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GB1463038A - Benzhydryloxyalkylamine derivatives and process for the preparation thereof - Google Patents

Benzhydryloxyalkylamine derivatives and process for the preparation thereof

Info

Publication number
GB1463038A
GB1463038A GB2630975A GB2630975A GB1463038A GB 1463038 A GB1463038 A GB 1463038A GB 2630975 A GB2630975 A GB 2630975A GB 2630975 A GB2630975 A GB 2630975A GB 1463038 A GB1463038 A GB 1463038A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
acid addition
addition salts
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2630975A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of GB1463038A publication Critical patent/GB1463038A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The compounds of the general formula (I) in which X = halogen atom, methyl or methoxy groups; n = 2, 3 or 4; A = together with a nitrogen atom a partially or completely saturated heterocycle which is optionally substituted by 1 to 2 methoxy groups and has 6 to 10 members and which can also, where appropriate, consist of a plurality of rings, and the acid addition salts formed with pharmaceutically compatible acids, are obtained by reacting compounds of the formula (II) in the presence of a base with benzhydrol derivatives or benzhydryl derivatives, and if required, converting the resulting compounds of the formula (I), preferably without previous isolation, into their pharmaceutically compatible acid addition salts. In the formula (II), Y = halogen atom or hydroxyl group and m = 2, 3 or 4. <IMAGE> The compounds of the general formula (I) and their acid addition salts have a delayed antihistamine effect.
GB2630975A 1974-06-24 1975-06-20 Benzhydryloxyalkylamine derivatives and process for the preparation thereof Expired GB1463038A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUEE2248A HU168506B (en) 1974-06-24 1974-06-24

Publications (1)

Publication Number Publication Date
GB1463038A true GB1463038A (en) 1977-02-02

Family

ID=10995563

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2630975A Expired GB1463038A (en) 1974-06-24 1975-06-20 Benzhydryloxyalkylamine derivatives and process for the preparation thereof

Country Status (19)

Country Link
JP (1) JPS51125088A (en)
AT (1) AT343110B (en)
CA (1) CA1044230A (en)
CH (1) CH609687A5 (en)
CS (1) CS188961B2 (en)
DD (1) DD118427A5 (en)
DE (1) DE2528194C2 (en)
DK (1) DK138540B (en)
ES (1) ES438834A1 (en)
FI (1) FI60863C (en)
FR (1) FR2276040A1 (en)
GB (1) GB1463038A (en)
HU (1) HU168506B (en)
IL (1) IL47451A (en)
NL (1) NL181330C (en)
PL (1) PL99800B1 (en)
SE (1) SE420722B (en)
SU (1) SU569287A3 (en)
YU (1) YU37350B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101486687B (en) * 2009-02-17 2012-01-04 回音必集团抚州制药有限公司 Preparation technique of setastine hydrochloride
CN102417489A (en) * 2011-11-01 2012-04-18 回音必集团抚州制药有限公司 Setastine hydrochloride crystal form F and preparation method thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3265363D1 (en) * 1981-05-12 1985-09-19 Ici Plc 1,1-bis phenylalkan-1-ols and processes for their preparation
JPH057664U (en) * 1991-02-05 1993-02-02 株式会社慶華園 Double-wrapped food

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101486687B (en) * 2009-02-17 2012-01-04 回音必集团抚州制药有限公司 Preparation technique of setastine hydrochloride
CN102417489A (en) * 2011-11-01 2012-04-18 回音必集团抚州制药有限公司 Setastine hydrochloride crystal form F and preparation method thereof

Also Published As

Publication number Publication date
DK279175A (en) 1975-12-25
IL47451A0 (en) 1975-08-31
DK138540B (en) 1978-09-25
DE2528194A1 (en) 1976-02-19
DE2528194C2 (en) 1982-10-14
YU149175A (en) 1983-04-27
YU37350B (en) 1984-08-31
JPS51125088A (en) 1976-11-01
NL181330B (en) 1987-03-02
PL99800B1 (en) 1978-08-31
IL47451A (en) 1978-10-31
ATA464875A (en) 1977-09-15
NL181330C (en) 1987-08-03
SE420722B (en) 1981-10-26
DK138540C (en) 1979-02-26
FR2276040A1 (en) 1976-01-23
JPS563870B2 (en) 1981-01-27
FI60863C (en) 1982-04-13
CH609687A5 (en) 1979-03-15
HU168506B (en) 1976-05-28
DD118427A5 (en) 1976-03-05
AU8207475A (en) 1976-12-16
SU569287A3 (en) 1977-08-15
AT343110B (en) 1978-05-10
FI751845A7 (en) 1975-12-25
ES438834A1 (en) 1977-01-16
CS188961B2 (en) 1979-03-30
CA1044230A (en) 1978-12-12
NL7507447A (en) 1975-12-30
SE7507165L (en) 1975-12-29
FR2276040B1 (en) 1982-06-18
FI60863B (en) 1981-12-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years

Effective date: 19950619