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ATE528722T1 - Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung - Google Patents

Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung

Info

Publication number
ATE528722T1
ATE528722T1 AT08754418T AT08754418T ATE528722T1 AT E528722 T1 ATE528722 T1 AT E528722T1 AT 08754418 T AT08754418 T AT 08754418T AT 08754418 T AT08754418 T AT 08754418T AT E528722 T1 ATE528722 T1 AT E528722T1
Authority
AT
Austria
Prior art keywords
image data
compartments
data clustering
pixel characterization
present
Prior art date
Application number
AT08754418T
Other languages
English (en)
Inventor
Jason Christiansen
Robert Pinard
Mark Gustavson
Brian Bourke
Dylan Reilly
Gregory Tedeschi
Original Assignee
Historx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Historx Inc filed Critical Historx Inc
Application granted granted Critical
Publication of ATE528722T1 publication Critical patent/ATE528722T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/22—Matching criteria, e.g. proximity measures
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Data Mining & Analysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Multimedia (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Artificial Intelligence (AREA)
  • General Engineering & Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Evolutionary Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Color Television Image Signal Generators (AREA)
AT08754418T 2007-05-14 2008-05-14 Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung ATE528722T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91785307P 2007-05-14 2007-05-14
PCT/US2008/006116 WO2008143849A2 (en) 2007-05-14 2008-05-14 Compartment segregation by pixel characterization using image data clustering

Publications (1)

Publication Number Publication Date
ATE528722T1 true ATE528722T1 (de) 2011-10-15

Family

ID=39624329

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08754418T ATE528722T1 (de) 2007-05-14 2008-05-14 Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung

Country Status (8)

Country Link
US (2) US8335360B2 (de)
EP (1) EP2156370B1 (de)
JP (1) JP5425762B2 (de)
AT (1) ATE528722T1 (de)
CA (1) CA2690612C (de)
DK (1) DK2156370T3 (de)
ES (1) ES2374686T3 (de)
WO (1) WO2008143849A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8594410B2 (en) * 2006-08-28 2013-11-26 Definiens Ag Context driven image mining to generate image-based biomarkers
US8518649B2 (en) 2007-04-04 2013-08-27 {hacek over (S)}árka O. Southern Systems and methods for analyzing persistent homeostatic perturbations
ES2374686T3 (es) 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
JP5593221B2 (ja) 2007-06-15 2014-09-17 ヒストロックス，インコーポレイテッド． 顕微鏡機器を標準化するための方法およびシステム
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7978258B2 (en) * 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
US8189884B2 (en) * 2008-03-26 2012-05-29 General Electric Company Methods for assessing molecular expression of subcellular molecules
ES2573945T3 (es) * 2008-09-16 2016-06-13 Novartis Ag Cuantificación reproducible de expresión de biomarcadores
US8588486B2 (en) * 2009-06-18 2013-11-19 General Electric Company Apparatus and method for isolating a region in an image
US8824769B2 (en) 2009-10-16 2014-09-02 General Electric Company Process and system for analyzing the expression of biomarkers in a cell
US8320655B2 (en) * 2009-10-16 2012-11-27 General Electric Company Process and system for analyzing the expression of biomarkers in cells
US20110091081A1 (en) * 2009-10-16 2011-04-21 General Electric Company Method and system for analyzing the expression of biomarkers in cells in situ in their tissue of origin
US8644608B2 (en) * 2009-10-30 2014-02-04 Eiffel Medtech Inc. Bone imagery segmentation method and apparatus
US8634626B2 (en) * 2010-06-29 2014-01-21 The Chinese University Of Hong Kong Registration of 3D tomography images
WO2012075377A1 (en) 2010-12-03 2012-06-07 Historx, Inc. Identification of cancer patients likely to benefit from radiation therapy
US20120270752A1 (en) * 2011-04-22 2012-10-25 Ge Global Research Analyzing the expression of biomarkers in cells with moments
US8831327B2 (en) * 2011-08-30 2014-09-09 General Electric Company Systems and methods for tissue classification using attributes of a biomarker enhanced tissue network (BETN)
JP5953035B2 (ja) * 2011-11-28 2016-07-13 学校法人慶應義塾 病理診断支援装置、病理診断支援方法、及び病理診断支援プログラム
WO2013112601A1 (en) * 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Methods of treatment of cancer
US20140357596A1 (en) * 2012-01-24 2014-12-04 Millennium Pharmaceuticals, Inc. Method of treatment of nasopharyngeal cancer
EP2972376B1 (de) 2013-03-15 2018-12-05 Eisai Inc. Verfahren zur bestimmung der prognose von kolorektalkarzinom
WO2014172345A2 (en) * 2013-04-15 2014-10-23 Massachusetts Institute Of Technology Fully automated system and method for image segmentation and quality control of protein microarrays
CN108136216B (zh) * 2015-10-23 2021-08-24 诺华股份有限公司 对包含肿瘤组织的样品评分的方法
WO2018085859A1 (en) * 2016-11-07 2018-05-11 Ayasdi, Inc. Dimension grouping and reduction for model generation, testing, and documentation
US11915810B2 (en) * 2016-12-14 2024-02-27 Reliant Immune Diagnostics, Inc. System and method for transmitting prescription to pharmacy using self-diagnostic test and telemedicine
EP3591574A3 (de) * 2018-07-06 2020-01-15 Universität Zürich Verfahren und computerprogramm zum clustern von grossen multiplexierten ortsaufgelösten daten einer biologischen probe
EP3644044B1 (de) * 2018-10-24 2020-12-23 Leica Biosystems Imaging, Inc. Kamerabelichtungssteuerung bei der erfassung von fluoreszenz-in-situ-hybridisierungs-bildern
US20230083087A1 (en) * 2020-03-26 2023-03-16 Neogen Food Safety Us Holco Corporation Microorganic detection system with worklists

Family Cites Families (218)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1914322A (en) 1929-01-22 1933-06-13 Everett H Bickley Device for the comparison of colors
US3958122A (en) 1974-12-19 1976-05-18 United Technologies Corporation Exhaust gas analyzer having pressure and temperature compensation
DE3037622C2 (de) 1980-10-04 1987-02-26 Theodor Prof. Dr.-Ing. 1000 Berlin Gast Einrichtung zur Bestimmung der Oberflächengüte
US4480189A (en) 1981-11-20 1984-10-30 Kasei Optonix, Ltd. Thermoluminescence dosimeter reader
US4557599A (en) 1984-03-06 1985-12-10 General Signal Corporation Calibration and alignment target plate
DE3429541C2 (de) 1984-08-10 1992-10-22 Seidenberg, Jürgen, Dipl.-Ing., 5100 Aachen Verfahren zur gleichzeitigen Bestimmung der Wellenlänge und der Strahlungsleistung einer monochromatischen Lichtquelle
US4902131A (en) 1985-03-28 1990-02-20 Kabushiki Kaisha Toshiba Surface inspection method and apparatus therefor
US4998284A (en) 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
JPH07119Y2 (ja) 1988-03-18 1995-01-11 三和シヤッター工業株式会社 電動式昇降ベッド
US4927266A (en) 1987-03-30 1990-05-22 Anritsu Corporation Optical signal generating apparatus and optical power meter calibrating system using the same
US4892817A (en) 1987-09-21 1990-01-09 Biogenex Laboratories Stable phosphatase substrate composition
US4912034A (en) 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US5015098A (en) 1987-10-05 1991-05-14 X-Rite, Incorporated Densitometer with error correction
JPH0663758B2 (ja) 1987-10-14 1994-08-22 株式会社東芝 パターンの測定方法
DE3800427C2 (de) 1988-01-09 1997-05-28 Breitmeier Ulrich Gerät zum Ermitteln des Abstands eines auf einer Prüffläche liegenden Prüfpunktes von einer Referenzfläche
US5068909A (en) 1989-05-18 1991-11-26 Applied Imaging Corporation Method and apparatus for generating quantifiable video displays
US5070455A (en) 1989-11-22 1991-12-03 Singer Imaging, Inc. Imaging system and method using scattered and diffused radiation
US5115673A (en) 1990-07-20 1992-05-26 The United States Of America As Represented By The United States National Aeronautics And Space Administration Non-destructive method for determining elastic moduli of material
US5244787A (en) 1991-01-31 1993-09-14 Biogenex Laboratories Antigen retrieval in formalin-fixed tissues using microwave energy
US6411377B1 (en) 1991-04-02 2002-06-25 Hitachi, Ltd. Optical apparatus for defect and particle size inspection
US5126577A (en) 1991-06-27 1992-06-30 Electro-Optical Industries, Inc. Infrared target plate handling apparatus with improved thermal control
KR960002145B1 (ko) 1991-07-30 1996-02-13 가부시기가이샤 히다찌세이사구쇼 박막트랜지스터 액정기판의 검사방법 및 그 장치
CA2084099C (en) 1991-12-06 1996-06-18 James V. Bacus Method and apparatus for automated cell analysis
US5578452A (en) 1992-01-16 1996-11-26 Biogenex Laboratories Enhancement of immunochemical staining in aldehyde-fixed tissues
US5254845A (en) 1992-08-18 1993-10-19 Applied Imaging International Limited Automatic focusing system using focal length-changing element
US6026174A (en) 1992-10-14 2000-02-15 Accumed International, Inc. System and method for automatically detecting malignant cells and cells having malignancy-associated changes
US5889881A (en) 1992-10-14 1999-03-30 Oncometrics Imaging Corp. Method and apparatus for automatically detecting malignancy-associated changes
US6252242B1 (en) 1992-12-03 2001-06-26 Brown & Sharpe Surface Inspection Systems, Inc. High speed optical inspection apparatus using Gaussian distribution analysis and method therefore
US5427910A (en) 1992-12-09 1995-06-27 Compucyte Corporation Method of cytogenetic analysis
US5517193A (en) 1993-04-30 1996-05-14 International Business Machines Corporation Meteorological workstation
US5587833A (en) 1993-07-09 1996-12-24 Compucyte Corporation Computerized microscope specimen encoder
US5492837A (en) 1993-08-27 1996-02-20 Biogenex Laboratories Mounting medium for microscope slide preparations
US5439649A (en) 1993-09-29 1995-08-08 Biogenex Laboratories Automated staining apparatus
US6136540A (en) 1994-10-03 2000-10-24 Ikonisys Inc. Automated fluorescence in situ hybridization detection of genetic abnormalities
US6309601B1 (en) 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US5489386A (en) 1994-01-31 1996-02-06 Applied Imaging Density gradient medium for the separation of cells
US5422018A (en) 1994-01-31 1995-06-06 Applied Imaging Centrifuge tube and adaptor
US5432054A (en) 1994-01-31 1995-07-11 Applied Imaging Method for separating rare cells from a population of cells
US6632598B1 (en) 1994-03-11 2003-10-14 Biogenex Laboratories Deparaffinization compositions and methods for their use
US6451551B1 (en) 1994-03-11 2002-09-17 Biogenex Laboratories Releasing embedding media from tissue specimens
US5561556A (en) 1994-04-21 1996-10-01 Compucyte Corporation Slide analysis system with slide having self contained microscope analysis information
US5602574A (en) * 1994-08-31 1997-02-11 Hewlett-Packard Company Matrix pen arrangement for inkjet printing
US5672881A (en) 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
US5978497A (en) 1994-09-20 1999-11-02 Neopath, Inc. Apparatus for the identification of free-lying cells
DE19532897A1 (de) 1994-09-27 1996-03-28 Zeiss Carl Fa Verfahren zur Belichtungssteuerung bei Mikroskopkameras und entsprechendes Photomikroskop
US5633945A (en) 1994-10-05 1997-05-27 Compucyte Corporation Accuracy in cell mitosis analysis
US5523207A (en) 1994-10-17 1996-06-04 Compucyte Corporation Method for accurate counting of probe spots in cell nuclei
GB2294376B (en) 1994-10-18 1999-02-10 Rank Cintel Ltd Method and apparatus for correcting noise in a film scanner
DE69519980T2 (de) 1994-12-28 2001-06-07 Siemens Corp. Research, Inc. Verfahren und Gerät zur Detektion und Interpretation von Untertiteln in digitalen Videosignalen
US5694212A (en) 1995-06-20 1997-12-02 Compucyte Corporation Method for calibrating specimen with specimen holder of a microscope
US5717198A (en) 1995-07-10 1998-02-10 Qc Optics, Inc. Pellicle reflectivity monitoring system having means for compensating for portions of light reflected by the pellicle
CA2185511C (en) 1995-09-15 2008-08-05 Vladimir Dadeshidze Cytological specimen analysis system with individualized patient data
DE69635717T2 (de) 1995-10-30 2006-08-31 Arkray, Inc. Verfahren zum Bestimmen eines Analyten und Vorrichtung dafür
CA2236268A1 (en) 1995-11-30 1997-06-05 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6151405A (en) 1996-11-27 2000-11-21 Chromavision Medical Systems, Inc. System and method for cellular specimen grading
US6418236B1 (en) 1999-06-24 2002-07-09 Chromavision Medical Systems, Inc. Histological reconstruction and automated image analysis
US6718053B1 (en) 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6330349B1 (en) 1995-11-30 2001-12-11 Chromavision Medical Systems, Inc. Automated method for image analysis of residual protein
US6239868B1 (en) 1996-01-02 2001-05-29 Lj Laboratories, L.L.C. Apparatus and method for measuring optical characteristics of an object
US6882873B2 (en) 1996-01-17 2005-04-19 Respironics, Inc. Method and system for determining bilirubin concentration
US6165739A (en) 1996-03-13 2000-12-26 Compucyte Corporation Multiple simultaneous testing media
DE69725611T2 (de) 1996-05-15 2004-07-29 Biogenex Laboratories, San Ramon Nicht-Nukleotid verknüpfende Reagentien
US6292582B1 (en) 1996-05-31 2001-09-18 Lin Youling Method and system for identifying defects in a semiconductor
US6458585B1 (en) 1996-08-14 2002-10-01 Nexell Therapeutics Inc. Cytokine-free culture of dendritic cells
US6031930A (en) 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6404906B2 (en) 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6272235B1 (en) 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US5731156A (en) 1996-10-21 1998-03-24 Applied Imaging, Inc. Use of anti-embryonic hemoglobin antibodies to identify fetal cells
US5880473A (en) 1997-07-28 1999-03-09 Applied Imaging, Inc. Multifluor-fluorescence in-situ hybridization (M-FISH) imaging techniques using multiple multiband filters with image registration
WO1998017992A2 (en) 1996-10-25 1998-04-30 Applied Imaging, Inc. Multifluor-fluorescence in situ hybridization (m-fish) imaging techniques using multiple multiband filters with image registration
US5916750A (en) 1997-01-08 1999-06-29 Biogenex Laboratories Multifunctional linking reagents for synthesis of branched oligomers
US6087134A (en) 1997-01-14 2000-07-11 Applied Imaging Corporation Method for analyzing DNA from a rare cell in a cell population
US5885840A (en) 1997-02-10 1999-03-23 Compucyte Corp. Multiple assays of cell specimens
GB9704054D0 (en) 1997-02-27 1997-04-16 Univ Cambridge Tech Assay
US5948359A (en) 1997-03-21 1999-09-07 Biogenex Laboratories Automated staining apparatus
DE69816289T2 (de) 1997-04-25 2004-04-22 Universiteit Van Amsterdam Photobleichbare lumineszenzschichten zur kalibrierung und standardisierung in optischer mikroskopie
US6259807B1 (en) 1997-05-14 2001-07-10 Applied Imaging Corp. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6169816B1 (en) 1997-05-14 2001-01-02 Applied Imaging, Inc. Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images
US6052190A (en) 1997-09-09 2000-04-18 Utoptics, Inc. Highly accurate three-dimensional surface digitizing system and methods
US6002788A (en) 1997-09-24 1999-12-14 Compucyte Corporation Method and device for rendering cells observable with laser scanning cytometry
US5962234A (en) 1997-10-20 1999-10-05 Applied Imaging Corporation Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells
US6746873B1 (en) 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
US6699710B1 (en) 1998-02-25 2004-03-02 The United States Of America As Represented By The Department Of Health And Human Services Tumor tissue microarrays for rapid molecular profiling
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
US6495106B1 (en) 1998-03-24 2002-12-17 Biogenex Laboratories Automated staining apparatus
US6606413B1 (en) 1998-06-01 2003-08-12 Trestle Acquisition Corp. Compression packaged image transmission for telemicroscopy
US6049220A (en) 1998-06-10 2000-04-11 Boxer Cross Incorporated Apparatus and method for evaluating a wafer of semiconductor material
WO2000011208A1 (en) 1998-08-25 2000-03-02 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
DE19915057A1 (de) 1999-04-01 2000-10-19 Forschungszentrum Borstel Monoklonale Antikörper gegen das humane Mcm3 Protein, Verfahren zu ihrer Herstellung und ihre Verwendung
AU762085B2 (en) 1999-04-13 2003-06-19 Chromavision Medical Systems, Inc. Histological reconstruction and automated image analysis
US6876760B1 (en) 2000-12-04 2005-04-05 Cytokinetics, Inc. Classifying cells based on information contained in cell images
AU5606500A (en) 1999-06-18 2001-01-09 Applied Imaging Corporation High efficiency methods for combined immunocytochemistry and in-situ hybridization
US6453060B1 (en) 1999-06-29 2002-09-17 Tri Path Imaging, Inc. Method and apparatus for deriving separate images from multiple chromogens in a branched image analysis system
EP1198956A1 (de) 1999-07-13 2002-04-24 Chromavision Medical Systems, Inc. Gerät um genauefarbpegel in echtzeit anzuwenden
AU6347700A (en) 1999-07-13 2001-04-24 Chromavision Medical Systems, Inc. Apparatus for counting color transitions and areas in real time camera images
CA2380182A1 (en) 1999-08-04 2001-02-15 Chromavision Medical Systems, Inc. Method and apparatus for applying color thresholds in light microscopy
EP1336850A1 (de) 1999-10-12 2003-08-20 Connex Gesellschaft zur Optimierung von Forschung und Entwicklung Verbessertes Verfahren zum Nachweis von Säure-resistenten Mikroorganismen im Stuhl
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US6852986B1 (en) 1999-11-12 2005-02-08 E. I. Du Pont De Nemours And Company Fluorometer with low heat-generating light source
JP2001211896A (ja) 1999-11-26 2001-08-07 Olympus Optical Co Ltd 画像解析方法、装置、及び記録媒体
GB0001568D0 (en) 2000-01-24 2000-03-15 Isis Innovation Method and apparatus for measuring surface configuration
US20050230315A1 (en) 2003-01-13 2005-10-20 Regents Of The University Of Michigan Protein microarray system
US6778714B1 (en) 2000-03-10 2004-08-17 Imagexpert, Inc. Portable image analysis system
US6408048B2 (en) 2000-03-14 2002-06-18 Therma-Wave, Inc. Apparatus for analyzing samples using combined thermal wave and X-ray reflectance measurements
US7236623B2 (en) 2000-04-24 2007-06-26 International Remote Imaging Systems, Inc. Analyte recognition for urinalysis diagnostic system
US6518554B1 (en) 2000-05-24 2003-02-11 Chromavision Medical Systems, Inc. Reverse focusing methods and systems
US6522744B1 (en) 2000-05-31 2003-02-18 Jung-Hsun Chiang Volume control apparatus of telephone
IL136884A0 (en) 2000-06-19 2001-06-14 Yissum Res Dev Co A system for cancer detection and typing and for grading of malignancy
AU2001277964A1 (en) 2000-07-21 2002-02-05 The Trustees Of Columbia University In The City Of New York Method and apparatus for image mosaicing
US6816625B2 (en) 2000-08-16 2004-11-09 Lewis Jr Clarence A Distortion free image capture system and method
US6674058B1 (en) 2000-09-20 2004-01-06 Compucyte Corporation Apparatus and method for focusing a laser scanning cytometer
US7262799B2 (en) 2000-10-25 2007-08-28 Canon Kabushiki Kaisha Image sensing apparatus and its control method, control program, and storage medium
US7298402B2 (en) 2000-10-26 2007-11-20 Olympus Corporation Image-pickup apparatus with expanded dynamic range capabilities
GB2406908B (en) 2000-12-04 2005-07-27 Cytokinetics Inc Classifying cells based on information contained in cell images
US20030215936A1 (en) 2000-12-13 2003-11-20 Olli Kallioniemi High-throughput tissue microarray technology and applications
US6466690C1 (en) 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
JP3576523B2 (ja) 2000-12-26 2004-10-13 オリンパス株式会社 蛍光輝度測定方法及び装置
US6993169B2 (en) 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
DE10109130B4 (de) 2001-02-24 2015-02-19 Carl Zeiss Microscopy Gmbh Verfahren zur Aufzeichnung und Darstellung von Fluoreszenzbildern mit hoher räumlicher Auflösung
WO2002072867A2 (en) 2001-03-08 2002-09-19 Chromavision Medical Systems, Inc. Apparatus and method for labeling rows and columns in an irregular array
JP2002287039A (ja) 2001-03-22 2002-10-03 Olympus Optical Co Ltd 顕微鏡用撮影装置
DE10119005A1 (de) 2001-04-18 2002-10-24 Roche Diagnostics Gmbh Verfahren zur Proteinexpression ausgehend von stabilisierter linearer kurzer DNA in zellfreien in vitro-Transkription/Translations-Systemen mit Exonuklease-haltigen Lysaten oder in einem zellulären System enthaltend Exonukleasen
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US7123756B2 (en) 2001-04-27 2006-10-17 Fuji Photo Film Co., Ltd. Method and apparatus for standardized fluorescence image generation
DE10121064A1 (de) 2001-04-28 2002-10-31 Evotec Ag Vorrichtung und Verfahren zur optischen Messung von chemischen und/oder biologischen Proben
WO2002098280A2 (en) 2001-06-04 2002-12-12 Ikonisys Inc. Method for detecting infectious agents using computer controlled automated image analysis
WO2002099429A1 (en) 2001-06-05 2002-12-12 Genomics, Ltd. Compositions and methods for the detection of biomarkers associated with cardiovascular disease
US7133543B2 (en) 2001-06-12 2006-11-07 Applied Imaging Corporation Automated scanning method for pathology samples
US7116354B2 (en) 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
JP3788279B2 (ja) 2001-07-09 2006-06-21 株式会社日立製作所 パターン検査方法及び装置
US7332290B2 (en) 2001-08-02 2008-02-19 The Regents Of The University Of Michigan Dectection of AMACR cancer markers in urine
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US6648506B2 (en) 2001-09-07 2003-11-18 Board Of Trustees Of Michigan State University Fluorescence emission ratio imaging thermography for use in heat transfer analysis
US6697509B2 (en) 2001-10-04 2004-02-24 Chromavision Medical Systems, Inc. Method and apparatus for scoring the uptake of markers in cells
US7383134B2 (en) 2002-01-15 2008-06-03 Piper James R Method and/or system for analyzing biological samples using a computer system
EP1468266A4 (de) 2002-01-22 2009-03-11 Beckman Coulter Inc Umweltabgeschlossenes system für ein durchflusszytometer
US7205154B2 (en) 2002-01-31 2007-04-17 Agilent Technologies, Inc. Calibrating array scanners
US20030165263A1 (en) * 2002-02-19 2003-09-04 Hamer Michael J. Histological assessment
JP2003284713A (ja) 2002-03-28 2003-10-07 Konica Corp 医用画像処理装置、画像処理パラメータの補正方法、プログラム、記憶媒体
JP2003294734A (ja) 2002-03-29 2003-10-15 Mitsubishi Chemicals Corp 分子間の相互作用の分析方法
WO2003088123A1 (de) 2002-04-16 2003-10-23 Evotec Oai Ag Verfahren zur untersuchung chemischer und/oder biologischer proben mittels partikelbildern
WO2003093810A1 (en) 2002-05-03 2003-11-13 Vialogy Corporation System and method for characterizing microarray output data
US20040027618A1 (en) 2002-06-03 2004-02-12 Fuji Photo Film Co., Ltd. Image defect detecting method
US20050037406A1 (en) 2002-06-12 2005-02-17 De La Torre-Bueno Jose Methods and apparatus for analysis of a biological specimen
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US6800249B2 (en) 2002-06-14 2004-10-05 Chromavision Medical Systems, Inc. Automated slide staining apparatus
US20060127946A1 (en) 2002-08-16 2006-06-15 Montagu Jean I Reading of fluorescent arrays
CA2500805A1 (en) 2002-09-13 2004-03-25 Arcturus Bioscience, Inc. Interactive and automated tissue image analysis
US7173663B2 (en) 2002-10-31 2007-02-06 Freescale Semiconductor, Inc. Automatic exposure control system for a digital camera
GB2395263A (en) 2002-11-12 2004-05-19 Qinetiq Ltd Image analysis
GB2396406A (en) 2002-12-17 2004-06-23 Qinetiq Ltd Image analysis
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7062079B2 (en) 2003-02-14 2006-06-13 Ikonisys, Inc. Method and system for image segmentation
US7233340B2 (en) 2003-02-27 2007-06-19 Applied Imaging Corp. Linking of images to enable simultaneous viewing of multiple objects
US7064829B2 (en) 2003-03-20 2006-06-20 Timbre Technologies, Inc. Generic interface for an optical metrology system
GB2401431B (en) 2003-04-02 2005-04-27 Amersham Biosciences Uk Ltd Method of, and computer software for, classification of cells into subpopulations
US7171054B2 (en) 2003-05-01 2007-01-30 Eastman Kodak Company Scene-based method for determining focus
US7084386B2 (en) 2003-05-02 2006-08-01 International Business Machines Corporation System and method for light source calibration
JP2004354346A (ja) 2003-05-30 2004-12-16 Olympus Corp 測定装置
FI116246B (fi) 2003-06-30 2005-10-14 Nokia Corp Menetelmä ja järjestelmä digitaalisessa kuvannuksessa valotuksen säätämiseksi ja vastaava laite
JP4504644B2 (ja) 2003-08-26 2010-07-14 オリンパス株式会社 顕微鏡像撮像装置及び顕微鏡像撮像方法
US8068988B2 (en) 2003-09-08 2011-11-29 Ventana Medical Systems, Inc. Method for automated processing of digital images of tissue micro-arrays (TMA)
US20050136549A1 (en) 2003-10-30 2005-06-23 Bioimagene, Inc. Method and system for automatically determining diagnostic saliency of digital images
US7760927B2 (en) 2003-09-10 2010-07-20 Bioimagene, Inc. Method and system for digital image based tissue independent simultaneous nucleus cytoplasm and membrane quantitation
WO2005055925A2 (en) 2003-09-10 2005-06-23 Board Of Regents, The University Of Texas System 14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types
WO2005027015A2 (en) 2003-09-10 2005-03-24 Bioimagene, Inc. Method and system for quantitatively analyzing biological samples
DE10343375A1 (de) 2003-09-17 2005-04-28 Axaron Bioscience Ag Verfahren zur Detektion und Analyse von Protein-Protein-Interaktionen
US20050282179A1 (en) 2003-12-05 2005-12-22 Applera Corporation Biomarkers for interferon-alpha response in hepatitis C virus infected patients
JP2005181244A (ja) 2003-12-24 2005-07-07 Yokogawa Electric Corp 光量分布補正方法およびバイオチップ読取装置
WO2005076197A2 (en) 2004-01-31 2005-08-18 Bioimagene, Inc. Method and system for morphology based mitosis identification and classification of digital images
WO2005076216A2 (en) 2004-02-03 2005-08-18 Bioimagene, Inc. Method and system for automaticed digital image based flourescent in situ hybridization (fish) analysis
CN101001569B (zh) 2004-02-06 2010-05-26 韦克福里斯特大学健康科学院 评估组织特性和检测病人整体心脏损害的系统
JP4338551B2 (ja) 2004-03-04 2009-10-07 富士フイルム株式会社 画像再生方法、画像再生装置及び画像再生プログラム
WO2005096225A1 (en) 2004-03-27 2005-10-13 Bioimagene, Inc. Method and system for automated detection of immunohistochemical (ihc) patterns
US7330250B2 (en) 2004-05-18 2008-02-12 Agilent Technologies, Inc. Nondestructive evaluation of subsurface damage in optical elements
JP2005331394A (ja) 2004-05-20 2005-12-02 Olympus Corp 画像処理装置
WO2005114578A1 (en) 2004-05-21 2005-12-01 Bioimagene, Inc. Method and system for automated quantitation of tissue micro-array (tma) digital image analysis
JP4577891B2 (ja) * 2004-07-16 2010-11-10 株式会社リコー 光記録媒体
JP2008509400A (ja) 2004-08-06 2008-03-27 コンピュサイト コーポレイション 染色サンプルにおける光吸収のカラー表示型単色光吸収定量法
KR20070061893A (ko) 2004-09-22 2007-06-14 트리패스 이미징, 인코포레이티드 유방암 예후를 평가하기 위한 방법 및 조성물
WO2006039396A2 (en) 2004-10-01 2006-04-13 Ambion, Inc. Non-embedded tissue microarray technology for protein and nucleic acid analyses
CA2587765A1 (en) 2004-11-17 2006-05-26 Immunivest Corporation Magnetic enrichment of circulating cells, fragments and debris for enabling hts proteomics and genomics in disease detection
WO2006060646A2 (en) 2004-12-03 2006-06-08 Board Of Regents, The University Of Texas System Cell microarray for profiling of cellular phenotypes and gene function
JP2006194711A (ja) 2005-01-13 2006-07-27 Matsushita Electric Ind Co Ltd 蛍光発光色素の性能評価方法および性能評価装置
JP4982385B2 (ja) * 2005-02-01 2012-07-25 アムニス コーポレイション イメージングフローサイトメータを使用した血液及び細胞の分析
GB0503087D0 (en) 2005-02-15 2005-03-23 Medical Solutions Plc Apparatus and method for processing of specimen images for use in computer analysis thereof
WO2007024264A2 (en) 2005-02-23 2007-03-01 Bioimagene, Inc. Method and system for digital image based tissue independent simultaneous nucleus, cytoplasm and membrane quantitation
WO2006102233A2 (en) 2005-03-18 2006-09-28 Immunivest Corporation Method and apparatus for imaging target components in a biological sample using permanent magnets
EP2386854A1 (de) 2005-04-19 2011-11-16 Prediction Sciences LLC Diagnostische Marker von Brustkrebsbehandlung und -progression sowie Verwendungsverfahren dafür
BRPI0501535B8 (pt) 2005-04-26 2021-07-27 Mario Augusto Pazoti método de identificação do guignardia citricarpa
WO2006122251A2 (en) 2005-05-10 2006-11-16 Bioimagene, Inc. Method and system for automated digital image analysis of prostrate neoplasms using morphologic patterns
CA2611591A1 (en) * 2005-06-08 2006-12-14 Vanderbilt University Analysis of tissue samples surrounding malignancies
WO2006133460A2 (en) 2005-06-09 2006-12-14 Yale University Methods for diagnosing and treating breast cancer based on a her/er ratio
AT501944B1 (de) * 2005-06-15 2007-06-15 Tissuegnostics Gmbh Verfahren zum segmentieren von leukozyten
US7557963B2 (en) 2005-08-12 2009-07-07 Seiko Epson Corporation Label aided copy enhancement
GB2430026A (en) 2005-09-09 2007-03-14 Qinetiq Ltd Automated selection of image regions
EP1934607B1 (de) 2005-10-13 2013-08-28 Fundação D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud Multiplex in situ immunochemische analyse
JP4863692B2 (ja) 2005-11-02 2012-01-25 株式会社島津製作所 イメージ質量分析装置
US7199360B1 (en) 2006-01-13 2007-04-03 Jean Montagu System and method for calibrating a fluorescence microscope
WO2007095644A2 (en) 2006-02-16 2007-08-23 Ventana Medical Systems, Inc. Reagents and methods for cancer prognosis and pathological staging
US20080118437A1 (en) 2006-03-01 2008-05-22 Regents Of The University Of Michigan Diagnosis and treatment O prostate cancer
JP4748719B2 (ja) 2006-03-02 2011-08-17 国立大学法人大阪大学 生細胞内の特定タンパク質の定量方法および標準蛍光マイクロビーズの作製方法
JP2007271484A (ja) 2006-03-31 2007-10-18 Toyobo Co Ltd 細胞成分分析装置の感度を向上する方法
JP4864519B2 (ja) 2006-04-11 2012-02-01 浜松ホトニクス株式会社 光測定装置、光測定方法、及び光測定プログラム
US20090311734A1 (en) 2006-05-12 2009-12-17 Jan Greve Laser Illumination System in Fluorescent Microscopy
US7709222B2 (en) 2006-07-13 2010-05-04 Yale University Methods for making cancer prognoses based on subcellular localization of biomarkers
ES2431846T5 (es) 2006-07-25 2016-10-17 The Procter & Gamble Company Métodos y productos para analizar tejidos gingivales
CN101674820B (zh) 2006-12-26 2013-09-25 药品循环公司 在联合治疗中应用组蛋白脱乙酰酶抑制剂并监测生物标志物的方法
ES2374686T3 (es) 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
JP5593221B2 (ja) 2007-06-15 2014-09-17 ヒストロックス，インコーポレイテッド． 顕微鏡機器を標準化するための方法およびシステム
US7873215B2 (en) 2007-06-27 2011-01-18 Seiko Epson Corporation Precise identification of text pixels from scanned document images
CA2604317C (en) 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
WO2009020621A1 (en) 2007-08-07 2009-02-12 Historx, Inc. Method and system for determining an optimal dilution of a reagent
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
US7978258B2 (en) 2007-08-31 2011-07-12 Historx, Inc. Automatic exposure time selection for imaging tissue
TWI335252B (en) 2007-11-30 2011-01-01 Ind Tech Res Inst Calibration strip and the laser calibration system using thereof
ES2573945T3 (es) 2008-09-16 2016-06-13 Novartis Ag Cuantificación reproducible de expresión de biomarcadores

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JP5425762B2 (ja) 2014-02-26
DK2156370T3 (da) 2012-01-23
ES2374686T3 (es) 2012-02-21
US8335360B2 (en) 2012-12-18
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EP2156370B1 (de) 2011-10-12
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