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AR247737A1 - Un procedimiento para la fabricacion de compuestos. - Google Patents

Un procedimiento para la fabricacion de compuestos.

Info

Publication number
AR247737A1
AR247737A1 AR89314395A AR31439589A AR247737A1 AR 247737 A1 AR247737 A1 AR 247737A1 AR 89314395 A AR89314395 A AR 89314395A AR 31439589 A AR31439589 A AR 31439589A AR 247737 A1 AR247737 A1 AR 247737A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
compound
formula
cycloalkylthiazole
Prior art date
Application number
AR89314395A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/366,097 external-priority patent/US5001140A/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of AR247737A1 publication Critical patent/AR247737A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

FABRICACION DE COMPUESTOS DE FORMULA (I), DONDE R ES HIDROGENO O ALQUILO, R1, R2, R3 Y R4, INDEPENDIENTEMENTE, SON HIDROGENO, ALQUILO, ALQUENILO, CICLOALQUILO O FENILO SUSTITUIDO O NO POR HASTA 3 ALQUILO, ALCOXI O HALOGENO, O R1 Y R2 JUNTO CON EL CARBONO AL CUAL ESTAN ENLAZADOS SON ALQUILENO SUSTITUIDO O NO POR ALQUILO Y N ES 0, 1, 2 O 3, QUE COMPRENDE: A) ACILAR UN COMPUESTO DE FORMULA(X), CON UN COMPUESTO DE FORMULA (XI) O (XII), DONDE R'' ES ALQUILO E Y ES HIDROXI O UN GRUPO SALIENTE, O B) HIDROLIZAR UN COMPUESTO DE FORMULA (XIII), DONDE UNO DE R3 Y R4 NO ES HIDROGENO, CON UNA BASE, Y C) CONVERTIR UN COMPUESTO (I) CON R HIDROGENO, EN UNA SAL CON UNA BASE FARMACEUTICAMENTE ACEPTABLE.
AR89314395A 1988-07-15 1989-07-14 Un procedimiento para la fabricacion de compuestos. AR247737A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22611288A 1988-07-15 1988-07-15
US33904689A 1989-04-17 1989-04-17
US07/366,097 US5001140A (en) 1989-04-17 1989-06-13 Cycloalkylthiazoles

Publications (1)

Publication Number Publication Date
AR247737A1 true AR247737A1 (es) 1995-03-31

Family

ID=27397563

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89314395A AR247737A1 (es) 1988-07-15 1989-07-14 Un procedimiento para la fabricacion de compuestos.

Country Status (21)

Country Link
EP (1) EP0355353B1 (es)
JP (1) JPH0737454B2 (es)
KR (1) KR960010352B1 (es)
AR (1) AR247737A1 (es)
AU (1) AU626308B2 (es)
BG (1) BG60765B2 (es)
CA (1) CA1333906C (es)
CS (1) CS417291A3 (es)
DE (1) DE68913856T2 (es)
DK (1) DK350989A (es)
ES (1) ES2052825T3 (es)
FI (1) FI93953C (es)
HU (2) HU203087B (es)
IE (1) IE64011B1 (es)
IL (1) IL90958A0 (es)
MC (1) MC2049A1 (es)
MX (1) MX9203632A (es)
NO (1) NO175476C (es)
NZ (1) NZ229928A (es)
PH (1) PH27275A (es)
PT (1) PT91179B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273986A (en) * 1992-07-02 1993-12-28 Hoffmann-La Roche Inc. Cycloalkylthiazoles
EP0643045B1 (de) * 1993-09-10 2000-03-08 Novartis AG Chinolin-Verbindungen als Leukotriene Antagonisten
US5508408A (en) * 1993-09-10 1996-04-16 Ciba-Geigy Corporation Quinoline compound
AU3522895A (en) * 1994-09-13 1996-03-29 F. Hoffmann-La Roche Ag A process of making (e)-4-{3-{2-(4-cycloalkyl-2-thiazolyl) ethenyl}phenyl}amino-2 ,2-alkyldiyl-4-oxobutanoic acid anoic acid
AU4879296A (en) * 1995-03-03 1996-09-23 F. Hoffmann-La Roche Ag Polymorphic b form of (e)-4-{{3-{2-(4-cyclobutyl-2-thiazolyl)ethenyl}phenyl}amino} -2,2-diethyl-4-oxobutanoic acid tanoic acid
WO1996033181A1 (en) * 1995-04-21 1996-10-24 Daiichi Pharmaceutical Co., Ltd. Ethynylthiazole derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤

Also Published As

Publication number Publication date
DK350989D0 (da) 1989-07-14
NO175476B (no) 1994-07-11
KR960010352B1 (ko) 1996-07-30
MX9203632A (es) 1992-07-01
EP0355353B1 (en) 1994-03-16
JPH0737454B2 (ja) 1995-04-26
DE68913856T2 (de) 1994-10-20
FI893434A (fi) 1990-01-16
CS417291A3 (en) 1992-09-16
JPH0269468A (ja) 1990-03-08
NO892914L (no) 1990-01-16
PH27275A (en) 1993-05-04
FI893434A0 (fi) 1989-07-14
AU3828089A (en) 1990-01-18
AU626308B2 (en) 1992-07-30
PT91179B (pt) 1995-03-01
NO892914D0 (no) 1989-07-14
MC2049A1 (fr) 1990-07-17
BG60765B2 (bg) 1996-02-29
HU203087B (en) 1991-05-28
IL90958A0 (en) 1990-02-09
CA1333906C (en) 1995-01-10
KR900001665A (ko) 1990-02-27
HUT52489A (en) 1990-07-28
ES2052825T3 (es) 1994-07-16
EP0355353A3 (en) 1990-03-07
PT91179A (pt) 1990-02-08
EP0355353A2 (en) 1990-02-28
DK350989A (da) 1990-01-16
HU211268A9 (en) 1995-11-28
NO175476C (no) 1994-10-19
DE68913856D1 (de) 1994-04-21
NZ229928A (en) 1992-08-26
FI93953B (fi) 1995-03-15
IE64011B1 (en) 1995-06-28
IE892294L (en) 1990-01-15
FI93953C (fi) 1995-06-26

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