ZA200500791B - Pyrimidyl sulphone amide derivatives as chemokine receptor modulators - Google Patents
Pyrimidyl sulphone amide derivatives as chemokine receptor modulators Download PDFInfo
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- ZA200500791B ZA200500791B ZA200500791A ZA200500791A ZA200500791B ZA 200500791 B ZA200500791 B ZA 200500791B ZA 200500791 A ZA200500791 A ZA 200500791A ZA 200500791 A ZA200500791 A ZA 200500791A ZA 200500791 B ZA200500791 B ZA 200500791B
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- compound
- composition
- phenyl
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- pharmaceutically acceptable
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- -1 Pyrimidyl sulphone amide Chemical class 0.000 title claims description 120
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- 125000001424 substituent group Chemical group 0.000 claims description 69
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 60
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 32
- 239000012453 solvate Substances 0.000 claims description 32
- 125000000217 alkyl group Chemical group 0.000 claims description 30
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
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- MSDQKJCHBXZYQG-UHFFFAOYSA-N n-[2-[(3-chloro-2-fluorophenyl)methylsulfanyl]-6-(1-hydroxypropan-2-ylamino)pyrimidin-4-yl]morpholine-4-sulfonamide Chemical compound N=1C(SCC=2C(=C(Cl)C=CC=2)F)=NC(NC(CO)C)=CC=1NS(=O)(=O)N1CCOCC1 MSDQKJCHBXZYQG-UHFFFAOYSA-N 0.000 claims description 2
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GBGB0217431.6A GB0217431D0 (en) | 2002-07-27 | 2002-07-27 | Novel compounds |
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ZA200500791A ZA200500791B (en) | 2002-07-27 | 2005-01-26 | Pyrimidyl sulphone amide derivatives as chemokine receptor modulators |
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KR (2) | KR20110033313A (es) |
CN (1) | CN100345829C (es) |
AR (1) | AR040700A1 (es) |
AU (1) | AU2003281684B2 (es) |
BR (1) | BR0312967A (es) |
CA (1) | CA2493785C (es) |
CO (1) | CO5680479A2 (es) |
EG (1) | EG25893A (es) |
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GB (1) | GB0217431D0 (es) |
HK (1) | HK1076465A1 (es) |
IL (1) | IL166290A0 (es) |
IS (1) | IS7697A (es) |
MX (1) | MXPA05000960A (es) |
MY (1) | MY139561A (es) |
NO (1) | NO330531B1 (es) |
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PL (1) | PL375400A1 (es) |
RU (1) | RU2342366C2 (es) |
TW (1) | TWI340038B (es) |
UA (1) | UA80283C2 (es) |
WO (1) | WO2004011443A1 (es) |
ZA (1) | ZA200500791B (es) |
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DE60318219T2 (de) | 2002-08-24 | 2009-01-15 | Astrazeneca Ab | PYRIMIDINDERIVATE ALS MODULATOREN DER AKTIVITuT VON CHEMOKINREZEPTOREN |
GB0401269D0 (en) * | 2004-01-21 | 2004-02-25 | Astrazeneca Ab | Compounds |
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US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
CN102796081B (zh) * | 2004-08-28 | 2015-04-22 | 阿斯利康(瑞典)有限公司 | 作为趋化因子受体调节剂的嘧啶磺酰胺衍生物 |
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NZ585085A (en) * | 2007-11-16 | 2012-08-31 | Abbott Lab | Method of treating arthritis using arylsulfonamide compounds |
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CN102105150B (zh) | 2008-05-21 | 2014-03-12 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
RU2011101661A (ru) * | 2008-07-16 | 2012-08-27 | Астразенека Аб (Se) | Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний |
JP5731538B2 (ja) | 2009-12-23 | 2015-06-10 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | Crth2モジュレーター |
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AU2011278115B2 (en) | 2010-07-13 | 2014-11-06 | Astrazeneca Ab | New crystalline forms of N-[2-[[(2,3-difluoropheny)methyl) thio]-6{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]oxy} 4-pyrimidinyl]-1-azetidinesulfonamide |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
KR101946664B1 (ko) | 2011-07-12 | 2019-02-11 | 아스트라제네카 아베 | 케모카인 수용체 조절제로서의 n-(6-((2r,3s)-3,4-디히드록시부탄-2-일옥시)-2-(4-플루오로벤질티오)피리미딘-4-일)-3-메틸아제티딘-1-술폰아미드 |
US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
BR112018007161B1 (pt) | 2015-10-09 | 2024-01-16 | Galapagos Nv | COMPOSTOS PIRAZOLO[3,4-b]PIRIDIN-6-CARBOXAMIDA N-SULFONILADA, COMPOSIÇÃO FARMACÊUTICA CONTENDO OS DITOS COMPOSTOS E USOS DOS MESMOS PARA TRATAR FIBROSE CÍSTICA |
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2002
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2003
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- 2003-07-23 MX MXPA05000960A patent/MXPA05000960A/es active IP Right Grant
- 2003-07-23 ES ES03740844T patent/ES2392965T3/es not_active Expired - Lifetime
- 2003-07-23 EP EP03740844A patent/EP1527051B1/en not_active Expired - Lifetime
- 2003-07-23 AU AU2003281684A patent/AU2003281684B2/en not_active Ceased
- 2003-07-23 PL PL03375400A patent/PL375400A1/xx not_active Application Discontinuation
- 2003-07-23 CN CNB038221497A patent/CN100345829C/zh not_active Expired - Fee Related
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- 2003-07-23 US US10/522,871 patent/US7582644B2/en not_active Expired - Fee Related
- 2003-07-23 UA UAA200500513A patent/UA80283C2/uk unknown
- 2003-07-23 WO PCT/GB2003/003175 patent/WO2004011443A1/en active Application Filing
- 2003-07-25 TW TW092120405A patent/TWI340038B/zh not_active IP Right Cessation
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- 2003-07-25 MY MYPI20032818A patent/MY139561A/en unknown
- 2003-07-28 EG EG2003070726A patent/EG25893A/xx active
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- 2005-01-24 CO CO05005309A patent/CO5680479A2/es not_active Application Discontinuation
- 2005-01-26 ZA ZA200500791A patent/ZA200500791B/en unknown
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- 2005-09-27 HK HK05108513.6A patent/HK1076465A1/xx not_active IP Right Cessation
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