[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK1951659T3 - Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf - Google Patents

Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf

Info

Publication number
DK1951659T3
DK1951659T3 DK06850138.6T DK06850138T DK1951659T3 DK 1951659 T3 DK1951659 T3 DK 1951659T3 DK 06850138 T DK06850138 T DK 06850138T DK 1951659 T3 DK1951659 T3 DK 1951659T3
Authority
DK
Denmark
Prior art keywords
glucagon receptor
preparation
receptor antagonists
therapeutic use
compounds
Prior art date
Application number
DK06850138.6T
Other languages
English (en)
Inventor
Mark Donald Chappell
Scott Eugene Conner
Philip Arthur Hipskind
Jason Eric Lamar
Guoxin Zhu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK1951659T3 publication Critical patent/DK1951659T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK06850138.6T 2005-11-18 2006-11-10 Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf DK1951659T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73797905P 2005-11-18 2005-11-18
PCT/US2006/060769 WO2007114855A2 (en) 2005-11-18 2006-11-10 Glucagon receptor antagonists, preparation and therapeutic uses

Publications (1)

Publication Number Publication Date
DK1951659T3 true DK1951659T3 (da) 2010-10-11

Family

ID=38470878

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06850138.6T DK1951659T3 (da) 2005-11-18 2006-11-10 Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf

Country Status (12)

Country Link
US (1) US8076374B2 (da)
JP (1) JP5100657B2 (da)
CN (1) CN101309894B (da)
AT (1) ATE473961T1 (da)
AU (1) AU2006341392B2 (da)
BR (1) BRPI0618484A2 (da)
CA (1) CA2629321C (da)
DE (1) DE602006015509D1 (da)
DK (1) DK1951659T3 (da)
ES (1) ES2346246T3 (da)
PT (1) PT1951659E (da)
WO (1) WO2007114855A2 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455756T1 (de) * 2004-06-14 2010-02-15 Lilly Co Eli Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung
ES2720430T3 (es) 2007-02-09 2019-07-22 Metabasis Therapeutics Inc Antagonistas novedosos del receptor de glucagón
ES2527670T3 (es) 2008-08-13 2015-01-28 Metabasis Therapeutics, Inc. Antagonistas de glucagón
AR073412A1 (es) 2008-10-03 2010-11-03 Schering Corp Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende.
EP2480077B1 (en) 2009-09-22 2015-02-18 Merck Sharp & Dohme Corp. Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
AU2011346670B2 (en) 2010-12-23 2015-05-07 Pfizer Inc. Glucagon receptor modulators
ME02502B (me) 2011-02-08 2017-02-20 Pfizer Modulator glukagonskog receptora
RU2013157388A (ru) * 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
WO2015066252A1 (en) 2013-11-04 2015-05-07 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions thereof, and methods of use
WO2015191900A1 (en) 2014-06-12 2015-12-17 Ligand Pharmaceuticals, Inc. Glucagon antagonists
US10201617B2 (en) 2014-10-24 2019-02-12 Zhuhai Beihai Biotech Co., Ltd. 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
EP3752249A1 (en) 2018-02-13 2020-12-23 Ligand Pharmaceuticals, Inc. Glucagon receptor antagonists
CN110143935B (zh) * 2019-06-03 2022-09-30 华侨大学 一种2,5-二取代呋喃衍生物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420557D0 (en) * 1994-10-12 1994-11-30 Zeneca Ltd Aromatic compounds
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
EP1463715A1 (en) 2001-12-03 2004-10-06 Novo Nordisk A/S Novel glucagon antagonists
AU2003233780A1 (en) 2002-06-27 2004-01-19 Novo Nordisk A/S Novel glucagon antagonists/inverse agonists
AU2003291959A1 (en) * 2002-12-20 2004-07-14 Novo Nordisk A/S Novel glucagon antagonists
WO2004063147A1 (en) * 2003-01-10 2004-07-29 Novo Nordisk A/S Salts and solvates of glucagon antagonists
US20080254182A1 (en) 2004-04-26 2008-10-16 Laurens Last Packaged Flowable Ice Product, Such as a Milk Shake

Also Published As

Publication number Publication date
WO2007114855A2 (en) 2007-10-11
WO2007114855A3 (en) 2007-11-29
JP2009519227A (ja) 2009-05-14
CA2629321A1 (en) 2007-10-11
ATE473961T1 (de) 2010-07-15
US20080319074A1 (en) 2008-12-25
JP5100657B2 (ja) 2012-12-19
CA2629321C (en) 2013-08-06
AU2006341392B2 (en) 2012-05-17
AU2006341392A1 (en) 2007-10-11
ES2346246T3 (es) 2010-10-13
PT1951659E (pt) 2010-09-10
US8076374B2 (en) 2011-12-13
CN101309894A (zh) 2008-11-19
BRPI0618484A2 (pt) 2011-08-30
DE602006015509D1 (de) 2010-08-26
CN101309894B (zh) 2012-10-03

Similar Documents

Publication Publication Date Title
NO20074567L (no) Glucagonreseptorantagoniser, fremstilling og terapeutisk anvendelse
DK1957484T3 (da) Glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser
NO20070213L (no) Glucagon reseptorantagonister, fremstilling og terapeutiske anvendelser
DK1951659T3 (da) Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf
WO2007106181A3 (en) Glucagon receptor antagonists, preparation and therapeutic uses
WO2007120270A3 (en) Glucagon receptor antagonists, preparation and therapeutic uses
DK1735278T3 (da) Histamin H3-receptormidler, fremstilling og terapeutiske anvendelser
DK1861360T3 (da) Pyrrolidin-derivater som histamin-H3-receptorantagonister
ATE523488T1 (de) Histamin-h3-rezeptor-mittel, deren herstellung und therapeutische verwendung