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AR092348A1 - DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc - Google Patents

DERIVADOS DE ARIL-SULTAMO COMO MODULADORES DE RORc

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Publication number
AR092348A1
AR092348A1 ARP130102439A ARP130102439A AR092348A1 AR 092348 A1 AR092348 A1 AR 092348A1 AR P130102439 A ARP130102439 A AR P130102439A AR P130102439 A ARP130102439 A AR P130102439A AR 092348 A1 AR092348 A1 AR 092348A1
Authority
AR
Argentina
Prior art keywords
alkyl
aminocarbonyl
alkoxy
several times
substituted once
Prior art date
Application number
ARP130102439A
Other languages
English (en)
Inventor
Rene Olivier
Gobbi Alberto
Gaines Simon
Ward Stuart
Bodil Van Niel Monique
Vesey David
Fauber Benjamin
Original Assignee
Hoffmann La Roche
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Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR092348A1 publication Critical patent/AR092348A1/es

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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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Abstract

Reivindicación 1: Un compuesto de la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en la que: m es el número 0 ó 1; n es el número 0 ó 1; p es un número de 0 a 3; q es el número de 0, 1 ó 2; r es un número de 1 a 3; A es: un enlace; -(CRʲRᵏ)ₜ-; -C(O)-(CRʲRᵏ)ₜ-; -(CRʲRᵏ)ₜ-C(O)-; -NRᵃ-(CRʲRᵏ)ₜ-; -(CRʲRᵏ)ₜ-NRᵃ-; -C(O)NRᵃ-(CRʲRᵏ)ₜ-; -(CRʲRᵏ)ₜ-NRᵃC(O)-; -O-(CRʲRᵏ)ₜ-; -(CRʲRᵏ)ₜ-O-; -S-(CRʲRᵏ)ₜ-; -(CRʲRᵏ)ₜ-S-; -SO₂-(CRʲRᵏ)ₜ-; o -(CRʲRᵏ)ₜ-SO₂-; t es un número de 0 a 4; W es: -CRᵇRᶜ-; -O-; -S-; -SO₂-; o -NRᵈ-; uno de X¹, X², X³ y X⁴ es N y los demás son CRᵉ; o dos de X¹, X², X³ y X⁴ son N y los demás son CRᵉ; o tres de X¹, X², X³ y X⁴ son N y el restante es CRᵉ; o cada uno de X¹, X², X³ y X⁴ es CRᵉ; Y es: -O-; -S-; SO₂-; -CRᶠRᵍ-; o -NRʰ-; Z es: CH; o N; R¹, R², R³, R⁴, R⁵, R⁶, R⁷ y R⁸ con independencia entre sí son: hidrógeno; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno; o R³ y R⁴ junto con el átomo al que están unidos pueden formar un grupo etileno; o R³ y R⁴ junto con los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o R⁵ y R⁶ junto con los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o R⁷ y R⁸ junto con los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o uno de R³ y R⁴ junto con uno de R⁵ y R⁶ y los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o uno de R⁵ y R⁶ junto con uno de R⁷ y R⁸ y los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; cada R⁹ es con independencia: alquilo C₁₋₆; halógeno; alcoxi C₁₋₆; o ciano; dichos restos alquilo C₁₋₆ pueden estar sin sustituir o sustituidos una o varias veces por halógeno; R¹⁰ es: hidrógeno; carboxi; (alquil C₁₋₆)-carbonilo; (alcoxi C₁₋₆)-carbonilo; oxo; hidroxi; aminocarbonilo; N-(alquil C₁₋₆)-aminocarbonilo; N,N-di(alquil C₁₋₆)-aminocarbonilo; ciano; hidroxi-alquilo C₁₋₆; N-(alcoxi C₁₋₆)-(alquil C₁₋₆)-amino-carbonilo; N-hidroxi-(alquil C₁₋₆)-aminocarbonilo; N-(alcoxi C₁₋₆)-aminocarbonilo; halógeno; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno u oxo; R¹¹ es: hidrógeno; halógeno; carboxi; (alquil C₁₋₆)-carbonilo; (alcoxi C₁₋₆)-carbonilo; oxo; hidroxi; aminocarbonilo; N-(alquil C₁₋₆)-aminocarbonilo; N,N-di-(alquil C₁₋₆)-aminocarbonilo; (alquil C₁₋₆)-sulfonil-amino; (alquil C₁₋₆)-sulfonil-amino-alquilo C₁₋₆ ciano; hidroxi-alquilo C₁₋₆ N-(alcoxi C₁₋₆)-(alquil C₁₋₆)-aminocarbonilo; N-hidroxi-(alquil C₁₋₆)-aminocarbonilo; N-(alcoxi C₁₋₆)-aminocarbonilo; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno u oxo; R¹² es: hidrógeno; halógeno; carboxi; (alquil C₁₋₆)-carbonilo; (alcoxi C₁₋₆)-carbonilo; oxo; hidroxi; aminocarbonilo; N-(alquil C₁₋₆)-aminocarbonilo; N,N-di-(alquil C₁₋₆) -aminocarbonilo; ciano; hidroxi-alquilo C₁₋₆; N-(alcoxi C₁₋₆)-(alquil C₁₋₆)-aminocarbonilo; N-hidroxi-(alquil C₁₋₆)-aminocarbonilo; N-(alcoxi C₁₋₆)-aminocarbonilo; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno u oxo; o R¹⁰ y R¹¹ junto con los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; Rᵃ, Rᵇ, Rᶜ y Rᵈ con independencia entre sí son: hidrógeno; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno; o Rᵇ y Rᶜ junto con los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o uno de Rᵇ y Rᶜ junto con uno de R⁷ y R⁸ y los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; o uno de Rᵇ y Rᶜ junto con uno de R⁵ y R⁶ y los átomos a los que están unidos pueden formar un anillo saturado o parcialmente saturado de tres, cuatro, cinco, seis o siete eslabones, que puede incluir opcionalmente uno o dos heteroátomos elegidos entre -O-, -NRᵃ- y -S-, y que puede estar opcionalmente sustituido una o varias veces por Rⁱ; cada Rᵉ es con independencia: hidrógeno; alquilo C₁₋₆; halógeno; alcoxi C₁₋₆; o ciano; dichos restos alquilo C₁₋₆ pueden estar sin sustituir o sustituidos una o varias veces por halógeno; Rᶠ es: hidrógeno; halógeno; o alquilo C₁₋₆, que puede estar sin sustituir o sustituido una o varias veces por halógeno; Rᵍ es: hidrógeno; alquilo C₁₋₆; cicloalquilo C₃₋₆; cicloalquenilo C₃₋₆; (cicloalquil C₃₋₆)-alquilo C₁₋₆; halógeno; (alquil C₁₋₆)-carbonilo; (cicloalquil C₃₋₆)-carbonilo; (cicloalquil C₃₋₆)-(alquil C₁₋₆)-carbonilo; ciano-(alquil C₁₋₆)-carbonilo; hidroxi-(alquil C₁₋₆)-carbonilo; alcoxi C₁₋₆-(alquil C₁₋₆)-carbonilo; carboxi; N-ciano-aminocarbonilo; N-ciano-N-(alquil C₁₋₆)-aminocarbonilo; N-(alquil C₁₋₆)-acetimidamidilo; N,N-di-(alquil C₁₋₆)-acetimidamidilo; N-ciano-N-(alquil C₁₋₆)-acetimidamidilo; N-hidroxi-acetimidamidilo; N-alcoxi C₁₋₆-acetimidamidilo; N-hidroxi-N-(alquil C₁₋₆)-acetimidamidilo; N-(alcoxi C₁₋₆)-N-(alquil C₁₋₆)-acetimidamidilo; 2-nitro-1-N-(alquil C₁₋₆)-amino-vinilo; formilo; (alquil C₁₋₆)-sulfonilo; (cicloalquil C₃₋₆)-sulfonilo; (cicloalquil C₃₋₆)-(alquil C₁₋₆)-sulfonilo; (alquil C₁₋₆)-sulfonil-alquilo C₁₋₆; aminocarbonilo; N-hidroxi-aminocarbonilo; N-(alcoxi C₁₋₆)-aminocarbonilo; N-(alquil C₁₋₆)-aminocarbonilo; aminocarbonil-alquilo C₁₋₆; N-(alquil C₁₋₆)-aminocarbonil-alquilo C₁₋₆; N,N-di-(alquil C₁₋₆)-aminocarbonil-alquilo C₁₋₆; (alcoxi C₁₋₆)-carbonilo; N-hidroxi-N-(alquil C₁₋₆)-aminocarbonilo; N-alcoxi C₁₋₆-N-(alquil C₁₋₆)-aminocarbonilo; N,N-di(alquil C₁₋₆)-aminocarbonilo; aminosulfonilo; N-(alquil C₁₋₆)-aminosulfonilo; N,N-di-(alquil C₁₋₆)-aminosulfonilo; ciano; alcoxi C₁₋₆ (alquil C₁₋₆)-sulfonil-amino; N-(alquil C₁₋₆)-sulfonil-aminocarbonilo; N-(alqui
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