NO20005295L - Effektiv rensing av adenovirus - Google Patents
Effektiv rensing av adenovirusInfo
- Publication number
- NO20005295L NO20005295L NO20005295A NO20005295A NO20005295L NO 20005295 L NO20005295 L NO 20005295L NO 20005295 A NO20005295 A NO 20005295A NO 20005295 A NO20005295 A NO 20005295A NO 20005295 L NO20005295 L NO 20005295L
- Authority
- NO
- Norway
- Prior art keywords
- adenovirus
- solution
- eluting
- applying
- sample solution
- Prior art date
Links
- 241000701161 unidentified adenovirus Species 0.000 title abstract 14
- 238000000034 method Methods 0.000 abstract 4
- 239000012539 chromatography resin Substances 0.000 abstract 3
- 239000012488 sample solution Substances 0.000 abstract 3
- 238000002835 absorbance Methods 0.000 abstract 2
- 238000005571 anion exchange chromatography Methods 0.000 abstract 2
- -1 dimethylaminopropyl Chemical group 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Inorganic materials [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 239000011259 mixed solution Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
- B01D15/345—Perfusive chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
- G01N2030/625—Detectors specially adapted therefor signal-to-noise ratio by measuring reference material, e.g. carrier without sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/075—Adenoviridae
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Dry Shavers And Clippers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8262898P | 1998-04-22 | 1998-04-22 | |
PCT/US1999/008843 WO1999054441A1 (en) | 1998-04-22 | 1999-04-22 | Efficient purification of adenovirus |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20005295D0 NO20005295D0 (no) | 2000-10-20 |
NO20005295L true NO20005295L (no) | 2000-11-30 |
Family
ID=22172352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20005295A NO20005295L (no) | 1998-04-22 | 2000-10-20 | Effektiv rensing av adenovirus |
Country Status (20)
Country | Link |
---|---|
US (3) | US6383795B1 (ja) |
EP (1) | EP1073721B1 (ja) |
JP (1) | JP2002512361A (ja) |
AT (1) | ATE303434T1 (ja) |
AU (1) | AU756889B2 (ja) |
BG (1) | BG104928A (ja) |
BR (1) | BR9909789A (ja) |
CA (1) | CA2328462C (ja) |
DE (1) | DE69927013T2 (ja) |
EA (1) | EA200001096A1 (ja) |
EE (1) | EE200000605A (ja) |
HU (1) | HUP0102209A2 (ja) |
IL (1) | IL139040A0 (ja) |
IS (1) | IS5673A (ja) |
MX (1) | MXPA00010338A (ja) |
NO (1) | NO20005295L (ja) |
PL (1) | PL343630A1 (ja) |
SK (1) | SK15682000A3 (ja) |
WO (1) | WO1999054441A1 (ja) |
ZA (1) | ZA200005363B (ja) |
Families Citing this family (52)
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ES2383640T3 (es) | 1996-11-20 | 2012-06-25 | Crucell Holland B.V. | Composiciones de adenovirus que pueden obtenerse mediante un método de producción y purificación mejorado |
US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
CA2364934C (fr) | 1999-02-22 | 2011-10-18 | Transgene S.A. | Procede d'obtention d'une preparation virale purifiee |
GB9915413D0 (en) * | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Propagation method |
US6447995B1 (en) | 2000-10-04 | 2002-09-10 | Genvec, Inc. | Utilizing intrinsic fluorescence to detect adenovirus |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
JP3547715B2 (ja) * | 2001-03-06 | 2004-07-28 | 榮 新垣 | ベクター精製用装置及び方法 |
CA2455499C (en) * | 2001-08-08 | 2011-06-21 | The Trustees Of The University Of Pennsylvania | Method for purification of viral vectors having proteins which bind sialic acid |
EP1371723A1 (en) * | 2002-06-12 | 2003-12-17 | Procorde GmbH | Process for preparing an adenovirus-containing preparation |
EP1638587A4 (en) | 2003-02-14 | 2007-04-18 | Univ Missouri | RECIPROCAL PROCEDURES AND COMPOSITIONS CONCERNING PROTEASOMAL INTERFERENCE |
US20040166091A1 (en) * | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
GB0304576D0 (en) * | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
JP2007523621A (ja) * | 2003-06-18 | 2007-08-23 | オニックス ファーマシューティカルズ,インコーポレイティド | ウイルスを精製するための方法 |
WO2005012537A2 (en) * | 2003-07-25 | 2005-02-10 | Genvec, Inc. | Adenoviral vector-based vaccines |
CN1860599A (zh) * | 2003-09-19 | 2006-11-08 | 霆激科技股份有限公司 | 半导体器件的制造 |
EP2168603A1 (en) | 2003-11-14 | 2010-03-31 | GenVec, Inc. | Therapeutic regimen for treating cancer |
WO2005080556A2 (en) * | 2004-02-23 | 2005-09-01 | Crucell Holland B.V. | Virus purification methods |
WO2005110492A2 (en) | 2004-04-12 | 2005-11-24 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of using adenoviral vectors to induce an immune response |
GB0411081D0 (en) * | 2004-05-18 | 2004-06-23 | Glaxo Group Ltd | Novel apparatus |
WO2006039045A2 (en) * | 2004-09-01 | 2006-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adenoviral vectors able to transduce apcs, potential use in immune response generation |
WO2006052302A2 (en) * | 2004-11-03 | 2006-05-18 | Introgen Therapeutics Inc. | Method of producing and purifying adenoviral vectors |
JP4626350B2 (ja) * | 2005-03-22 | 2011-02-09 | ソニー株式会社 | ハイブリダイゼーション検出に適する反応部などを有する流路系、該流路系を用いるハイブリダイゼーション検出装置 |
CA2602375C (en) | 2005-03-23 | 2018-07-24 | Genmab A/S | Antibodies against cd38 for treatment of multiple myeloma |
US8574595B2 (en) * | 2005-04-11 | 2013-11-05 | Crucell Holland B.V. | Virus purification using ultrafiltration |
KR101251157B1 (ko) | 2005-07-25 | 2013-04-10 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | Cd37-특이적 결합 분자 및 cd20-특이적 결합 분자를사용한 b-세포 감소 |
EP1951297A2 (en) * | 2005-11-10 | 2008-08-06 | GenVec, Inc. | Adenoviral vector-based foot-and-mouth disease vaccine |
EP1808697A1 (en) * | 2006-01-13 | 2007-07-18 | Novartis Vaccines and Diagnostics, Inc. | Use of an ion exchange matrix for determining the concentration of virus particles and/or virus antigens |
RU2487888C2 (ru) | 2006-06-12 | 2013-07-20 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи | Одноцепочечные мультивалентные связывающие белки с эффекторной функцией |
CN101990439A (zh) * | 2007-07-06 | 2011-03-23 | 特鲁比昂药品公司 | 具有置于c末端的特异性结合结构域的结合肽 |
MX2010004883A (es) | 2007-11-01 | 2010-11-10 | Perseid Therapeutics Llc | Polipeptidos y acidos nucleicos inmunosupresores. |
WO2009126944A1 (en) * | 2008-04-11 | 2009-10-15 | Trubion Pharmaceuticals, Inc. | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
DK2350268T3 (en) * | 2008-11-03 | 2015-03-23 | Crucell Holland Bv | PROCEDURE FOR PRODUCING ADENOVIRUS VECTORS |
US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
CA2786835C (en) | 2010-02-15 | 2021-08-31 | Crucell Holland B.V. | Method for the production of ad26 adenoviral vectors |
TW201823463A (zh) | 2010-03-23 | 2018-07-01 | 美商英翠克頌公司 | 條件性表現治療性蛋白質之載體、包含該載體之宿主細胞及彼等之用途 |
WO2012122025A2 (en) | 2011-03-04 | 2012-09-13 | Intrexon Corporation | Vectors conditionally expressing protein |
CN102590431B (zh) * | 2012-02-10 | 2014-04-02 | 济南康众医药科技开发有限公司 | 一种治疗咳嗽的中药药物组合物检测方法 |
US20160074532A1 (en) | 2014-09-07 | 2016-03-17 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene editing anti-viral transfer vector immune responses |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
CN110325203A (zh) | 2017-01-07 | 2019-10-11 | 西莱克塔生物科技公司 | 与合成纳米载体偶联的免疫抑制剂的模式化给药 |
EP3694543A1 (en) | 2017-10-13 | 2020-08-19 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
GB201806736D0 (en) * | 2018-04-25 | 2018-06-06 | Ge Healthcare Bioprocess R&D Ab | Method for virus purification |
WO2020172509A1 (en) | 2019-02-21 | 2020-08-27 | Unleash Immuno Oncolytics, Inc. | Oncolytic adenoviral vector and methods of use |
CN114126666A (zh) | 2019-04-28 | 2022-03-01 | 西莱克塔生物科技公司 | 用于治疗针对病毒转移载体具有预先存在的免疫力的对象的方法 |
BR112021023594A2 (pt) | 2019-05-28 | 2022-02-08 | Selecta Biosciences Inc | Métodos e composições para resposta imune de vetor de transferência antiviral atenuada |
WO2021011436A1 (en) * | 2019-07-12 | 2021-01-21 | Sangamo Therapeutics, Inc. | Separation and quantification of empty and full viral capsid particles |
CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
WO2023064367A1 (en) | 2021-10-12 | 2023-04-20 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
US20230357437A1 (en) | 2022-03-09 | 2023-11-09 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
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US4788223A (en) | 1985-07-26 | 1988-11-29 | Rohm And Haas Company | Low-rinse, high-capacity, weakly basic acrylic ion exchange resin |
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JPH06504482A (ja) * | 1991-01-04 | 1994-05-26 | パーセプティブ バイオシステムズ インコーポレイテッド | 親水性スルホンアミド結合コーティング |
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US5268097A (en) | 1992-06-19 | 1993-12-07 | Sepracor Inc. | Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same |
US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
CA2184132C (en) * | 1995-09-21 | 2011-03-15 | Kristina J. Hennessy | An adjuvanted vaccine which is substantially free of non-host albumin |
BR9710030A (pt) * | 1996-07-01 | 1999-08-10 | Rhone Poulenc Rorer Sa | Processo de produção de adenovírus recombinantes processo de purificação de adenovírus recombinantes a partir de um meio biológico preparação viral purificada composição farmacêutica e utilização de iodixanol-5,5'-[(2-Hidroxipropil-1,3-Propanottl)-Bis[N,N'-Bis(2,3-Didroxipropil-2,4,6-Triodo-1,3-Benzenocarboxamida] |
ES2383640T3 (es) * | 1996-11-20 | 2012-06-25 | Crucell Holland B.V. | Composiciones de adenovirus que pueden obtenerse mediante un método de producción y purificación mejorado |
KR100762033B1 (ko) | 1998-12-31 | 2007-10-04 | 아방티 파르마 소시에테 아노님 | 바이러스 입자의 분리방법 |
CA2364934C (fr) | 1999-02-22 | 2011-10-18 | Transgene S.A. | Procede d'obtention d'une preparation virale purifiee |
-
1999
- 1999-04-22 EA EA200001096A patent/EA200001096A1/ru unknown
- 1999-04-22 US US09/296,962 patent/US6383795B1/en not_active Expired - Lifetime
- 1999-04-22 PL PL99343630A patent/PL343630A1/xx unknown
- 1999-04-22 JP JP2000544773A patent/JP2002512361A/ja active Pending
- 1999-04-22 BR BR9909789-3A patent/BR9909789A/pt not_active Application Discontinuation
- 1999-04-22 AT AT99918788T patent/ATE303434T1/de not_active IP Right Cessation
- 1999-04-22 DE DE69927013T patent/DE69927013T2/de not_active Expired - Lifetime
- 1999-04-22 SK SK1568-2000A patent/SK15682000A3/sk unknown
- 1999-04-22 WO PCT/US1999/008843 patent/WO1999054441A1/en active IP Right Grant
- 1999-04-22 HU HU0102209A patent/HUP0102209A2/hu unknown
- 1999-04-22 EE EEP200000605A patent/EE200000605A/xx unknown
- 1999-04-22 MX MXPA00010338A patent/MXPA00010338A/es unknown
- 1999-04-22 CA CA2328462A patent/CA2328462C/en not_active Expired - Lifetime
- 1999-04-22 AU AU36620/99A patent/AU756889B2/en not_active Ceased
- 1999-04-22 IL IL13904099A patent/IL139040A0/xx unknown
- 1999-04-22 EP EP99918788A patent/EP1073721B1/en not_active Expired - Lifetime
-
2000
- 2000-10-03 ZA ZA200005363A patent/ZA200005363B/xx unknown
- 2000-10-20 NO NO20005295A patent/NO20005295L/no not_active Application Discontinuation
- 2000-10-20 IS IS5673A patent/IS5673A/is unknown
- 2000-11-08 BG BG104928A patent/BG104928A/xx unknown
-
2001
- 2001-11-30 US US09/997,909 patent/US6586226B2/en not_active Expired - Lifetime
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2003
- 2003-05-05 US US10/429,303 patent/US7141406B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
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EA200001096A1 (ru) | 2001-04-23 |
PL343630A1 (en) | 2001-08-27 |
EP1073721B1 (en) | 2005-08-31 |
WO1999054441A8 (en) | 2000-02-24 |
SK15682000A3 (sk) | 2001-05-10 |
WO1999054441A1 (en) | 1999-10-28 |
BG104928A (en) | 2001-09-28 |
US6383795B1 (en) | 2002-05-07 |
US20030203469A1 (en) | 2003-10-30 |
MXPA00010338A (es) | 2005-06-17 |
US20020034735A1 (en) | 2002-03-21 |
US7141406B2 (en) | 2006-11-28 |
AU3662099A (en) | 1999-11-08 |
ATE303434T1 (de) | 2005-09-15 |
ZA200005363B (en) | 2001-09-25 |
JP2002512361A (ja) | 2002-04-23 |
US6586226B2 (en) | 2003-07-01 |
NO20005295D0 (no) | 2000-10-20 |
DE69927013D1 (de) | 2005-10-06 |
IS5673A (is) | 2000-10-20 |
EE200000605A (et) | 2002-04-15 |
AU756889B2 (en) | 2003-01-23 |
HUP0102209A2 (hu) | 2001-09-28 |
EP1073721A1 (en) | 2001-02-07 |
DE69927013T2 (de) | 2006-06-29 |
IL139040A0 (en) | 2001-11-25 |
CA2328462A1 (en) | 1999-10-28 |
CA2328462C (en) | 2010-11-09 |
BR9909789A (pt) | 2000-12-26 |
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