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DE60100761D1 - Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel - Google Patents

Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel

Info

Publication number
DE60100761D1
DE60100761D1 DE60100761T DE60100761T DE60100761D1 DE 60100761 D1 DE60100761 D1 DE 60100761D1 DE 60100761 T DE60100761 T DE 60100761T DE 60100761 T DE60100761 T DE 60100761T DE 60100761 D1 DE60100761 D1 DE 60100761D1
Authority
DE
Germany
Prior art keywords
perindopril
tert
production
crystalline form
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60100761T
Other languages
English (en)
Other versions
DE60100761T2 (de
Inventor
Bruno Pfeiffer
Yves-Michel Ginot
Gerard Coquerel
Stephane Beilles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60100761(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60100761D1 publication Critical patent/DE60100761D1/de
Publication of DE60100761T2 publication Critical patent/DE60100761T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DE60100761T 2000-07-06 2001-07-06 Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel Expired - Lifetime DE60100761T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0008791A FR2811318B1 (fr) 2000-07-06 2000-07-06 Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR0008791 2000-07-06
PCT/FR2001/002169 WO2001083439A2 (fr) 2000-07-06 2001-07-06 NOUVELLE FORME CRISTALLINE η DU SEL DE TERT-BUTYLAMINE DU PERINDOPRIL, SON PROCEDE DE PREPARATION, ET LES COMPOSITIONS PHARMACEUTIQUES QUI LA CONTIENNENT

Publications (2)

Publication Number Publication Date
DE60100761D1 true DE60100761D1 (de) 2003-10-16
DE60100761T2 DE60100761T2 (de) 2004-07-15

Family

ID=8852170

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60100761T Expired - Lifetime DE60100761T2 (de) 2000-07-06 2001-07-06 Neue kristalline form gamma des tert-butylamin salzes von perindopril, verfahren zu deren herstellung und dieses enthaltende arzneimittel

Country Status (36)

Country Link
US (2) US20030158121A1 (de)
EP (1) EP1296948B1 (de)
JP (2) JP3592296B2 (de)
KR (1) KR100513572B1 (de)
CN (1) CN1328258C (de)
AP (1) AP1452A (de)
AR (1) AR029570A1 (de)
AT (1) ATE249435T1 (de)
AU (2) AU2001276420B2 (de)
BG (1) BG66239B1 (de)
BR (1) BR0112211A (de)
CA (1) CA2415447C (de)
CZ (1) CZ302022B6 (de)
DE (1) DE60100761T2 (de)
DK (1) DK1296948T3 (de)
EA (1) EA004275B1 (de)
EE (1) EE05286B1 (de)
ES (1) ES2206423T3 (de)
FR (1) FR2811318B1 (de)
GE (1) GEP20043362B (de)
HK (1) HK1058199A1 (de)
HR (1) HRP20030078B1 (de)
HU (1) HU228115B1 (de)
ME (1) ME01367B (de)
MX (1) MXPA02012904A (de)
NO (1) NO323445B1 (de)
NZ (1) NZ523311A (de)
OA (1) OA12306A (de)
PL (1) PL348491A1 (de)
PT (1) PT1296948E (de)
RS (1) RS51621B (de)
SI (1) SI1296948T1 (de)
SK (1) SK287452B6 (de)
UA (1) UA57187C2 (de)
WO (1) WO2001083439A2 (de)
ZA (1) ZA200300025B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2834893B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible de perindopril
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DK1636185T3 (da) * 2003-06-24 2012-05-07 Servier Lab Nye krystalformer af Perindopril erbumin
WO2005019173A1 (en) * 2003-08-21 2005-03-03 Hetero Drugs Limited Process for pure perindopril tert-butylamine salt
PT1675827E (pt) * 2003-10-21 2010-02-15 Servier Lab Novo processo para preparação de perindopril erbumina cristalina
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
PT1729739T (pt) * 2004-03-29 2016-12-01 Servier Lab Processo para a preparação de uma composição farmacêutica sólida
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
SG125975A1 (en) * 2005-03-11 2006-10-30 Servier Lab New alpha crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
SG125976A1 (en) * 2005-03-11 2006-10-30 Servier Lab New gama crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
WO2007017894A2 (en) * 2005-05-05 2007-02-15 Arch Pharmalabs Limited PREPARATION OF NOVEL CRYSTALLINE η(ETA) FORM OF PERINDOPRIL ERBUMINE
AU2006281684B2 (en) * 2005-08-12 2012-08-02 Lek Pharmaceuticals D.D. A process for the preparation of perindopril erbumine
CN101227902A (zh) * 2005-08-12 2008-07-23 桑多斯股份公司 培哚普利特丁胺的新结晶形式
EP1815857A1 (de) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. Pharmazeutische Zusammensetzung enthaltend Perindopril
WO2007092758A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Crystalline forms of perindopril erbumine
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
WO2008120241A2 (en) * 2007-03-29 2008-10-09 Ipca Laboratories Limited Novel alcohol solvates of perindopril erbumine
SI22543A (sl) * 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
AU2009263737B2 (en) * 2008-06-24 2013-10-24 Mylan Laboratories Ltd. Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof
KR200453510Y1 (ko) * 2009-02-09 2011-05-11 윤유원 튀김유 정제기
KR101041878B1 (ko) * 2009-03-26 2011-06-15 신준호 튀김장치용 찌꺼기 제거장치
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
EP3842035A1 (de) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Zusammensetzung zur herstellung von perindopril-arginin-granulaten, verfahren zu ihrer herstellung und pharmazeutische zusammensetzung damit

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2771010B1 (fr) * 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
NO323445B1 (no) 2007-05-07
ES2206423T3 (es) 2004-05-16
AU7642001A (en) 2001-11-12
CN1328258C (zh) 2007-07-25
FR2811318A1 (fr) 2002-01-11
AR029570A1 (es) 2003-07-02
EP1296948A2 (de) 2003-04-02
NO20030051L (no) 2003-01-06
SI1296948T1 (en) 2003-12-31
CZ2003358A3 (cs) 2003-05-14
BR0112211A (pt) 2003-05-06
PT1296948E (pt) 2003-12-31
EP1296948B1 (de) 2003-09-10
EE05286B1 (et) 2010-04-15
EA004275B1 (ru) 2004-02-26
HUP0102814A2 (hu) 2002-02-28
NZ523311A (en) 2004-06-25
RS51621B (sr) 2011-08-31
HUP0102814A3 (en) 2003-12-29
NO20030051D0 (no) 2003-01-06
BG66239B1 (bg) 2012-08-31
YU100302A (sh) 2003-08-29
AP2002002709A0 (en) 2002-12-31
EA200300104A1 (ru) 2003-06-26
GEP20043362B (en) 2004-06-10
AP1452A (en) 2005-07-11
JP2003531890A (ja) 2003-10-28
KR20030024774A (ko) 2003-03-26
HU0102814D0 (en) 2001-09-28
ZA200300025B (en) 2004-02-10
HRP20030078B1 (en) 2004-06-30
HU228115B1 (hu) 2012-11-28
ME01367B (me) 2013-12-20
DE60100761T2 (de) 2004-07-15
SK287452B6 (sk) 2010-10-07
WO2001083439A2 (fr) 2001-11-08
CZ302022B6 (cs) 2010-09-08
ATE249435T1 (de) 2003-09-15
MXPA02012904A (es) 2003-09-22
KR100513572B1 (ko) 2005-09-09
EE200300003A (et) 2004-08-16
SK1502003A3 (en) 2003-06-03
HRP20030078A2 (en) 2003-04-30
PL348491A1 (en) 2002-01-14
CA2415447C (fr) 2008-12-09
FR2811318B1 (fr) 2002-08-23
OA12306A (en) 2003-12-23
JP3592296B2 (ja) 2004-11-24
BG107534A (bg) 2003-12-31
US20030158121A1 (en) 2003-08-21
CN1440386A (zh) 2003-09-03
HK1058199A1 (en) 2004-05-07
AU2001276420B2 (en) 2006-11-16
JP5016184B2 (ja) 2012-09-05
WO2001083439A3 (fr) 2002-02-07
DK1296948T3 (da) 2004-01-05
JP2005002120A (ja) 2005-01-06
CA2415447A1 (fr) 2001-11-08
US20040248817A1 (en) 2004-12-09
UA57187C2 (uk) 2003-06-16

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Legal Events

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8363 Opposition against the patent
8365 Fully valid after opposition proceedings