[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

AR119731A1 - Inhibidores del inflamasoma nlrp3 - Google Patents

Inhibidores del inflamasoma nlrp3

Info

Publication number
AR119731A1
AR119731A1 ARP200101272A ARP200101272A AR119731A1 AR 119731 A1 AR119731 A1 AR 119731A1 AR P200101272 A ARP200101272 A AR P200101272A AR P200101272 A ARP200101272 A AR P200101272A AR 119731 A1 AR119731 A1 AR 119731A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
independently selected
substituents independently
optionally substituted
Prior art date
Application number
ARP200101272A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR119731A1 publication Critical patent/AR119731A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente se refiere a compuestos de piridazin-3-il fenol de la fórmula (1), en donde R¹, R², R³, R⁴, R⁵ y Z están definidos en la presente, que inhiben la actividad del inflamasoma de la proteína 3 del receptor tipo NOD (NLRP3). La presente además se refiere a procesos para su preparación, composiciones farmacéuticas y medicamentos que los contienen, y a su uso en el tratamiento de enfermedades y trastornos mediados por NLRP3. Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde R¹ es Cl, CH₃, -OCF₃, o CF₃; R² es H, halo, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo; R³, R⁴ son H, CN, C₁₋₄ alquilo, o halo-C₁₋₄ alquilo; Z es -O-, o -NH-(CH₂)ₙ-, en donde n es 0, 1, ó 2; R⁵ es un heterociclilo mono o bicíclico, opcionalmente sustituido con 1 a 2 sustituyentes independientemente seleccionados entre C₁₋₄ alquilo, halo-C₁₋₄ alquilo, hidroxi-C₁₋₄ alquilo, -OH, halo, oxo, y -CO₂H; o R⁵ es un arilo o heteroarilo, opcionalmente sustituido con 1 a 2 sustituyentes independientemente seleccionados entre halo, halo-C₁₋₄ alquilo, C₁₋₄ alquilo, y -SO₂NH₂; o R⁵ es C₃₋₆ cicloalquilo opcionalmente sustituido con 1 a 3 sustituyentes independientemente seleccionados entre C₁₋₄ alquilo, halo, halo-C₁₋₄ alquilo, y -OH; o R⁵ es C₂₋₆ alquilo sustituido con 1 o más sustituyentes independientemente seleccionados entre -OH, C₁₋₄ alcoxi, halo, -NH₂, -NH(C₁₋₄ alquilo), y -N(C₁₋₄ alquilo)₂.
ARP200101272A 2019-05-17 2020-05-05 Inhibidores del inflamasoma nlrp3 AR119731A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962849245P 2019-05-17 2019-05-17

Publications (1)

Publication Number Publication Date
AR119731A1 true AR119731A1 (es) 2022-01-05

Family

ID=70779818

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200101272A AR119731A1 (es) 2019-05-17 2020-05-05 Inhibidores del inflamasoma nlrp3

Country Status (23)

Country Link
US (2) US11254653B2 (es)
EP (1) EP3969441A1 (es)
JP (1) JP7558975B2 (es)
KR (1) KR20220008887A (es)
CN (1) CN113784957A (es)
AR (1) AR119731A1 (es)
AU (1) AU2020277738B2 (es)
BR (1) BR112021022796A2 (es)
CA (1) CA3138226A1 (es)
CL (1) CL2021003012A1 (es)
CO (1) CO2021015030A2 (es)
CR (1) CR20210552A (es)
CU (1) CU20210094A7 (es)
DO (1) DOP2021000228A (es)
EC (1) ECSP21080740A (es)
IL (1) IL287042B1 (es)
JO (1) JOP20210307A1 (es)
MX (1) MX2021013941A (es)
PE (1) PE20220133A1 (es)
SA (1) SA521430853B1 (es)
SG (1) SG11202111029PA (es)
TW (1) TW202110809A (es)
WO (1) WO2020234715A1 (es)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
CN115279739A (zh) 2020-03-27 2022-11-01 安斯泰来制药株式会社 取代哒嗪化合物
WO2022135567A1 (zh) * 2020-12-25 2022-06-30 上海拓界生物医药科技有限公司 一类含哒嗪的化合物及其医药用途
WO2022166890A1 (zh) * 2021-02-08 2022-08-11 南京明德新药研发有限公司 取代的哒嗪苯酚类衍生物
JP2024508017A (ja) 2021-03-04 2024-02-21 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｌｒｐ３を調節する４－アルコキシ－６－オキソ－ピリダジン誘導体
AU2022230212A1 (en) 2021-03-04 2023-10-19 Janssen Pharmaceutica Nv 4-amino-6-oxo-pyridazine derivatives modulating nlrp3
US11319319B1 (en) * 2021-04-07 2022-05-03 Ventus Therapeutics U.S., Inc. Compounds for inhibiting NLRP3 and uses thereof
US11932630B2 (en) 2021-04-16 2024-03-19 Novartis Ag Heteroaryl aminopropanol derivatives
JPWO2022230912A1 (es) * 2021-04-28 2022-11-03
IL307188A (en) 2021-05-12 2023-11-01 Hoffmann La Roche NLRP3 inhibitors
AR126053A1 (es) 2021-06-04 2023-09-06 Hoffmann La Roche Derivados de triazina
WO2022253326A1 (zh) * 2021-06-05 2022-12-08 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
US20240327413A1 (en) * 2021-06-29 2024-10-03 Zomagen Biosciences Ltd Nlrp3 modulators
BR112023026976A2 (pt) 2021-07-02 2024-03-12 Astrazeneca Ab Inibidores do inflamassoma nlrp3
AU2022312986A1 (en) 2021-07-21 2024-03-07 Nico Therapeutics, Inc. Annulated pyridazine compound
CR20240093A (es) 2021-08-25 2024-05-23 Ptc Therapeutics Inc Inhibidores de NLRP3
WO2023028536A1 (en) 2021-08-25 2023-03-02 Ptc Therapeutics, Inc. 1,2,4-triazine derivatives useful as inhibitors of nlrp3
JP2024535475A (ja) * 2021-09-30 2024-09-30 オリジアント ファーマシューティカル カンパニー リミテッド 置換ヘテロアリールフタラジン誘導体の医薬使用及びその調製方法
CN116102535A (zh) 2021-10-22 2023-05-12 索智生物科技（浙江）有限公司 一种含氮化合物、其制备方法及应用
KR20230066899A (ko) 2021-11-08 2023-05-16 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
JP2024540445A (ja) * 2021-11-17 2024-10-31 エフ． ホフマン－ラ ロシュ アーゲー 複素環式ｎｌｒｐ３阻害剤
EP4433459A1 (en) 2021-11-19 2024-09-25 F. Hoffmann-La Roche AG Pyridazine derivatives as inhibitors of nlrp3
WO2023129987A1 (en) * 2021-12-29 2023-07-06 Neumora Therapeutics, Inc. Pyridazine derivatives as modulators of nlrp3 inflammasome and related methods
IL314025A (en) * 2022-01-07 2024-08-01 Transthera Sciences Nanjing Inc NLRP3 inflammasome inhibitor and uses thereof
TW202345836A (zh) * 2022-03-25 2023-12-01 美商凡特斯治療美國公司 可用作ＮＬＲＰ３衍生物之吡啶并－〔３，４－ｄ〕噠嗪胺衍生物
WO2023186020A1 (en) * 2022-03-31 2023-10-05 Hangzhou Highlightll Pharmaceutical Co., Ltd Nlrp3 inflammasome inhibitors
LU501764B1 (en) 2022-03-31 2023-10-02 Leibniz Inst Fuer Naturstoff Forschung Und Infektionsbiologie E V Hans Knoell Inst Hki Gasdermin e expression in human t cells as a marker for proinflammatory t cell functions
AR129012A1 (es) * 2022-04-07 2024-07-03 Takeda Pharmaceuticals Co Derivados de piridazina fusionados
TW202409013A (zh) * 2022-05-13 2024-03-01 美商凡特斯治療美國公司 用於抑制ｎｌｒｐ３之側氧基吲哚啉基醯胺衍生物及其用途
WO2023220408A1 (en) * 2022-05-13 2023-11-16 Neumora Therapeutics, Inc. Modulators of nlrp3 inflammasome and related products and methods
WO2023232917A1 (en) * 2022-06-03 2023-12-07 F. Hoffmann-La Roche Ag Novel compounds
WO2024006559A1 (en) * 2022-07-01 2024-01-04 Neumora Therapeutics, Inc. Modulators of nlrp3 inflammasome and related products and methods
WO2024012551A1 (zh) * 2022-07-14 2024-01-18 南京明德新药研发有限公司 氘取代的哒嗪苯并噻吩化合物及其应用
US20240034735A1 (en) 2022-07-14 2024-02-01 Ac Immune Sa Novel compounds
WO2024017924A1 (en) * 2022-07-21 2024-01-25 F. Hoffmann-La Roche Ag Nlrp3 inhibitors
WO2024023266A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa Novel compounds
US20240067627A1 (en) 2022-08-03 2024-02-29 Novartis Ag Nlrp3 inflammasome inhibitors
WO2024033845A1 (en) * 2022-08-10 2024-02-15 Takeda Pharmaceutical Company Limited Heterocyclic compound
KR20240022938A (ko) 2022-08-12 2024-02-20 제일약품주식회사 Nlrp3 저해제로서의 신규한 화합물 및 이를 포함하는 약학적 조성물
CN116789674B (zh) * 2022-08-24 2024-05-24 杭州高光制药有限公司 Nlrp3炎性小体抑制剂
WO2024064245A1 (en) 2022-09-23 2024-03-28 Merck Sharp & Dohme Llc Phthalazine derivatives useful as inhibitors of nod-like receptor protein 3
WO2024090469A1 (ja) * 2022-10-26 2024-05-02 アステラス製薬株式会社 縮環ピリダジン誘導体
WO2024097629A1 (en) * 2022-10-31 2024-05-10 Ventus Therapeutics U.S., Inc. Bridged bicyclic heterocycloalkyl pyrido-[3,4-d]pyridazine amine derivatives useful as nlrp3 inhibitors
WO2024097598A1 (en) * 2022-11-02 2024-05-10 Merck Sharp & Dohme Llc Triazines useful as inhibitors of nod-like receptor protein 3
WO2024094185A1 (zh) * 2022-11-04 2024-05-10 药捷安康(南京)科技股份有限公司 Nlrp3炎症小体抑制剂及其应用
WO2024094150A1 (en) * 2022-11-04 2024-05-10 Insilico Medicine Ip Limited Nlrp3 inflammasome inhibitors and uses thereof
WO2024099992A1 (en) * 2022-11-09 2024-05-16 F. Hoffmann-La Roche Ag Triazinone derivatives as nlrp3 inhibitors
WO2024099996A1 (en) * 2022-11-09 2024-05-16 F. Hoffmann-La Roche Ag Triazinone derivatives as nlrp3 inhibitors
WO2024099993A1 (en) * 2022-11-09 2024-05-16 F. Hoffmann-La Roche Ag Triazinone derivatives as nlrp3 inhibitors
WO2024121086A1 (en) * 2022-12-07 2024-06-13 F. Hoffmann-La Roche Ag Novel compounds as modulators of nlrp3 inhibition
WO2024138045A1 (en) * 2022-12-23 2024-06-27 Neumora Therapeutics, Inc. Modulators of nlrp3 inflammasome and related products and methods
TW202432558A (zh) * 2022-12-27 2024-08-16 大陸商正大天晴藥業集團股份有限公司 一種噠嗪稠芳環化合物及其用途
WO2024140824A1 (zh) * 2022-12-28 2024-07-04 长春金赛药业有限责任公司 哒嗪类nlrp3抑制剂化合物、药物组合物及其制备方法和应用
WO2024141534A1 (en) 2022-12-28 2024-07-04 Astrazeneca Ab Crystalline forms of nlrp3 inflammasome inhibitors, chemical processes and chemical compounds
WO2024141535A1 (en) 2022-12-28 2024-07-04 Astrazeneca Ab Nlrp3 inflammasome inhibitors
WO2024148029A2 (en) * 2023-01-03 2024-07-11 Kodiak Sciences Inc. Organic compounds as nlrp3 inhibitors
WO2024148148A1 (en) * 2023-01-04 2024-07-11 The Trustees Of Columbia University In The City Of New York Pyridazine based small molecule inhibitor of cognitive impairment
WO2024157953A1 (ja) * 2023-01-24 2024-08-02 第一三共株式会社 置換ベンゼン化合物
WO2024158941A2 (en) * 2023-01-27 2024-08-02 Mwyngil Therapeutics, Inc. Inhibitors of nlrp3
WO2024160690A1 (en) 2023-01-31 2024-08-08 Janssen Pharmaceutica Nv 2-(pyridazin-3-yl)-5-(trifluoromethyl)phenols as nlrp3 inhibitors
WO2024160694A1 (en) 2023-01-31 2024-08-08 Janssen Pharmaceutica Nv [1,2,4]TRIAZOLO[4,3-a]PYRIDINES AND [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS NLRP3 INHIBITORS
WO2024160693A1 (en) 2023-01-31 2024-08-08 Janssen Pharmaceutica Nv Pyridin-2(1h)-ones and pyrimidin-4(3h)-ones as nlrp3 inhibitors
WO2024160692A1 (en) 2023-01-31 2024-08-08 Janssen Pharmaceutica Nv Imidazo[1,2-d][1,2,4]triazines as nlrp3 inhibitors
WO2024160691A1 (en) 2023-01-31 2024-08-08 Janssen Pharmaceutica Nv PYRROLO[1,2-d][1,2,4]TRIAZINES AND PYRAZOLO[1,5-d] [1,2,4]TRIAZINES AS NLRP3 INHIBITORS
WO2024169858A1 (zh) * 2023-02-17 2024-08-22 成都赜灵生物医药科技有限公司 六元氮杂环类化合物及其用途
WO2024217462A1 (zh) * 2023-04-18 2024-10-24 南京明德新药研发有限公司 五氟化硫取代的芳环化合物及其应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2510997A1 (fr) 1981-08-10 1983-02-11 Sanofi Sa Nouveaux derives de la methyl-4 phenyl-6 pyridazine, procede pour leur preparation et medicaments actifs sur le systeme nerveux central en contenant
PT93060B (pt) 1989-02-07 1995-12-29 Sanofi Sa Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem
FR2663326B2 (fr) 1989-11-17 1992-10-16 Sanofi Sa Derives de la pyridazine, procede de preparation et compositions pharmaceutiques en contenant.
FR2676444B1 (fr) 1991-05-16 1995-03-10 Sanofi Elf Nouveaux derives d'amino-3 pyridazines actifs sur le systeme nerveux central, procede de preparation et compositions pharmaceutiques en contenant.
US6602872B1 (en) 1999-12-13 2003-08-05 Merck & Co., Inc. Substituted pyridazines having cytokine inhibitory activity
EP1745039A4 (en) 2004-05-08 2009-07-22 Neurogen Corp 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES
US20080139598A1 (en) 2006-11-07 2008-06-12 Joseph Barbosa Amine-linked Multicyclic Compounds and Methods of Their Use
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
WO2010128152A1 (en) 2009-05-07 2010-11-11 Novartis Ag Fused heterocyclic c-glycosides for the treatment of diabetes
US8163704B2 (en) 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
CN102510867A (zh) 2009-10-20 2012-06-20 诺瓦提斯公司 糖苷衍生物及其用途
SG186378A1 (en) 2010-06-23 2013-01-30 Hanmi Science Co Ltd Novel fused pyrimidine derivatives for inhibition of tyrosine kinase activity
WO2012016133A2 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Ros1 kinase inhibitors for the treatment of glioblastoma and other p53-deficient cancers
DK2603081T3 (en) 2010-08-10 2017-01-16 Celgene Avilomics Res Inc COLLECTED BY A BTK INHIBITOR
JP2014503528A (ja) 2010-12-14 2014-02-13 エレクトロプホレトイクス リミテッド カゼインキナーゼ１δ（ＣＫ１δ）阻害剤及びタウオパチーなどの神経変性疾患の治療におけるその使用
CU24152B1 (es) 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
HRP20220886T1 (hr) 2011-06-10 2022-10-28 Merck Patent Gmbh Pripravci i postupci za proizvodnju pirimidina i spojeva piridina s btk inhibicijskom aktivnošću
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
EP2786996B1 (en) 2011-11-29 2016-09-14 ONO Pharmaceutical Co., Ltd. Purinone derivative hydrochloride
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
US8729263B2 (en) 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
LT3181567T (lt) 2012-09-10 2019-07-25 Principia Biopharma Inc. Pirazolpirimidino junginiai kaip kinazės slopikliai
RU2693382C2 (ru) 2012-11-28 2019-07-02 Интерсепт Фармасьютикалз, Инк. Лечение заболевания дыхательной системы
JO3564B1 (ar) 2013-03-08 2020-07-05 Novartis Ag ببتيدات وتركيبات لعلاج ضرر المفاصل
JO3377B1 (ar) 2013-03-11 2019-03-13 Takeda Pharmaceuticals Co مشتقات بيريدينيل وبيريدينيل مندمج
DK2989106T3 (en) 2013-04-25 2017-03-20 Beigene Ltd CONDENSED HETEROCYCLIC COMPOUNDS AS PROTEINKINASE INHIBITORS
SG11201603026PA (en) 2013-11-05 2016-05-30 Novartis Ag Compositions and methods for modulating farnesoid x receptors
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
EP3076974A1 (en) 2013-12-05 2016-10-12 Acerta Pharma B.V. Therapeutic combination of a pi3k inhibitor and a btk inhibitor
BR112016011170B1 (pt) 2013-12-20 2023-01-10 Novartis Ag Derivados de ácido heteroaril butanóico, seus usos, combinação e composição farmacêutica
WO2015110923A2 (en) 2014-01-21 2015-07-30 Acerta Pharma B.V. Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia usng a btk inhibitor
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
UY36032A (es) 2014-03-14 2015-10-30 Novartis Ag Moléculas de anticuerpo que se unen a lag-3 y usos de las mismas
WO2015175487A1 (en) 2014-05-13 2015-11-19 Novartis Ag Compounds and compositions for inducing chondrogenesis
CN103965169A (zh) 2014-05-30 2014-08-06 彭正中 一种化合物及其制备方法与用途
WO2016022626A1 (en) 2014-08-06 2016-02-11 Merck Sharp & Dohme Corp. Heterocyclic cgrp receptor antagonists
TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對ｐｄ－ｌ１之抗體分子及其用途
MY188048A (en) 2014-10-24 2021-11-12 Bristol Myers Squibb Co Indole carboxamide compounds useful as kinase inhibitors
US20180015088A1 (en) 2014-12-24 2018-01-18 Principia Biopharma Inc. Site specific dosing of a btk inhibitor
MX2017009408A (es) 2015-01-20 2017-10-02 Merial Inc Compuestos antihelminticos, composiciones y metodo para usar los mismos.
JP6884102B2 (ja) 2015-02-09 2021-06-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんの治療のための化合物
MA41598A (fr) 2015-02-25 2018-01-02 Constellation Pharmaceuticals Inc Composés thérapeutiques de pyridazine et leurs utilisations
EP3303334B1 (en) 2015-06-03 2021-06-02 Principia Biopharma Inc. Tyrosine kinase inhibitors
EP3307732A1 (en) 2015-06-10 2018-04-18 Biogen MA Inc. Forms and compositions of biaryl inhibitors of bruton's tyrosine kinase
EP3359159B1 (en) 2015-10-09 2023-06-07 ACEA Therapeutics, Inc. Pharmaceutical compositions of a pyrrolopyrimidine kinase inhibitor, and methods of making same
KR20180073599A (ko) 2015-11-04 2018-07-02 메르크 파텐트 게엠베하 Btk 억제 활성을 갖는 피리미딘 및 피리딘 화합물을 사용하여 암 치료하는 방법
EA201800367A1 (ru) 2015-12-10 2019-02-28 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы лечения болезни хантингтона
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
MX2018008131A (es) 2016-01-05 2018-09-03 Jiangsu Hengrui Medicine Co Forma cristalina del inhibidor de la btk quinasa y metodo de preparacion de la misma.
AU2017207991A1 (en) 2016-01-15 2018-08-02 Ohio State University Pyridazine derivatives as EAAT2 activators
KR101865120B1 (ko) 2016-06-29 2018-06-08 숭실대학교 산학협력단 테스트 노드 기반의 무선 측위 방법 및 그 장치
CN109600989B (zh) 2016-06-29 2022-11-04 普林斯匹亚生物制药公司 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂
EP3272739A1 (en) * 2016-07-20 2018-01-24 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
KR20200017476A (ko) 2017-06-14 2020-02-18 피티씨 테라퓨틱스, 인크. Rna 스플라이싱의 변경 방법
US11613542B2 (en) * 2017-08-15 2023-03-28 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
RU2020115095A (ru) 2017-10-12 2021-11-12 Революшн Медсинз, Инк. Пиридиновые, пиразиновые и триазиновые соединения в качестве аллостерических ингибиторов shp2
MX2020004423A (es) 2017-11-09 2020-08-06 Inflazome Ltd Nuevos compuestos de sulfonamida carboxamida.
JP2021521200A (ja) 2018-04-10 2021-08-26 スカイホーク・セラピューティクス・インコーポレーテッド 癌の処置のための化合物
JP7387630B2 (ja) 2018-04-26 2023-11-28 オーリジーン オンコロジー リミテッド Ｓｍａｒｃａ２／４分解剤としてのピリダジン誘導体

Also Published As

Publication number Publication date
MX2021013941A (es) 2022-03-11
US11208399B2 (en) 2021-12-28
TW202110809A (zh) 2021-03-16
KR20220008887A (ko) 2022-01-21
JOP20210307A1 (ar) 2023-01-30
PE20220133A1 (es) 2022-01-27
AU2020277738A1 (en) 2021-11-18
CA3138226A1 (en) 2020-11-26
BR112021022796A2 (pt) 2022-04-12
SG11202111029PA (en) 2021-12-30
US20220251067A1 (en) 2022-08-11
US11254653B2 (en) 2022-02-22
US20200361898A1 (en) 2020-11-19
AU2020277738B2 (en) 2023-03-02
CL2021003012A1 (es) 2022-09-09
CR20210552A (es) 2021-11-26
WO2020234715A1 (en) 2020-11-26
CU20210094A7 (es) 2022-06-06
JP7558975B2 (ja) 2024-10-01
JP2022532354A (ja) 2022-07-14
US20200361899A1 (en) 2020-11-19
EP3969441A1 (en) 2022-03-23
DOP2021000228A (es) 2021-12-15
IL287042B1 (en) 2024-10-01
IL287042A (en) 2021-12-01
CO2021015030A2 (es) 2021-11-30
SA521430853B1 (ar) 2024-08-05
CN113784957A (zh) 2021-12-10
ECSP21080740A (es) 2021-12-30

Similar Documents

Publication Publication Date Title
AR119731A1 (es) Inhibidores del inflamasoma nlrp3
CO2019008531A2 (es) Análogos de atazanavir (atv) para tratar infecciones por vih.
PE20230249A1 (es) Compuestos de heteroarilo biciclicos y usos de estos
CO2022001357A2 (es) Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina
AR114971A1 (es) Compuestos de purinona y su uso en el tratamiento del cáncer
AR111315A1 (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
AR111314A1 (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
AR088175A1 (es) 3-pirimidin-4-il-oxazolidin-2-onas utiles para tratar cancer y composiciones farmaceuticas que las contienen
AR094668A1 (es) Amidas como moduladores de canales de sodio
AR106865A1 (es) Piridinas sustituidas y métodos de uso
AR111878A1 (es) Derivados de indolina sustituidos como inhibidores de la replicación vírica de dengue
AR111494A1 (es) Compuestos de anilinoquinazolina c₅ y su uso en el tratamiento del cáncer
AR108906A1 (es) Heterociclos de biarilmetilo
AR087915A1 (es) N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la bace1
AR093937A1 (es) Compuestos quimicos
AR117229A1 (es) Compuestos heteroaromáticos como inhibidores de vanina
AR087868A1 (es) Compuestos de triazolopiridina como moduladores de la tirosina quinasa c-met
CO2023013321A2 (es) Compuestos de oxoisoindolina sustituidos con piridinilo
AR115906A1 (es) Derivados de haloalilamina sulfona como inhibidores de lisil oxidasas
ECSP19084722A (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
AR088639A1 (es) Composicion farmaceutica oftalmica, compuestos antimicrobianos a base de carbolina
AR125479A1 (es) Inhibidores de il4i1 y métodos de uso
AR127235A1 (es) Pirazoloquinolinas inhibidoras de kras
AR124189A1 (es) Compuestos y procedimientos de uso de los mismos
AR125122A1 (es) Actividad antiviral de inhibidores de vps34