ZA200210100B - Methods for treating hepatitis delta virus infection with beta-L-2' deoxy-nucleosides. - Google Patents

Methods for treating hepatitis delta virus infection with beta-L-2' deoxy-nucleosides. Download PDF

Info

Publication number: ZA200210100B
Authority: ZA; South Africa
Prior art keywords: hepatitis; pharmaceutically acceptable; substance; composition; acceptable salt
Prior art date: 2000-05-26

Application number

ZA200210100A

Other languages

English (en)

Inventor

Jean-Pierre Sommadossi

Martin L Bryant

Original Assignee

Idenix Cayman Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-26

Filing date

2002-12-12

Publication date

2004-06-22

2002-12-12 Application filed by Idenix Cayman Ltd filed Critical Idenix Cayman Ltd

2004-06-22 Publication of ZA200210100B publication Critical patent/ZA200210100B/en

Links

238000000034 method Methods 0.000 title claims abstract description 116
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150000003839 salts Chemical class 0.000 claims abstract description 160
238000011282 treatment Methods 0.000 claims abstract description 150
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239000003795 chemical substances by application Substances 0.000 claims description 82
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125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
SCHZCUMIENIQMY-UHFFFAOYSA-N tris(trimethylsilyl)silicon Chemical compound C[Si](C)(C)[Si]([Si](C)(C)C)[Si](C)(C)C SCHZCUMIENIQMY-UHFFFAOYSA-N 0.000 description 1
230000035899 viability Effects 0.000 description 1
238000012800 visualization Methods 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
229960000523 zalcitabine Drugs 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical class [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200210100A 2000-05-26 2002-12-12 Methods for treating hepatitis delta virus infection with beta-L-2' deoxy-nucleosides. ZA200210100B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20753800P	2000-05-26	2000-05-26

Publications (1)

Publication Number	Publication Date
ZA200210100B true ZA200210100B (en)	2004-06-22

Family

ID=22771005

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ZA200210100A ZA200210100B (en)	2000-05-26	2002-12-12	Methods for treating hepatitis delta virus infection with beta-L-2' deoxy-nucleosides.
ZA200404304A ZA200404304B (en)	2000-05-26	2004-06-01	Methods for treating hepatitis delta virus infection with beta-I-2' deoxy-nucleosides.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ZA200404304A ZA200404304B (en)	2000-05-26	2004-06-01	Methods for treating hepatitis delta virus infection with beta-I-2' deoxy-nucleosides.

Country Status (18)

Country	Link
US (1)	US6596700B2 (de)
EP (1)	EP1292313B1 (de)
JP (1)	JP2004513070A (de)
KR (1)	KR100854398B1 (de)
CN (1)	CN100490818C (de)
AT (1)	ATE275406T1 (de)
AU (3)	AU2001263484B2 (de)
BR (1)	BR0111195A (de)
CA (1)	CA2410488C (de)
DE (1)	DE60105424T2 (de)
EA (1)	EA005890B1 (de)
ES (1)	ES2227203T3 (de)
HK (1)	HK1050999A1 (de)
IL (1)	IL153078A0 (de)
MX (1)	MXPA02011641A (de)
TR (1)	TR200402565T4 (de)
WO (1)	WO2001091737A2 (de)
ZA (2)	ZA200210100B (de)

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2001
- 2001-05-29 KR KR1020027015985A patent/KR100854398B1/ko not_active IP Right Cessation
- 2001-05-29 EA EA200201263A patent/EA005890B1/ru not_active IP Right Cessation
- 2001-05-29 MX MXPA02011641A patent/MXPA02011641A/es active IP Right Grant
- 2001-05-29 CN CNB018134297A patent/CN100490818C/zh not_active Expired - Fee Related
- 2001-05-29 ES ES01937785T patent/ES2227203T3/es not_active Expired - Lifetime
- 2001-05-29 IL IL15307801A patent/IL153078A0/xx not_active IP Right Cessation
- 2001-05-29 EP EP01937785A patent/EP1292313B1/de not_active Expired - Lifetime
- 2001-05-29 WO PCT/US2001/017301 patent/WO2001091737A2/en active IP Right Grant
- 2001-05-29 AU AU2001263484A patent/AU2001263484B2/en not_active Ceased
- 2001-05-29 TR TR2004/02565T patent/TR200402565T4/xx unknown
- 2001-05-29 AT AT01937785T patent/ATE275406T1/de not_active IP Right Cessation
- 2001-05-29 DE DE60105424T patent/DE60105424T2/de not_active Expired - Fee Related
- 2001-05-29 BR BR0111195-7A patent/BR0111195A/pt not_active Application Discontinuation
- 2001-05-29 JP JP2001587753A patent/JP2004513070A/ja active Pending
- 2001-05-29 CA CA002410488A patent/CA2410488C/en not_active Expired - Fee Related
- 2001-05-29 AU AU6348401A patent/AU6348401A/xx active Pending
- 2001-05-29 US US09/867,110 patent/US6596700B2/en not_active Expired - Fee Related
2002
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2003
- 2003-04-22 HK HK03102836A patent/HK1050999A1/xx not_active IP Right Cessation
2004
- 2004-06-01 ZA ZA200404304A patent/ZA200404304B/xx unknown
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Also Published As

Publication number	Publication date
EA005890B1 (ru)	2005-06-30
ATE275406T1 (de)	2004-09-15
DE60105424D1 (de)	2004-10-14
HK1050999A1 (en)	2003-07-18
AU2001263484B2 (en)	2006-12-14
IL153078A0 (en)	2003-06-24
WO2001091737A3 (en)	2002-05-30
EA200201263A1 (ru)	2003-06-26
AU6348401A (en)	2001-12-11
EP1292313B1 (de)	2004-09-08
DE60105424T2 (de)	2005-09-22
EP1292313A2 (de)	2003-03-19
WO2001091737A2 (en)	2001-12-06
AU2006252214A1 (en)	2007-01-18
KR100854398B1 (ko)	2008-08-26
ES2227203T3 (es)	2005-04-01
US20020035085A1 (en)	2002-03-21
CA2410488A1 (en)	2001-12-06
BR0111195A (pt)	2004-07-20
ZA200404304B (en)	2005-03-30
US6596700B2 (en)	2003-07-22
CN100490818C (zh)	2009-05-27
KR20030031487A (ko)	2003-04-21
TR200402565T4 (tr)	2004-12-21
JP2004513070A (ja)	2004-04-30
CN1444483A (zh)	2003-09-24
CA2410488C (en)	2009-10-27
MXPA02011641A (es)	2004-07-30

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AU2001263484A1 (en)	2002-02-28	Methods of treating hepatitis delta virus infection with beta-l-2'- deoxy-nucleosides
AU2011211428B2 (en)	2013-02-07	Beta-L-2'-Deoxy Nucleosides for the treatment of Hepatitis B
EP1431304B1 (de)	2014-12-03	Beta-L-2'-Deoxy-Nukleoside für die Behandlung von Hepatitis B
CA2599597A1 (en)	2000-02-24	.beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b