BG43189A3 - Method for preparing of acetylic ester of erythromycine stearate - Google Patents

Method for preparing of acetylic ester of erythromycine stearate

Info

Publication number: BG43189A3
Authority: BG; Bulgaria
Prior art keywords: ester; stearate; compound; erythromycin; acetylic
Prior art date: 1984-01-06

Application number

BG068285A

Other languages

Bulgarian (bg)

English (en)

Inventor

Martti Marvola

Esko Marttila

Jaakko Votila

Aino Pippuri

Pekka Kairisalo

Erkki Honkanen

Original Assignee

Orion- Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-06

Filing date

1985-01-05

Publication date

1988-04-15

1985-01-05 Application filed by Orion- Yhtymae Oy filed Critical Orion- Yhtymae Oy

1988-04-15 Publication of BG43189A3 publication Critical patent/BG43189A3/xx

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 4
150000002148 esters Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 2
YAVZHCFFUATPRK-YZPBMOCRSA-N Erythromycin stearate Chemical compound CCCCCCCCCCCCCCCCCC(O)=O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 YAVZHCFFUATPRK-YZPBMOCRSA-N 0.000 abstract 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 1
238000010521 absorption reaction Methods 0.000 abstract 1
-1 acetyl halide Chemical class 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
229960004142 erythromycin stearate Drugs 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
239000002547 new drug Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
210000002784 stomach Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Coloring (AREA)

BG068285A 1984-01-06 1985-01-05 Method for preparing of acetylic ester of erythromycine stearate BG43189A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK5884A DK149776C (da)	1984-01-06	1984-01-06	Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen

Publications (1)

Publication Number	Publication Date
BG43189A3 true BG43189A3 (en)	1988-04-15

Family

ID=8089251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG068285A BG43189A3 (en)	1984-01-06	1985-01-05	Method for preparing of acetylic ester of erythromycine stearate

Country Status (38)

Country	Link
US (1)	US4599326A (de)
JP (1)	JPS60158197A (de)
KR (1)	KR900006237B1 (de)
AT (1)	AT386414B (de)
AU (1)	AU565688B2 (de)
BE (1)	BE901411A (de)
BG (1)	BG43189A3 (de)
CA (1)	CA1224461A (de)
CH (1)	CH666275A5 (de)
CS (1)	CS247191B2 (de)
CY (1)	CY1462A (de)
DE (1)	DE3500179A1 (de)
DK (1)	DK149776C (de)
ES (1)	ES8605818A1 (de)
FI (1)	FI77249C (de)
FR (1)	FR2557878B1 (de)
GB (1)	GB2152502B (de)
HK (1)	HK11590A (de)
HU (1)	HU196221B (de)
IE (1)	IE57967B1 (de)
IL (1)	IL73885A (de)
IS (1)	IS2968A7 (de)
IT (1)	IT1184304B (de)
KE (1)	KE3841A (de)
LU (1)	LU85721A1 (de)
MA (1)	MA20316A1 (de)
MX (1)	MX156277A (de)
NL (1)	NL8403979A (de)
NO (1)	NO160263C (de)
NZ (1)	NZ210606A (de)
PH (1)	PH22471A (de)
PL (1)	PL144349B1 (de)
PT (1)	PT79777B (de)
RO (1)	RO91262B (de)
SE (1)	SE461854B (de)
SU (1)	SU1410866A3 (de)
YU (1)	YU44485B (de)
ZA (1)	ZA8410143B (de)

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* Cited by examiner, † Cited by third party
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US4863741A (en) *	1985-03-25	1989-09-05	Abbott Laboratories	Tablet composition for drug combinations
US4874614A (en) *	1985-03-25	1989-10-17	Abbott Laboratories	Pharmaceutical tableting method
JP3382159B2 (ja) *	1998-08-05	2003-03-04	株式会社東芝	情報記録媒体とその再生方法及び記録方法
US10004729B2 (en)	2002-07-05	2018-06-26	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8840928B2 (en)	2002-07-05	2014-09-23	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
JP4694207B2 (ja) *	2002-07-05	2011-06-08	コルジウムファーマシューティカル，インコーポレイテッド	オピオイドおよび他の薬物に関する乱用抑止性の薬学的組成物
JP2007509976A (ja) *	2003-10-31	2007-04-19	アルザ・コーポレーシヨン	増加された鉄の吸収のための組成物及び投与形態
PT1765292T (pt)	2004-06-12	2017-12-29	Collegium Pharmaceutical Inc	Formulações de fármacos dissuasoras de abuso
US9895444B2 (en)	2004-08-25	2018-02-20	Aegis Therapeutics, Llc	Compositions for drug administration
WO2006025882A2 (en)	2004-08-25	2006-03-09	The Uab Research Foundation	Absorption enhancers for drug administration
WO2007149096A1 (en)	2006-06-23	2007-12-27	Aegis Therapeutics, Inc.	Stabilizing alkylglycoside compositions and methods thereof
US10668060B2 (en)	2009-12-10	2020-06-02	Collegium Pharmaceutical, Inc.	Tamper-resistant pharmaceutical compositions of opioids and other drugs
CN108892709A (zh)	2011-05-18	2018-11-27	欧莫德里斯制药公司	改良的肽药物
KR102365582B1 (ko)	2012-11-20	2022-02-18	메더리스 다이어비티즈, 엘엘씨	인슐린 저항성에 대한 개선된 펩티드 약제
ES2906975T3 (es)	2012-11-20	2022-04-21	Eumederis Pharmaceuticals Inc	Productos farmacéuticos de péptidos mejorados
WO2014140699A1 (en) *	2013-03-13	2014-09-18	Calyx Chemicals And Pharmaceuticals Ltd	A novel process of liberation of erythromycin and preparation of its salts
NZ757113A (en)	2014-05-28	2022-08-26	Mederis Diabetes Llc	Improved peptide pharmaceuticals for insulin resistance
US9737530B1 (en)	2016-06-23	2017-08-22	Collegium Pharmaceutical, Inc.	Process of making stable abuse-deterrent oral formulations
RU2019142102A (ru)	2017-05-19	2021-06-21	Лунелла Байотек, Инк.	Антимитосцины: направленные ингибиторы митохондриального биогенеза для эрадикации злокачественных стволовых клеток
WO2019108729A1 (en)	2017-12-01	2019-06-06	Lunella Biotech, Inc.	Repurposcins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2019157099A1 (en)	2018-02-06	2019-08-15	Aegis Therapeutics, Llc	Intranasal epinephrine formulations and methods for the treatment of disease
MX2020008132A (es)	2018-02-06	2020-11-18	Aegis Therapeutics Llc	Formulaciones de epinefrina intranasal y metodos para el tratamiento de enfermedades.
KR20210104830A (ko) *	2018-12-17	2021-08-25	루넬라 바이오테크 인코포레이티드	항노화를 위한 삼중 조합 요법
CN113573715A (zh) *	2018-12-17	2021-10-29	卢内拉生物技术有限公司	用于靶向线粒体和杀死癌症干细胞的三联疗法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1011117B (de) *	1953-11-16	1957-06-27	Abbott Lab	Verfahren zur Herstellung von reinen stabilen Erythromycin-Saeure-Additionssalzen
FR1179208A (fr) *	1953-11-16	1959-05-21	Abbott Lab	Procédé de préparation de sels d'érythromycine
GB834397A (en) *	1958-07-29	1960-05-04	Lilly Co Eli	Therapeutic compositions comprising erythromycin esters
US4150220A (en) *	1977-02-04	1979-04-17	Pfizer Inc.	Semi-synthetic 4"-erythromycin A derivatives
FR2473525A1 (fr) *	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

1984
- 1984-01-06 DK DK5884A patent/DK149776C/da not_active IP Right Cessation
- 1984-12-18 NZ NZ210606A patent/NZ210606A/en unknown
- 1984-12-20 IL IL73885A patent/IL73885A/xx not_active IP Right Cessation
- 1984-12-21 GB GB08432368A patent/GB2152502B/en not_active Expired
- 1984-12-21 AU AU37059/84A patent/AU565688B2/en not_active Ceased
- 1984-12-27 US US06/686,753 patent/US4599326A/en not_active Expired - Fee Related
- 1984-12-28 PT PT79777A patent/PT79777B/pt not_active IP Right Cessation
- 1984-12-28 IS IS2968A patent/IS2968A7/is unknown
- 1984-12-28 SE SE8406671A patent/SE461854B/sv not_active IP Right Cessation
- 1984-12-28 BE BE0/214265A patent/BE901411A/fr not_active IP Right Cessation
- 1984-12-28 ZA ZA8410143A patent/ZA8410143B/xx unknown
- 1984-12-31 NL NL8403979A patent/NL8403979A/nl not_active Application Discontinuation
1985
- 1985-01-02 MA MA20540A patent/MA20316A1/fr unknown
- 1985-01-02 NO NO850007A patent/NO160263C/no unknown
- 1985-01-02 FR FR8500005A patent/FR2557878B1/fr not_active Expired
- 1985-01-03 FI FI850023A patent/FI77249C/fi not_active IP Right Cessation
- 1985-01-03 AT AT0000985A patent/AT386414B/de not_active IP Right Cessation
- 1985-01-04 SU SU853836820A patent/SU1410866A3/ru active
- 1985-01-04 CA CA000471563A patent/CA1224461A/en not_active Expired
- 1985-01-04 DE DE19853500179 patent/DE3500179A1/de active Granted
- 1985-01-04 HU HU8537A patent/HU196221B/hu not_active IP Right Cessation
- 1985-01-04 PL PL1985251457A patent/PL144349B1/pl unknown
- 1985-01-04 CH CH31/85A patent/CH666275A5/de not_active IP Right Cessation
- 1985-01-04 YU YU20/85A patent/YU44485B/xx unknown
- 1985-01-04 LU LU85721A patent/LU85721A1/fr unknown
- 1985-01-04 ES ES539349A patent/ES8605818A1/es not_active Expired
- 1985-01-04 KR KR1019850000008A patent/KR900006237B1/ko not_active IP Right Cessation
- 1985-01-04 CS CS8596A patent/CS247191B2/cs unknown
- 1985-01-04 IT IT19012/85A patent/IT1184304B/it active
- 1985-01-04 IE IE22/85A patent/IE57967B1/en not_active IP Right Cessation
- 1985-01-05 BG BG068285A patent/BG43189A3/xx unknown
- 1985-01-07 JP JP60000744A patent/JPS60158197A/ja active Granted
- 1985-01-07 PH PH31689A patent/PH22471A/en unknown
- 1985-01-07 MX MX203973A patent/MX156277A/es unknown
- 1985-01-07 RO RO117230A patent/RO91262B/ro unknown
1988
- 1988-10-28 KE KE3841A patent/KE3841A/xx unknown
1989
- 1989-07-21 CY CY1462A patent/CY1462A/xx unknown
1990
- 1990-02-15 HK HK115/90A patent/HK11590A/xx unknown

Also Published As

Publication number	Publication date
FR2557878A1 (fr)	1985-07-12
JPH029040B2 (de)	1990-02-28
JPS60158197A (ja)	1985-08-19
IE57967B1 (en)	1993-06-02
PT79777B (en)	1986-10-21
DK5884A (da)	1985-07-07
RO91262A (ro)	1987-06-30
SE461854B (sv)	1990-04-02
IT1184304B (it)	1987-10-28
NL8403979A (nl)	1985-08-01
HUT37628A (en)	1986-01-23
DK149776C (da)	1987-04-21
PL251457A1 (en)	1985-11-05
CY1462A (en)	1989-07-21
DK149776B (da)	1986-09-29
NO160263C (no)	1989-03-29
NZ210606A (en)	1987-08-31
PL144349B1 (en)	1988-05-31
AU3705984A (en)	1985-07-11
NO850007L (no)	1985-07-08
IL73885A (en)	1988-10-31
AU565688B2 (en)	1987-09-24
ATA985A (de)	1988-01-15
CS247191B2 (en)	1986-12-18
GB8432368D0 (en)	1985-02-06
SE8406671L (sv)	1985-07-07
IT8519012A0 (it)	1985-01-04
MX156277A (es)	1988-08-04
HU196221B (en)	1988-10-28
HK11590A (en)	1990-02-23
PT79777A (en)	1985-01-01
FI77249B (fi)	1988-10-31
IE850022L (en)	1985-07-06
IS2968A7 (is)	1985-04-03
GB2152502B (en)	1987-10-07
KE3841A (en)	1989-04-07
ES539349A0 (es)	1986-04-01
IL73885A0 (en)	1985-03-31
DE3500179C2 (de)	1989-08-24
ZA8410143B (en)	1985-08-28
CH666275A5 (de)	1988-07-15
DE3500179A1 (de)	1985-07-18
US4599326A (en)	1986-07-08
MA20316A1 (fr)	1985-10-01
SE8406671D0 (sv)	1984-12-28
FR2557878B1 (fr)	1988-01-15
SU1410866A3 (ru)	1988-07-15
PH22471A (en)	1988-09-12
KR900006237B1 (ko)	1990-08-27
NO160263B (no)	1988-12-19
LU85721A1 (fr)	1985-07-24
BE901411A (fr)	1985-04-16
CA1224461A (en)	1987-07-21
FI77249C (fi)	1989-02-10
DK5884D0 (da)	1984-01-06
RO91262B (ro)	1987-07-01
AT386414B (de)	1988-08-25
ES8605818A1 (es)	1986-04-01
FI850023L (fi)	1985-07-07
GB2152502A (en)	1985-08-07
YU44485B (en)	1990-08-31
FI850023A0 (fi)	1985-01-03
KR850005452A (ko)	1985-08-26
YU2085A (en)	1987-12-31

Publication	Publication Date	Title
BG43189A3 (en)	1988-04-15	Method for preparing of acetylic ester of erythromycine stearate
RU94033835A (ru)	1996-04-20	Амиды органических кислот, способ их получения и фармацевтические композиции
SE8406138L (sv)	1985-06-09	Nya retinoider
GB1247612A (en)	1971-09-29	Lincomycin derivatives and the manufacture thereof
RU94042916A (ru)	1996-10-10	9a-n - (n'-карбамоил) - и 9a-n - (n'-тиокарбамоил) производные 9-деоксо- 9a - аза - 9a - гомоэтирмицина а, способ их получения и фармкомпозиция на их основе
GB1436978A (en)	1976-05-26	Choline derivatives and pharmaceutical compositions containing the same
SE7707689L (sv)	1978-01-04	2-brom-6-fluor-n-2-imidazolidinylidenbensamin dess syraadditionssalter, lekemedel innehallande dessa och forfarande for framstellning derav
ES427433A1 (es)	1976-07-16	Un procedimiento para preparar un compuesto quimico selec- cionado del grupo que consiste en o-tiocarbamato de nitroi- midazolil-etilo.
NO872574L (no)	1987-12-22	Fremgangsmte for fremstilling av terapeutisk aktive tetrahydro-benzotiazoler.
ES418743A1 (es)	1976-06-16	Un procedimiento para la preparacion del complejo antibio- tico de la butirosina.
SE7903200L (sv)	1979-10-11	Farmaceutiskt, serskilt diuretiskt verksamt preparat for parenteral administration
ES8203963A1 (es)	1982-04-16	Un procedimiento para la preparacion de una macrolida
SE8402361L (sv)	1984-11-05	Nya acylaminofenolderivat
SE8701019D0 (sv)	1987-03-11	Makrolidforening
IE43117L (en)	1976-12-16	Naphthacene derivatives
NO871187D0 (no)	1987-03-23	Fremgangsmaate til fremstilling av en blanding inneholdende indometacin.
ES407866A1 (es)	1975-10-01	Procedimiento para la obtencion de n - (dietilaminoetil) - 2 - metoxi - 5 - metilsulfonil - benzamida.
GB1463038A (en)	1977-02-02	Benzhydryloxyalkylamine derivatives and process for the preparation thereof
GB1433977A (en)	1976-04-28	Acyl derivatives
KR880009026A (ko)	1988-09-13	리파마이신 유도체 염
KR880002536A (ko)	1988-05-09	옥시란 슈도올리고삭카라이드, 이의 제조방법 및 이의 용도 및 약제학적 제제
JPS5432493A (en)	1979-03-09	Preparation of macrolide antibiotics derivatives
JPS57139015A (en)	1982-08-27	Remedy for infectious disease for oral administration
SE7707552L (sv)	1977-12-31	Antibiotikum bl580delta
SU667130A3 (ru)	1979-06-05	Способ получени соли лизина и -метил-(изопропил-2-инданил-5) уксусной кислоты