MX2018015892A - Derivados de acido boronico y usos terapeuticos de los mismos. - Google Patents
Derivados de acido boronico y usos terapeuticos de los mismos.Info
- Publication number
- MX2018015892A MX2018015892A MX2018015892A MX2018015892A MX2018015892A MX 2018015892 A MX2018015892 A MX 2018015892A MX 2018015892 A MX2018015892 A MX 2018015892A MX 2018015892 A MX2018015892 A MX 2018015892A MX 2018015892 A MX2018015892 A MX 2018015892A
- Authority
- MX
- Mexico
- Prior art keywords
- acid derivatives
- boronic acid
- therapeutic uses
- blis
- preparation
- Prior art date
Links
- 150000001642 boronic acid derivatives Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 238000012575 bio-layer interferometry Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- -1 for example Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
En la presente se describen compuestos antimicrobianos, composiciones, composiciones farmacéuticas, el método de uso y preparación de los mismos. Algunas modalidades se refieren a derivados de ácido borónico y su uso como agentes terapéuticos, por ejemplo, inhibidores de ß-lactamasa (BLI).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662357165P | 2016-06-30 | 2016-06-30 | |
PCT/US2017/039787 WO2018005662A1 (en) | 2016-06-30 | 2017-06-28 | Boronic acid derivatives and therapeutic uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018015892A true MX2018015892A (es) | 2019-06-20 |
Family
ID=60785544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018015892A MX2018015892A (es) | 2016-06-30 | 2017-06-28 | Derivados de acido boronico y usos terapeuticos de los mismos. |
Country Status (23)
Country | Link |
---|---|
US (5) | US10294249B2 (es) |
EP (1) | EP3478693B1 (es) |
JP (1) | JP7060245B2 (es) |
KR (1) | KR102403296B1 (es) |
CN (1) | CN109415386B (es) |
AU (1) | AU2017290060B2 (es) |
BR (1) | BR112018077015B1 (es) |
CA (1) | CA3026582A1 (es) |
CL (1) | CL2018003681A1 (es) |
CO (1) | CO2018013978A2 (es) |
DK (1) | DK3478693T3 (es) |
ES (1) | ES2894251T3 (es) |
IL (1) | IL263450B (es) |
MX (1) | MX2018015892A (es) |
MY (1) | MY196909A (es) |
PH (1) | PH12018502747A1 (es) |
PL (1) | PL3478693T3 (es) |
PT (1) | PT3478693T (es) |
SA (1) | SA518400742B1 (es) |
SG (1) | SG11201811549UA (es) |
UA (1) | UA124464C2 (es) |
WO (1) | WO2018005662A1 (es) |
ZA (1) | ZA201808327B (es) |
Families Citing this family (28)
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CA2807546C (en) | 2010-08-10 | 2022-08-23 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
US9403850B2 (en) | 2013-01-10 | 2016-08-02 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
CN106687465B (zh) | 2014-06-11 | 2019-04-16 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN108472284A (zh) | 2015-09-11 | 2018-08-31 | 维纳拓尔斯制药公司 | β-内酰胺酶抑制剂 |
CN109415386B (zh) * | 2016-06-30 | 2022-04-19 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
JOP20190188A1 (ar) | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك |
SG11201908181XA (en) | 2017-03-06 | 2019-10-30 | Venatorx Pharmaceuticals Inc | Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof |
US11267826B2 (en) | 2017-05-26 | 2022-03-08 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
WO2018218190A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
JP7377545B2 (ja) * | 2017-10-11 | 2023-11-10 | キューペックス バイオファーマ, インコーポレイテッド | ボロン酸誘導体およびその合成 |
EP3781576B1 (en) * | 2018-04-20 | 2024-06-12 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
WO2019226931A1 (en) | 2018-05-25 | 2019-11-28 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
JP7558165B2 (ja) * | 2018-11-29 | 2024-09-30 | ベナトルクス ファーマシューティカルズ,インク. | β-ラクタマーゼ阻害剤を含む組み合わせ組成物およびその使用 |
CN114340639A (zh) | 2019-06-19 | 2022-04-12 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
TW202123945A (zh) * | 2019-09-13 | 2021-07-01 | 日商鹽野義製藥股份有限公司 | 具有抗菌作用的醫藥組成物 |
MX2022004912A (es) | 2019-10-25 | 2022-08-25 | Sumitomo Pharma Co Ltd | Novedoso compuesto de anillo condensado sustituido. |
JP2023518418A (ja) * | 2020-03-18 | 2023-05-01 | キューペックス バイオファーマ, インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
US20250002508A1 (en) * | 2020-05-05 | 2025-01-02 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof |
US20240294554A1 (en) * | 2020-08-20 | 2024-09-05 | Phaeno Therapeutics Co., Ltd | Boracic acid compound |
WO2022217199A1 (en) * | 2021-04-05 | 2022-10-13 | Qpex Biopharma, Inc. | Ceftibuten dosing regimens |
MX2023012004A (es) | 2021-04-13 | 2023-10-20 | Tuojie Biotech Shanghai Co Ltd | DERIVADO DEL ÁCIDO BÓRICO QUE ACTÚA COMO INHIBIDOR DE LA ß-LACTAMASA. |
CN113150022B (zh) * | 2021-04-23 | 2022-12-06 | 四川大学 | 3-取代五元环状硼酸酯衍生物及其药物组合物和制药用途 |
TW202317085A (zh) * | 2021-10-19 | 2023-05-01 | 大陸商上海濟煜醫藥科技有限公司 | 三環類硼酸衍生物及其製備方法和應用 |
CN119384424A (zh) * | 2022-02-18 | 2025-01-28 | 辉诺生物医药科技(杭州)有限公司 | 新的硼酸类化合物的晶型及其制备方法 |
CN114716465B (zh) * | 2022-05-06 | 2024-05-24 | 上海中医药大学 | 一种双环硼酸酯类化合物的制备方法及其应用 |
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