ZA200501116B - Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor - Google Patents
Benzimidazole derivatives and their use as prodrugs of proton pump inhibitorInfo
- Publication number
- ZA200501116B ZA200501116B ZA200501116A ZA200501116A ZA200501116B ZA 200501116 B ZA200501116 B ZA 200501116B ZA 200501116 A ZA200501116 A ZA 200501116A ZA 200501116 A ZA200501116 A ZA 200501116A ZA 200501116 B ZA200501116 B ZA 200501116B
- Authority
- ZA
- South Africa
- Prior art keywords
- prodrugs
- proton pump
- pump inhibitor
- benzimidazole derivatives
- bioavailability
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39745902P | 2002-07-19 | 2002-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200501116B true ZA200501116B (en) | 2006-11-29 |
Family
ID=30771064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200501116A ZA200501116B (en) | 2002-07-19 | 2005-02-08 | Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US6897227B2 (de) |
| EP (1) | EP1556371B1 (de) |
| JP (1) | JP4463103B2 (de) |
| KR (2) | KR100788778B1 (de) |
| AT (1) | ATE323695T1 (de) |
| AU (1) | AU2003259154B2 (de) |
| BR (1) | BR0312802A (de) |
| CA (1) | CA2492718C (de) |
| CO (1) | CO5690576A2 (de) |
| DE (1) | DE60304726T2 (de) |
| DK (1) | DK1556371T3 (de) |
| ES (1) | ES2263028T3 (de) |
| HK (1) | HK1079207A1 (de) |
| IL (1) | IL166371A0 (de) |
| MX (1) | MXPA05000657A (de) |
| NO (1) | NO20050801L (de) |
| NZ (1) | NZ538221A (de) |
| PL (1) | PL375255A1 (de) |
| PT (1) | PT1556371E (de) |
| RU (1) | RU2292342C2 (de) |
| TW (1) | TW200502231A (de) |
| WO (1) | WO2004009583A2 (de) |
| ZA (1) | ZA200501116B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| AU2003254282A1 (en) * | 2002-08-01 | 2004-02-23 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| MXPA06000410A (es) * | 2003-07-15 | 2006-03-17 | Allergan Inc | Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones. |
| US20060241037A1 (en) * | 2003-10-03 | 2006-10-26 | Allergan Inc. | Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs |
| US20050075371A1 (en) * | 2003-10-03 | 2005-04-07 | Allergan, Inc. | Methods and compositions for the oral administration of prodrugs of proton pump inhibitors |
| US20070060621A1 (en) * | 2004-02-18 | 2007-03-15 | Hughes Patrick M | Methods and compositions for the administration of prodrugs of proton pump inhibitors |
| EP1715854A2 (de) * | 2004-02-18 | 2006-11-02 | Allergan, Inc. | Prodrugs für die intravenöse verabreichung von protonenpumpen-hemmern |
| BRPI0507796A (pt) * | 2004-03-11 | 2007-07-17 | Allergan Inc | métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico |
| ATE437869T1 (de) | 2004-04-28 | 2009-08-15 | Hetero Drugs Ltd | Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere |
| WO2007073301A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Benzoimidazole derivatives as prodrugs of proton pump inhibitors |
| US20070265311A1 (en) * | 2006-01-10 | 2007-11-15 | Rubino Mark P | Therapeutic Salt Compositions and Methods |
| AU2007248949B2 (en) * | 2006-05-09 | 2010-04-08 | Astrazeneca Ab | Parenteral formulation comprising proton pump inhibitor sterilized in its final container by ionizing radiation |
| US20070293543A1 (en) * | 2006-06-19 | 2007-12-20 | Edward Lee | THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z |
| US20100113524A1 (en) * | 2006-09-19 | 2010-05-06 | Garst Michael E | Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety |
| US20100317689A1 (en) * | 2006-09-19 | 2010-12-16 | Garst Michael E | Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety |
| KR20090035195A (ko) * | 2007-10-05 | 2009-04-09 | 엘지전자 주식회사 | 플라즈마 디스플레이 장치 |
| WO2009044976A1 (en) * | 2007-10-05 | 2009-04-09 | Lg Electronics Inc. | Plasma display device |
| KR100895333B1 (ko) * | 2007-11-01 | 2009-05-07 | 엘지전자 주식회사 | 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치 |
| WO2012051036A1 (en) | 2010-10-11 | 2012-04-19 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as crth2 antagonists |
| US9290453B2 (en) | 2010-12-23 | 2016-03-22 | Merck Sharp & Dohme Corp. | Quinolines and aza-quinolines as CRTH2 receptor modulators |
| CN103702985B (zh) | 2010-12-23 | 2016-02-17 | 默沙东公司 | 作为crth2受体调节剂的喹喔啉和氮杂喹喔啉 |
| WO2016112254A1 (en) * | 2015-01-09 | 2016-07-14 | The Regents Of The University Of California | Compositions and methods for treating gastrointestinal infections |
| CN108997177A (zh) * | 2018-09-04 | 2018-12-14 | 邵阳学院 | 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US430042A (en) * | 1890-06-10 | Valve | ||
| SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
| SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| IL76839A (en) | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| SE8505112D0 (sv) | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
| US4758597A (en) | 1987-05-15 | 1988-07-19 | University Patents, Inc. | Carenadiol and derivatives |
| US4965269A (en) | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
| US5045522A (en) | 1990-03-27 | 1991-09-03 | Phillips Petroleum Company | Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams |
| WO1991019712A1 (en) | 1990-06-20 | 1991-12-26 | Aktiebolaget Astra | Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| CZ288079B6 (cs) * | 1994-06-10 | 2001-04-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiopyridinové deriváty a jejich použití |
| US5708017A (en) | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| US6093734A (en) | 1998-08-10 | 2000-07-25 | Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin | Prodrugs of proton pump inhibitors |
| IL141083A0 (en) * | 1998-08-10 | 2002-02-10 | Partnership Of Michael E Garst | Prodrugs of proton pump inhibitors |
| DE69924651D1 (de) * | 1998-08-12 | 2005-05-12 | Gilead Sciences Inc | Verfahren zu Herstellung von 1,3-Oxathiolane Nukleosiden |
| SE0002476D0 (sv) | 2000-06-30 | 2000-06-30 | Astrazeneca Ab | New compounds |
| US6599167B2 (en) | 2000-09-27 | 2003-07-29 | Glenn Waltz | Game call holder and amplifying device |
| US20040039027A1 (en) * | 2000-10-12 | 2004-02-26 | Keiji Kamiyama | Benzimidazole compounds, process for producing the same and use thereof |
-
2003
- 2003-07-15 US US10/620,252 patent/US6897227B2/en not_active Expired - Lifetime
- 2003-07-15 BR BR0312802-4A patent/BR0312802A/pt not_active IP Right Cessation
- 2003-07-15 WO PCT/US2003/022419 patent/WO2004009583A2/en active IP Right Grant
- 2003-07-15 AT AT03765694T patent/ATE323695T1/de not_active IP Right Cessation
- 2003-07-15 DE DE60304726T patent/DE60304726T2/de not_active Expired - Lifetime
- 2003-07-15 JP JP2004523537A patent/JP4463103B2/ja not_active Expired - Fee Related
- 2003-07-15 DK DK03765694T patent/DK1556371T3/da active
- 2003-07-15 NZ NZ538221A patent/NZ538221A/en unknown
- 2003-07-15 KR KR1020057000899A patent/KR100788778B1/ko not_active IP Right Cessation
- 2003-07-15 AU AU2003259154A patent/AU2003259154B2/en not_active Ceased
- 2003-07-15 ES ES03765694T patent/ES2263028T3/es not_active Expired - Lifetime
- 2003-07-15 PT PT03765694T patent/PT1556371E/pt unknown
- 2003-07-15 MX MXPA05000657A patent/MXPA05000657A/es active IP Right Grant
- 2003-07-15 KR KR1020067026729A patent/KR100822981B1/ko not_active IP Right Cessation
- 2003-07-15 EP EP03765694A patent/EP1556371B1/de not_active Expired - Lifetime
- 2003-07-15 RU RU2005105564/04A patent/RU2292342C2/ru not_active IP Right Cessation
- 2003-07-15 CA CA2492718A patent/CA2492718C/en not_active Expired - Lifetime
- 2003-07-15 PL PL03375255A patent/PL375255A1/xx not_active Application Discontinuation
- 2003-11-07 TW TW092131253A patent/TW200502231A/zh unknown
-
2005
- 2005-01-18 IL IL16637105A patent/IL166371A0/xx unknown
- 2005-01-20 US US11/039,630 patent/US20050182101A1/en not_active Abandoned
- 2005-01-20 US US11/039,631 patent/US20050143423A1/en not_active Abandoned
- 2005-02-08 ZA ZA200501116A patent/ZA200501116B/xx unknown
- 2005-02-15 NO NO20050801A patent/NO20050801L/no not_active Application Discontinuation
- 2005-02-15 CO CO05013468A patent/CO5690576A2/es not_active Application Discontinuation
-
2006
- 2006-01-11 HK HK06100445A patent/HK1079207A1/xx not_active IP Right Cessation
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