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MX2017010672A - Heterociclos biciclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4). - Google Patents

Heterociclos biciclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4).

Info

Publication number
MX2017010672A
MX2017010672A MX2017010672A MX2017010672A MX2017010672A MX 2017010672 A MX2017010672 A MX 2017010672A MX 2017010672 A MX2017010672 A MX 2017010672A MX 2017010672 A MX2017010672 A MX 2017010672A MX 2017010672 A MX2017010672 A MX 2017010672A
Authority
MX
Mexico
Prior art keywords
fgfr4
inhibitors
heterocicles
bicycle
receiver
Prior art date
Application number
MX2017010672A
Other languages
English (en)
Other versions
MX383140B (es
Inventor
Yao Wenqing
Wu Liangxing
Lu Liang
Qian Ding-Quan
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55697447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017010672(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2017010672A publication Critical patent/MX2017010672A/es
Publication of MX383140B publication Critical patent/MX383140B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a heterociclos bicíclicos y composiciones farmacéuticas de estos, que son inhibidores de la enzima FGFR4 y son útiles en el tratamiento de enfermedades relacionadas con el FGFR4, como el cáncer.
MX2017010672A 2015-02-20 2016-02-19 Heterociclos bicíclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4). MX383140B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562118699P 2015-02-20 2015-02-20
US201562192661P 2015-07-15 2015-07-15
PCT/US2016/018770 WO2016134314A1 (en) 2015-02-20 2016-02-19 Bicyclic heterocycles as fgfr4 inhibitors

Publications (2)

Publication Number Publication Date
MX2017010672A true MX2017010672A (es) 2018-03-21
MX383140B MX383140B (es) 2025-03-13

Family

ID=55697447

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017010672A MX383140B (es) 2015-02-20 2016-02-19 Heterociclos bicíclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4).
MX2021006443A MX2021006443A (es) 2015-02-20 2016-02-19 Heterociclos bicíclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4).

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021006443A MX2021006443A (es) 2015-02-20 2016-02-19 Heterociclos bicíclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4).

Country Status (23)

Country Link
US (5) US9890156B2 (es)
EP (1) EP3259270A1 (es)
JP (2) JP6716586B2 (es)
KR (1) KR102643180B1 (es)
CN (2) CN107438608B (es)
AU (2) AU2016219816B2 (es)
BR (1) BR112017017727B1 (es)
CA (1) CA2976788C (es)
CL (1) CL2017002122A1 (es)
CO (1) CO2017008824A2 (es)
CR (1) CR20170388A (es)
EA (1) EA201791867A1 (es)
EC (1) ECSP17062716A (es)
IL (1) IL253869B (es)
MA (1) MA41551A (es)
MX (2) MX383140B (es)
MY (1) MY187265A (es)
PE (1) PE20180050A1 (es)
PH (2) PH12021550394A1 (es)
SG (2) SG10201907582WA (es)
TW (2) TWI817189B (es)
UA (1) UA121492C2 (es)
WO (1) WO2016134314A1 (es)

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WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
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AR111960A1 (es) * 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
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JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
CN115151539A (zh) 2019-12-04 2022-10-04 因赛特公司 Fgfr抑制剂的衍生物
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
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TW202442224A (zh) * 2023-03-20 2024-11-01 香港商英矽智能科技知識產權有限公司 Fgfr2與fgfr3之抑制劑及其用途
WO2024242495A1 (ko) * 2023-05-25 2024-11-28 주식회사 매직불릿테라퓨틱스 단백질 키나아제 억제용 신규 화합물 및 이를 포함하는 약학조성물
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