WO2011083999A2 - 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 - Google Patents
바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 Download PDFInfo
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- WO2011083999A2 WO2011083999A2 PCT/KR2011/000098 KR2011000098W WO2011083999A2 WO 2011083999 A2 WO2011083999 A2 WO 2011083999A2 KR 2011000098 W KR2011000098 W KR 2011000098W WO 2011083999 A2 WO2011083999 A2 WO 2011083999A2
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- Prior art keywords
- biguanide
- acid
- cancer
- aryl
- heteroaryl
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- GDGNZKQLXTXINK-UHFFFAOYSA-N CCCCN/C(/NC(N)=N)=N\CCc(cc1)ccc1Cl Chemical compound CCCCN/C(/NC(N)=N)=N\CCc(cc1)ccc1Cl GDGNZKQLXTXINK-UHFFFAOYSA-N 0.000 description 1
- NEUIZMGVFUFIBY-UHFFFAOYSA-N CN(CCc1ccccc1)/C(/NC(N)=N)=N\CCc1ccccc1 Chemical compound CN(CCc1ccccc1)/C(/NC(N)=N)=N\CCc1ccccc1 NEUIZMGVFUFIBY-UHFFFAOYSA-N 0.000 description 1
- NZHZASGZNVXXGG-UHFFFAOYSA-N NC(N/C(/NCCc1ccccc1)=N/CCc1ccccc1)=N Chemical compound NC(N/C(/NCCc1ccccc1)=N/CCc1ccccc1)=N NZHZASGZNVXXGG-UHFFFAOYSA-N 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- C07C277/02—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from cyanamide, calcium cyanamide or dicyandiamides
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- C07C277/04—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of guanidine from ammonium thiocyanate
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- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
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- C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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Definitions
- the present invention relates to a biguanide derivative, a preparation method thereof, and a pharmaceutical composition containing the same as an active ingredient, which exhibit an excellent AMPK ⁇ activation effect and cancer cell proliferation inhibitory effect even in a small amount compared to existing drugs.
- Diabetes mellitus is a disease characterized by persistent hyperglycemic symptoms. Carbohydrate metabolism abnormalities and lipid metabolism abnormalities are major conditions, and systemic complications due to hyperglycemia caused by impaired blood flow and decreased glucose utilization are aggravated. This diabetic condition is caused by insulin deficiency or insulin resistance, and diabetes caused by insulin resistance is called type 2 diabetes.
- Type 2 diabetes is caused by a condition in which insulin is unable to carry sugar into the cell due to a decrease in insulin receptors or a deficiency in the signaling system through the receptor, that is, a condition in which insulin develops resistance, It aggravates the direct vascular destruction and metabolic syndrome caused by hyperinsulinemia.
- sulfonylurea drugs are used in the pancreas It is a drug that lowers blood sugar by forcibly secreting insulin, and the effect of the drug disappears quickly, and abnormal lipid metabolism causes arteriosclerosis, weight gain, and brain damage due to hypoglycemia.
- the glitazone-based drug mainly needs to be administered only in combination with metformin by solving only the problem of insulin resistance to adipose tissue, causing side effects such as retinal vascular destruction, so there is a disadvantage that requires very careful use.
- Metformin does not cause hypoglycemia, solves insulin resistance in adipose, hepatic and muscle tissues, and has excellent hypoglycemic and It exhibits a glycated hemoglobin level lowering effect.
- Metformin is also known to activate AMP-activated protein kinase (AMPK), which physiologically regulates carbohydrate and lipid metabolism, thereby normalizing hyperglycemia, improving lipid status, and preventing menstrual irregularities, ovulation and pregnancy. It is reported to normalize.
- AMPK AMP-activated protein kinase
- the treatment of metformin in cancer cells lacking the p53 gene results in the discovery that metformin activates AMPK enzymes in cancer cells to alter energy metabolic pathways, resulting in the death of cancer cells due to inadequate adaptation to the altered metabolic pathways [Monica Buzzai, et al. Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth, Cancer Res 2007; 67: (14)].
- Josie M M Evans has shown a lower incidence of cancer in patients with type 2 diabetes than metformin treatment [Josie MM, Evans et al. BMJ. 2005, 330, 1304-1305.
- Samantha L. Bowker also reported that patients with type 2 diabetes who have metformin have lower cancer-related mortality than those who take sulfonylureas or take insulin [Samantha L et al. Diabetes Care. 2006, 29, 254-258.
- cancer stem cells are involved in the recurrence and metastasis of cancer.
- Cancer stem cells are less than 0.2% in cancer tissues, but conventional chemotherapy has a problem that can not remove cancer stem cells.
- Metformin has an anticancer effect on these cancer stem cells and is very well tolerated.
- metformin eliminates cancer stem cells when cancer stem cells show little change when doxorubicin, an anticancer agent, has been reported [Heather A. Hirsch et al., Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission, Cancer Res 2009; 69: (19). October 1, 2009].
- metformin is generally administered three times a day, and since a single dose is about 500 mg or more, a tablet containing at least about 1,500 mg of metformin is required to sustain the release of the drug once daily. It's too big to take.
- the current long-acting formulations contain only about 750 mg of metformin in one tablet, so there is a problem in that two or more tablets should be taken when administering. Accordingly, there is a need for a metformin-based material that exhibits better pharmacological action and improved physicochemical properties than conventional metformin.
- the present invention is to provide a novel biguanide derivative, or a pharmaceutically acceptable salt thereof, and a method for preparing the same, which exhibit excellent AMPK ⁇ activation effect and cancer cell proliferation effect even in a small amount compared to existing drugs.
- the present invention is to provide a pharmaceutical composition for treating diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, metabolic syndrome, cancer and the like as the active ingredient.
- the present invention provides N4-N5-substituted biguanide derivative compounds of Formula 1, or pharmaceutically acceptable salts thereof:
- R 1 , R 2 and R 3 are each independently,
- aryl and heteroaryl are C 1 - 4 alkyl, C 1 - 4 alkoxy, hydroxy and or halogen substituted with one or more non-hydrogen substituents selected from the group consisting will unsubstituted, non-hydrogen of the aryl and heteroaryl where substituents C 1 - 4 may be replaced by a more alkoxy, hydroxy or halogen-4 alkyl, C 1.
- a "substituted" group is where one or more hydrogen atoms have been replaced by one or more non-hydrogen atom groups, provided that the valence requirements are met and chemically stable compounds must be generated from the substitution.
- substituents are to be interpreted as being optionally substituted, unless expressly stated to be "unsubstituted.”
- Substituents for R 1 to R 3 on biguanides according to the present invention may each be substituted with one or more of the above defined substituents.
- Alkyl generally refers to linear and branched saturated hydrocarbon groups having the specified number of carbon atoms (eg, 1 to 12 carbon atoms). Examples of alkyl groups include, without limitation, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, isobutyl, tert-butyl, n-pentyl, n-hexyl, n-heptyl and the like. “Alkenyl” refers to an alkyl group containing at least one double bond.
- alkenyl groups include without limitation ethenyl, 1-propen-1-yl, 1-propen-2-yl, 2-propen-1-yl, allyl, and the like.
- Alkyl or alkenyl may be attached to the parent group or substrate at any ring atom unless the attachment would violate valence requirements.
- an alkyl group or alkenyl group may include one or more non-hydrogen substituents if the attachment does not violate valence requirements.
- Cycloalkyl means a saturated part and polycyclic hydrocarbon ring having a carbon atom number of specified comprises a ring generally (i.e., C 3 - 10 cycloalkyl is as ring members 3, 4, 5, 6, 7, 8, Cycloalkyl having 9 or 10 carbon atoms). Cycloalkyls can be attached to a parent group or substrate at any ring atom unless the attachment would violate valence requirements. Likewise, cycloalkyl groups may include one or more non-hydrogen substituents unless the attachment would violate valence requirements.
- Aryl refers to monovalent and divalent aromatic groups, respectively, including 5- and 6-membered monocyclic aromatic groups
- heteroaryl refers to 5- and 6- containing 1 to 4 heteroatoms independently selected from nitrogen, oxygen and sulfur. It refers to monovalent and divalent aromatic groups, respectively, including circular monocyclic aromatic groups.
- Examples of monocyclic aryl groups and heteroaryl groups include, without limitation, phenyl, pyridinyl, furanyl, pyrrolyl, thiophenyl, thiazolyl, isothiazolyl, imidazolyl, triazolyl, tetrazolyl, pyrazolyl, oxazolyl, Isoxoxazolyl, pyrazinyl, pyridazinyl, pyrimidinyl and the like.
- Aryl groups and heteroaryl groups also include bicyclic groups, tricyclic groups, etc., including fused 5- and 6-membered rings as defined above.
- polycyclic aryl groups and heteroaryl groups include without limitation isoquinolinyl, naphthyl, bifenyl, anthracenyl, pyrenyl, carbazolyl, benzoxazolyl, benzodioxazolyl, benzothiazolyl, benzoimidazolyl, benzo Thiophenyl, quinolinyl, indolyl, benzofuranyl, furinyl, indolizinyl and the like.
- the aryl group and heteroaryl group may be attached to the parent group or substrate at any ring atom as long as the attachment does not violate valence requirements.
- aryl and heteroaryl groups may include one or more non-hydrogen substituents unless the substitution would violate valence requirements.
- Non-hydrogen substituents of aryl and heteroaryl groups may also be substituted with additional non-hydrogen substituents.
- Alkoxy refers to alkyl-O-, wherein alkyl is defined above. Examples of alkoxy groups include without limitation methoxy, ethoxy and the like. Alkoxy may be attached to a parent group or substrate at any ring atom if the attachment does not violate valence requirements. Likewise, an alkoxy group may include one or more non-hydrogen substituents unless the attachment would violate valence requirements.
- Haldroxy stands for -OH and "halogen” means floro, chloro, bromo and iodo.
- R 1, R 2, R 3 are, each independently, C 1 - 12 alkyl; C 2 - 4 alkenyl; C 3 - 10 cycloalkyl; C 5 - 12 aryl and C 5 - 12 aryl or hetero-non-hydrogen substituents selected from the group consisting of a may be hydrogen.
- the C 1 - 12 alkyl may be substituted with one or more non-hydrogen substituents or unsubstituted straight or branched alkyl of 1 to 12 carbon atoms.
- the alkyl When substituted with a non-hydrogen substituent, the alkyl may be linear or branched alkyl having 1 to 6 carbon atoms, but is not limited thereto.
- the non-hydrogen substituents of alkyl include, but are not limited to, C 5 - may be selected from the 10-cycloalkyl, hydroxy, and the group consisting of halogen - 12 aryl, C 5 -12 heteroaryl, C 3.
- the non-hydrogen substituents may also be further substituted or unsubstituted.
- the aryl and heteroaryl are C 1 - 4 alkyl, C 1 - 4 alkoxy, hydroxy, and optionally substituted with one or more non-hydrogen substituents selected from the group consisting of halogen, and may be unsubstituted, the aryl here and a non-hydrogen substituent of the heteroaryl group are C 1 - 4 may be replaced by a more alkoxy, hydroxy or halogen-4 alkyl, C 1.
- R 1 , R 2 and R 3 are each independently,
- An unsubstituted C 1 - 7 alkyl; C 5 - 12 aryl, C 5 -12 heteroaryl, C 3 - 10 cycloalkyl, hydroxy, and C 1 is substituted by one or more non-hydrogen substituents selected from the group consisting of halogen-6-alkyl; C 1 - 6 alkoxy; The unsubstituted C 2 - 4 alkenyl; Unsubstituted C 3 - 10 cycloalkyl; Hydroxy; halogen; C 5 - 12 aryl and C 5 - represents a non-hydrogen substituent or a hydrogen is selected from the group consisting of 12-heteroaryl,
- aryl and heteroaryl are C 1 - 4 alkyl, substituted by halogen, C 1 - 4 alkyl, C 1 - 4 alkoxy, optionally substituted with one or more non-hydrogen substituents selected from the group consisting of hydroxy and halogen, or will unsubstituted , where the non-hydrogen substituent is C 1 - 4 may be replaced by a more alkoxy, hydroxy or halogen-4 alkyl, C 1.
- R 1 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl or C 5 - 12 substituted with a C 1-heteroaryl-6-alkyl; The unsubstituted C 2 - 4 alkenyl; Unsubstituted C 3 - 10 cycloalkyl; C 5 - 12 aryl and C 5 - represents a non-hydrogen substituents selected from the group consisting of 12-heteroaryl,
- R 2 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl; C 5 - 12 represents a heteroaryl group or hydrogen,
- R 3 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl or C 5 - 12 substituted with a C 1-heteroaryl-6-alkyl; Unsubstituted C 3 - 10 cycloalkyl; C 5 - 12 aryl; And C 5 - represents a non-hydrogen substituents selected from the group consisting of 12-heteroaryl,
- aryl and heteroaryl are C 1 - 4 alkyl, C 1 - 4 alkoxy, hydroxy and substituted by one or more non-hydrogen substituents selected from the group consisting of halogen, or may be unsubstituted, in which aryl and heteroaryl non-hydrogen substituent is C 1 - 4 may be replaced by a more alkoxy, hydroxy or halogen-4 alkyl, C 1.
- R 1 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl or C 5 - 12 substituted with a C 1-heteroaryl-6-alkyl; The unsubstituted C 2 - 4 alkenyl; Unsubstituted C 3 - 10 cycloalkyl; C 5 - 12 aryl; And C 5 - represents a non-hydrogen substituents selected from the group consisting of 12-heteroaryl,
- R 2 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl; C 5 - 12 represents a heteroaryl group or hydrogen,
- R 3 is C 1 unsubstituted-7-alkyl; C 5 - 12 aryl or C 5 - 12 substituted with a C 1-heteroaryl-6-alkyl; Unsubstituted C 3 - 10 cycloalkyl; C 5 - 12 aryl; And C 5 - represents a non-hydrogen substituents selected from the group consisting of 12-heteroaryl,
- aryl and heteroaryl are C 1 - 4 alkyl, C 1 - 4 alkoxy, hydroxy and substituted by one or more non-hydrogen substituents selected from the group consisting of halogen, or may be unsubstituted, where the aryl, and the ratio of the heteroaryl hydrogen substituent is C 1 - 4 alkyl, C 1 - 4 alkoxy, may be further substituted by hydroxy or halogen, aryl and heteroaryl is selected from phenyl, furanyl, thiophenyl, pyridinyl, benzodioxolyl, and naphthyl It may be selected from the group consisting of a teal.
- the compound of Formula 1 is N4-butyl-N5-cycloheptyl biguanide; N4-propyl-N5-methyl biguanide; N4-hexyl-N5-methyl biguanide; N4-allyl-N5-methyl biguanide; N4-benzyl-N5-methyl biguanide; N4- (phenethyl) -N5-methyl biguanide; N4-hexyl-N5- (butan-2-yl) biguanide; N4- (phenethyl) -N5- (butan-2-yl) biguanide; N4, N5-dibutyl biguanide; N4-hexyl-N5-butyl biguanide; N4-isopropyl-N5-butyl biguanide; N4- (butan-2-yl) -N5-butyl biguanide; N4-allyl-N5-
- the pharmaceutically acceptable salt of the compound of Formula 1 according to the present invention may be an acid addition salt formed using an organic acid or an inorganic acid.
- the organic acid is, for example, formic acid, acetic acid, propionic acid, lactic acid, butyric acid, isobutyric acid, trifluoroacetic acid, malic acid, maleic acid, malonic acid, fumaric acid, succinic acid, succinic acid monoamide, glutamic acid, tartaric acid, oxalic acid, citric acid, glycol Acids, glucuronic acid, ascorbic acid, benzoic acid, phthalic acid, salicylic acid, anthranilic acid, dichloroacetic acid, aminooxy acetic acid, benzenesulfonic acid, p-toluenesulfonic acid and methanesulfonic acid salts;
- Inorganic acids include, for example, hydrochloric acid, bromic acid, sulfuric acid, phosphoric acid, nitric acid
- the above-mentioned acid addition salts can be, for example, a) directly mixing the compound of formula 1 and acid, b) dissolving one of them in a solvent or a hydrous solvent, or c) compound of formula 1 and
- the acid can be prepared by placing it in an acid in a solvent or a hydration solvent and applying it to a general method for preparing a salt thereof.
- the compound of Formula 1 When the compound of Formula 1 has an acidic group such as a carboxyl group and a sulfonic acid group, the compound is a zwitterionic salt, and such salts are alkali metal salts (such as sodium salts and potassium salts), alkaline earth metal salts (such as calcium salts and Magnesium salts, etc.), inorganic acid salts such as aluminum salts and ammonium salts, and basic addition salts such as trimethylamine, triethylamine, pyridine, picoline, ethanolamine, diethanolamine, triethanolamine, dicyclohexyl Amines and N, N'-dibenzylethylenediamine salts).
- the salt of the compound of Formula 1 may be a basic amino acid salt (eg arginine, lysine and ornithine salt) and acidic amino acid salt (eg aspartic acid salt).
- the pharmaceutically acceptable salt of the compound of Formula 1 is formic acid, acetic acid, propionic acid, lactic acid, butyric acid, isobutyric acid, trifluoroacetic acid, malic acid, maleic acid, malonic acid, fumaric acid, succinic acid, succinic acid mono Amide, glutamic acid, tartaric acid, oxalic acid, citric acid, glycolic acid, glucuronic acid, ascorbic acid, benzoic acid, phthalic acid, salicylic acid, anthranilic acid, benzenesulfonic acid, p-toluenesulfonic acid, methanesulfonic acid, dichloroacetic acid, aminooxyacetic acid, hydrochloric acid, bromine Salts with acids selected from the group consisting of acid, sulfuric acid, phosphoric acid, nitric acid, carbonic acid and boric acid.
- the compound of formula 1 according to the present invention may be prepared through several methods.
- R 1 , R 2 , and R 3 are as defined in Chemical Formula 1, and in Chemical Formula 3, NCS represents isothiocyanate.
- the base is not limited thereto, but is selected from the group consisting of triethylamine, trimethylamine and diisopropylethylamine, and the organic solvent is not limited thereto, but dichloromethane, dichloroethane and dimethylformamide It may be selected from the group consisting of.
- the catalyst used in the desulfurization reaction is not limited thereto, but mercury oxide, iodomethane, iodomethane / silver nitrate, iodomethane / mercury chloride, peroxide, copper or zinc may be used.
- Mercury oxide can be used.
- the preparation method may be represented by the following Scheme 1, for example, and described in stages as follows:
- the thiourea compound of formula (4) which is used as an intermediate in the preparation method of the compound of formula (1), may be obtained by converting a substituted amine of formula (2) into a thiourea compound of formula (4) by reacting with a compound of formula (3) in an organic solvent in the presence of a base. .
- the compound of Formula 4 may be desulfurized with the compound of Formula 5 in the presence of a catalyst in an organic solvent to obtain the compound of Formula 1.
- Triethylamine or diisopropylethylamine may be used as a base used in preparing the thiourea compound of Formula 4, and dichloromethane, dichloroethane or dimethylformamide may be used as the organic solvent.
- the reaction temperature is in the range of 0 ° C to room temperature.
- the thiourea compound of formula (4) obtained above is dissolved in a suitable organic solvent (for example, methanol, ethanol, 1,4-dioxane or dimethyl formamide, etc.), and then a catalyst is added and the mixture is stirred under reflux.
- a catalyst for example, methanol, ethanol, 1,4-dioxane or dimethyl formamide, etc.
- the amount of the catalyst is about 1 to 2 molar equivalents relative to compound 4
- the amount of formula 5 is 1 to 2 molar equivalents relative to compound 4
- the reaction temperature is in the range up to the reflux temperature of the solvent used (for example, in case of ethanol). Room temperature to 90 ° C).
- the resultant is filtered and, for example, by adjusting the pH of the reaction solution to about 4 to 5 using an acid such as hydrochloric acid, and concentrating and purifying the resulting solution.
- acceptable salts can be obtained.
- the compound of Formula 1 thus obtained or a pharmaceutically acceptable salt thereof exhibits hypoglycemic action and hypolipidemic action even at a lower dose than conventional drugs.
- Diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, metabolic syndrome and the like can be usefully used.
- the present invention provides a medicament comprising the compound of Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
- the present invention also provides diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome, metabolic syndrome, cancer, myalgia with the compound of Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
- a pharmaceutical composition for treating a disease selected from the group consisting of muscle cell damage and rhabdomyolysis, the use of the compound of formula 1 or a pharmaceutically acceptable salt thereof for the treatment of the disease and a therapeutically effective amount of the compound of formula 1 Or a pharmaceutically acceptable salt thereof is provided to the subject.
- the diabetes can be insulin independent diabetes.
- the cancer may be breast cancer, colon cancer, gastric cancer, liver cancer, lung cancer, blood cancer, prostate cancer, brain cancer, pancreatic cancer, ovarian cancer, or endometrial cancer.
- the pharmaceutical composition of the present invention comprises at least one pharmaceutically acceptable carrier in addition to the active ingredient.
- 'pharmaceutically acceptable carrier refers to known pharmaceutical excipients that are useful when formulating pharmaceutically active compounds for administration and which are virtually nontoxic and insensitive under the conditions of use. The exact proportion of such excipients is determined by standard pharmaceutical practices, as well as solubility and chemical properties of the active compound, the route of administration chosen.
- compositions of the present invention may be formulated in a form suitable for the desired method of administration using suitable and physiologically acceptable excipients, disintegrants, sweeteners, binders, coatings, swelling agents, lubricants, lubricants, flavoring agents and the like. have.
- the pharmaceutical composition is not limited thereto, but may be formulated in the form of tablets, capsules, pills, granules, powders, injections or solutions.
- the 'subject' means a warm-blooded animal such as a mammal suffering from a specific disease, disorder or disease, and for example, human, orangutan, chimpanzee, mouse, rat, dog, cow, chicken, pig. , Chlorine, sheep, and the like, but are not limited to these examples.
- Treatment also includes, but is not limited to, alleviating the symptom, removing the cause of the symptom temporarily or permanently, or preventing or slowing the appearance of the symptom and the progression of the disease, disorder or condition described above.
- An effective amount of the active ingredient of the pharmaceutical composition of the present invention means an amount required to achieve the treatment of the disease.
- the type of disease, the severity of the disease, the type and amount of the active and other ingredients contained in the composition, the type of formulation and the age, weight, general health, sex and diet, sex and diet, time of administration, route of administration and composition of the patient It can be adjusted according to various factors including the rate of secretion, the duration of treatment, and the drug used concurrently.
- the compound of Formula 1 may be administered at a dose ranging from 0.5 to 100 mg per kg, based on 60 kg of adult male, once to several times daily.
- the dosage may vary depending on the various factors exemplified above, and in some cases may be administered in an amount less or greater than the dosage range.
- the biguanide derivative of Formula 1 according to the present invention exhibits excellent AMPK ⁇ activation effect and cancer cell proliferation inhibitory effect even in a small amount compared to conventional drugs, such as diabetes, obesity, hyperlipidemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic disease. It can be usefully used for the treatment of ovarian syndrome, metabolic syndrome, cancer and the like.
- Example 1 Except for using the amine compound corresponding to the target compound in step (1-1) and (1-2) of Example 1 instead of 1-butylamine and 1-heptylamine, respectively, in the same manner as in Example 1 Thiourea was synthesized, and the target compound of Examples 2 to 50 was prepared by the same method as in Step (1-3) of Example 1.
- HCT116 cells derived from human colorectal cancer were used, and cell growth was inhibited to 50% using MTT (3- (4,5-dimethylsaazol-2-yl) -2.5-ditetrazolium bromide) reagent.
- Concentration (cell growth inhibitory concentration, GIC50) value was measured to determine the cancer cell proliferation inhibitory effect of biguanide derivatives.
- HCT116 cells were placed in 96-well plates in a DMEM medium containing 10% calf serum so that the number of cells was about 5000, and incubated for 24 hours.
- 100 ⁇ M (or 200 ⁇ M), 25 ⁇ M, 6.25 uM, 1.56 uM, and 0.39 uM were treated with the culture solution for 48 hours to obtain GIC 50 values of each compound.
- MTT was added to the culture to check for living cells after treatment of the compound and further incubated for 3 hours.
- the resulting formazan tristal (formazane crystal) was dissolved using dimethyl sulfoxide (DMSO) and the absorbance of the solution was measured at 560 nm.
- DMSO dimethyl sulfoxide
- the number of cells surviving in the well plate treated with the compounds synthesized in Example compared to the number of cells cultured in the well plate not treated with the compound is expressed as% of cell viability according to each treatment concentration.
- a graph of cell viability curves was prepared, and the growth inhibitory effect was confirmed by calculating the concentration (GIC50) of the compound at which growth was inhibited to 50%.
- Example GIC50 (uM) @ HCT116 Example GIC50 (uM) @ HCT116 Metformin HCl 2172 One > 200 26 > 100 2 > 100 27 > 100 3 > 100 28 > 100 4 > 100 29 > 200 5 > 100 30 > 200 6 > 100 31 > 100 7 > 100 32 > 100 8 > 100 33 6.5 9 > 100 34 18.7 10 30.3 35 104.7 11 > 100 36 9.3 12 > 200 37 12.4 13 > 200 38 > 100 14 > 100 39 > 100 15 > 200 40 85.6 16 34.7 41 42.8 17 126.3 42 76.0 18 > 200 43 70.2 19 > 100 44 > 100 20 54.1 45 > 100 21 13.5 46 99.1 22 > 100 47 > 100 23 35.3 48 > 100 24 > 100 49 > 100 25 26.5 50 59.1
- MCF7 cells derived from human breast cancer cells were used, and the AMPK ⁇ immunoassay kit (Invitrogen, catalog No. KHO0651) was used to confirm the effect of AMPK ⁇ (5'-AMP-activated protein kinase alpha) activation by biguanide derivatives.
- MCF7 cells were cultured in DMEM medium containing 10% calf serum, placed in 6-well plates with 5 ⁇ 10 5 cells, and then cultured in an incubator fed with 5% CO 2 .
- the derivatives synthesized in Example were treated in the culture solution at 50 uM and then incubated for 24 hours.
- 20 ug of cell lysate was obtained by protein quantification. Phosphorylated degree of 172 residues (Thr172) was confirmed and the result was obtained.
- the degree of AMPK ⁇ activation by the biguanide derivative was that of phosphorylated AMPK ⁇ in the cells cultured in the presence of the compounds synthesized in the above example, compared to the phosphorylated AMPK ⁇ in the cells cultured without the biguanide derivative. Indicated.
- the derivatives synthesized in the above example effectively inhibit the survival of cancer cells, in particular, colon cancer cells, in inhibiting cancer cell proliferation.
- the compounds showing better AMPK ⁇ activation effect at 20 times lower concentration than the control group metformin in AMPK ⁇ activation may be determined to be at least 20 times more effective than the control group.
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Abstract
Description
실시예 | GIC50 (uM) @ HCT116 | 실시예 | GIC50 (uM) @ HCT116 |
Metformin HCl | 2172 | ||
1 | >200 | 26 | >100 |
2 | >100 | 27 | >100 |
3 | >100 | 28 | >100 |
4 | >100 | 29 | >200 |
5 | >100 | 30 | >200 |
6 | >100 | 31 | >100 |
7 | >100 | 32 | >100 |
8 | >100 | 33 | 6.5 |
9 | >100 | 34 | 18.7 |
10 | 30.3 | 35 | 104.7 |
11 | >100 | 36 | 9.3 |
12 | >200 | 37 | 12.4 |
13 | >200 | 38 | >100 |
14 | >100 | 39 | >100 |
15 | >200 | 40 | 85.6 |
16 | 34.7 | 41 | 42.8 |
17 | 126.3 | 42 | 76.0 |
18 | >200 | 43 | 70.2 |
19 | >100 | 44 | >100 |
20 | 54.1 | 45 | >100 |
21 | 13.5 | 46 | 99.1 |
22 | >100 | 47 | >100 |
23 | 35.3 | 48 | >100 |
24 | >100 | 49 | >100 |
25 | 26.5 | 50 | 59.1 |
실시예 | AMPK 활성화 | ||
0 | 50 uM | fold | |
Metformin HCl | 6.8 | 21.5 (@ 1mM) | 3.2 |
1 | 5.3 | 21.1 | 4.0 |
2 | 6.8 | 6.5 | 1.0 |
3 | 6.8 | 35.5 | 5.2 |
4 | 6.8 | 5.3 | 0.8 |
5 | 6.8 | 10.8 | 1.6 |
6 | 6.8 | 33.1 | 4.9 |
7 | 6.8 | 39.5 | 5.8 |
8 | 6.8 | 18.4 | 2.7 |
9 | 6.8 | 25.6 | 3.8 |
10 | 5.3 | 38.1 | 7.2 |
11 | 6.8 | 4.2 | 0.6 |
12 | 5.3 | 8.1 | 1.5 |
13 | 5.3 | 20.5 | 3.9 |
14 | 6.8 | 23.2 | 3.4 |
15 | 5.3 | 19.4 | 3.7 |
16 | 5.3 | 35.3 | 6.7 |
17 | 6.8 | 26.3 | 3.9 |
18 | 5.3 | 9.6 | 1.8 |
19 | 6.8 | 19.1 | 2.8 |
20 | 4.9 | 7.2 | 1.5 |
21 | N.D | ||
22 | 6.8 | 29.9 | 4.4 |
23 | 2.5 | 19.5 | 7.8 |
24 | 6.8 | 29.9 | 4.4 |
25 | 2.5 | 16.7 | 6.7 |
26 | 6.8 | 15.4 | 2.3 |
27 | 6.8 | 18.7 | 2.7 |
28 | 6.8 | 6.7 | 1.0 |
29 | 5.3 | 5.5 | 1.0 |
30 | 5.3 | 7.3 | 1.4 |
31 | 6.8 | 44.6 | 6.6 |
32 | 6.8 | 16.9 | 2.5 |
33 | N.D | ||
34 | 2.5 | 20.8 | 8.3 |
35 | 6.8 | 9.0 | 1.3 |
36 | N.D | ||
37 | 2.5 | 10.2 | 4.1 |
38 | 6.8 | 22.0 | 3.2 |
39 | 6.8 | 6.4 | 0.9 |
40 | 5.3 | 20.5 | 3.9 |
41 | 2.5 | 10.1 | 4.0 |
42 | 5.3 | 31.5 | 5.9 |
43 | 5.3 | 23.8 | 4.5 |
44 | 6.8 | 12.8 | 1.9 |
45 | 6.8 | 7.1 | 1.0 |
46 | 5.3 | 19.5 | 3.7 |
47 | 6.8 | 7.2 | 1.1 |
48 | 6.8 | 6.6 | 1.0 |
49 | 6.8 | 35.2 | 5.2 |
50 | 5.3 | 21.4 | 4.0 |
Claims (20)
- 하기 화학식 1의 화합물 또는 그의 약학적으로 허용가능한 염:[화학식 1]상기 식에서,R1, R2 및 R3은 각각 독립적으로, C5 - 12아릴, C5 - 12헤테로아릴, C3 - 10사이클로알킬, 하이드록시, 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소 치환기로 치환되거나 비치환된 C1 - 12알킬; C1 - 12알콕시; C2 - 4알케닐; C3 - 10사이클로알킬; 하이드록시; 할로겐; C5 - 12아릴; 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기 또는 수소를 나타내고,상기 아릴 및 헤테로아릴은 C1 - 4알킬, 할로겐으로 치환된 C1 - 4알킬, C1 - 4알콕시, 하이드록시 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소치환기로 치환되거나 비치환된 것이며, 여기에서 아릴 및 헤테로아릴의 비수소치환기는 C1 - 4알킬, C1 - 4알콕시, 하이드록시 또는 할로겐으로 추가로 치환될 수 있다.
- 제1항에 있어서,R1, R2 및 R3은 각각 독립적으로,비치환된 C1 - 7알킬; C5 - 12아릴, C5 -12 헤테로아릴, C3 - 10사이클로알킬, 하이드록시, 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소 치환기로 치환된 C1 - 6알킬; C1 - 6알콕시; 비치환된 C2 - 4알케닐; 비치환된 C3 - 10사이클로알킬; 하이드록시; 할로겐; C5 - 12아릴 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기 또는 수소를 나타내고,상기 아릴 및 헤테로아릴은 C1 - 4알킬, C1 - 4알콕시, 하이드록시 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소치환기로 치환되거나 비치환된 것이며, 여기에서 아릴 및 헤테로아릴의 비수소치환기는 C1 - 4알킬, C1 - 4알콕시, 하이드록시 또는 할로겐으로 추가로 치환되거나 비치환된 것인화학식 1의 화합물 또는 그의 약학적으로 허용가능한 염.
- 제2항에 있어서,R1은 비치환된 C1 - 7알킬; C5 - 12아릴 또는 C5 - 12헤테로아릴로 치환된 C1 - 6알킬; 비치환된 C2 - 4알케닐; 비치환된 C3 - 10사이클로알킬; C5 - 12아릴 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기를 나타내고,R2는 비치환된 C1 - 7알킬; C5 - 12아릴; C5 - 12헤테로아릴 또는 수소를 나타내며,R3는 비치환된 C1 - 7알킬; C5 - 12아릴 또는 C5 - 12헤테로아릴로 치환된 C1 - 6알킬; 비치환된 C3 - 10사이클로알킬, C5 - 12아릴; 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기를 나타내고,상기 아릴 및 헤테로아릴은 C1 - 4알킬, C1 - 4알콕시, 하이드록시 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소치환기로 치환되거나 비치환된 것이며, 여기에서 아릴 및 헤테로아릴의 비수소치환기는 C1 - 4알킬, C1 - 4알콕시, 하이드록시 또는 할로겐으로 추가로 치환되거나 비치환된 것인화학식 1의 화합물 또는 그의 약학적으로 허용가능한 염.
- 제3항에 있어서,R1은 비치환된 C1 - 7알킬; C5 - 12아릴 또는 C5 - 12헤테로아릴로 치환된 C1 - 6알킬; 비치환된 C2 - 4알케닐; 비치환된 C3 - 10사이클로알킬; C5 - 12아릴; 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기를 나타내고,R2는 비치환된 C1 - 7알킬; C5 - 12아릴; C5 - 12헤테로아릴 또는 수소를 나타내며,R3는 비치환된 C1 - 7알킬; C5 - 12아릴 또는 C5 - 12헤테로아릴로 치환된 C1 - 6알킬; 비치환된 C3 - 10사이클로알킬; C5 - 12아릴; 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기를 나타내고,상기 아릴 및 헤테로아릴은 C1 - 4알킬, C1 - 4알콕시, 하이드록시 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소치환기로 치환되거나 비치환될 수 있고, 여기에서 아릴 및 헤테로아릴의 비수소치환기는 C1 - 4알킬, C1 - 4알콕시, 하이드록시 또는 할로겐으로 추가로 치환되거나 비치환된 것이며, 상기 아릴 및 헤테로아릴은 페닐, 퓨란일, 티오펜일, 피리딘일, 벤조다이옥솔일, 및 나프틸로 이루어진 군으로부터 선택되는 것인화학식 1의 화합물 또는 그의 약학적으로 허용가능한 염.
- 제1항에 있어서,상기 화학식 1의 화합물이N4-부틸-N5-사이클로헵틸 바이구아나이드;N4-프로필-N5-메틸 바이구아나이드;N4-헥실-N5-메틸 바이구아나이드;N4-알릴-N5-메틸 바이구아나이드;N4-벤질-N5-메틸 바이구아나이드;N4-(펜에틸)-N5-메틸 바이구아나이드;N4-헥실-N5-(부탄-2-일) 바이구아나이드;N4-(펜에틸)-N5-(부탄-2-일) 바이구아나이드;N4,N5-디부틸 바이구아나이드;N4-헥실-N5-부틸 바이구아나이드;N4-이소프로필-N5-부틸 바이구아나이드;N4-(부탄-2-일)-N5-부틸 바이구아나이드;N4-알릴-N5-부틸 바이구아나이드;N4-사이클로펜틸-N5-부틸 바이구아나이드;N4-(퓨란-2-일)메틸-N5-부틸 바이구아나이드;N4-아다만틸-N5-부틸 바이구아나이드;N4-(4-브로모)페닐-N5-부틸 바이구아나이드;N4-벤질-N5-부틸 바이구아나이드;N4-(2-클로로)벤질-N5-부틸 바이구아나이드;N4-(3-클로로)벤질-N5-부틸 바이구아나이드;N4-(4-클로로)벤질-N5-부틸 바이구아나이드;N4-(4-메톡시)벤질-N5-부틸 바이구아나이드;N4-(3,4-디클로로)벤질-N5-부틸 바이구아나이드;N4-(티오펜-2-일)에틸-N5-부틸 바이구아나이드;N4-((4-클로로)펜에틸)-N5-부틸 바이구아나이드;N4-(피리딘-3-일)메틸-N5-사이클로헥실 바이구아나이드;N4-(펜에틸)-N5-사이클로헥실 바이구아나이드;N4-(피리딘-3-일)메틸-N5-페닐 바이구아나이드;N4-알릴-N5-벤질 바이구아나이드 염산염;N4-사이클로펜틸-N5-벤질 바이구아나이드;N4-사이클로헵틸-N5-벤질 바이구아나이드;N4-(퓨란-2-일)메틸-N5-벤질 바이구아나이드;N4-부틸-N5-(펜에틸) 바이구아나이드;N4-1-아다만틸-N5-(펜에틸) 바이구아나이드;N4-페닐-N5-(펜에틸) 바이구아나이드;N4-(4-클로로)페닐-N5-(펜에틸) 바이구아나이드;N4-(4-트리플로로메틸)페닐-N5-(펜에틸) 바이구아나이드;N4-(퓨란-2-일)메틸-N5-(펜에틸) 바이구아나이드;N4-(벤조[1,3]다이옥솔-5-일)메틸-N5-(펜에틸) 바이구아나이드;N4-벤질-N5-(펜에틸) 바이구아나이드;N4-(4-플로로)벤질-N5-(펜에틸) 바이구아나이드;N4-(티오펜-2-일)에틸-N5-(펜에틸) 바이구아나이드;N4,N5-디(펜에틸) 바이구아나이드;N4-메틸-N5,N5-(벤질)(메틸) 바이구아나이드;N4-부틸-N5,N5-(벤질)(이소프로필) 바이구아나이드;N4-(4-메톡시)벤질-N5,N5-(메틸)(1-나프틸메틸) 바이구아나이드;N4-(펜에틸)-N5,N5-(메틸)(펜에틸) 바이구아나이드;N4-(펜에틸)-N5,N5-(부틸)(에틸) 바이구아나이드;N4-(펜에틸)-N5,N5-디헥실 바이구아나이드; 또는N4-(펜에틸)-N5,N5-(벤질)(부틸) 바이구아나이드인화학식 1의 화합물 또는 그의 약학적으로 허용가능한 염.
- 제1항에 있어서,상기 약학적으로 허용가능한 염이 포름산, 아세트산, 프로피온산, 락트산, 부티르산, 이소부티르산, 트리플루오로아세트산, 말산, 말레산, 말론산, 푸마르산, 숙신산, 숙신산 모노아미드, 글루탐산, 타르타르산, 옥살산, 시트르산, 글리콜산, 글루쿠론산, 아스코르브산, 벤조산, 프탈산, 살리실산, 안트라닐산, 벤젠술폰산, p-톨루엔술폰산, 메탄술폰산, 디클로로아세트산, 아미노옥시 아세트산, 염산, 브롬산, 황산, 인산, 질산, 탄산 및 붕산으로 구성된 군으로부터 선택된 산과의 염인상기 화학식 1의 화합물 또는 그의 약학적으로 허용되는 염.
- 하기 화학식 2의 화합물을 염기의 존재 하에 하기 화학식 3의 화합물과 유기용매 중에서 반응시켜 하기 화학식 4의 화합물을 얻는 단계; 및화학식 4의 화합물을 촉매의 존재하에 화학식 5의 화합물과 탈황반응시켜 화학식 1의 화합물을 얻는 단계를 포함하는 하기 화학식 1의 화합물의 제조방법:[화학식 1][화학식 2][화학식 3][화학식 4][화학식 5]상기 식에서,R1, R2 및 R3은 각각 독립적으로,C5 - 12아릴, C5 -12 헤테로아릴, C3 - 10사이클로알킬, 하이드록시, 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소 치환기로 치환되거나 비치환된 C1-12알킬; C1 - 12알콕시; C2 - 4알케닐; C3 - 10사이클로알킬; 하이드록시; 할로겐; C5 - 12아릴; 및 C5 - 12헤테로아릴로 이루어진 군으로부터 선택되는 비수소치환기 또는 수소를 나타내고,상기 아릴 및 헤테로아릴은 C1 - 4알킬, 할로겐으로 치환된 C1 - 4알킬, C1 - 4알콕시, 하이드록시 및 할로겐으로 이루어진 군으로부터 선택되는 하나 이상의 비수소치환기로 치환되거나 비치환된 것이며, 여기에서 아릴 및 헤테로아릴의 비수소치환기는 C1 - 4알킬, C1 - 4알콕시, 하이드록시 또는 할로겐으로 추가로 치환될 수 있고,상기 NCS는 이소티오시아네이트를 나타낸다.
- 제7항에 있어서,상기 염기가 트리에틸아민, 트리메틸아민 및 디이소프로필에틸아민으로 이루어진 군으로부터 선택되고, 유기용매가 디클로로메탄, 디클로로에탄 및 디메틸포름아미드로 이루어진 군으로부터 선택되는 것을 특징으로 하는 방법.
- 제7항에 있어서,상기 촉매는 산화수은, 아이오도메탄, 아이오도메탄/질산은, 아이오도메탄/염화수은, 퍼옥사이드, 구리 또는 아연인 방법.
- 제1항의 화합물 또는 그의 약학적으로 허용가능한 염을 유효성분으로 포함하는 의약.
- 제1항의 화합물 또는 그의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 당뇨, 비만, 고지혈증, 고콜레스테롤혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군, 대사성 증후군, 암, 근육통, 근육세포 손상 및 횡문근 융해로 이루어진 군으로부터 선택되는 질환의 치료용 약학 조성물.
- 제11항에 있어서,상기 당뇨병이 인슐린 비의존성 당뇨병인 약학 조성물.
- 제11항에 있어서,상기 암은 유방암, 대장암, 위암, 간암, 폐암, 혈액암, 전립선암, 뇌암, 췌장암, 난소암, 또는 자궁내막암인 약학 조성물.
- 제11항에 있어서,상기 약학 조성물은 정제, 캅셀제, 캅셀제, 환제, 과립제, 산제, 주사제 또는 액제의 형태로 제제화되는 것인 약학 조성물.
- 제1항의 화합물 또는 그의 약학적으로 허용가능한 염의 당뇨, 비만, 고지혈증, 고콜레스테롤혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군, 대사성 증후군, 암, 근육통, 근육세포 손상 및 횡문근 융해로 이루어진 군으로부터 선택되는 질환의 치료용 의약의 제조를 위한 용도.
- 제15항에 있어서,상기 당뇨병이 인슐린 비의존성 당뇨병인 용도.
- 제15항에 있어서,상기 암은 유방암, 대장암, 위암, 간암, 폐암, 혈액암, 전립선암, 뇌암, 췌장암, 난소암, 또는 자궁내막암인 용도.
- 치료상 유효량의 제1항의 화합물 또는 그의 약학적으로 허용가능한 염을 대상체에 투여하는 것을 포함하는 당뇨, 비만, 고지혈증, 고콜레스테롤혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군, 대사성 증후군, 암, 근육통, 근육세포 손상 및 횡문근 융해로 이루어진 군으로부터 선택되는 질환의 치료 방법.
- 제18항에 있어서,상기 당뇨병이 인슐린 비의존성 당뇨병인 방법.
- 제18항에 있어서,상기 암은 유방암, 대장암, 위암, 간암, 폐암, 혈액암, 전립선암, 뇌암, 췌장암, 난소암, 또는 자궁내막암인 방법.
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CN201180005604.XA CN102725264B (zh) | 2010-01-06 | 2011-01-06 | 双胍衍生物、其制备方法以及包含其作为活性成分的药物组合物 |
US13/520,905 US9133110B2 (en) | 2010-01-06 | 2011-01-06 | Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient |
EP11731937A EP2522654A2 (en) | 2010-01-06 | 2011-01-06 | Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient |
US14/847,692 US9464042B2 (en) | 2010-01-06 | 2015-09-08 | Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient |
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KR1020110001442A KR101285719B1 (ko) | 2010-01-06 | 2011-01-06 | 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 |
KR10-2011-0001442 | 2011-01-06 |
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US14/847,692 Division US9464042B2 (en) | 2010-01-06 | 2015-09-08 | Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient |
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PCT/KR2011/000098 WO2011083999A2 (ko) | 2010-01-06 | 2011-01-06 | 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 |
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US (5) | US9133110B2 (ko) |
EP (2) | EP2522654A2 (ko) |
JP (1) | JP2013516461A (ko) |
KR (4) | KR101274981B1 (ko) |
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US10278931B2 (en) | 2015-10-13 | 2019-05-07 | Innopharmascreen Inc. | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
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- 2011-01-06 EP EP11731936.8A patent/EP2522653A4/en not_active Withdrawn
- 2011-01-06 JP JP2012547967A patent/JP2013516461A/ja active Pending
- 2011-01-06 KR KR1020110001438A patent/KR101274981B1/ko active IP Right Grant
- 2011-01-06 CN CN2011800056035A patent/CN102725263A/zh active Pending
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- 2011-01-06 CN CN201180005604.XA patent/CN102725264B/zh active Active
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- 2011-01-06 WO PCT/KR2011/000098 patent/WO2011083999A2/ko active Application Filing
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Cited By (2)
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WO2013022278A2 (en) | 2011-08-08 | 2013-02-14 | Hanall Biopharma Co., Ltd. | N1-cyclic amine-n5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same |
US10278931B2 (en) | 2015-10-13 | 2019-05-07 | Innopharmascreen Inc. | Composition for treatment of inflammatory bowel disease and atopic dermatitis |
Also Published As
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KR101715984B1 (ko) | 2017-03-14 |
US20120283299A1 (en) | 2012-11-08 |
US20120309799A1 (en) | 2012-12-06 |
WO2011083998A3 (ko) | 2011-10-27 |
CN102725263A (zh) | 2012-10-10 |
WO2011083998A2 (ko) | 2011-07-14 |
EP2522653A4 (en) | 2013-06-12 |
CN102725264A (zh) | 2012-10-10 |
WO2011083999A3 (ko) | 2011-11-17 |
KR20110081095A (ko) | 2011-07-13 |
US10376480B2 (en) | 2019-08-13 |
US20160317478A1 (en) | 2016-11-03 |
US9464042B2 (en) | 2016-10-11 |
US20150376123A1 (en) | 2015-12-31 |
US20180256520A1 (en) | 2018-09-13 |
KR20130069704A (ko) | 2013-06-26 |
US9416098B2 (en) | 2016-08-16 |
KR101285719B1 (ko) | 2013-07-18 |
EP2522654A2 (en) | 2012-11-14 |
JP2013516461A (ja) | 2013-05-13 |
KR101274981B1 (ko) | 2013-06-18 |
EP2522653A2 (en) | 2012-11-14 |
KR20110081093A (ko) | 2011-07-13 |
US9133110B2 (en) | 2015-09-15 |
KR101704683B1 (ko) | 2017-02-09 |
KR20130060250A (ko) | 2013-06-07 |
US9993446B2 (en) | 2018-06-12 |
CN102725264B (zh) | 2014-12-17 |
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