NO20024339L - 1,2,3,4-Tetrahydroisokinolin-derivater - Google Patents
1,2,3,4-Tetrahydroisokinolin-derivaterInfo
- Publication number
- NO20024339L NO20024339L NO20024339A NO20024339A NO20024339L NO 20024339 L NO20024339 L NO 20024339L NO 20024339 A NO20024339 A NO 20024339A NO 20024339 A NO20024339 A NO 20024339A NO 20024339 L NO20024339 L NO 20024339L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- pharmaceutical compositions
- tetrahydroisoquinoline derivatives
- derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0002245 | 2000-03-14 | ||
| PCT/EP2001/002733 WO2001068609A1 (en) | 2000-03-14 | 2001-03-12 | 1,2,3,4-tetrahydroisoquinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20024339L true NO20024339L (no) | 2002-09-11 |
| NO20024339D0 NO20024339D0 (no) | 2002-09-11 |
| NO324932B1 NO324932B1 (no) | 2008-01-07 |
Family
ID=8163870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20024339A NO324932B1 (no) | 2000-03-14 | 2002-09-11 | 1,2,3,4-Tetrahydroisokinolin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike samt slike forbindelser anvendt til fremstilling av medikament for behandling av sykdommer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6703392B2 (no) |
| JP (1) | JP4009460B2 (no) |
| KR (2) | KR100842698B1 (no) |
| CN (1) | CN100393703C (no) |
| AT (1) | ATE286500T1 (no) |
| AU (2) | AU2001260113B2 (no) |
| BR (1) | BRPI0109200B8 (no) |
| CA (1) | CA2402431C (no) |
| DE (1) | DE60108236T2 (no) |
| ES (1) | ES2234840T3 (no) |
| HU (1) | HU227811B1 (no) |
| IL (2) | IL150986A0 (no) |
| MX (1) | MXPA02008797A (no) |
| NO (1) | NO324932B1 (no) |
| NZ (1) | NZ520624A (no) |
| PT (1) | PT1274687E (no) |
| WO (1) | WO2001068609A1 (no) |
| ZA (1) | ZA200206467B (no) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002044172A1 (en) * | 2000-11-28 | 2002-06-06 | Smithkline Beecham P.L.C. | Morpholine derivatives as antagonists of orexin receptors |
| GB0126292D0 (en) * | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
| GB0130388D0 (en) * | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| ATE496884T1 (de) | 2002-10-11 | 2011-02-15 | Actelion Pharmaceuticals Ltd | Sulphonylaminoessigsaeure derivate und deren verwendung als orexin rezeptor antagoniste |
| GB0225884D0 (en) * | 2002-11-06 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2006518757A (ja) * | 2003-02-24 | 2006-08-17 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性のアミノシクロペンチル縮合ヘテロ３環アミドモジュレーター |
| EP1611104B1 (en) * | 2003-03-26 | 2009-07-01 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinolyl acetamide derivatives for use as orexin receptor antagonists |
| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
| JP2007523846A (ja) | 2003-04-28 | 2007-08-23 | アクテリオン ファマシューティカルズ リミテッド | キノキサリノン誘導体 |
| US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
| US7459444B2 (en) * | 2004-01-23 | 2008-12-02 | Janssen Pharmaceutica N.V. | Inhibitors of chymase |
| US20100048513A1 (en) | 2008-08-20 | 2010-02-25 | Hawkins Michael J | Novel inhibitors of chymase |
| WO2005118548A1 (en) * | 2004-03-01 | 2005-12-15 | Actelion Pharmaceuticals Ltd | Substituted 1,2,3,4-tetrahydroisoquinoline derivatives |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| EP1814590B2 (en) | 2004-11-01 | 2013-12-11 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| US20060178307A1 (en) * | 2005-01-26 | 2006-08-10 | The Regents Of The University Of California | Modulation of NMDA receptor currents via orexin receptor and/or CRF receptor |
| US20090286723A1 (en) | 2005-02-11 | 2009-11-19 | Amylin Pharmaceuticals, Inc. | Hybrid Polypeptides with Selectable Properties |
| US7501395B2 (en) | 2005-04-25 | 2009-03-10 | Eisai R & D Management Co., Ltd. | Method of screening for antianxiety drugs |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| CA2609388C (en) | 2005-05-30 | 2013-08-06 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
| JPWO2007018248A1 (ja) | 2005-08-10 | 2009-02-19 | 萬有製薬株式会社 | ピリドン化合物 |
| EP2330125A3 (en) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| WO2007024004A1 (ja) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | フェニルピリドン誘導体 |
| EP1939194A4 (en) | 2005-09-07 | 2010-12-08 | Banyu Pharma Co Ltd | AROMATIC SUBSTITUTED BICYLIC PYRIDONE DERIVATIVE |
| CN101277960A (zh) | 2005-09-29 | 2008-10-01 | 默克公司 | 作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物 |
| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
| US8163770B2 (en) | 2005-10-27 | 2012-04-24 | Msd. K. K. | Benzoxathiin derivative |
| BRPI0618354B8 (pt) | 2005-11-10 | 2021-05-25 | Banyu Pharma Co Ltd | composto e seu uso, composição farmacêutica, preventivo ou remédio |
| CN101374831B (zh) * | 2006-01-26 | 2011-04-27 | 埃科特莱茵药品有限公司 | 四氢吡喃抗生素 |
| EP1998774A1 (en) * | 2006-03-15 | 2008-12-10 | Actelion Pharmaceuticals Ltd. | Tetrahydroisoquinoline derivatives to enhance memory function |
| ES2566481T3 (es) * | 2006-04-12 | 2016-04-13 | Merck Sharp & Dohme Corp. | Antagonistas del canal de calcio de tipo T de piridil amida |
| JP2009535324A (ja) * | 2006-04-26 | 2009-10-01 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピラゾロ−テトラヒドロピリジン誘導体 |
| JP2009543785A (ja) | 2006-07-14 | 2009-12-10 | メルク エンド カムパニー インコーポレーテッド | 架橋ジアゼパンオレキシン受容体アンタゴニスト |
| CN101511833A (zh) * | 2006-08-28 | 2009-08-19 | 埃科特莱茵药品有限公司 | 1,4,5,6,7,8-六氢-1,2,5-三氮杂-甘菊环烃衍生物 |
| US8173629B2 (en) | 2006-09-22 | 2012-05-08 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| WO2008038692A1 (fr) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | dÉrivÉ de diarylcÉtimine |
| PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
| CA2669561A1 (en) * | 2006-12-22 | 2008-07-03 | Actelion Pharmaceuticals Ltd | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| ES2365444T3 (es) * | 2007-04-04 | 2011-10-05 | F. Hoffmann-La Roche Ag | Heterociclos como antagonistas de orexina. |
| WO2008143856A1 (en) | 2007-05-18 | 2008-11-27 | Merck & Co., Inc. | Oxo bridged diazepan orexin receptor antagonists |
| CN101679366B (zh) | 2007-05-23 | 2013-08-07 | 默沙东公司 | 吡啶基哌啶食欲素受体拮抗剂 |
| JP2010528007A (ja) | 2007-05-23 | 2010-08-19 | メルク・シャープ・エンド・ドーム・コーポレイション | シクロプロピルピロリジンオレキシン受容体アンタゴニスト |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| PE20091010A1 (es) * | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
| AU2008317353B2 (en) | 2007-10-24 | 2014-08-07 | Merck Sharp & Dohme Llc | Heterocycle phenyl amide T-type calcium channel antagonists |
| JP5829399B2 (ja) | 2007-12-28 | 2015-12-09 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ３置換３，４−ジヒドロ−１ｈ−イソキノリン化合物、その製造方法及びその使用 |
| WO2009110510A1 (ja) | 2008-03-06 | 2009-09-11 | 萬有製薬株式会社 | アルキルアミノピリジン誘導体 |
| WO2009119726A1 (ja) | 2008-03-28 | 2009-10-01 | 萬有製薬株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
| RU2010151951A (ru) | 2008-05-20 | 2012-06-27 | Ньюроджесэкс, Инк. (Us) | Общие пролекарства гепатопротектора и ацетаминофена |
| WO2009154132A1 (ja) | 2008-06-19 | 2009-12-23 | 萬有製薬株式会社 | スピロジアミン-ジアリールケトオキシム誘導体 |
| EP2307417A2 (en) * | 2008-06-25 | 2011-04-13 | Actelion Pharmaceuticals Ltd. | 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine compounds |
| CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| CA2731358A1 (en) | 2008-07-30 | 2010-02-04 | Banyu Pharmaceutical Co., Ltd. | 5/5-or 5/6-membered condensed ring cycloalkylamine derivative |
| EP2161266A1 (en) | 2008-08-22 | 2010-03-10 | EVOTEC Neurosciences GmbH | Benzofuran derivatives as orexin receptor antagonists |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2010064212A1 (en) | 2008-12-05 | 2010-06-10 | Actelion Pharmaceuticals Ltd | Method for obtaining an optically pure 1,2,3,4 tetrahydro-isoquinoline derivative |
| WO2010075069A1 (en) | 2008-12-16 | 2010-07-01 | Schering Corporation | Bicyclic pyranone derivatives as nicotinic acid receptor agonists |
| EP2379547A1 (en) | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| EP2504316A1 (en) | 2009-11-23 | 2012-10-03 | MSD Oss B.V. | Heterocylic compounds as antagonists of the orexin receptors |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| WO2011138266A1 (en) | 2010-05-03 | 2011-11-10 | Evotec Ag | Indolizine and imidazopyridine derivatives as orexin receptor antagonists |
| WO2011138265A2 (en) | 2010-05-03 | 2011-11-10 | Evotec Ag | Indole and indazole derivatives as orexin receptor antagonists |
| EP2402322A1 (en) | 2010-07-02 | 2012-01-04 | Actelion Pharmaceuticals Ltd. | 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US8796258B2 (en) | 2011-02-25 | 2014-08-05 | Merck Sharp & Dohme Corp. | Cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| DK2758060T3 (en) | 2011-09-19 | 2018-03-05 | Eth Zuerich | ROR gamma modulators for the treatment of diabetes II complications |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| US9527875B2 (en) | 2012-08-02 | 2016-12-27 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2014100719A2 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| CN104994848A (zh) | 2013-02-22 | 2015-10-21 | 默沙东公司 | 抗糖尿病二环化合物 |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| EP2781217A1 (en) | 2013-03-18 | 2014-09-24 | ETH Zurich | ROR gamma modulators |
| WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| BR112017003745A2 (pt) | 2014-08-29 | 2017-12-05 | Tes Pharma S R L | inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico |
| CN105198809A (zh) * | 2015-09-24 | 2015-12-30 | 绍兴文理学院 | 一种2-（1-酰亚胺基甲基）-1,2,3,4-四氢异喹啉衍生物及其合成方法与应用 |
| CN105418498A (zh) * | 2015-12-30 | 2016-03-23 | 绍兴文理学院 | 一种1,2,3,4-四氢异喹啉衍生物及其合成方法与应用 |
| WO2017194548A1 (en) | 2016-05-10 | 2017-11-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
| MX2019004321A (es) | 2016-10-14 | 2019-06-12 | Tes Pharma S R L | Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa. |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| KR20210111248A (ko) | 2018-11-20 | 2021-09-10 | 테스 파마 에스.알.엘. | α-아미노-β-카르복시뮤콘산 세미알데하이드 데카르복실라제의 저해제 |
| CN112538100B (zh) * | 2020-12-16 | 2022-06-24 | 河南中医药大学 | 一种从黄柏中提取的具有抗炎活性的异喹啉生物碱苷类化合物及其制备方法与应用 |
| KR102695633B1 (ko) * | 2021-12-17 | 2024-08-14 | 한국화학연구원 | 피리미딘을 포함하는 테트라하이드로이소퀴놀린 유도체 및 이의 결핵 치료제 용도 |
| TW202342433A (zh) * | 2022-02-25 | 2023-11-01 | 比利時魯汶大學 | 用於抑制ｙａｐ／ｔａｚ—ｔｅａｄ之二氫喹唑啉酮及相關類似物 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE204917C (no) | ||||
| DE258817C (no) | ||||
| CA205079A (en) * | 1920-10-26 | Nelson Lionel | Gas producer | |
| DE261158C (no) | ||||
| CA110459A (en) * | 1907-12-09 | 1908-02-25 | Charles Albert Keller | Electric furnace |
| CA173523A (en) * | 1916-04-01 | 1916-11-28 | Raymond B. Price | Textile material |
| CA170679A (en) * | 1916-05-26 | 1916-07-11 | Edwin W. Webb | Car brake |
| US3480714A (en) | 1966-02-07 | 1969-11-25 | Ciba Geigy Corp | N-substituted isoquinolines as antiprotozoal agents |
| DD204917A1 (de) * | 1981-12-31 | 1983-12-14 | Gerhard Kempter | Verfahren zur herstellung phenylsubstituierter und benzkondensierter cycloalkylaminoacetanilide |
| JPS6153268A (ja) | 1984-08-24 | 1986-03-17 | Hokuriku Seiyaku Co Ltd | アントラニルアミド誘導体 |
| DD261158A1 (de) * | 1987-01-08 | 1988-10-19 | Univ Halle Wittenberg | Verfahren zur herstellung von 2-aminoalkyl-3,4-dihydro-4-oxo-7h-pyrrolo 2.3-d pyrimidinen |
| DD258817A1 (de) * | 1987-01-19 | 1988-08-03 | Univ Halle Wittenberg | Verfahren zur herstellung von 2-(aminoalkyl) -pyrimido-4,5'-5,4 pyrrolo 3,2-f 1,4 thiazepinderivaten |
| AU652996B2 (en) | 1991-01-11 | 1994-09-15 | Laboratoires Glaxo S.A. | Acridine derivatives |
| NZ268587A (en) * | 1993-06-22 | 1998-01-26 | Knoll Ag | 1-cycloalkyl substituted tetrahydroisoquinoline derivatives and pharmaceutical compositions |
| JPH07267961A (ja) | 1994-03-30 | 1995-10-17 | Taisho Pharmaceut Co Ltd | ベンゾフロ［３，２−ｄピリミジン−４−オン誘導体 |
| JPH1095766A (ja) | 1996-09-19 | 1998-04-14 | Sanwa Kagaku Kenkyusho Co Ltd | アセトアミド誘導体、及びその用途 |
| WO1998023593A1 (en) * | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
| AR016817A1 (es) | 1997-08-14 | 2001-08-01 | Smithkline Beecham Plc | Derivados de fenilurea o feniltiourea, procedimiento para su preparacion, coleccion de compuestos, compuestos intermediarios, composicion farmaceutica,metodo de tratamiento y uso de dichos compuestos para la manufactura de un medicamento |
| US6372757B1 (en) * | 1998-05-08 | 2002-04-16 | Smithkline Beecham P.L.C. | Phenylurea and phenylthio urea derivatives |
| WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
| GB9827467D0 (en) | 1998-12-15 | 1999-02-10 | Zeneca Ltd | Chemical compounds |
| GB9914015D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| GB9914025D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| WO2001002368A1 (en) | 1999-07-06 | 2001-01-11 | Vertex Pharmaceuticals Incorporated | N-heterocyclic derivatives with neuronal activity |
-
2001
- 2001-03-12 PT PT01933685T patent/PT1274687E/pt unknown
- 2001-03-12 IL IL15098601A patent/IL150986A0/xx active IP Right Grant
- 2001-03-12 ES ES01933685T patent/ES2234840T3/es not_active Expired - Lifetime
- 2001-03-12 AT AT01933685T patent/ATE286500T1/de active
- 2001-03-12 KR KR1020027011533A patent/KR100842698B1/ko active IP Right Grant
- 2001-03-12 WO PCT/EP2001/002733 patent/WO2001068609A1/en active IP Right Grant
- 2001-03-12 DE DE60108236T patent/DE60108236T2/de not_active Expired - Lifetime
- 2001-03-12 AU AU2001260113A patent/AU2001260113B2/en not_active Expired
- 2001-03-12 CA CA002402431A patent/CA2402431C/en not_active Expired - Lifetime
- 2001-03-12 KR KR1020077016214A patent/KR20070087103A/ko active Search and Examination
- 2001-03-12 AU AU6011301A patent/AU6011301A/xx active Pending
- 2001-03-12 JP JP2001567703A patent/JP4009460B2/ja not_active Expired - Lifetime
- 2001-03-12 NZ NZ520624A patent/NZ520624A/xx not_active IP Right Cessation
- 2001-03-12 MX MXPA02008797A patent/MXPA02008797A/es active IP Right Grant
- 2001-03-12 HU HU0300207A patent/HU227811B1/hu unknown
- 2001-03-12 US US10/239,693 patent/US6703392B2/en not_active Expired - Lifetime
- 2001-03-12 CN CNB018063268A patent/CN100393703C/zh not_active Expired - Lifetime
- 2001-03-12 BR BRPI0109200A patent/BRPI0109200B8/pt not_active IP Right Cessation
-
2002
- 2002-07-30 IL IL150986A patent/IL150986A/en unknown
- 2002-08-13 ZA ZA200206467A patent/ZA200206467B/en unknown
- 2002-09-11 NO NO20024339A patent/NO324932B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ520624A (en) | 2004-02-27 |
| US20030176415A1 (en) | 2003-09-18 |
| BRPI0109200B8 (pt) | 2021-05-25 |
| HUP0300207A2 (en) | 2003-05-28 |
| IL150986A0 (en) | 2003-02-12 |
| KR20020080465A (ko) | 2002-10-23 |
| IL150986A (en) | 2007-07-04 |
| HU227811B1 (en) | 2012-03-28 |
| MXPA02008797A (es) | 2005-09-08 |
| US6703392B2 (en) | 2004-03-09 |
| DE60108236T2 (de) | 2005-12-22 |
| BRPI0109200B1 (pt) | 2015-08-11 |
| ES2234840T3 (es) | 2005-07-01 |
| BR0109200A (pt) | 2003-06-03 |
| AU6011301A (en) | 2001-09-24 |
| NO20024339D0 (no) | 2002-09-11 |
| NO324932B1 (no) | 2008-01-07 |
| PT1274687E (pt) | 2005-04-29 |
| CN1416420A (zh) | 2003-05-07 |
| DE60108236D1 (de) | 2005-02-10 |
| WO2001068609B1 (en) | 2002-02-21 |
| KR100842698B1 (ko) | 2008-07-01 |
| KR20070087103A (ko) | 2007-08-27 |
| HUP0300207A3 (en) | 2005-07-28 |
| ATE286500T1 (de) | 2005-01-15 |
| JP4009460B2 (ja) | 2007-11-14 |
| JP2003527374A (ja) | 2003-09-16 |
| AU2001260113B2 (en) | 2006-04-06 |
| WO2001068609A1 (en) | 2001-09-20 |
| CN100393703C (zh) | 2008-06-11 |
| ZA200206467B (en) | 2003-11-13 |
| CA2402431A1 (en) | 2001-09-20 |
| CA2402431C (en) | 2009-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60108236D1 (de) | 1,2,3,4-tetrahydroisochinolin-derivate | |
| NO20034230L (no) | 1,2,3,4-tetrahydroisokinolin-derivater som urotensin II reseptor-antagonister | |
| IL155806A0 (en) | Novel benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists | |
| MXPA03004780A (es) | Nuevas sulfamidas. | |
| NO20051102L (no) | Sulfonylamino-eddiksyre-derivater | |
| MXPA05010137A (es) | Derivados de tetrahidroisoquinolil acetamida para usarse como antagonistas del receptor de orexina. | |
| NO20042844L (no) | 4-(piperidyl- og pyrrolidyl-alkyl-ureido)-kinoliner som uprotensin II reseptor-antagonister | |
| ATE383345T1 (de) | Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten. | |
| MXPA04001252A (es) | Nuevos heterociclos benzo-fusionados como antagonistas de endotelina. | |
| IL168836A (en) | Pyrimidine-sulfamides and their use as endothelin receptor antagonist | |
| WO2002024665A8 (en) | Arylalkane-sulfonamides having endothelin-antagonist activity | |
| MXPA04001773A (es) | Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos. | |
| MXPA03000430A (es) | Nuevas arileteno-sulfonamidas. | |
| MXPA03000606A (es) | Derivados de benzofurano y su uso como agentes antibacterianos. | |
| MXPA02006250A (es) | Derivados de butino diol. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |