ZA200300025B - $G(Y) crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same. - Google Patents

$G(Y) crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same. Download PDF

Info

Publication number: ZA200300025B
Authority: ZA; South Africa
Prior art keywords: compound; formula; crystalline form; pharmaceutical composition; preparation
Prior art date: 2000-07-06

Application number

ZA200300025A

Other languages

English (en)

Inventor

Bruno Pfeiffer

Yves-Michel Ginot

Gerard Coquerel

Stephane Beilles

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-06

Filing date

2003-01-02

Publication date

2004-02-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200300025(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-01-02 Application filed by Servier Lab filed Critical Servier Lab

2004-02-10 Publication of ZA200300025B publication Critical patent/ZA200300025B/en

Links

IYNMDWMQHSMDDE-MHXJNQAMSA-N perindopril erbumine Chemical class CC(C)(C)N.C1CCC[C@@H]2N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H](C(O)=O)C[C@@H]21 IYNMDWMQHSMDDE-MHXJNQAMSA-N 0.000 title claims description 11
239000008194 pharmaceutical composition Substances 0.000 title claims description 11
238000002360 preparation method Methods 0.000 title claims description 10
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 18
238000000034 method Methods 0.000 claims description 17
150000001875 compounds Chemical class 0.000 claims description 16
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 15
239000007787 solid Substances 0.000 claims description 11
238000001914 filtration Methods 0.000 claims description 10
238000010992 reflux Methods 0.000 claims description 6
238000000634 powder X-ray diffraction Methods 0.000 claims description 5
239000000725 suspension Substances 0.000 claims description 4
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims description 3
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 3
229910052802 copper Inorganic materials 0.000 claims description 3
239000010949 copper Substances 0.000 claims description 3
238000010586 diagram Methods 0.000 claims description 3
239000002934 diuretic Substances 0.000 claims description 3
230000001882 diuretic effect Effects 0.000 claims description 3
239000003814 drug Substances 0.000 claims description 3
208000024172 Cardiovascular disease Diseases 0.000 claims description 2
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 claims description 2
229960004569 indapamide Drugs 0.000 claims description 2
231100000252 nontoxic Toxicity 0.000 claims description 2
230000003000 nontoxic effect Effects 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 2
239000000969 carrier Substances 0.000 claims 1
239000003112 inhibitor Substances 0.000 claims 1
IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 6
229960002582 perindopril Drugs 0.000 description 6
238000005259 measurement Methods 0.000 description 3
150000003839 salts Chemical class 0.000 description 2
239000003826 tablet Substances 0.000 description 2
YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 2
XRMDCWJNPDVAFI-UHFFFAOYSA-N 2,2,6,6-tetramethyl-1-oxopiperidin-1-ium-4-ol Chemical compound CC1(C)CC(O)CC(C)(C)[N+]1=O XRMDCWJNPDVAFI-UHFFFAOYSA-N 0.000 description 1
102000005862 Angiotensin II Human genes 0.000 description 1
101800000734 Angiotensin-1 Proteins 0.000 description 1
102400000344 Angiotensin-1 Human genes 0.000 description 1
101800000733 Angiotensin-2 Proteins 0.000 description 1
101800004538 Bradykinin Proteins 0.000 description 1
102400000967 Bradykinin Human genes 0.000 description 1
108091028072 EteRNA Proteins 0.000 description 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 1
206010019280 Heart failures Diseases 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 1
229950006323 angiotensin ii Drugs 0.000 description 1
208000037849 arterial hypertension Diseases 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000008298 dragée Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

ZA200300025A 2000-07-06 2003-01-02 $G(Y) crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same. ZA200300025B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0008791A FR2811318B1 (fr)	2000-07-06	2000-07-06	Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number	Publication Date
ZA200300025B true ZA200300025B (en)	2004-02-10

Family

ID=8852170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200300025A ZA200300025B (en)	2000-07-06	2003-01-02	$G(Y) crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same.

Country Status (36)

Country	Link
US (2)	US20030158121A1 (zh)
EP (1)	EP1296948B1 (zh)
JP (2)	JP3592296B2 (zh)
KR (1)	KR100513572B1 (zh)
CN (1)	CN1328258C (zh)
AP (1)	AP1452A (zh)
AR (1)	AR029570A1 (zh)
AT (1)	ATE249435T1 (zh)
AU (2)	AU2001276420B2 (zh)
BG (1)	BG66239B1 (zh)
BR (1)	BR0112211A (zh)
CA (1)	CA2415447C (zh)
CZ (1)	CZ302022B6 (zh)
DE (1)	DE60100761T2 (zh)
DK (1)	DK1296948T3 (zh)
EA (1)	EA004275B1 (zh)
EE (1)	EE05286B1 (zh)
ES (1)	ES2206423T3 (zh)
FR (1)	FR2811318B1 (zh)
GE (1)	GEP20043362B (zh)
HK (1)	HK1058199A1 (zh)
HR (1)	HRP20030078B1 (zh)
HU (1)	HU228115B1 (zh)
ME (1)	ME01367B (zh)
MX (1)	MXPA02012904A (zh)
NO (1)	NO323445B1 (zh)
NZ (1)	NZ523311A (zh)
OA (1)	OA12306A (zh)
PL (1)	PL348491A1 (zh)
PT (1)	PT1296948E (zh)
RS (1)	RS51621B (zh)
SI (1)	SI1296948T1 (zh)
SK (1)	SK287452B6 (zh)
UA (1)	UA57187C2 (zh)
WO (1)	WO2001083439A2 (zh)
ZA (1)	ZA200300025B (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2811319B1 (fr)	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2834893B1 (fr) *	2002-01-23	2004-02-27	Servier Lab	Composition pharmaceutique orodispersible de perindopril
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DK1636185T3 (da) *	2003-06-24	2012-05-07	Servier Lab	Nye krystalformer af Perindopril erbumin
WO2005019173A1 (en) *	2003-08-21	2005-03-03	Hetero Drugs Limited	Process for pure perindopril tert-butylamine salt
PT1675827E (pt) *	2003-10-21	2010-02-15	Servier Lab	Novo processo para preparação de perindopril erbumina cristalina
SI21704A (en) *	2004-01-14	2005-08-31	Lek Farmacevtska Druzba Dd	New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI21703A (en)	2004-01-14	2005-08-31	Lek Farmacevtska Druzba Dd	Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
PT1729739T (pt) *	2004-03-29	2016-12-01	Servier Lab	Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
SI21881A (sl)	2004-10-15	2006-04-30	Diagen, Smartno Pri Ljubljani, D.O.O.	Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
SG125975A1 (en) *	2005-03-11	2006-10-30	Servier Lab	New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125976A1 (en) *	2005-03-11	2006-10-30	Servier Lab	New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
JP2006290825A (ja) *	2005-04-13	2006-10-26	Shiono Chemical Co Ltd	アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) *	2005-05-05	2007-02-15	Arch Pharmalabs Limited	PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
AU2006281684B2 (en) *	2005-08-12	2012-08-02	Lek Pharmaceuticals D.D.	A process for the preparation of perindopril erbumine
CN101227902A (zh) *	2005-08-12	2008-07-23	桑多斯股份公司	培哚普利特丁胺的新结晶形式
EP1815857A1 (en)	2006-02-02	2007-08-08	LEK Pharmaceuticals D.D.	A pharmaceutical composition comprising perindopril
WO2007092758A2 (en) *	2006-02-03	2007-08-16	Dr. Reddy's Laboratories Ltd.	Crystalline forms of perindopril erbumine
FR2897866B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) *	2006-02-28	2008-04-18	Servier Lab	Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2008114270A1 (en) *	2007-03-22	2008-09-25	Aarti Healthcare Limited	Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
WO2008120241A2 (en) *	2007-03-29	2008-10-09	Ipca Laboratories Limited	Novel alcohol solvates of perindopril erbumine
SI22543A (sl) *	2007-06-27	2008-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nove soli perindoprila
AU2009263737B2 (en) *	2008-06-24	2013-10-24	Mylan Laboratories Ltd.	Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof
KR200453510Y1 (ko) *	2009-02-09	2011-05-11	윤유원	튀김유 정제기
KR101041878B1 (ko) *	2009-03-26	2011-06-15	신준호	튀김장치용 찌꺼기 제거장치
SI23149A (sl)	2009-09-21	2011-03-31	Silverstone Pharma	Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt)	2010-09-29	2013-01-16	Inst Superior Tecnico	Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
EP3842035A1 (en)	2019-12-23	2021-06-30	KRKA, d.d., Novo mesto	Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620703B1 (fr) *	1987-09-17	1991-10-04	Adir	Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2771010B1 (fr) *	1997-11-19	2003-08-15	Adir	Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811319B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) *	2000-07-06	2002-08-23	Adir	Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

2000
- 2000-07-06 FR FR0008791A patent/FR2811318B1/fr not_active Expired - Fee Related
2001
- 2001-06-07 UA UA2003021019A patent/UA57187C2/uk unknown
- 2001-07-05 HU HU0102814A patent/HU228115B1/hu not_active IP Right Cessation
- 2001-07-06 DE DE60100761T patent/DE60100761T2/de not_active Expired - Lifetime
- 2001-07-06 US US10/312,903 patent/US20030158121A1/en not_active Abandoned
- 2001-07-06 MX MXPA02012904A patent/MXPA02012904A/es active IP Right Grant
- 2001-07-06 ME MEP-2008-672A patent/ME01367B/me unknown
- 2001-07-06 CA CA002415447A patent/CA2415447C/fr not_active Expired - Fee Related
- 2001-07-06 NZ NZ523311A patent/NZ523311A/en not_active IP Right Cessation
- 2001-07-06 OA OA1200200399A patent/OA12306A/en unknown
- 2001-07-06 SK SK150-2003A patent/SK287452B6/sk not_active IP Right Cessation
- 2001-07-06 KR KR10-2003-7000117A patent/KR100513572B1/ko not_active IP Right Cessation
- 2001-07-06 ES ES01954060T patent/ES2206423T3/es not_active Expired - Lifetime
- 2001-07-06 AT AT01954060T patent/ATE249435T1/de active
- 2001-07-06 AR ARP010103224A patent/AR029570A1/es not_active Application Discontinuation
- 2001-07-06 RS YU100302A patent/RS51621B/sr unknown
- 2001-07-06 JP JP2001580868A patent/JP3592296B2/ja not_active Expired - Fee Related
- 2001-07-06 PT PT01954060T patent/PT1296948E/pt unknown
- 2001-07-06 CZ CZ20030358A patent/CZ302022B6/cs not_active IP Right Cessation
- 2001-07-06 EA EA200300104A patent/EA004275B1/ru not_active IP Right Cessation
- 2001-07-06 BR BR0112211-8A patent/BR0112211A/pt not_active Application Discontinuation
- 2001-07-06 DK DK01954060T patent/DK1296948T3/da active
- 2001-07-06 WO PCT/FR2001/002169 patent/WO2001083439A2/fr active IP Right Grant
- 2001-07-06 EE EEP200300003A patent/EE05286B1/xx not_active IP Right Cessation
- 2001-07-06 AU AU2001276420A patent/AU2001276420B2/en not_active Ceased
- 2001-07-06 SI SI200130029T patent/SI1296948T1/xx unknown
- 2001-07-06 EP EP01954060A patent/EP1296948B1/fr not_active Expired - Lifetime
- 2001-07-06 PL PL01348491A patent/PL348491A1/xx not_active Application Discontinuation
- 2001-07-06 GE GE5074A patent/GEP20043362B/en unknown
- 2001-07-06 AP APAP/P/2002/002709A patent/AP1452A/en active
- 2001-07-06 CN CNB018123538A patent/CN1328258C/zh not_active Expired - Fee Related
- 2001-07-06 AU AU7642001A patent/AU7642001A/xx active Pending
2003
- 2003-01-02 ZA ZA200300025A patent/ZA200300025B/en unknown
- 2003-01-06 NO NO20030051A patent/NO323445B1/no not_active IP Right Cessation
- 2003-02-05 BG BG107534A patent/BG66239B1/bg unknown
- 2003-02-06 HR HR20030078A patent/HRP20030078B1/xx not_active IP Right Cessation
2004
- 2004-02-12 HK HK04100948A patent/HK1058199A1/xx not_active IP Right Cessation
- 2004-03-29 US US10/811,727 patent/US20040248817A1/en not_active Abandoned
- 2004-07-13 JP JP2004206157A patent/JP5016184B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO323445B1 (no)	2007-05-07
ES2206423T3 (es)	2004-05-16
AU7642001A (en)	2001-11-12
CN1328258C (zh)	2007-07-25
FR2811318A1 (fr)	2002-01-11
AR029570A1 (es)	2003-07-02
EP1296948A2 (fr)	2003-04-02
NO20030051L (no)	2003-01-06
SI1296948T1 (en)	2003-12-31
CZ2003358A3 (cs)	2003-05-14
BR0112211A (pt)	2003-05-06
PT1296948E (pt)	2003-12-31
EP1296948B1 (fr)	2003-09-10
EE05286B1 (et)	2010-04-15
EA004275B1 (ru)	2004-02-26
HUP0102814A2 (hu)	2002-02-28
NZ523311A (en)	2004-06-25
RS51621B (sr)	2011-08-31
HUP0102814A3 (en)	2003-12-29
NO20030051D0 (no)	2003-01-06
BG66239B1 (bg)	2012-08-31
YU100302A (sh)	2003-08-29
AP2002002709A0 (en)	2002-12-31
EA200300104A1 (ru)	2003-06-26
GEP20043362B (en)	2004-06-10
AP1452A (en)	2005-07-11
JP2003531890A (ja)	2003-10-28
KR20030024774A (ko)	2003-03-26
HU0102814D0 (en)	2001-09-28
HRP20030078B1 (en)	2004-06-30
HU228115B1 (hu)	2012-11-28
ME01367B (me)	2013-12-20
DE60100761T2 (de)	2004-07-15
SK287452B6 (sk)	2010-10-07
WO2001083439A2 (fr)	2001-11-08
CZ302022B6 (cs)	2010-09-08
ATE249435T1 (de)	2003-09-15
MXPA02012904A (es)	2003-09-22
KR100513572B1 (ko)	2005-09-09
EE200300003A (et)	2004-08-16
SK1502003A3 (en)	2003-06-03
HRP20030078A2 (en)	2003-04-30
PL348491A1 (en)	2002-01-14
CA2415447C (fr)	2008-12-09
DE60100761D1 (de)	2003-10-16
FR2811318B1 (fr)	2002-08-23
OA12306A (en)	2003-12-23
JP3592296B2 (ja)	2004-11-24
BG107534A (bg)	2003-12-31
US20030158121A1 (en)	2003-08-21
CN1440386A (zh)	2003-09-03
HK1058199A1 (en)	2004-05-07
AU2001276420B2 (en)	2006-11-16
JP5016184B2 (ja)	2012-09-05
WO2001083439A3 (fr)	2002-02-07
DK1296948T3 (da)	2004-01-05
JP2005002120A (ja)	2005-01-06
CA2415447A1 (fr)	2001-11-08
US20040248817A1 (en)	2004-12-09
UA57187C2 (uk)	2003-06-16

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NZ570366A (en)	2011-05-27	Beta-crystalline form of perindopril arginine salt, method for making same, and pharmaceutical compositions containing same
AU2006235841A1 (en)	2006-11-23	Novel beta crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it