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AR247557A1 - Un procedimiento para la obtencion de derivados de la piridazina - Google Patents

Un procedimiento para la obtencion de derivados de la piridazina

Info

Publication number
AR247557A1
AR247557A1 AR90318401A AR31840190A AR247557A1 AR 247557 A1 AR247557 A1 AR 247557A1 AR 90318401 A AR90318401 A AR 90318401A AR 31840190 A AR31840190 A AR 31840190A AR 247557 A1 AR247557 A1 AR 247557A1
Authority
AR
Argentina
Prior art keywords
formula
methyl
linear
substituted
preparation
Prior art date
Application number
AR90318401A
Other languages
English (en)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8915137A external-priority patent/FR2654727B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of AR247557A1 publication Critical patent/AR247557A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

OBTENCION DE DERIVADOS DE LA PIRIDAZINA FORMULA (I) EN LA CUAL: AR ES FENILO SUSTITUIDO POR R1 Y R2 O PIRIDILO SUSTITUIDO O NO POR UN METILO O UN METOXI, O TIENILO SUSTITUIDO O NO POR UN CLORO, UN METILO O UN METOXI; R1 Y R2 SON HIDROGENO, HALOGENO, TRIFLUOROMETILO, HIDROXILO, ALCOXI O ALQUILO; R3 ES ALQUILO LINEAL O RAMIFICADO CICLOALQUILO, BENCILO, FENETILO O AR' UN FENILO SUSTITUIDO POR R1 Y R2; R4 ES DE FORMULA III EN LA CUAL X1 ES HIDROGENO O METILO; R5 ES ALQUILO LINEAL; R6 ES ALQUILO LINEAL O TAMBIEN R5 Y R6 JUNTO CON EL NITROGENO AL CUAL ESTAN ENLAZADOS SON MORFOLINA, PIRROLIDINA O PIPERIDINA; ASI COMO SUS SALES CON ACIDOS MINERALES U ORGANICOS, EN DONDE SE HACE REACCIONAR UNA AMINA DE FORMULA R4NH2 SOBRE UNA CLORO-6-PIRIDAZINA DE FORMULA (II), Y EVENTUALMENTE, SE SALIFICA EL COMPUESTO ASI OBTENIDO CON UN ACIDO MINERAL U ORGANICO.
AR90318401A 1989-11-17 1990-11-16 Un procedimiento para la obtencion de derivados de la piridazina AR247557A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8915137A FR2654727B1 (fr) 1989-11-17 1989-11-17 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR909007533A FR2663326B2 (fr) 1989-11-17 1990-06-15 Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.

Publications (1)

Publication Number Publication Date
AR247557A1 true AR247557A1 (es) 1995-01-31

Family

ID=26227673

Family Applications (1)

Application Number Title Priority Date Filing Date
AR90318401A AR247557A1 (es) 1989-11-17 1990-11-16 Un procedimiento para la obtencion de derivados de la piridazina

Country Status (21)

Country Link
EP (1) EP0429344B1 (es)
JP (1) JPH03170465A (es)
KR (1) KR0164599B1 (es)
AR (1) AR247557A1 (es)
AT (1) ATE143010T1 (es)
AU (1) AU639043B2 (es)
CA (1) CA2030133A1 (es)
DE (1) DE69028602T2 (es)
DK (1) DK0429344T3 (es)
ES (1) ES2094146T3 (es)
FI (1) FI101881B (es)
FR (1) FR2663326B2 (es)
GR (1) GR3021933T3 (es)
HK (1) HK1000597A1 (es)
HU (2) HU207852B (es)
IE (1) IE75697B1 (es)
IL (1) IL96384A (es)
LV (1) LV11972B (es)
NO (1) NO178967C (es)
NZ (1) NZ236107A (es)
PT (1) PT95902B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2665442B1 (fr) * 1990-07-31 1992-12-04 Sanofi Sa Derives d'alkyl-6 pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) * 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
KR100443893B1 (ko) * 1996-01-15 2004-10-15 얀센 파마슈티카 엔.브이. 혈관형성억제제피리다진아민
DK1042293T3 (da) * 1997-12-19 2008-07-14 Amgen Inc Substituerede pyridin- og pyridazinforbindelser og deres farmaceutiske anvendelse
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP2004532628A (ja) 2001-03-23 2004-10-28 アドバンスド バイオニュートリション 生物活性蛋白質を含有する微生物を用いた水産養殖および農業における疾病制御の輸送
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
WO2007066601A1 (ja) 2005-12-07 2007-06-14 Sumitomo Chemical Company, Limited ピリダジン化合物及びその用途
FR2904314A1 (fr) * 2006-07-26 2008-02-01 Centre Nat Rech Scient Composes pyridaziniques et pyrroliques lineaires, procedes d'obtention et applications
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) * 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
AR119731A1 (es) 2019-05-17 2022-01-05 Novartis Ag Inhibidores del inflamasoma nlrp3
CN115279739A (zh) * 2020-03-27 2022-11-01 安斯泰来制药株式会社 取代哒嗪化合物
WO2022166890A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 取代的哒嗪苯酚类衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510998B1 (fr) * 1981-08-07 1986-01-10 Sanofi Sa Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent
FR2540113A1 (fr) * 1983-01-27 1984-08-03 Sanofi Sa Acides derives de la pyridazine actifs sur le systeme nerveux central
DE3629929A1 (de) * 1986-09-03 1988-03-10 Thomae Gmbh Dr K Neue sulfonamido-aethylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
PT93060B (pt) * 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2642648B1 (fr) * 1989-02-07 1991-06-21 Sanofi Sa Utilisation de derives d'alkyl-5 pyridazine comme medicaments actifs sur le systeme cholinergique

Also Published As

Publication number Publication date
JPH03170465A (ja) 1991-07-24
FI905663A0 (fi) 1990-11-15
DE69028602D1 (de) 1996-10-24
PT95902B (pt) 1998-01-30
EP0429344A1 (fr) 1991-05-29
NO178967C (no) 1996-07-10
IL96384A (en) 1995-10-31
HUT56078A (en) 1991-07-29
EP0429344B1 (fr) 1996-09-18
FI905663A (fi) 1991-05-18
FI101881B1 (fi) 1998-09-15
PT95902A (pt) 1991-09-13
AU6667290A (en) 1991-05-23
CA2030133C (es) 1991-05-18
ES2094146T3 (es) 1997-01-16
CA2030133A1 (en) 1991-05-18
GR3021933T3 (en) 1997-03-31
AU639043B2 (en) 1993-07-15
HU907178D0 (en) 1991-05-28
FR2663326B2 (fr) 1992-10-16
NZ236107A (en) 1992-10-28
IE904145A1 (en) 1991-05-22
HK1000597A1 (en) 1998-04-09
IL96384A0 (en) 1991-08-16
HU211351A9 (en) 1995-11-28
HU207852B (en) 1993-06-28
LV11972A (lv) 1998-02-20
NO904984L (no) 1991-05-21
KR0164599B1 (ko) 1999-01-15
NO904984D0 (no) 1990-11-16
FI101881B (fi) 1998-09-15
LV11972B (lv) 1998-04-20
KR910009672A (ko) 1991-06-28
NO178967B (no) 1996-04-01
DE69028602T2 (de) 1997-04-03
ATE143010T1 (de) 1996-10-15
DK0429344T3 (es) 1997-03-03
IE75697B1 (en) 1997-09-10
FR2663326A2 (fr) 1991-12-20

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