[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BRPI0604250A - forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma - Google Patents

forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma

Info

Publication number
BRPI0604250A
BRPI0604250A BRPI0604250-3A BRPI0604250A BRPI0604250A BR PI0604250 A BRPI0604250 A BR PI0604250A BR PI0604250 A BRPI0604250 A BR PI0604250A BR PI0604250 A BRPI0604250 A BR PI0604250A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
compositions containing
crystalline form
preparation
containing same
Prior art date
Application number
BRPI0604250-3A
Other languages
English (en)
Inventor
Stephane Horvath
Marie-Noulle Auguste
Gerard Damen
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36589231&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0604250(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI0604250A publication Critical patent/BRPI0604250A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

FORMA CRISTALINA DELTA DE CLORIDRATO DE IVABRADINA, PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO A MESMA. Forma o<sym>-cristalina de cloridrato de ivabradina da fórmula (I): caracterizada por seu diagrama de difração de raio x de pó. medicamentos.
BRPI0604250-3A 2005-10-11 2006-10-10 forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma BRPI0604250A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0510352A FR2891826B1 (fr) 2005-10-11 2005-10-11 Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number Publication Date
BRPI0604250A true BRPI0604250A (pt) 2007-08-21

Family

ID=36589231

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0604250-3A BRPI0604250A (pt) 2005-10-11 2006-10-10 forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma

Country Status (30)

Country Link
US (3) US7358240B2 (pt)
EP (2) EP1956005A1 (pt)
JP (1) JP2007112796A (pt)
KR (1) KR20070040311A (pt)
CN (1) CN1948292A (pt)
AP (1) AP2303A (pt)
AR (1) AR056572A1 (pt)
AU (1) AU2006228027B2 (pt)
BR (1) BRPI0604250A (pt)
CA (1) CA2564367C (pt)
CO (1) CO5790166A1 (pt)
CR (1) CR8645A (pt)
EA (1) EA010296B1 (pt)
EC (1) ECSP066915A (pt)
FR (1) FR2891826B1 (pt)
GE (1) GEP20094653B (pt)
GT (1) GT200600450A (pt)
IL (1) IL178544A (pt)
MA (1) MA28626B1 (pt)
MX (1) MXPA06011766A (pt)
MY (1) MY139508A (pt)
NO (1) NO20064596L (pt)
NZ (1) NZ550435A (pt)
PE (1) PE20070492A1 (pt)
SA (1) SA06270370B1 (pt)
SG (1) SG131858A1 (pt)
TW (1) TWI377946B (pt)
UA (1) UA90265C2 (pt)
WO (1) WO2007042656A1 (pt)
ZA (1) ZA200608403B (pt)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
ATE544754T1 (de) * 2006-11-30 2012-02-15 Cadila Healthcare Ltd Verfahren zur herstellung von ivabradinhydrochlorid
CN101353325B (zh) * 2007-07-27 2011-11-09 上海优拓医药科技有限公司 稳定型盐酸伊伐布雷定结晶及其制备方法
KR101478855B1 (ko) 2007-05-30 2015-01-02 인드-스위프트 래버러토리즈 리미티드 이바브라딘 히드로클로라이드 및 그의 다형태의 제조방법
ES2402765T3 (es) 2008-12-22 2013-05-08 Krka, D.D., Novo Mesto Procedimiento de preparación de ivabradina
CN101774969B (zh) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
EA201290772A1 (ru) 2010-02-12 2013-02-28 КРКА, д.д., НОВО МЕСТО Новые формы ивабрадина гидрохлорида
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
WO2012025940A1 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Polymorphic form of ivabradine hydrochloride and process for preparation thereof
US9440924B2 (en) 2011-08-02 2016-09-13 Sandoz Ag Acetone solvate of ivabradine hydrochloride
EP2589594A1 (en) * 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
WO2013064427A1 (en) 2011-11-04 2013-05-10 Synthon Bv A process for making crystalline delta-form of ivabradine hydrochloride
EP3156399A1 (en) * 2011-11-14 2017-04-19 Cadila Healthcare Limited Polymorphic forms of ivabradine hydrochloride
EP2948432B1 (en) 2013-01-24 2018-09-19 Synthon BV Process for making ivabradine
EP2781509B2 (en) 2013-03-19 2023-06-14 Chemo Research, S.L. New polymorph of ivabradine hydrochloride and method for its preparation
CZ305096B6 (cs) 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice
MX363389B (es) 2013-12-12 2019-03-20 Synthon Bv Composicion farmaceutica que comprende ivabradina amorfa.
EP2774606B1 (en) 2014-02-14 2019-01-30 Synthon B.V. Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV
CZ2014478A3 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
WO2016102423A1 (en) 2014-12-22 2016-06-30 Ratiopharm Gmbh Composition comprising ivabradine in a dissolved form
GR1008821B (el) 2015-06-11 2016-08-01 Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων Φαρμακευτικο σκευασμα που περιλαμβανει υδροχλωρικη ιβαμπραδινη και μεθοδος παρασκευης αυτου
CN107056706B (zh) * 2015-12-21 2020-05-05 江苏恒瑞医药股份有限公司 一种用于制备盐酸伊伐布雷定α晶型的方法
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
IT202000025312A1 (it) 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB9017453D0 (en) 1990-08-09 1990-09-26 Mcivor Robert C Fluid additive regulating apparatus
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CA2504863A1 (en) * 2005-04-21 2006-10-21 Larry J. Chernoff Integrated valve system

Also Published As

Publication number Publication date
AR056572A1 (es) 2007-10-10
US20080161284A1 (en) 2008-07-03
FR2891826A1 (fr) 2007-04-13
SG131858A1 (en) 2007-05-28
AU2006228027B2 (en) 2011-08-25
US7867997B2 (en) 2011-01-11
NZ550435A (en) 2007-12-21
EP1956005A1 (fr) 2008-08-13
EA200601662A1 (ru) 2007-04-27
GEP20094653B (en) 2009-03-25
MXPA06011766A (es) 2007-04-10
US20090318419A1 (en) 2009-12-24
EA010296B1 (ru) 2008-08-29
EP1775288A1 (fr) 2007-04-18
ZA200608403B (en) 2008-06-25
TWI377946B (en) 2012-12-01
MA28626B1 (fr) 2007-06-01
IL178544A0 (en) 2007-02-11
CA2564367C (fr) 2010-05-18
FR2891826B1 (fr) 2007-12-28
IL178544A (en) 2017-04-30
TW200800222A (en) 2008-01-01
AU2006228027A1 (en) 2007-04-26
MY139508A (en) 2009-10-30
JP2007112796A (ja) 2007-05-10
WO2007042656A1 (fr) 2007-04-19
CN1948292A (zh) 2007-04-18
US7358240B2 (en) 2008-04-15
PE20070492A1 (es) 2007-06-23
AP2006003762A0 (en) 2006-10-31
NO20064596L (no) 2007-04-12
UA90265C2 (ru) 2010-04-26
SA06270370B1 (ar) 2010-03-23
GT200600450A (es) 2007-06-18
US20070082885A1 (en) 2007-04-12
CA2564367A1 (fr) 2007-04-11
KR20070040311A (ko) 2007-04-16
ECSP066915A (es) 2007-05-30
CO5790166A1 (es) 2007-08-31
CR8645A (es) 2007-06-08
AP2303A (en) 2011-10-31

Similar Documents

Publication Publication Date Title
BRPI0604250A (pt) forma cristalina delta de cloridrato de ivabradina, processo para sua preparação e composições farmacêuticas contendo a mesma
BRPI0604253A (pt) forma deltad-cristalina de cloridrato de ivabradina, um processo para sua preparação e composições farmacêuticas contendo-as
BRPI0600795A (pt) forma betad-cristalina de cloridrato de ivabradina, um processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0600696A (pt) forma gamad-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0603043A (pt) forma cristalina iv de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
BRPI0600623A (pt) forma beta-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0600796B8 (pt) forma gama-cristalina de cloridrato de ivabradina, processo para preparação do mesmo e composições farmacêuticas contendo o mesmo
BRPI0804994A2 (pt) forma cristalina vi de agomelatina, um processo para a sua preparação e composições farmacêuticas contendo-a
CY1118637T1 (el) Νεα κρυσταλλικη μορφη iii της αγομελατινης, μεθοδος παρασκευης αυτης και οι φαρμακευτικες συνθεσεις που την περιεχουν
BRPI0603059A (pt) forma cristalina v de agomelatina, um processo para sua preparação e composições farmacêuticas contendo-a
CU20060193A7 (es) Procedimiento de preparación de la forma cristalina delta del clorhidrato de la ivabradina y las composiciones farmacéuticas que lo contienen
CU20060195A7 (es) Forma cristalina delta-d del clorhidrato de la ivabradina, su procedimiento de preparación, y las composiciones farmacéuticas que lo contienen

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL