DK1951659T3 - Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf - Google Patents
Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse herafInfo
- Publication number
- DK1951659T3 DK1951659T3 DK06850138.6T DK06850138T DK1951659T3 DK 1951659 T3 DK1951659 T3 DK 1951659T3 DK 06850138 T DK06850138 T DK 06850138T DK 1951659 T3 DK1951659 T3 DK 1951659T3
- Authority
- DK
- Denmark
- Prior art keywords
- glucagon receptor
- preparation
- receptor antagonists
- therapeutic use
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73797905P | 2005-11-18 | 2005-11-18 | |
PCT/US2006/060769 WO2007114855A2 (en) | 2005-11-18 | 2006-11-10 | Glucagon receptor antagonists, preparation and therapeutic uses |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1951659T3 true DK1951659T3 (da) | 2010-10-11 |
Family
ID=38470878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06850138.6T DK1951659T3 (da) | 2005-11-18 | 2006-11-10 | Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf |
Country Status (12)
Country | Link |
---|---|
US (1) | US8076374B2 (da) |
JP (1) | JP5100657B2 (da) |
CN (1) | CN101309894B (da) |
AT (1) | ATE473961T1 (da) |
AU (1) | AU2006341392B2 (da) |
BR (1) | BRPI0618484A2 (da) |
CA (1) | CA2629321C (da) |
DE (1) | DE602006015509D1 (da) |
DK (1) | DK1951659T3 (da) |
ES (1) | ES2346246T3 (da) |
PT (1) | PT1951659E (da) |
WO (1) | WO2007114855A2 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE455756T1 (de) * | 2004-06-14 | 2010-02-15 | Lilly Co Eli | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung |
ES2720430T3 (es) | 2007-02-09 | 2019-07-22 | Metabasis Therapeutics Inc | Antagonistas novedosos del receptor de glucagón |
ES2527670T3 (es) | 2008-08-13 | 2015-01-28 | Metabasis Therapeutics, Inc. | Antagonistas de glucagón |
AR073412A1 (es) | 2008-10-03 | 2010-11-03 | Schering Corp | Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende. |
EP2480077B1 (en) | 2009-09-22 | 2015-02-18 | Merck Sharp & Dohme Corp. | Pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use |
AU2011346670B2 (en) | 2010-12-23 | 2015-05-07 | Pfizer Inc. | Glucagon receptor modulators |
ME02502B (me) | 2011-02-08 | 2017-02-20 | Pfizer | Modulator glukagonskog receptora |
RU2013157388A (ru) * | 2011-07-22 | 2015-08-27 | Пфайзер Инк. | Хинолинильные модуляторы глюкагонового рецептора |
WO2015066252A1 (en) | 2013-11-04 | 2015-05-07 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions thereof, and methods of use |
WO2015191900A1 (en) | 2014-06-12 | 2015-12-17 | Ligand Pharmaceuticals, Inc. | Glucagon antagonists |
US10201617B2 (en) | 2014-10-24 | 2019-02-12 | Zhuhai Beihai Biotech Co., Ltd. | 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin |
EP3752249A1 (en) | 2018-02-13 | 2020-12-23 | Ligand Pharmaceuticals, Inc. | Glucagon receptor antagonists |
CN110143935B (zh) * | 2019-06-03 | 2022-09-30 | 华侨大学 | 一种2,5-二取代呋喃衍生物的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9420557D0 (en) * | 1994-10-12 | 1994-11-30 | Zeneca Ltd | Aromatic compounds |
NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
EP1463715A1 (en) | 2001-12-03 | 2004-10-06 | Novo Nordisk A/S | Novel glucagon antagonists |
AU2003233780A1 (en) | 2002-06-27 | 2004-01-19 | Novo Nordisk A/S | Novel glucagon antagonists/inverse agonists |
AU2003291959A1 (en) * | 2002-12-20 | 2004-07-14 | Novo Nordisk A/S | Novel glucagon antagonists |
WO2004063147A1 (en) * | 2003-01-10 | 2004-07-29 | Novo Nordisk A/S | Salts and solvates of glucagon antagonists |
US20080254182A1 (en) | 2004-04-26 | 2008-10-16 | Laurens Last | Packaged Flowable Ice Product, Such as a Milk Shake |
-
2006
- 2006-11-10 CA CA2629321A patent/CA2629321C/en not_active Expired - Fee Related
- 2006-11-10 DE DE602006015509T patent/DE602006015509D1/de active Active
- 2006-11-10 JP JP2008541450A patent/JP5100657B2/ja not_active Expired - Fee Related
- 2006-11-10 BR BRPI0618484-7A patent/BRPI0618484A2/pt not_active IP Right Cessation
- 2006-11-10 US US12/093,598 patent/US8076374B2/en not_active Expired - Fee Related
- 2006-11-10 DK DK06850138.6T patent/DK1951659T3/da active
- 2006-11-10 AU AU2006341392A patent/AU2006341392B2/en not_active Ceased
- 2006-11-10 WO PCT/US2006/060769 patent/WO2007114855A2/en active Application Filing
- 2006-11-10 AT AT06850138T patent/ATE473961T1/de active
- 2006-11-10 PT PT06850138T patent/PT1951659E/pt unknown
- 2006-11-10 ES ES06850138T patent/ES2346246T3/es active Active
- 2006-11-10 CN CN2006800428747A patent/CN101309894B/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2007114855A2 (en) | 2007-10-11 |
WO2007114855A3 (en) | 2007-11-29 |
JP2009519227A (ja) | 2009-05-14 |
CA2629321A1 (en) | 2007-10-11 |
ATE473961T1 (de) | 2010-07-15 |
US20080319074A1 (en) | 2008-12-25 |
JP5100657B2 (ja) | 2012-12-19 |
CA2629321C (en) | 2013-08-06 |
AU2006341392B2 (en) | 2012-05-17 |
AU2006341392A1 (en) | 2007-10-11 |
ES2346246T3 (es) | 2010-10-13 |
PT1951659E (pt) | 2010-09-10 |
US8076374B2 (en) | 2011-12-13 |
CN101309894A (zh) | 2008-11-19 |
BRPI0618484A2 (pt) | 2011-08-30 |
DE602006015509D1 (de) | 2010-08-26 |
CN101309894B (zh) | 2012-10-03 |
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