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MA29432B1 - Antagonistes du recepteur du glucagon, leur preparation et leurs utilisations therapeutiques - Google Patents

Antagonistes du recepteur du glucagon, leur preparation et leurs utilisations therapeutiques

Info

Publication number
MA29432B1
MA29432B1 MA30221A MA30221A MA29432B1 MA 29432 B1 MA29432 B1 MA 29432B1 MA 30221 A MA30221 A MA 30221A MA 30221 A MA30221 A MA 30221A MA 29432 B1 MA29432 B1 MA 29432B1
Authority
MA
Morocco
Prior art keywords
compounds
glucagon receptor
preparation
methods
receptor antagonists
Prior art date
Application number
MA30221A
Other languages
English (en)
Inventor
Mark Donald Chappell
Scott Eugene Conner
Allie Edward Tripp
Guoxin Zhu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694345&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA29432(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA29432B1 publication Critical patent/MA29432B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES NOUVEAUX COMPOSÉS DE FORMULE (I) OU DES SELS ASSOCIÉS ACCEPTABLES PHARMACEUTIQUEMENT QUI POSSÈDENT UN ANTAGONISTE DU RÉCEPTEUR DU GLUCAGON OU UNE ACTIVITÉ AGONISTE INVERSE, AINSI QUE DES MÉTHODES D'UTILISATION DE CES COMPOSÉS ET INTERMÉDIAIRES ET DES MÉTHODES DE PRÉPARATION DE TELS COMPOSÉS. DANS UN AUTRE MODE DE RÉALISATION, CETTE INVENTION A POUR OBJET DES COMPOSITIONS PHARMACEUTIQUES RENFERMANT DES COMPOSÉS DE FORMULE (I), AINSI QUE DES MÉTHODES LES EMPLOYANT DANS LE TRAITEMENT DE TROUBLES DIABÉTIQUES ET D'AUTRES TROUBLES MÉTABOLIQUES LIÉS AU GLUCAGON, ET SIMILAIRE.
MA30221A 2005-02-11 2007-09-11 Antagonistes du recepteur du glucagon, leur preparation et leurs utilisations therapeutiques MA29432B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65249205P 2005-02-11 2005-02-11

Publications (1)

Publication Number Publication Date
MA29432B1 true MA29432B1 (fr) 2008-05-02

Family

ID=36694345

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30221A MA29432B1 (fr) 2005-02-11 2007-09-11 Antagonistes du recepteur du glucagon, leur preparation et leurs utilisations therapeutiques

Country Status (25)

Country Link
US (1) US8084489B2 (fr)
EP (1) EP1856090B1 (fr)
JP (1) JP4988604B2 (fr)
KR (1) KR20070104409A (fr)
CN (1) CN101115735B (fr)
AT (1) ATE445609T1 (fr)
AU (1) AU2006213894B2 (fr)
BR (1) BRPI0607015A2 (fr)
CA (1) CA2597073C (fr)
CR (1) CR9304A (fr)
CY (1) CY1109624T1 (fr)
DE (1) DE602006009773D1 (fr)
DK (1) DK1856090T3 (fr)
EA (1) EA200701705A1 (fr)
ES (1) ES2332470T3 (fr)
IL (1) IL184932A0 (fr)
MA (1) MA29432B1 (fr)
MX (1) MX2007009661A (fr)
NO (1) NO20074567L (fr)
PL (1) PL1856090T3 (fr)
PT (1) PT1856090E (fr)
SI (1) SI1856090T1 (fr)
TN (1) TNSN07313A1 (fr)
WO (1) WO2006086488A2 (fr)
ZA (1) ZA200706354B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA013003B1 (ru) * 2004-06-14 2010-02-26 Эли Лилли Энд Компани Антагонисты рецептора глюкагона, их получение и терапевтическое применение
CA2678265C (fr) 2007-02-09 2015-10-13 Metabasis Therapeutics, Inc. Nouveaux antagonistes du recepteur au glucagon
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
ES2714207T3 (es) 2008-08-13 2019-05-27 Metabasis Therapeutics Inc Antagonistas de glucagón
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
MX2013006768A (es) 2010-12-23 2013-07-22 Pfizer Moduladores de receptor de glucagon.
EP2673260B1 (fr) 2011-02-08 2016-08-17 Pfizer Inc Modulateur du récepteur de glucagon
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120053A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
WO2012120055A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2013014569A1 (fr) 2011-07-22 2013-01-31 Pfizer Inc. Modulateurs des récepteurs de quinolinylglucagon
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
TW201427658A (zh) 2012-12-10 2014-07-16 Merck Sharp & Dohme 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
EP3065736B1 (fr) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation
WO2015191900A1 (fr) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Antagonistes du glucagon
EP3350200A4 (fr) 2015-09-18 2019-03-27 Wake Forest University Health Services Analogues d'angiotensine (1-7) et procédés associés
CA2914601A1 (fr) * 2015-12-11 2017-06-11 Wake Forest University Health Sciences Analogues d'angiotensine-(1-7) et methodes associees
KR20190044079A (ko) 2016-08-30 2019-04-29 리제너론 파마슈티칼스 인코포레이티드 글루카곤 수용체 신호전달을 간섭함에 의한 중증 인슐린 저항성의 치료 방법
EP3529278A1 (fr) 2016-10-20 2019-08-28 Regeneron Pharmaceuticals, Inc. Méthodes d'abaissement de niveaux de glycémie
JP2020531532A (ja) 2017-08-22 2020-11-05 リジェネロン・ファーマシューティカルズ・インコーポレイテッド グルカゴン受容体シグナル伝達に干渉することによって尿素サイクル異常症を治療する方法
CN111954560A (zh) 2018-02-13 2020-11-17 配体药物公司 胰高血糖素受体拮抗剂
BR112022010735A2 (pt) 2019-12-20 2022-08-23 Bayer Ag Tiofeno carboxamidas substituídos, ácidos tiofeno carboxílicos e derivados dos mesmos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003048109A1 (fr) * 2001-12-03 2003-06-12 Novo Nordisk A/S Nouveaux antagonistes de glucagon
JP2006500325A (ja) * 2002-06-27 2006-01-05 ノボ ノルディスク アクティーゼルスカブ 新規なグルカゴンアンタゴニスト
US7989457B2 (en) * 2004-05-28 2011-08-02 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses
EA013003B1 (ru) 2004-06-14 2010-02-26 Эли Лилли Энд Компани Антагонисты рецептора глюкагона, их получение и терапевтическое применение

Also Published As

Publication number Publication date
US20100137417A1 (en) 2010-06-03
SI1856090T1 (sl) 2010-02-26
EA200701705A1 (ru) 2008-02-28
DE602006009773D1 (de) 2009-11-26
ZA200706354B (en) 2008-11-26
PT1856090E (pt) 2009-11-18
CA2597073C (fr) 2014-11-25
US8084489B2 (en) 2011-12-27
AU2006213894B2 (en) 2011-12-08
NO20074567L (no) 2007-11-08
JP2008530102A (ja) 2008-08-07
ES2332470T3 (es) 2010-02-05
CR9304A (es) 2008-03-31
KR20070104409A (ko) 2007-10-25
ATE445609T1 (de) 2009-10-15
IL184932A0 (en) 2007-12-03
CY1109624T1 (el) 2014-08-13
WO2006086488A2 (fr) 2006-08-17
CN101115735B (zh) 2013-01-09
AU2006213894A1 (en) 2006-08-17
EP1856090A2 (fr) 2007-11-21
TNSN07313A1 (en) 2008-12-31
EP1856090B1 (fr) 2009-10-14
WO2006086488A3 (fr) 2006-12-14
CA2597073A1 (fr) 2006-08-17
PL1856090T3 (pl) 2010-02-26
DK1856090T3 (da) 2009-11-30
MX2007009661A (es) 2007-09-25
BRPI0607015A2 (pt) 2009-12-01
CN101115735A (zh) 2008-01-30
JP4988604B2 (ja) 2012-08-01

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