CA2076467A1 - Skin whitening preparations - Google Patents

Skin whitening preparations

Info

Publication number: CA2076467A1
Authority: CA; Canada
Prior art keywords: composition according; weight; flavonoid; group; derivative
Prior art date: 1991-08-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002076467A

Other languages

English (en)

French (fr)

Inventor

Meir Stern

Nira Hadas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fischer Pharmaceuticals Ltd

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-23

Filing date

1992-08-20

Publication date

1993-02-24

1992-08-20 Application filed by Individual filed Critical Individual

1993-02-24 Publication of CA2076467A1 publication Critical patent/CA2076467A1/en

Status Abandoned legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title description 5
230000002087 whitening effect Effects 0.000 title description 4
239000000203 mixture Substances 0.000 claims abstract description 33
229930003935 flavonoid Natural products 0.000 claims abstract description 21
150000002215 flavonoids Chemical class 0.000 claims abstract description 21
235000017173 flavonoids Nutrition 0.000 claims abstract description 21
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 14
240000000073 Achillea millefolium Species 0.000 claims abstract description 13
235000007754 Achillea millefolium Nutrition 0.000 claims abstract description 13
241000218231 Moraceae Species 0.000 claims abstract description 7
235000008708 Morus alba Nutrition 0.000 claims abstract description 7
235000010323 ascorbic acid Nutrition 0.000 claims abstract description 7
229960005070 ascorbic acid Drugs 0.000 claims abstract description 7
239000011668 ascorbic acid Substances 0.000 claims abstract description 7
AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 claims abstract description 5
AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 claims abstract description 5
230000000694 effects Effects 0.000 claims abstract description 5
230000000699 topical effect Effects 0.000 claims abstract description 5
241000208680 Hamamelis mollis Species 0.000 claims abstract description 4
ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 claims abstract description 4
235000002020 sage Nutrition 0.000 claims abstract description 4
229940118846 witch hazel Drugs 0.000 claims abstract description 4
102000003425 Tyrosinase Human genes 0.000 claims abstract description 3
108060008724 Tyrosinase Proteins 0.000 claims abstract description 3
239000003638 chemical reducing agent Substances 0.000 claims abstract 4
239000006210 lotion Substances 0.000 claims description 20
QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 19
239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 19
235000010385 ascorbyl palmitate Nutrition 0.000 claims description 19
239000000284 extract Substances 0.000 claims description 19
BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims description 19
229960004705 kojic acid Drugs 0.000 claims description 19
WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims description 19
239000006071 cream Substances 0.000 claims description 15
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
229960005193 avobenzone Drugs 0.000 claims description 9
TYYHDKOVFSVWON-UHFFFAOYSA-N 2-butyl-2-methoxy-1,3-diphenylpropane-1,3-dione Chemical compound C=1C=CC=CC=1C(=O)C(OC)(CCCC)C(=O)C1=CC=CC=C1 TYYHDKOVFSVWON-UHFFFAOYSA-N 0.000 claims description 7
239000000419 plant extract Substances 0.000 claims description 7
YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 6
229960001679 octinoxate Drugs 0.000 claims description 6
239000004408 titanium dioxide Substances 0.000 claims description 6
235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 4
LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 claims description 3
239000004261 Ascorbyl stearate Substances 0.000 claims description 3
244000303040 Glycyrrhiza glabra Species 0.000 claims description 3
235000019276 ascorbyl stearate Nutrition 0.000 claims description 3
239000007921 spray Substances 0.000 claims description 3
235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
150000000996 L-ascorbic acids Chemical class 0.000 claims description 2
238000005282 brightening Methods 0.000 claims description 2
229940010454 licorice Drugs 0.000 claims description 2
229940078752 magnesium ascorbyl phosphate Drugs 0.000 claims description 2
HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 claims description 2
241000196324 Embryophyta Species 0.000 claims 1
241000202807 Glycyrrhiza Species 0.000 claims 1
229960005196 titanium dioxide Drugs 0.000 claims 1
239000002537 cosmetic Substances 0.000 abstract description 4
OFUHPGMOWVHNPN-QWZFGMNQSA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] (9z,12z)-octadeca-9,12-dienoate Chemical compound O1[C@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CCC2=C(C)C(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)=C(C)C(C)=C21 OFUHPGMOWVHNPN-QWZFGMNQSA-N 0.000 description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
239000004615 ingredient Substances 0.000 description 12
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 11
229940101267 panthenol Drugs 0.000 description 11
235000020957 pantothenol Nutrition 0.000 description 11
239000011619 pantothenol Substances 0.000 description 11
239000003755 preservative agent Substances 0.000 description 11
238000009472 formulation Methods 0.000 description 10
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
210000003491 skin Anatomy 0.000 description 10
239000000499 gel Substances 0.000 description 8
241000722941 Achillea Species 0.000 description 7
229940069445 licorice extract Drugs 0.000 description 7
229950008882 polysorbate Drugs 0.000 description 6
229920000136 polysorbate Polymers 0.000 description 6
235000007866 Chamaemelum nobile Nutrition 0.000 description 5
244000042664 Matricaria chamomilla Species 0.000 description 5
235000007232 Matricaria chamomilla Nutrition 0.000 description 5
235000021355 Stearic acid Nutrition 0.000 description 5
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
229960000541 cetyl alcohol Drugs 0.000 description 5
GKKMCECQQIKAHA-UHFFFAOYSA-N hexadecyl dihydrogen phosphate;2-(2-hydroxyethylamino)ethanol Chemical compound OCCNCCO.CCCCCCCCCCCCCCCCOP(O)(O)=O GKKMCECQQIKAHA-UHFFFAOYSA-N 0.000 description 5
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 5
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 5
CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 description 5
230000002335 preservative effect Effects 0.000 description 5
239000008117 stearic acid Substances 0.000 description 5
ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 4
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
229920002125 Sokalan® Polymers 0.000 description 4
UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 description 4
210000002752 melanocyte Anatomy 0.000 description 4
IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 3
239000000049 pigment Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 2
235000003880 Calendula Nutrition 0.000 description 2
240000001432 Calendula officinalis Species 0.000 description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
-1 Tocopheryl palmitate Chemical compound 0.000 description 2
239000010949 copper Substances 0.000 description 2
229910052802 copper Inorganic materials 0.000 description 2
210000002510 keratinocyte Anatomy 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
OGNVQLDIPUXYDH-ZPKKHLQPSA-N (2R,3R,4S)-3-(2-methylpropanoylamino)-4-(4-phenyltriazol-1-yl)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid Chemical compound CC(C)C(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)OC(C(O)=O)=C[C@@H]1N1N=NC(C=2C=CC=CC=2)=C1 OGNVQLDIPUXYDH-ZPKKHLQPSA-N 0.000 description 1
SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
244000003377 Allium tuberosum Species 0.000 description 1
235000005338 Allium tuberosum Nutrition 0.000 description 1
241000518994 Conta Species 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
230000009920 chelation Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
210000000805 cytoplasm Anatomy 0.000 description 1
MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
SDIXRDNYIMOKSG-UHFFFAOYSA-L disodium methyl arsenate Chemical compound [Na+].[Na+].C[As]([O-])([O-])=O SDIXRDNYIMOKSG-UHFFFAOYSA-L 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
229940049294 glyceryl stearate se Drugs 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229960004502 levodopa Drugs 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
230000003061 melanogenesis Effects 0.000 description 1
210000002780 melanosome Anatomy 0.000 description 1
239000011707 mineral Substances 0.000 description 1
WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 1
210000003463 organelle Anatomy 0.000 description 1
230000002265 prevention Effects 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
KJCLYACXIWMFCC-UHFFFAOYSA-M sodium;5-benzoyl-4-hydroxy-2-methoxybenzenesulfonate Chemical compound [Na+].C1=C(S([O-])(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 KJCLYACXIWMFCC-UHFFFAOYSA-M 0.000 description 1
150000003611 tocopherol derivatives Chemical class 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Birds (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Botany (AREA)
Microbiology (AREA)
Mycology (AREA)
Inorganic Chemistry (AREA)
Dispersion Chemistry (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA002076467A 1991-08-23 1992-08-20 Skin whitening preparations Abandoned CA2076467A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL99291A IL99291A (en)	1991-08-23	1991-08-23	Cosmetic preparations
IL099,291		1991-08-23

Publications (1)

Publication Number	Publication Date
CA2076467A1 true CA2076467A1 (en)	1993-02-24

Family

ID=11062833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002076467A Abandoned CA2076467A1 (en)	1991-08-23	1992-08-20	Skin whitening preparations

Country Status (9)

Country	Link
AU (1)	AU654030B2 (es)
CA (1)	CA2076467A1 (es)
CH (1)	CH684739A5 (es)
DE (1)	DE4227806A1 (es)
ES (1)	ES2050074B1 (es)
FR (1)	FR2680466B3 (es)
GB (1)	GB2259014B (es)
IL (1)	IL99291A (es)
PT (1)	PT100800B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1913866B (zh) *	2004-01-30	2013-03-13	捷通国际有限公司	减少皮肤色素沉着的整体组合物及方法

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2904628B2 (ja) *	1991-12-19	1999-06-14	同和鉱業株式会社	色白化粧料
FR2708851B1 (fr) *	1993-08-12	1995-09-22	Oreal	Composition cosmétique comprenant l'association d'un nanopigment d'oxydes métalliques et d'un agent antioxydant, et son utilisation pour la protection de la peau et des cheveux.
IL109012A (en) *	1994-03-17	1998-09-24	Fischer Pharma Ltd	Skin whitening composition comprising glycyrrhyza glabra and hydroxy acids
FR2723316B1 (fr) *	1994-08-04	1996-10-04	Thorel Jean Noel	Compositions et preparations depigmentantes de la peau, a usages pharmaceutiques ou cosmetiques
DE4444238A1 (de)	1994-12-13	1996-06-20	Beiersdorf Ag	Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
FR2735688B1 (fr) *	1995-06-26	1997-08-14	Oreal	Utilisation en association d'un alpha-hydroxyacide et d'un oxyde de titane pour le blanchiment de la peau
FR2736263B1 (fr) *	1995-07-07	1997-09-26	C3D Sarl	Composition dermocosmetique depigmentante et son utilisation
FR2736829B1 (fr) *	1995-07-20	1997-09-12	Oreal	Composition pour lutter contre les taches et/ou le vieillissement de la peau, ses utilisations
FR2745179B1 (fr) *	1996-02-28	1998-04-10	Gattefosse Holding	Melange maitre actif pour la preparation d'une composition dermocosmetique, composition dermocosmetique contenant ce melange, et methode pour la preparation de ce melange
FR2746008B1 (fr) *	1996-03-14	1998-05-29		Composition a usage topique anti-vieillissement
US6162419A (en) *	1996-11-26	2000-12-19	Nicholas V. Perricone	Stabilized ascorbyl compositions
CN1265025A (zh) *	1997-06-20	2000-08-30	玫琳凯有限公司	包含增白剂和剥离剂的化妆品组合物
DE19750030A1 (de) *	1997-11-12	1999-05-20	Merck Patent Gmbh	Lichtstabile kosmetische Formulierung enthaltend Butylmethoxydibenzoylmethan
DE19755504A1 (de) *	1997-12-13	1999-06-17	Beiersdorf Ag	Verwendung von Flavonen und Flavonoiden gegen die UV-induzierte Zersetzung von Dibenzoylmethan und dessen Derivaten
DE19807774A1 (de) *	1998-02-24	1999-08-26	Beiersdorf Ag	Verwendung von Flavonen bzw. Flavanonen bzw. Flavonoiden zum Schutze von Ascorbinsäure und/oder Ascorbylverbindungen gegen Oxidation
AU3573399A (en) *	1998-04-29	1999-11-16	Avon Products Inc.	Skin whitening composition
DE19845319A1 (de) *	1998-10-01	2000-04-06	Beiersdorf Ag	Verwendung von oberflächenaktiven Substanzen zur Stabilisierung von Flavonen, Flavanonen bzw. Flavonoiden, synergistische Gemische aus Flavonen, Flavanonen bzw. Flavonoiden und oberflächenaktiven Substanzen sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
DE19845266A1 (de) *	1998-10-01	2000-04-06	Beiersdorf Ag	Verwendung von Butylhydroxytoluol zur Stabilisierung von Flavonen, Flavanonen bzw. Flavonoiden, synergistische Gemische aus Flavonen, Flavanonen bzw. Flavonoiden und Butylhydroxytoluol sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
DE19845322A1 (de) *	1998-10-01	2000-04-06	Beiersdorf Ag	Verwendung von 2-tert.-Butylhydrochinon zur Stabilisierung von Flavonen, Flavanonen bzw. Flavonoiden, synergistische Gemische aus Flavonen, Flavanonen bzw. Flavonoiden und 2-tert.-Butylhydrochinon sowie kosmetische und dermatologische Zubereitungen mit einem Gehalt an solchen Gemischen
CZ20011527A3 (cs) *	1998-11-13	2001-10-17	The Procter & Gamble Company	Emulze olej ve vodě
AU1458599A (en) *	1998-11-13	2000-06-05	Procter & Gamble Company, The	A skin lightening composition containing an ascorbic acid compound
US5980904A (en) *	1998-11-18	1999-11-09	Amway Corporation	Skin whitening composition containing bearberry extract and a reducing agent
FR2787710B1 (fr) *	1998-12-29	2001-02-23	Clarins	Composition cosmetique a effet eclaircissant pour la peau
DE19923713A1 (de) *	1999-05-22	2000-11-23	Beiersdorf Ag	Kosmetische oder dermatologische Lichtschutzzubereitungen mit einem Gehalt an Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden und Benzotriazol sowie die Verwendung von UV-Filtersubstanzen, welche das Strukturmotiv des Benzotriazols aufweisen, zur Stabilisierung von Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden
DE19923712A1 (de) *	1999-05-22	2000-11-23	Beiersdorf Ag	Wirkstoffkombination aus sulfonierten UV-Filtersubstanzen und Flavonderivaten und/oder Flavanonderivaten, insbesondere Flavonoiden, sowie kosmetische Zubereitungen, solche Wirkstoffkombinationen enthaltend
DE19923715A1 (de) *	1999-05-22	2000-11-23	Beiersdorf Ag	Kosmetische oder dermatologische Lichtschutzzubereitungen mit einem Gehalt an Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden und s-Triazin sowie die Verwendung von UV-Filtersubstanzen, welche das Strukturmotiv des s-Triazins aufweisen, zur Stabilisierung von Flavonderivaten und/oder Flavanonderivaten, insbesondere von Flavonoiden
DE19925499A1 (de) *	1999-06-04	2000-12-07	Beiersdorf Ag	Verwendung von Ascorbinsäure und einem oder mehreren Flavonderivaten und/oder Flavononderivaten, insbesondere Flavonoiden zur Herstellung kosmetischer oder dermatologischer Zubereitungen zur Prophylaxe oder Linderung des Sonnenbrandes
CA2377334A1 (en) *	1999-06-15	2000-12-21	Benjamin D. Gordon	Compositions and systems for the treatment of hyperpigmentation
GB9917103D0 (en) *	1999-07-22	1999-09-22	Secr Defence	Barrier cream
GB9917729D0 (en) *	1999-07-28	1999-09-29	Boots Co Plc	Hair care composition
US6521668B2 (en) *	1999-12-14	2003-02-18	Avon Products, Inc.	Cosmetic composition and methods of use
EP1147764A3 (en) *	2000-04-19	2002-03-20	Nof Corporation	Cosmetic composition
GB0026018D0 (en)	2000-10-24	2000-12-13	Novartis Nutrition Ag	New composition
FR2816502B1 (fr) *	2000-11-10	2003-04-11	Oreal	Composition cosmetique comprenant un derive d'aminophenol et un isoflavonoide
JP2002212054A (ja) *	2001-01-16	2002-07-31	Tsumura & Co	浴用剤組成物
FR2820973B1 (fr) *	2001-02-19	2003-05-23	Oreal	Composition comportant de la vitamine c preparee durant l'application, utilisation d'enzymes pour la formation de vitamine c a usage topique et procede de traitement cosmetique
US6436378B1 (en) *	2001-02-28	2002-08-20	Colgate-Palmolive Company	Composition
US7189759B2 (en)	2001-05-23	2007-03-13	Medicis Pharmaceutical Corporation	Compositions for the treatment of pigmentation disorders and methods for their manufacture
WO2003039502A1 (de) *	2001-11-09	2003-05-15	Beiersdorf Ag	Kosmetische und/oder dermatologische zubereitung enthaltend octadecendicarbonsäure und uv-filtersubstanzen
DE10215342A1 (de) *	2002-03-28	2003-10-23	Coty Bv	Hautaufhellendes Kosmetikum
US6844014B1 (en)	2002-07-22	2005-01-18	Stephen Rafkin	Herbal healing lotion for veterinary use
DE10238449A1 (de) *	2002-08-22	2004-03-04	Beiersdorf Ag	Kosmetische und/oder dermatologische Zubereitung
KR101161568B1 (ko) *	2003-12-15	2012-07-04	포라 가세이 고교 가부시키가이샤	피부 외용제
WO2005094770A1 (en) *	2004-03-30	2005-10-13	Unilever Plc	Skin lightening compositions comprising vitamines and flavonoids
DE102004042299A1 (de)	2004-08-27	2006-03-23	Lancaster Group Gmbh	Kosmetisches Aufhellungs- und Reinigungsmittel für die Haut
ES2255862B1 (es) *	2004-12-27	2007-07-16	Sesderma, S.L.	Aditivos para peelings cutaneos.
JP2006290886A (ja) *	2005-04-06	2006-10-26	Engelhard Lyon Sa	少なくとも１種のアウロンを適用することによる美容的脱色素沈着ケア方法
FR2884250B1 (fr) *	2005-04-06	2010-01-08	Coletica	Utilisation des aurones pour leur activite depigmentante ou inhibitrice de la melanogenese dans des compositions cosmetiques ou dermatologiques
DE102007007612A1 (de) *	2007-02-13	2008-08-14	Beiersdorf Ag	Verfahren zur Depigmentierung der Haut
US9056209B2 (en) *	2009-06-17	2015-06-16	Kao Corporation	Apigenin-containing composition
KR101716325B1 (ko) *	2011-02-28	2017-03-15	(주)아모레퍼시픽	열 차단 지수의 생성 방법
TW201532621A (zh) *	2013-04-22	2015-09-01	Neocutis Sa	抗氧化劑組成物及其使用方法
DE102013208865A1 (de) *	2013-05-14	2014-11-20	Beiersdorf Ag	Stabilisierte Zubereitungen mit einem Gehalt an Ascorbinsäure und Phosphationen
US9132117B2 (en)	2013-06-17	2015-09-15	Kgk Synergize, Inc	Compositions and methods for glycemic control of subjects with impaired fasting glucose
FR3007981B1 (fr) *	2013-07-05	2016-01-22	Oreal	Association d'extrait d'hamamelis virginiana, d'escine, et d'acide ascorbique
CN105125418A (zh) *	2014-05-31	2015-12-09	尹连花	一种护肤去斑霜制剂及其制备方法
DE102014211185A1 (de)	2014-06-11	2015-12-17	Henkel Ag & Co. Kgaa	Kosmetische Zusammensetzungen zur Hautaufhellung
GB2544046A (en) *	2015-10-30	2017-05-10	Boots Co Plc	Skin care composition and method thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2543437B1 (fr) *	1983-03-30	1987-07-10	Duraffourd Alain	Composition pour regenerer le collagene du tissu conjonctif de la peau et son procede de preparation
FR2582941B3 (fr) *	1985-06-11	1987-10-09	Moreau Lavaud Reine	Composition cosmetique a base d'extraits de feuilles du murier
JPS6360911A (ja) *	1986-09-01	1988-03-17	Riyuuhoudou Seiyaku Kk	アスコルビン酸含有組成物
FR2616328B1 (fr) *	1987-06-12	1990-03-02	Moet Hennessy Rech	Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un extrait de murier, ou au moins une flavone, en particulier une kuwanone et composition pharmaceutique, notamment dermatologique, a activite depigmentante, ou anti-inflammatoire, ou cosmetique, l'incorporant
JPH0278611A (ja) *	1988-09-13	1990-03-19	Kansai Paint Co Ltd	皮膚洗浄料
GB8910366D0 (en) *	1989-05-05	1989-06-21	Unilever Plc	Skin composition
TW197375B (es) *	1990-11-19	1993-01-01	Hayashibara Biochem Lab

1991
- 1991-08-23 IL IL99291A patent/IL99291A/xx not_active IP Right Cessation
1992
- 1992-08-20 CA CA002076467A patent/CA2076467A1/en not_active Abandoned
- 1992-08-21 FR FR9210195A patent/FR2680466B3/fr not_active Expired - Lifetime
- 1992-08-21 GB GB9217821A patent/GB2259014B/en not_active Expired - Fee Related
- 1992-08-21 DE DE4227806A patent/DE4227806A1/de not_active Withdrawn
- 1992-08-21 CH CH2610/92A patent/CH684739A5/de not_active IP Right Cessation
- 1992-08-21 PT PT100800A patent/PT100800B/pt not_active IP Right Cessation
- 1992-08-21 ES ES09201822A patent/ES2050074B1/es not_active Expired - Lifetime
- 1992-08-21 AU AU21220/92A patent/AU654030B2/en not_active Ceased

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1913866B (zh) *	2004-01-30	2013-03-13	捷通国际有限公司	减少皮肤色素沉着的整体组合物及方法

Also Published As

Publication number	Publication date
GB9217821D0 (en)	1992-10-07
ES2050074A1 (es)	1994-05-01
FR2680466A1 (fr)	1993-02-26
ES2050074B1 (es)	1994-12-16
PT100800A (pt)	1994-02-28
AU654030B2 (en)	1994-10-20
CH684739A5 (de)	1994-12-15
GB2259014B (en)	1996-02-28
GB2259014A (en)	1993-03-03
DE4227806A1 (de)	1993-02-25
AU2122092A (en)	1993-02-25
FR2680466B3 (fr)	1993-11-19
PT100800B (pt)	1999-07-30
IL99291A0 (en)	1992-07-15
IL99291A (en)	1997-04-15

Publication	Publication Date	Title
CA2076467A1 (en)	1993-02-24	Skin whitening preparations
EP1073446B1 (en)	2009-01-07	Skin whitening composition
EP2114362B1 (en)	2018-07-18	Cosmetic composition for skin whitening comprising a mixture of arctiin and arctigenin
US20040166069A1 (en)	2004-08-26	Boosting Tyrosinase Inhibiting Activity of Skin Whitening and Sunscreen Compositions
WO2006117055A1 (en)	2006-11-09	Skin lightening composition comprising a conjugated linoleic acid and niacinamide
US6436378B1 (en)	2002-08-20	Composition
JPH05306231A (ja)	1993-11-19	皮膚外用剤
JP3601875B2 (ja)	2004-12-15	化粧料
JP2000504307A (ja)	2000-04-11	色素脱失外皮用および／または化粧用組成物
WO2000000162A1 (en)	2000-01-06	Skin whitening composition
US20020150601A1 (en)	2002-10-17	Use of folic acid and/or derivatives thereof for the preparation of cosmetic or dermatological preparations for the prophylaxis of damage to DNA intrinsic to the skin and/or for the repair of existing damage to DNA intrinsic to the skin
KR102255580B1 (ko)	2021-05-25	마테 추출물 및 트라넥삼산의 혼합물을 유효성분으로 포함하는 화장료 조성물
WO2010115472A2 (en)	2010-10-14	Topical skin lightening composition
EP1338269B1 (de)	2005-07-27	Verwendung von Kreatinin und/oder Kreatinin-Derivaten zur Aufhellung der Haut und Milderung von Pigmentstörungen
KR100495454B1 (ko)	2005-06-14	피토라이트를 포함하는 미백 화장료 조성물
JPH0118044B2 (es)	1989-04-03
JP2002114629A (ja)	2002-04-16	化粧料
EP1945308A1 (de)	2008-07-23	Topisch anwendbare zusammensetzung für die verwendung als hautaufhellungsmittel
JPH1036215A (ja)	1998-02-10	皮膚外用剤
JP2002121110A (ja)	2002-04-23	化粧料
KR100879133B1 (ko)	2009-01-19	비수유화 미백 화장료 조성물 및 그의 제조방법
JPH04282305A (ja)	1992-10-07	皮膚化粧料
JP2000053523A (ja)	2000-02-22	美白に好適な皮膚外用剤
JPH04244005A (ja)	1992-09-01	化粧料
KR20050031150A (ko)	2005-04-06	야기시리구멍쇠미역 추출물을 함유하는멜라닌생합성저해용 조성물

Legal Events

Date	Code	Title	Description
1997-07-10	EEER	Examination request
2002-08-20	FZDE	Discontinued

CA2076467A1 - Skin whitening preparations - Google Patents

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Cited By (1)

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Cited By (1)

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