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MD4371B1 - Derivaţi de benzo¢f]¢1,4]oxazepin-5-one ca modulatori ai canalelor ionice - Google Patents

Derivaţi de benzo¢f]¢1,4]oxazepin-5-one ca modulatori ai canalelor ionice

Info

Publication number
MD4371B1
MD4371B1 MDA20130095A MD20130095A MD4371B1 MD 4371 B1 MD4371 B1 MD 4371B1 MD A20130095 A MDA20130095 A MD A20130095A MD 20130095 A MD20130095 A MD 20130095A MD 4371 B1 MD4371 B1 MD 4371B1
Authority
MD
Moldova
Prior art keywords
oxazepine
benzo
derivatives
ion channel
channel modulators
Prior art date
Application number
MDA20130095A
Other languages
English (en)
Russian (ru)
Other versions
MD4371C1 (ro
MD20130095A2 (ro
Inventor
Britton Kenneth Corkey
Elfatih Elzein
Robert H. Jiang
Rao V. Kalla
Dmitry Koltun
Xiaofen Li
Ruben Martinez
Eric Q. Parkhill
Thao Perry
Jeff Zablocki
Chandrasekar Venkataramani
Michael Graupe
Juan Guerrero
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46513866&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD4371(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of MD20130095A2 publication Critical patent/MD20130095A2/ro
Publication of MD4371B1 publication Critical patent/MD4371B1/ro
Publication of MD4371C1 publication Critical patent/MD4371C1/ro

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
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    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Cardiology (AREA)
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  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
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  • Obesity (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Luminescent Compositions (AREA)
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Abstract

Prezenta invenţie se referă la compuşi noi inhibitori ai canalelor de sodiu şi la utilizarea lor în tratamentul diferitelor stări de boală, inclusiv al bolilor cardiovasculare şi al diabetului.Structura compuşilor revendicaţi este prezentată prin formula II:unde R2, R3, R4, R10, R17 , m şi n sunt definiţi în descriere.Compuşii funcţionează ca blocatori ai canalelor de sodiu de curent întârziat.
MDA20130095A 2011-07-01 2012-06-29 Derivaţi de benzo[f][1,4]oxazepin-5-one ca modulatori ai canalelor ionice MD4371C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161503980P 2011-07-01 2011-07-01
US201161582160P 2011-12-30 2011-12-30
PCT/US2012/045086 WO2013006485A1 (en) 2011-07-01 2012-06-29 Fused benzoxazepinones as ion channel modulators

Publications (3)

Publication Number Publication Date
MD20130095A2 MD20130095A2 (ro) 2014-04-30
MD4371B1 true MD4371B1 (ro) 2015-09-30
MD4371C1 MD4371C1 (ro) 2016-07-31

Family

ID=46513866

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20130095A MD4371C1 (ro) 2011-07-01 2012-06-29 Derivaţi de benzo[f][1,4]oxazepin-5-one ca modulatori ai canalelor ionice

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Country Link
US (5) US8586732B2 (ro)
EP (6) EP3088395B1 (ro)
JP (2) JP5889407B2 (ro)
KR (2) KR101608927B1 (ro)
CN (2) CN106995415A (ro)
AP (1) AP2013007300A0 (ro)
AR (1) AR086828A1 (ro)
AU (1) AU2012279236B2 (ro)
BR (1) BR112013032361A2 (ro)
CA (1) CA2838223A1 (ro)
CL (1) CL2013003598A1 (ro)
CO (1) CO6821960A2 (ro)
CR (1) CR20130658A (ro)
CY (1) CY1117915T1 (ro)
DK (1) DK2726466T3 (ro)
EA (2) EA027356B1 (ro)
EC (1) ECSP13013083A (ro)
ES (6) ES2792864T3 (ro)
HK (6) HK1196602A1 (ro)
HR (1) HRP20160952T1 (ro)
HU (1) HUE029398T2 (ro)
IL (2) IL230022B (ro)
MD (1) MD4371C1 (ro)
ME (1) ME02546B (ro)
MX (1) MX336810B (ro)
NZ (2) NZ716245A (ro)
PE (1) PE20140690A1 (ro)
PL (1) PL2726466T3 (ro)
PT (1) PT2726466T (ro)
RS (1) RS55024B1 (ro)
SI (1) SI2726466T1 (ro)
SM (1) SMT201600271B (ro)
TW (4) TWI622583B (ro)
UA (1) UA115529C2 (ro)
UY (1) UY34171A (ro)
WO (1) WO2013006485A1 (ro)
ZA (1) ZA201308981B (ro)

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