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AR072001A1 - Inmunoglobulina con dominio variable dual y usos de la misma - Google Patents

Inmunoglobulina con dominio variable dual y usos de la misma

Info

Publication number
AR072001A1
AR072001A1 ARP090101994A ARP090101994A AR072001A1 AR 072001 A1 AR072001 A1 AR 072001A1 AR P090101994 A ARP090101994 A AR P090101994A AR P090101994 A ARP090101994 A AR P090101994A AR 072001 A1 AR072001 A1 AR 072001A1
Authority
AR
Argentina
Prior art keywords
tnf
1beta
rankl
variable domain
ige
Prior art date
Application number
ARP090101994A
Other languages
English (en)
Inventor
Rajesh V Kamath
Carolyn A Cuff
Hamish J Allen
Tariq Ghayur
Peter C Isakson
Lisa M Olson
Chengbin Wu
Margaret Hugunin
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41398845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR072001(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR072001A1 publication Critical patent/AR072001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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Abstract

Prote¡nas de union multivalentes y multiespec¡ficas producidas por ingenier¡a genetica, metodos para elaborarlas y, espec¡ficamente, sus usos en la prevencion, el diagnostico y/o el tratamiento de enfermedades. Conjugado de inmunoglobulina,  cido nucleico, vector, celula huesped, metodo para producir la prote¡na de union, composicion farmaceutica. Reivindicacion 1: Una prote¡na de union que comprende una cadena polipept¡dica, caracterizada porque dicha cadena polipept¡dica comprende VD1-(X1)n-VD2-C-(X2)n, en donde; VD1 es un primer dominio variable de la cadena pesada; VD2 es un segundo dominio variable de la cadena pesada; C es un dominio constante de la cadena pesada; X1 es un conector, con la condicion de que no sea CH1; X2 es una region Fc; y n es 0 o 1; en donde la prote¡na de union es capaz de unir un par de ant¡genos seleccionados del grupo formado por TNF y lL-17A; TNF y RANKL; TNF y VEGF; TNF y SOST; TNF y DKK; TNF y alfaVbeta3; TNF y NGF; TNF y IL-23p19; TNF y IL-6; TNF y IL-6R; TNF y CD-20; IgE y lL-13; lL-13 y IL-23p19; IgE y lL-4; IgE y IL-9; lL-13 y IL-9; IL-l3 y IL-4; IL-6R y VEGF; IL-6R y lL-17A; IL-6R y RANKL; IL-17A y IL-1beta; IL-1beta y RANKL; IL-1beta y VEGF; RANKL y CD-20; y IL-1alfa y IL-1beta.
ARP090101994A 2008-06-03 2009-06-03 Inmunoglobulina con dominio variable dual y usos de la misma AR072001A1 (es)

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