorice and lily extract and a kumquat and mint extract; mixing rhizoma Pinelliae Preparata extract, Glycyrrhrizae radix Bulbus Lilii extract, herba Menthae extract, fructus Fortunellae margaritae extract, flos Lonicerae flos Chrysanthemi extract, sweetening agent, and antiseptic, sterilizing, and making into oral liquid. The method comprises the following specific steps:

1) adding 6 times of purified water into Fortunella margarita (lour.) Swingle and Eriobotrya japonica, fully grinding in a colloid mill to homogenate, mixing and stirring for 2 hours, and filtering to obtain filtrate;

6) mixing the cumquat and loquat extract, the honeysuckle and chrysanthemum extract, the pinellia ternate preparata extract, the licorice root and lily extract and the green orange mint extract according to the mass ratio of 1:1:1:1:1, adding honey, white granulated sugar and sodium benzoate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 5.

Example 6

An antitussive oral liquid is prepared from the following raw materials in parts by mass: 35 parts of kumquat, 30 parts of loquat, 12 parts of honeysuckle, 12 parts of chrysanthemum, 30 parts of amur lilac seed, 12 parts of rhizoma pinellinae praeparata, 12 parts of liquorice, 10 parts of lily, 6 parts of kumquat and 6 parts of mint;

1) adding 6 times of purified water into Fortunella margarita (lour.) Swingle and Eriobotrya japonica, stirring and grinding in a colloid mill to homogenate, mixing and stirring for 2 hr, and filtering to obtain filtrate;

6) mixing the cumquat and loquat extract, the honeysuckle and chrysanthemum extract, the amur lilium extract, the licorice and lily extract and the green orange mint extract according to the mass ratio of 1:1:1:1:1, adding honey, white granulated sugar, sodium citrate and sodium benzoate, carrying out pasteurization and filling to obtain the cough-relieving oral liquid 6.

Pharmacodynamic experiments prove that the cough-relieving oral liquid 1, the cough-relieving oral liquid 2, the cough-relieving oral liquid 3, the cough-relieving oral liquid 4, the cough-relieving oral liquid 5 and the cough-relieving oral liquid 6 have the following cough-relieving curative effects:

126 patients diagnosed with cough and asthma with phlegm at the clinic age of 12-45 years have different degrees of cough and asthma with phlegm. The patients are divided into an observation group 1, an observation group 2, an observation group 3, an observation group 4, an observation group 5, an observation group 6 and a control group according to the sequence of the treatment, and the cases in each group are basically similar in age, disease degree, course and the like.

Observing group 1, 12-45 years old and 18 people with average age of 31.8 years old and disease course of 3-4 days, administering the cough relieving oral solution 1 of example 1 for treatment, and orally administering three times per day with 10ml each time, and the treatment course is 3 days;

observing group 2, 12-45 years old and 18 people with average age of 32.4 years old and disease course of 3-4 days, administering the cough relieving oral solution 2 of example 2 for treatment, and orally administering three times per day with 10ml each time, and the treatment course is 3 days;

the observation group 3, 12-45 years old and 18 people with the average age of 33.8 years old and the course of disease of 3-4 days, is treated by the cough relieving oral solution 3 of the embodiment 3, and is orally administered three times a day, 10ml each time, and the course of treatment is 3 days;

the observation group 4, 12-45 years old and 18 people with the average age of 35.6 years old and the course of disease of 3-4 days, is treated by the cough relieving oral solution 4 of the example 4, and is orally administered three times a day, 10ml each time, and the course of treatment is 3 days;

the observation group 5, 12-45 years old, 18 people, 35.8 years old with average age, 3-4 days course, is given the cough relieving oral solution 5 of example 5 for treatment, and is orally administered three times per day, 10ml each time, and the treatment course is 3 days;

the observation group 6, 12-45 years old and 18 people with the average age of 34.5 years old and the course of disease of 3-4 days, is treated by the cough relieving oral solution 6 of the example 6, and is orally administered three times a day, 10ml each time, and the course of treatment is 3 days;

the control group is 10-45 years old, 18 people with average age of 33.7 years old and the course of disease is 3-4 days, and the control group is administered with cough relieving exocarpium Citri rubrum oral liquid for oral treatment three times a day, 10ml each time, and the treatment course is 3 days.

The curative effect standard is as follows: (1) and (3) clinical control: no cough, no phlegm and no asthma after 3 days of treatment, (2) obvious effect: no or only slight cough, no or little phlegm, asthma; (3) the method has the following advantages: the treatment of the clinical symptoms and the pharyngeal physical signs for more than 3 days is obviously improved; (4) and (4) invalidation: after 3 days of treatment, no improvement or aggravation of clinical symptoms and pharyngeal physical signs exists, and the asthma is not relieved. The specific therapeutic effect is shown in table 1:

TABLE 1 comparison of patient outcomes

Group of	Clinical control	Number of effective people	Number of effective persons	Number of invalid persons	Total effective rate (%)
						Observation group 1	8	5	5	0	100％
Observation group 2	4	5	3	6	67％
						Observation group 3	5	6	3	4	78％
Observation group 4	5	4	4	5	72％
						Observation group 5	6	4	5	3	83％
Observation group 6	5	3	3	7	61％
						Control group	7	5	6	0	100％

As can be seen from table 1: the observation groups 1, 2, 3, 4, 5 and 6 had significant antitussive effects after taking antitussive oral liquid 1, 2, 3, 4, 5 and 6 according to the present invention.

According to the technical scheme, the invention provides an antitussive oral liquid which is prepared from the following raw materials in parts by mass: 20-35 parts of kumquat, 15-30 parts of loquat, 6-12 parts of honeysuckle and 6-12 parts of chrysanthemum; fully grinding the kumquats, the loquats and the purified water in a colloid mill, mixing and filtering to prepare a kumquat and loquats extracting solution; the honeysuckle and the chrysanthemum are subjected to ethanol reflux extraction, filtration and concentration to prepare a honeysuckle and chrysanthemum extract; mixing the extractive solution of Fortunella margarita and Eriobotrya japonica with sweetener and antiseptic, and sterilizing. The invention is prepared from pure natural raw materials, and contains various traditional Chinese medicine components beneficial to human body; the cumquat and the loquat in the raw materials are purely natural and medicinal and edible raw materials without toxic and side effects, wherein the cumquat is sweet and warm in property, can regulate qi, relieve depression, relieve cough and reduce phlegm, is supplemented with the loquat to quench thirst and lower qi, promote lung qi, stop vomiting and reverse, remove upper-jiao heat and moisten five internal organs, and has the effects of promoting the production of body fluid to quench thirst, relieving cough and moistening lung; meanwhile, the honeysuckle contains the pharmacological active ingredients such as chlorogenic acid and luteolin glycoside, can clear away heat and toxic materials and is mainly used for treating epidemic febrile disease fever, heat toxin and bloody dysentery, carbuncle, cellulitis and furunculosis; the chrysanthemum can dispel wind and clear heat, calm liver and improve vision; pharmacodynamic experiments prove that the traditional Chinese medicine composition has the advantages of small side effect, quick response and obvious curative effect, and simultaneously has the health-care effects of invigorating stomach and spleen, promoting the production of body fluid to quench thirst, relieving cough and moistening lung.

Claims

1. The cough-relieving oral liquid is characterized by being prepared from the following raw materials in parts by mass: 20-35 parts of kumquat, 15-30 parts of loquat, 6-12 parts of honeysuckle and 6-12 parts of chrysanthemum;

2. The cough-relieving oral liquid according to claim 1, wherein the raw materials further comprise, by mass, 15-30 parts of amur lilac bark, 6-12 parts of rhizoma pinellinae praeparata, 6-12 parts of liquorice, 5-10 parts of lily, 3-5 parts of tangerine and 3-5 parts of mint.

3. The cough relieving oral liquid of claim 2, wherein the combination of the amur lilac seed and the rhizoma pinellinae praeparata, the combination of the licorice root and the lily, the combination of the kumquat and the mint are extracted by ethanol reflux, filtered and concentrated to obtain an amur lilac seed extract, a licorice root and lily extract and a kumquat and mint extract;

4. The antitussive oral liquid according to claim 1 or 3, wherein the sweetener is one or both of honey and white granulated sugar.

5. The oral liquid of claim 1 or 3, wherein the preservative is one or both of sodium citrate and sodium benzoate.

6. The cough-relieving oral liquid according to claim 1, wherein the kumquat and loquat extract is prepared by adding 6 times of purified water to kumquat and loquat, fully mixing by a colloid mill, grinding into a homogenate, mixing and stirring for 1-3 h, and filtering.

7. The cough-relieving oral liquid of claim 3, wherein the extract of pinellia ternata thunbergii is prepared by the steps of: adding 10 times of 75% ethanol into the amur lilac fruit and the rhizoma pinellinae praeparata, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain the extract of rhizoma Pinelliae Preparata.

8. The antitussive oral liquid according to claim 3, wherein the licorice-lily extract is prepared by the steps of: adding 10 times of 75% ethanol into the liquorice and the lily, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain Glycyrrhrizae radix and Bulbus Lilii extract.

9. The cough-relieving oral liquid of claim 3, wherein the preparation of the extract of Mentha Fortunei comprises the steps of: adding 10 times of 75% ethanol into the green oranges and the mint, performing reflux extraction for 1.5-2.5 h, and filtering; adding 8 times of 75% ethanol, performing reflux extraction for 1-2 h, and filtering; mixing the two filtrates, and concentrating the filtrate under reduced pressure to concentration of 1.1g/mL to obtain herba Menthae extract.

10. The cough-relieving oral liquid of claim 3, wherein the cough-relieving oral liquid is prepared by mixing the extracts of pinellia ternata (thunb.) makino, lilium brownii, and mentha lividans with the extract of loquat, and the extract of chrysanthemum, adding the sweetener and the preservative, mixing uniformly, and pasteurizing.