[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BR0312802A - Pró-drogas de inibidores de bombas de próton - Google Patents

Pró-drogas de inibidores de bombas de próton

Info

Publication number
BR0312802A
BR0312802A BR0312802-4A BR0312802A BR0312802A BR 0312802 A BR0312802 A BR 0312802A BR 0312802 A BR0312802 A BR 0312802A BR 0312802 A BR0312802 A BR 0312802A
Authority
BR
Brazil
Prior art keywords
proton pump
pump inhibitor
inhibitor prodrugs
prodrugs
group
Prior art date
Application number
BR0312802-4A
Other languages
English (en)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Michael E Garst
George Sachs
Jai Moo Shin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael E Garst, George Sachs, Jai Moo Shin filed Critical Michael E Garst
Publication of BR0312802A publication Critical patent/BR0312802A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

"PRó-DROGAS DE INIBIDORES DE BOMBA DE PRóTON". Pró-drogas de inibidores de bomba de próton de Fórmulas 1 a 4, onde os símbolos são como definidos na especificação, e o grupo R inclui pelo menos um grupo acídico ou seu sal farmaceuticamente aceitável, têm biodisponibilidade e solubilidade aquosa.
BR0312802-4A 2002-07-19 2003-07-15 Pró-drogas de inibidores de bombas de próton BR0312802A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
PCT/US2003/022419 WO2004009583A2 (en) 2002-07-19 2003-07-15 Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor

Publications (1)

Publication Number Publication Date
BR0312802A true BR0312802A (pt) 2005-04-19

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312802-4A BR0312802A (pt) 2002-07-19 2003-07-15 Pró-drogas de inibidores de bombas de próton

Country Status (23)

Country Link
US (3) US6897227B2 (pt)
EP (1) EP1556371B1 (pt)
JP (1) JP4463103B2 (pt)
KR (2) KR100788778B1 (pt)
AT (1) ATE323695T1 (pt)
AU (1) AU2003259154B2 (pt)
BR (1) BR0312802A (pt)
CA (1) CA2492718C (pt)
CO (1) CO5690576A2 (pt)
DE (1) DE60304726T2 (pt)
DK (1) DK1556371T3 (pt)
ES (1) ES2263028T3 (pt)
HK (1) HK1079207A1 (pt)
IL (1) IL166371A0 (pt)
MX (1) MXPA05000657A (pt)
NO (1) NO20050801L (pt)
NZ (1) NZ538221A (pt)
PL (1) PL375255A1 (pt)
PT (1) PT1556371E (pt)
RU (1) RU2292342C2 (pt)
TW (1) TW200502231A (pt)
WO (1) WO2004009583A2 (pt)
ZA (1) ZA200501116B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
US7211590B2 (en) * 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
EP1644352A1 (en) * 2003-07-15 2006-04-12 Allergan, Inc. Process for preparing isomerically pure prodrugs of proton pump inhibitors
US20060241037A1 (en) * 2003-10-03 2006-10-26 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump ihhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20070060621A1 (en) * 2004-02-18 2007-03-15 Hughes Patrick M Methods and compositions for the administration of prodrugs of proton pump inhibitors
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
AU2005222574A1 (en) * 2004-03-11 2005-09-29 Allergan, Inc. Methods and compositions for the treatment of conditions related to gastric acid secretion
US7176319B2 (en) 2004-04-28 2007-02-13 Hetero Drugs Limited Process for substituted sulfoxides
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
US20070265311A1 (en) * 2006-01-10 2007-11-15 Rubino Mark P Therapeutic Salt Compositions and Methods
BRPI0711048A2 (pt) * 2006-05-09 2011-08-23 Astrazeneca Ab formulações parenteral esterilizada e sólida estáveis, solução para administração parenteral, processos para a preparação de uma formulação e para a fabricação de um produto, método para prevenir ou tratar doenças gastrintestinais, uso de uma formulação sólida estável
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
US9290453B2 (en) 2010-12-23 2016-03-22 Merck Sharp & Dohme Corp. Quinolines and aza-quinolines as CRTH2 receptor modulators
AU2011349524B2 (en) 2010-12-23 2016-06-02 Merck Sharp & Dohme Corp. Quinoxalines and aza-quinoxalines as CRTH2 receptor modulators
JP2018502155A (ja) * 2015-01-09 2018-01-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 胃腸感染症を治療するための組成物及び方法
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
EP0593463B1 (en) 1990-06-20 1999-09-15 Astra Aktiebolag Dialkoxy-pyridinyl-benzimidazole derivatives, process for their preparation and their pharmaceutical use
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
PL181801B1 (pl) * 1994-06-10 2001-09-28 Byk Gulden Lomberg Chem Fab Podstawione aryloalkilotioalkilotiopirydyny do zwalczania bakterii Helicobacter oraz srodek leczniczy zawierajacy podstawione aryloalkilotioalkilotiopirydyny PL
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
WO2000009498A1 (en) * 1998-08-10 2000-02-24 Partnership Of Michael E. Garst, George Sachs And Jai Moo Shin Prodrugs of proton pump inhibitors
US6093734A (en) 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
ATE282034T1 (de) * 1998-08-12 2004-11-15 Gilead Sciences Inc Verfahren zur herstellung von 1,3- oxathiolannukleoside
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
AU2001294228A1 (en) * 2000-10-12 2002-04-22 Takeda Chemical Industries Ltd. Benzimidazole compounds, process for producing the same and use thereof

Also Published As

Publication number Publication date
DE60304726D1 (de) 2006-05-24
DK1556371T3 (da) 2006-08-21
US20050143423A1 (en) 2005-06-30
KR20050047078A (ko) 2005-05-19
WO2004009583A3 (en) 2004-03-18
HK1079207A1 (en) 2006-03-31
EP1556371B1 (en) 2006-04-19
US20050182101A1 (en) 2005-08-18
RU2292342C2 (ru) 2007-01-27
NO20050801L (no) 2005-02-15
NZ538221A (en) 2006-11-30
EP1556371A2 (en) 2005-07-27
ES2263028T3 (es) 2006-12-01
PT1556371E (pt) 2006-09-29
CA2492718A1 (en) 2004-01-29
KR100822981B1 (ko) 2008-04-16
JP4463103B2 (ja) 2010-05-12
CO5690576A2 (es) 2006-10-31
AU2003259154C1 (en) 2004-02-09
ATE323695T1 (de) 2006-05-15
IL166371A0 (en) 2006-01-16
ZA200501116B (en) 2006-11-29
JP2005536519A (ja) 2005-12-02
MXPA05000657A (es) 2005-08-19
WO2004009583A2 (en) 2004-01-29
RU2005105564A (ru) 2005-10-10
AU2003259154B2 (en) 2006-12-07
DE60304726T2 (de) 2007-08-09
KR20070005029A (ko) 2007-01-09
TW200502231A (en) 2005-01-16
AU2003259154A1 (en) 2004-02-09
PL375255A1 (en) 2005-11-28
US20040102484A1 (en) 2004-05-27
CA2492718C (en) 2010-12-21
KR100788778B1 (ko) 2007-12-27
US6897227B2 (en) 2005-05-24

Similar Documents

Publication Publication Date Title
BR0312802A (pt) Pró-drogas de inibidores de bombas de próton
ECSP034460A (es) Nuevos compuestos heterociclicos, su preparacion y su utilizacion como medicamentos, en especial como antibacterianos
BR0009641A (pt) Derivados de 1,4-benzotiazepin-1,1-dióxido, substituìdos com radicais de açúcar, processo para produção dos mesmos, medicamentos contendo esses compostos e sua utilização
HN2002000152A (es) Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco
BR0115605A (pt) Derivados de naftaleno
BR0312513A (pt) Derivados de glicosìdeo de tiofeno, processos para a produção dos mesmos, medicamentos que contêm esses compostos e uso dos mesmos
BR0114917A (pt) Inibidores de pirimidina-2,4,6-triona metaloproteinase
BR0017030A (pt) Derivados de tiazolilamida
BRPI0419305B8 (pt) compostos inibidores de p38, composições farmacêuticas compreendendo os mesmos e usos dos referidos compostos na preparação de medicamentos
BR0206501A (pt) Inibidores de cruzipaìna e outras cisteìna proteases
BRPI0015254C1 (pt) compostos derivados de carbamoiloxialquil-azólio, seu uso, bem como composição farmacêutica compreendendo os mesmos.
PT1295890E (pt) Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao
BR0109598A (pt) Inibidores de quinase de proteìna tricìclicos
BR0307461A (pt) Derivados de quinazolinona e seu uso como agonistas de cb
AR034370A1 (es) Una preparacion farmaceutica acuosa de cilostazol para uso parenteral
BR0112521A (pt) Indolquinazolinonas
BR0212535A (pt) Compostos e composições como inibidores de catepsina
EA200600833A1 (ru) Тиазолидиноны, их получение и применение как фармацевтических агентов
BRPI0512986A (pt) novos derivados de hidantoìna
BR0108990A (pt) Processo para preparação de derivados de pirimidona com atividade antifungos
BR0211903A (pt) Isoxazolopiridinonas
BRPI0517033A (pt) novos derivados de hidantoìna como inibidores de metaloproteinase
BR0113581A (pt) Derivados de aril-piperazinas e seu uso como psicofármacos
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
BR0112655A (pt) Derivados de pirrolidino como inibidores de metaloproteases

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: WINSTON PHARMACEUTICALS LLC (US) , THE REGENTS OF

Free format text: TRANSFERIDO DE: MICHAEL E. GARST, GEORGE SACHS E JAI MOO SHIN

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 401/00, C07D 401/12, C07D 401/14, C07D 409/14, A61K 31/4427, A61K 31/4439, A61P 1/04, A61P 11/04, A61P 11/06, A61P 31/04, A61P 43/00

Ipc: C07D 401/00 (2011.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2162 DE 12/06/2012.