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BG104863A - Inhibitors of caspases - Google Patents

Inhibitors of caspases

Info

Publication number
BG104863A
BG104863A BG104863A BG10486300A BG104863A BG 104863 A BG104863 A BG 104863A BG 104863 A BG104863 A BG 104863A BG 10486300 A BG10486300 A BG 10486300A BG 104863 A BG104863 A BG 104863A
Authority
BG
Bulgaria
Prior art keywords
compounds
gamma
diseases
relates
interferon
Prior art date
Application number
BG104863A
Other languages
Bulgarian (bg)
English (en)
Inventor
Marion Wannamaker
Guy Bemis
Paul Charifson
David Lauffer
Michael Mullican
Mark Murcko
Keith Wilson
James Janetka
Robert Davies
Anne-Laure Grillot
Zhan Shi
Cornelia Forster
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of BG104863A publication Critical patent/BG104863A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
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    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
BG104863A 1998-03-19 2000-10-16 Inhibitors of caspases BG104863A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7877098P 1998-03-19 1998-03-19
PCT/US1999/005919 WO1999047545A2 (fr) 1998-03-19 1999-03-19 Inhibiteurs de caspases

Publications (1)

Publication Number Publication Date
BG104863A true BG104863A (en) 2001-04-30

Family

ID=22146109

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104863A BG104863A (en) 1998-03-19 2000-10-16 Inhibitors of caspases

Country Status (34)

Country Link
US (3) US6531474B1 (fr)
EP (6) EP2261233A3 (fr)
JP (3) JP4594520B2 (fr)
KR (2) KR100898094B1 (fr)
CN (1) CN1321129C (fr)
AP (1) AP2000001919A0 (fr)
AR (1) AR019011A1 (fr)
AT (1) ATE410439T1 (fr)
AU (1) AU769033B2 (fr)
BG (1) BG104863A (fr)
BR (2) BRPI9909660B8 (fr)
CA (1) CA2324226C (fr)
CZ (1) CZ302281B6 (fr)
DE (1) DE69939689D1 (fr)
DK (1) DK1064298T3 (fr)
ES (1) ES2315010T3 (fr)
GE (1) GEP20043163B (fr)
HK (1) HK1035733A1 (fr)
HU (1) HU227920B1 (fr)
ID (1) ID27002A (fr)
IL (3) IL138469A0 (fr)
IS (1) IS5622A (fr)
NO (1) NO331829B1 (fr)
NZ (2) NZ506963A (fr)
PL (1) PL204619B1 (fr)
PT (1) PT1064298E (fr)
RU (1) RU2274642C2 (fr)
SI (1) SI1064298T1 (fr)
SK (1) SK286736B6 (fr)
TR (1) TR200103406T2 (fr)
TW (1) TWI243828B (fr)
UA (2) UA74133C2 (fr)
WO (1) WO1999047545A2 (fr)
ZA (1) ZA200004652B (fr)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047545A2 (fr) * 1998-03-19 1999-09-23 Vertex Pharmaceuticals Incorporated Inhibiteurs de caspases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US6720415B2 (en) 1998-12-02 2004-04-13 Princeton University Compositions and methods for regulating bacterial pathogenesis
US7326542B2 (en) 1998-12-02 2008-02-05 Princeton University Compositions and methods for regulating bacterial pathogenesis
AU7766900A (en) * 1999-10-13 2001-04-23 Merck Frosst Canada & Co. Nicotinyl aspartyl ketones as inhibitors of caspase-3
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NO331829B1 (no) 2012-04-16
PL343611A1 (en) 2001-08-27
WO1999047545A2 (fr) 1999-09-23
AU3098699A (en) 1999-10-11
BRPI9909660B1 (pt) 2018-09-18
HUP0103575A2 (hu) 2002-02-28
DE69939689D1 (de) 2008-11-20
US20030232986A1 (en) 2003-12-18
US7358273B2 (en) 2008-04-15
CZ20003409A3 (cs) 2001-01-17
WO1999047545A3 (fr) 1999-11-25
EP2261233A2 (fr) 2010-12-15
GEP20043163B (en) 2004-01-26
NZ506963A (en) 2003-10-31
EP2261232A3 (fr) 2011-04-20
JP4594520B2 (ja) 2010-12-08
EP2011800A2 (fr) 2009-01-07
KR20080020703A (ko) 2008-03-05
US8691848B2 (en) 2014-04-08
IL206621A0 (en) 2010-12-30
JP2006206600A (ja) 2006-08-10
NO20004546D0 (no) 2000-09-12
EP2261234A3 (fr) 2011-04-20
CN1323314A (zh) 2001-11-21
NO20004546L (no) 2000-11-09
ZA200004652B (en) 2002-04-24
TR200103406T2 (tr) 2002-06-21
BR9909660A (pt) 2000-11-21

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