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YU48714B - Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje - Google Patents

Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje

Info

Publication number
YU48714B
YU48714B YU134891A YU134891A YU48714B YU 48714 B YU48714 B YU 48714B YU 134891 A YU134891 A YU 134891A YU 134891 A YU134891 A YU 134891A YU 48714 B YU48714 B YU 48714B
Authority
YU
Yugoslavia
Prior art keywords
alkyl
opt
substd
phenyl
rran
Prior art date
Application number
YU134891A
Other languages
English (en)
Other versions
YU134891A (sh
Inventor
Jean Gubin
Jean Lucchetti
Henri Inion
Pierre Chatelain
Gilbert G. Rosseels
Steven Kilenyi
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of YU134891A publication Critical patent/YU134891A/sh
Publication of YU48714B publication Critical patent/YU48714B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Cosmetics (AREA)

Abstract

Derivati benzofurana, benzotiofena, indola i indolina, sledece opste formule: u kojoj: Het predstavlja jednu od grupa u kojima: T predstavlja grupu: u kojoj: R i Ra mogu biti identicni ili razliciti i svaka predstavlja: - vodonik, - C1-C4 alkil radikal, - radikal -SO2R' u kojem R' predstavlja C1-C6 alkil radikal, normalan ili racvast, trifluorometil radikal, fenil radikal koji je eventualno supstituisan sa C1-C4 alkil radikalom, benzil radikal koji je eventualno supstituisan sa C1-C4 alkil radikalom ili banzoil radikal koji je eventualno supstituisan sa C1-C4 alkil radikalom, Ra i R' mogu da grade sa atomom azota sulfonamidne grupe prsten koji sadrzi od 3 do 6 atoma ugljenika, T' predstavlja: - nitro grupu, - grupu R , takvu kao sto je definisano napred. T" predstavlja - benziloksikarbonilamino grupu, - grupu u kojoj T"1 predstavlja vodonik ili C1-C4 alkil grupu, - grupu u kojoj T"2 i T"3 mogu da budu identicni ili razliciti i predstavljaju vodonik ili C1-C4 alkil grupu ili T"2 i T"3 grade sa atomom azota za koji su vezani, prsten koji sadrzi od 4 do 6 atoma ugljenika, - grupu R , takvu kao sto je definisano napred, X predstavlja -O- ili -S-, Y predstavqa radikal ili -CH2- u kojem R5 predstavlja vodonik, C1-C4 alkil radikal ili acil radikal formule u kojoj R'4 predstavlja C1-C4 alkil radikal, R1 predstavlja radikal C1-C6 alkil, fenil koji je eventualno supstituisan sa radikalom C1-C4 alkil ili halogeno fenil; R2 predstavlja: - vodonik, - C1-C6 alkil linearan ili racvast; R3 predstavlja: - C1-C6 alkil linearan ili racvast; - radikal formule: -Alk-R6 u kojoj Alk predstavlja prostu vezu ili C1-C5 alkilen radikal normalan ili racvast i R6 predstavlja radikal takav kao sto je piridil, fenil, fenoksi, 3,4-metilendioksi fenil ili grupu fenil ili fenoksi koja je supstituisana sa jednim ili sa vise supstituenata, identicnih ili razlicitih koji se biraju iz grupe koja obuhvata halogene, grupu C1-C4 alkil ili C1-C4 alkoksi, R2 i R3 kada se uzmu zajedno, predstavljaju radikal C3-C6 alkilen ili C3-C6 alkenilen koji je eventualno supstituisan sa fenil radikalom ili je eventualno prekinut sa -O-, -NH-, -N= ili =N-R7, gde R7 predstavlja radikal C1-C4 alkil ili fenil; R4 predstavlja: - vodonik, - C1-C4 alkil radikal, - radikal -SO2R1' u kojem R'1 predstavlja C1-C4 alkil radikal, fenil radikal koji je eventualno supstituisan sa C1-C4 alkil radikalom, benzil radikal koji je eventualno supstitusan sa C1-C4 alkil radikalom, - radikal: u kojem R'4 i R"4, identicni ili razliciti predstavqaju C1-C4 alkil radikal i m predstavlja ceo broj od 1 do 3; A predstavlja -O-, -S- ili W, W' i Z su takvi da: - kada su identicni W i W' predstavljaju CH- ili N, Z predstavlja -O-; - kada W predstavlja i W, predstavlja , Z predstavlja -CH=C-R'8 gde R8 i R'8 su identicni ili razliciti i predstavljaju atom halogena ili radikal C1-C4 alkil ili C1-C4 alkoksi, n predstavlja ceo broj od 1 do 5, u slucaju kada R4 predstavlja radikal -SO2R'1, T', grupu nitro ili cikliziranu grupu , kao i njiho
YU134891A 1990-08-06 1991-08-05 Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje YU48714B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9010036A FR2665444B1 (fr) 1990-08-06 1990-08-06 Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.

Publications (2)

Publication Number Publication Date
YU134891A YU134891A (sh) 1994-01-20
YU48714B true YU48714B (sh) 1999-07-28

Family

ID=9399463

Family Applications (1)

Application Number Title Priority Date Filing Date
YU134891A YU48714B (sh) 1990-08-06 1991-08-05 Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje

Country Status (32)

Country Link
US (1) US5223510A (sh)
EP (1) EP0471609B1 (sh)
JP (1) JP2795759B2 (sh)
KR (1) KR100190673B1 (sh)
AT (1) ATE145645T1 (sh)
BR (1) BR9103354A (sh)
CA (1) CA2047773C (sh)
CZ (1) CZ288527B6 (sh)
DE (1) DE69123304T2 (sh)
DK (1) DK0471609T3 (sh)
ES (1) ES2096639T3 (sh)
FI (1) FI114914B (sh)
FR (1) FR2665444B1 (sh)
GR (1) GR3022593T3 (sh)
HK (1) HK1000108A1 (sh)
HU (2) HU218271B (sh)
IE (1) IE912595A1 (sh)
IL (1) IL98991A (sh)
MA (1) MA22249A1 (sh)
MY (1) MY107655A (sh)
NO (1) NO179042C (sh)
NZ (1) NZ239232A (sh)
OA (1) OA09513A (sh)
PL (1) PL168044B1 (sh)
PT (1) PT98576B (sh)
RU (1) RU2095357C1 (sh)
SG (1) SG49205A1 (sh)
SK (1) SK283527B6 (sh)
TN (1) TNSN91070A1 (sh)
TW (1) TW199095B (sh)
YU (1) YU48714B (sh)
ZA (1) ZA915934B (sh)

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