BR112015014619A2 - tratamento de transtornos do ritmo circadiano - Google Patents
tratamento de transtornos do ritmo circadianoInfo
- Publication number
- BR112015014619A2 BR112015014619A2 BR112015014619A BR112015014619A BR112015014619A2 BR 112015014619 A2 BR112015014619 A2 BR 112015014619A2 BR 112015014619 A BR112015014619 A BR 112015014619A BR 112015014619 A BR112015014619 A BR 112015014619A BR 112015014619 A2 BR112015014619 A2 BR 112015014619A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- circadian rhythm
- rhythm disorders
- patients
- circadian
- Prior art date
Links
- 208000017164 Chronobiology disease Diseases 0.000 title abstract 2
- 230000027288 circadian rhythm Effects 0.000 abstract 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000008447 perception Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2864—Sleep disorders
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Primary Health Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
resumo tratamento de transtornos do ritmo circadiano representações desta invenção relacionam-se com o uso de um agonista de melatonina no tratamento de ritmos circadianos de funcionamento livre em pacientes, incluindo pacientes com deficiências na percepção da luz, p.ex., pacientes cegos, e aos métodos para medir o ritmo circadiano.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261738985P | 2012-12-18 | 2012-12-18 | |
US201261738987P | 2012-12-18 | 2012-12-18 | |
US201361755896P | 2013-01-23 | 2013-01-23 | |
US13/751,011 US8785492B2 (en) | 2012-01-26 | 2013-01-25 | Treatment of circadian rhythm disorders |
PCT/US2013/023315 WO2013112951A2 (en) | 2012-01-26 | 2013-01-25 | Treatment of circadian rhythm disorders |
US201361903354P | 2013-11-12 | 2013-11-12 | |
PCT/US2013/076311 WO2014100292A1 (en) | 2012-12-18 | 2013-12-18 | Treatment of circadian rhythm disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015014619A2 true BR112015014619A2 (pt) | 2017-07-11 |
Family
ID=50979184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015014619A BR112015014619A2 (pt) | 2012-12-18 | 2013-12-18 | tratamento de transtornos do ritmo circadiano |
Country Status (15)
Country | Link |
---|---|
US (2) | US9730910B2 (pt) |
EP (2) | EP3767297A1 (pt) |
JP (4) | JP6144358B2 (pt) |
KR (4) | KR20170058464A (pt) |
CN (2) | CN110200958A (pt) |
AU (5) | AU2013361459A1 (pt) |
BR (1) | BR112015014619A2 (pt) |
CA (2) | CA3158157A1 (pt) |
CL (1) | CL2015001700A1 (pt) |
ES (1) | ES2805376T3 (pt) |
IL (2) | IL266159B2 (pt) |
MX (3) | MX2015007909A (pt) |
RU (1) | RU2748386C2 (pt) |
WO (1) | WO2014100292A1 (pt) |
ZA (1) | ZA201504579B (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
EP3620794A1 (en) | 2012-01-26 | 2020-03-11 | Vanda Pharmaceuticals Inc. | Determining a circadian rhythm |
JP6144358B2 (ja) * | 2012-12-18 | 2017-06-07 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 概日リズム障害の治療 |
WO2015117048A1 (en) * | 2014-01-31 | 2015-08-06 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
CN115304596A (zh) | 2015-10-30 | 2022-11-08 | 纽罗克里生物科学有限公司 | Valbenazine盐及其多晶形物 |
DK3394057T3 (da) | 2015-12-23 | 2022-04-11 | Neurocrine Biosciences Inc | Syntetisk fremgangsmåde til fremstilling af (S)-(2R,3R,11BR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11B-hexahydro-1H-pyrido[2,1,-A]isoquinolin-2-yl 2-amino-3-methylbutanoat-di(4-methylbenzensulfonat) |
WO2018140095A2 (en) | 2017-01-27 | 2018-08-02 | Obrien Christopher F | Methods for the administration of certain vmat2 inhibitors |
ES2965488T3 (es) | 2017-08-02 | 2024-04-15 | Vanda Pharmaceuticals Inc | Uso de tasimelteón para el tratamiento de trastornos afectivos en pacientes mayoritariamente negroafricanos |
IL309802A (en) | 2017-09-21 | 2024-02-01 | Neurocrine Biosciences Inc | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
US20200230127A1 (en) | 2017-10-10 | 2020-07-23 | Neurocrine Biosciences, Inc. | Methods for the Administration of Certain VMAT2 Inhibitors |
US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
WO2020037022A1 (en) | 2018-08-15 | 2020-02-20 | Neurocrine Biosciences, Inc. | Methods for the administration of certain vmat2 inhibitors |
EP3671757A1 (en) * | 2018-12-18 | 2020-06-24 | Koninklijke Philips N.V. | System and method for determining a level of alertness |
CN113993516A (zh) * | 2019-02-13 | 2022-01-28 | 万达制药公司 | 改善睡眠的方法 |
JP7348613B2 (ja) * | 2019-04-18 | 2023-09-21 | 株式会社こどもみらい | 個人別の概日リズムに基づく生活時刻の提示システム |
JP6722911B1 (ja) * | 2019-04-18 | 2020-07-15 | 株式会社こどもみらい | 個人別の概日リズムに基づく生活時刻の提示システム |
CN114641284A (zh) * | 2019-06-29 | 2022-06-17 | 万带兰制药公司 | 他司美琼在治疗睡眠异常中的应用 |
US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
Family Cites Families (35)
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IL50699A0 (en) | 1975-10-28 | 1976-12-31 | Ici America Inc | Triazole derivatives |
DE3466215D1 (en) | 1983-05-18 | 1987-10-22 | Univ Monash | The use of melatonin for the manufacture of a medicament |
IL79264A0 (en) | 1986-06-27 | 1986-09-30 | Univ Ramot | Tryptamine derivatives,pharmaceutical compositions containing them and their use in an assay for melatonin receptors |
US4997845A (en) | 1987-02-02 | 1991-03-05 | Eli Lilly And Company | β-alkylmelatonins as ovulation inhibitors |
US5093352A (en) | 1988-11-14 | 1992-03-03 | Whitby Research, Inc. | Antidepressant agents |
US5151446A (en) | 1989-09-25 | 1992-09-29 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
IT1251544B (it) | 1991-05-13 | 1995-05-17 | Gabriele Biella | Composizioni farmaceutiche attive nella terapia dei disturbi del sonno comprendenti melatonina o un suo derivato in associazione con un derivato benzodiazepinico |
US6180657B1 (en) | 1993-11-18 | 2001-01-30 | Eli Lilly And Company | Melatonin derivatives for use in treating desynchronization disorders |
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SK284521B6 (sk) | 1995-02-01 | 2005-05-05 | Neurim Pharmaceuticals (1991) Ltd. | Použitie melatonínu na prípravu farmaceutického prostriedku |
CA2235803A1 (en) * | 1995-10-24 | 1997-05-01 | The Trustees Of The University Of Pennsylvania | Method of adjusting the circadian rhythm of a mammal |
PL190499B1 (pl) | 1996-12-10 | 2005-12-30 | Bristol Myers Squibb Co | Pochodna benzodioksolu, benzofuranu, dihydrobenzofuranu lub benzodioksanu, jej zastosowanie i kompozycja farmaceutyczna |
US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
AUPO588297A0 (en) | 1997-03-26 | 1997-04-24 | Luminis Pty Limited | Mediation in melatonin production |
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EP1189900B1 (en) | 1999-06-30 | 2004-01-14 | Bristol-Myers Squibb Company | Heterocyclic aminopyrrolidine derivatives as melatonergic agents |
JP5067998B2 (ja) | 2001-10-30 | 2012-11-07 | ノバルティス アーゲー | イロペリドンおよび星形ポリマーのデポー製剤 |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
IL155666A (en) * | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
JP2005080603A (ja) | 2003-09-10 | 2005-03-31 | Kumamoto Technology & Industry Foundation | 生体リズム障害の度合の判断方法 |
WO2005063240A1 (en) | 2003-12-22 | 2005-07-14 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of hypertension |
AU2004308962A1 (en) | 2003-12-24 | 2005-07-14 | Sepracor Inc. | Melatonin combination therapy for improving sleep quality |
KR101146807B1 (ko) | 2005-07-29 | 2012-05-21 | 반다 파마슈티칼즈, 인코퍼레이티드. | 각성을 향상시키는 방법 |
US7754902B2 (en) | 2006-05-18 | 2010-07-13 | Vanda Pharmaceuticals, Inc. | Ruthenium(II) catalysts for use in stereoselective cyclopropanations |
US20090105333A1 (en) | 2006-05-22 | 2009-04-23 | Gunther Birznieks | Melatonin agonist treatment |
AU2007253704A1 (en) | 2006-05-22 | 2007-11-29 | Vanda Pharmaceuticals, Inc. | Treatment for depressive disorders |
JP5590676B2 (ja) | 2007-09-13 | 2014-09-17 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Per3vntr遺伝子型に基づく睡眠パラメータ及び睡眠誘導化合物に対する応答の予測 |
WO2009084023A2 (en) | 2007-10-19 | 2009-07-09 | Glenmark Generics Limited | Amorphous ramelteon and process for the preparation thereof |
JP5558016B2 (ja) * | 2009-03-17 | 2014-07-23 | 株式会社 資生堂 | 概日リズム調整剤 |
EP2453891A1 (en) | 2009-07-16 | 2012-05-23 | Vanda Pharmaceuticals Inc. | Use of a melatonin agonist for the treatment of sleep disorders including primary insomnia |
EP3620794A1 (en) | 2012-01-26 | 2020-03-11 | Vanda Pharmaceuticals Inc. | Determining a circadian rhythm |
JP6144358B2 (ja) * | 2012-12-18 | 2017-06-07 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 概日リズム障害の治療 |
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2013
- 2013-12-18 JP JP2015549658A patent/JP6144358B2/ja active Active
- 2013-12-18 CA CA3158157A patent/CA3158157A1/en active Pending
- 2013-12-18 AU AU2013361459A patent/AU2013361459A1/en not_active Abandoned
- 2013-12-18 WO PCT/US2013/076311 patent/WO2014100292A1/en active Application Filing
- 2013-12-18 RU RU2015129349A patent/RU2748386C2/ru active
- 2013-12-18 IL IL266159A patent/IL266159B2/en unknown
- 2013-12-18 CN CN201910541736.2A patent/CN110200958A/zh active Pending
- 2013-12-18 KR KR1020177013614A patent/KR20170058464A/ko not_active Application Discontinuation
- 2013-12-18 KR KR1020157018602A patent/KR20150093236A/ko active Application Filing
- 2013-12-18 MX MX2015007909A patent/MX2015007909A/es active IP Right Grant
- 2013-12-18 EP EP20176129.3A patent/EP3767297A1/en active Pending
- 2013-12-18 KR KR1020207024197A patent/KR102269761B1/ko active IP Right Grant
- 2013-12-18 CA CA2893542A patent/CA2893542C/en active Active
- 2013-12-18 KR KR1020197024087A patent/KR102148990B1/ko active IP Right Grant
- 2013-12-18 BR BR112015014619A patent/BR112015014619A2/pt not_active Application Discontinuation
- 2013-12-18 CN CN201380066605.4A patent/CN105142630A/zh active Pending
- 2013-12-18 EP EP13817826.4A patent/EP2934509B1/en active Active
- 2013-12-18 ES ES13817826T patent/ES2805376T3/es active Active
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2014
- 2014-10-09 US US14/510,321 patent/US9730910B2/en active Active
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2015
- 2015-06-04 IL IL239246A patent/IL239246B/en active IP Right Grant
- 2015-06-17 CL CL2015001700A patent/CL2015001700A1/es unknown
- 2015-06-18 MX MX2020012689A patent/MX2020012689A/es unknown
- 2015-06-18 MX MX2019006218A patent/MX2019006218A/es unknown
- 2015-06-24 ZA ZA2015/04579A patent/ZA201504579B/en unknown
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2017
- 2017-04-13 JP JP2017080081A patent/JP6317503B2/ja active Active
- 2017-07-07 US US15/643,664 patent/US20170304256A1/en not_active Abandoned
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2018
- 2018-03-29 JP JP2018064884A patent/JP2018138554A/ja active Pending
- 2018-07-24 AU AU2018208633A patent/AU2018208633A1/en not_active Abandoned
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2019
- 2019-08-23 AU AU2019219847A patent/AU2019219847A1/en not_active Abandoned
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2020
- 2020-01-16 JP JP2020005354A patent/JP6826216B2/ja active Active
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