[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2009135615A3 - Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells - Google Patents

Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells Download PDF

Info

Publication number
WO2009135615A3
WO2009135615A3 PCT/EP2009/003076 EP2009003076W WO2009135615A3 WO 2009135615 A3 WO2009135615 A3 WO 2009135615A3 EP 2009003076 W EP2009003076 W EP 2009003076W WO 2009135615 A3 WO2009135615 A3 WO 2009135615A3
Authority
WO
WIPO (PCT)
Prior art keywords
prophylaxis
regulatory
cells
formation
treatment
Prior art date
Application number
PCT/EP2009/003076
Other languages
German (de)
French (fr)
Other versions
WO2009135615A8 (en
WO2009135615A2 (en
Inventor
Daniela Paulsen
Nina Brunner
Dorothy Bray
Original Assignee
Aicuris Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41152787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009135615(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to RU2010149999/15A priority Critical patent/RU2531936C2/en
Priority to KR1020167020193A priority patent/KR20160092048A/en
Priority to SI200930229T priority patent/SI2288372T1/en
Priority to ES09741834T priority patent/ES2378957T3/en
Priority to MX2010012214A priority patent/MX2010012214A/en
Priority to CA2723761A priority patent/CA2723761C/en
Priority to JP2011507816A priority patent/JP5651583B2/en
Priority to AU2009244039A priority patent/AU2009244039B2/en
Priority to DK09741834.7T priority patent/DK2288372T3/en
Priority to EP09741834A priority patent/EP2288372B1/en
Priority to BRPI0912411A priority patent/BRPI0912411B8/en
Priority to UAA201014444A priority patent/UA102099C2/en
Priority to KR1020157013806A priority patent/KR101687506B1/en
Application filed by Aicuris Gmbh & Co. Kg filed Critical Aicuris Gmbh & Co. Kg
Priority to PL09741834T priority patent/PL2288372T3/en
Priority to AT09741834T priority patent/ATE544465T1/en
Priority to CN2009801266762A priority patent/CN102088996A/en
Publication of WO2009135615A2 publication Critical patent/WO2009135615A2/en
Publication of WO2009135615A3 publication Critical patent/WO2009135615A3/en
Publication of WO2009135615A8 publication Critical patent/WO2009135615A8/en
Priority to IL209128A priority patent/IL209128A/en
Priority to US12/941,885 priority patent/US20110150826A1/en
Priority to ZA2010/08129A priority patent/ZA201008129B/en
Priority to HR20120296T priority patent/HRP20120296T1/en
Priority to US14/752,726 priority patent/US9616105B2/en
Priority to IL250435A priority patent/IL250435A0/en
Priority to US15/439,866 priority patent/US20170173117A1/en
Priority to US15/439,845 priority patent/US10086046B2/en
Priority to IL253790A priority patent/IL253790A0/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464454Enzymes
    • A61K39/464456Tyrosinase or tyrosinase related proteinases [TRP-1 or TRP-2]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46449Melanoma antigens
    • A61K39/464491Melan-A/MART
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46449Melanoma antigens
    • A61K39/464492Glycoprotein 100 [Gp100]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • A61K2039/55527Interleukins
    • A61K2039/55533IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/23Interleukins [IL]
    • C12N2501/2302Interleukin-2 (IL-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)

Abstract

The invention relates to means for the treatment and/or prophylaxis of an autoimmune disease, means for the formation of regulatory T-cells (TReg) in a living thing, and different methods that use the claimed means.
PCT/EP2009/003076 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells WO2009135615A2 (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
UAA201014444A UA102099C2 (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
AT09741834T ATE544465T1 (en) 2008-05-08 2009-04-28 AN IL-2 MUTEIN FOR THE TREATMENT OR PROPHYLAXIS OF AN AUTOIMMUNE DISEASE
PL09741834T PL2288372T3 (en) 2008-05-08 2009-04-28 An il-2 mutant for use in the treatment or prophylaxis of autoimmune disease
ES09741834T ES2378957T3 (en) 2008-05-08 2009-04-28 An IL-2 mutein for the treatment or prophylaxis of an autoimmune disease
KR1020167020193A KR20160092048A (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
CA2723761A CA2723761C (en) 2008-05-08 2009-04-28 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t cells
JP2011507816A JP5651583B2 (en) 2008-05-08 2009-04-28 Agents for the treatment and / or prevention of autoimmune diseases and agents for the formation of regulatory T cells
AU2009244039A AU2009244039B2 (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T-cells
DK09741834.7T DK2288372T3 (en) 2008-05-08 2009-04-28 IL-2 mutant for the treatment or prophylaxis of an autoimmune disease
EP09741834A EP2288372B1 (en) 2008-05-08 2009-04-28 An il-2 mutant for use in the treatment or prophylaxis of autoimmune disease
BRPI0912411A BRPI0912411B8 (en) 2008-05-08 2009-04-28 use of a human interleukin-2 mutein (hil-2 mutein) and pharmaceutical composition for the treatment and/or prophylaxis of an autoimmune disease
CN2009801266762A CN102088996A (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T-cells
KR1020157013806A KR101687506B1 (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
RU2010149999/15A RU2531936C2 (en) 2008-05-08 2009-04-28 Medication, intended for treatment and/or prevention of autoimmune disease and for formation of regulatory n-cells
SI200930229T SI2288372T1 (en) 2008-05-08 2009-04-28 An il-2 mutant for use in the treatment or prophylaxis of autoimmune disease
MX2010012214A MX2010012214A (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells.
IL209128A IL209128A (en) 2008-05-08 2010-11-04 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
US12/941,885 US20110150826A1 (en) 2008-05-08 2010-11-08 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t cells
ZA2010/08129A ZA201008129B (en) 2008-05-08 2010-11-12 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
HR20120296T HRP20120296T1 (en) 2008-05-08 2012-04-03 An il-2 mutant for use in the treatment or prophylaxis of autoimmune disease
US14/752,726 US9616105B2 (en) 2008-05-08 2015-06-26 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T cells
IL250435A IL250435A0 (en) 2008-05-08 2017-02-05 Use of human hil-2-mutein for the preparation of an agent for the formation of regulatory t-cells
US15/439,866 US20170173117A1 (en) 2008-05-08 2017-02-22 Agent for the treatment and or prophylaxis of an autoimmune disease and for the formation of regulatory t cells
US15/439,845 US10086046B2 (en) 2008-05-08 2017-02-22 Agent for the treatment and or prophylaxis of an autoimmune disease and for the formation of regulatory T cells
IL253790A IL253790A0 (en) 2008-05-08 2017-08-02 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102008023820.1 2008-05-08
DE102008023820A DE102008023820A1 (en) 2008-05-08 2008-05-08 An agent for the treatment and / or prophylaxis of an autoimmune disease and for the production of regulatory T cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/941,885 Continuation US20110150826A1 (en) 2008-05-08 2010-11-08 Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t cells

Publications (3)

Publication Number Publication Date
WO2009135615A2 WO2009135615A2 (en) 2009-11-12
WO2009135615A3 true WO2009135615A3 (en) 2010-06-24
WO2009135615A8 WO2009135615A8 (en) 2010-10-28

Family

ID=41152787

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/003076 WO2009135615A2 (en) 2008-05-08 2009-04-28 Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells

Country Status (28)

Country Link
US (4) US20110150826A1 (en)
EP (1) EP2288372B1 (en)
JP (2) JP5651583B2 (en)
KR (3) KR101554056B1 (en)
CN (2) CN110935025A (en)
AR (1) AR071756A1 (en)
AT (1) ATE544465T1 (en)
AU (1) AU2009244039B2 (en)
BR (1) BRPI0912411B8 (en)
CA (1) CA2723761C (en)
CL (1) CL2009001099A1 (en)
CY (1) CY1112469T1 (en)
DE (1) DE102008023820A1 (en)
DK (1) DK2288372T3 (en)
ES (1) ES2378957T3 (en)
HR (1) HRP20120296T1 (en)
IL (3) IL209128A (en)
MX (1) MX2010012214A (en)
PE (1) PE20091967A1 (en)
PL (1) PL2288372T3 (en)
PT (1) PT2288372E (en)
RU (1) RU2531936C2 (en)
SI (1) SI2288372T1 (en)
TW (1) TWI510622B (en)
UA (1) UA102099C2 (en)
UY (1) UY31816A (en)
WO (1) WO2009135615A2 (en)
ZA (1) ZA201008129B (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008023820A1 (en) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg An agent for the treatment and / or prophylaxis of an autoimmune disease and for the production of regulatory T cells
WO2010085495A1 (en) 2009-01-21 2010-07-29 Amgen Inc. Compositions and methods of treating inflammatory and autoimmune diseases
US11090363B2 (en) 2009-07-10 2021-08-17 University of Pittsburgh—of the Commonwealth System of Higher Education Vasoactive intestinal peptide release from microparticles
WO2011006029A1 (en) 2009-07-10 2011-01-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Artificial cell constructs for inducing immunological tolerance
CU23734A1 (en) * 2009-11-27 2011-11-15 Centro Inmunologia Molecular IMMUNOMODULATOR POLIPEPTIDES DERIVED FROM IL-2 WITH ANTIGONIST ACTIVITY OF THIS CITOCINE USED IN CANCER THERAPY AND CHRONIC INFECTIOUS DISEASES
WO2012012737A2 (en) * 2010-07-23 2012-01-26 The University Of Toledo Stable tregs and related materials and methods
CU23923B1 (en) * 2010-11-12 2013-07-31 Ct De Inmunología Molecular POLYPEPTIDES DERIVED FROM IL-2 WITH AGONIST ACTIVITY
ES2811624T3 (en) 2011-03-11 2021-03-12 Hopitaux Paris Assist Publique IL-2 Dosage Regimen to Treat Systemic Lupus Erythematosus
PL3443979T3 (en) 2011-03-11 2020-11-16 Assistance Publique - Hôpitaux De Paris Il-2 dosage regimen for treating systemic lupus erythematosus
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
SG11201504558TA (en) 2012-12-11 2015-07-30 Einstein Coll Med Methods for high throughput receptor:ligand identification
ES2704731T3 (en) 2014-02-06 2019-03-19 Hoffmann La Roche Interleukin 2 fusion proteins and uses thereof
ES2717831T3 (en) 2014-08-11 2019-06-25 Delinia Inc Modified IL-2 variants that selectively activate regulatory T cells for the treatment of autoimmune diseases
MY188430A (en) 2015-04-10 2021-12-08 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
JP7422480B2 (en) * 2016-05-04 2024-01-26 アムジエン・インコーポレーテツド Interleukin-2 mutant protein for regulatory T cell proliferation
AU2017266905B2 (en) 2016-05-18 2022-12-15 Albert Einstein College Of Medicine, Inc. Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
AU2017268348A1 (en) 2016-05-18 2018-10-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CA3041334A1 (en) 2016-11-08 2018-05-17 Delinia, Inc. Il-2 variants for the treatment of autoimmune diseases
EP4360647A3 (en) 2016-12-22 2024-07-24 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
US11851471B2 (en) 2017-01-09 2023-12-26 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CN110520438A (en) * 2017-02-03 2019-11-29 匹兹堡大学联邦系统高等教育 Oncolytic viral therapy
AU2018234628B2 (en) 2017-03-15 2023-07-20 Cue Biopharma, Inc. Methods for modulating an immune response
US10961310B2 (en) 2017-03-15 2021-03-30 Pandion Operations, Inc. Targeted immunotolerance
EP3630163A4 (en) 2017-05-24 2021-06-09 Pandion Operations, Inc. Targeted immunotolerance
KR102219926B1 (en) 2017-09-15 2021-02-25 주식회사 카인사이언스 Use of a peptide as a therapeutic agent
KR102164417B1 (en) 2017-09-15 2020-10-13 주식회사 카인사이언스 Use of a peptide as a therapeutic agent
CN111615396A (en) 2017-11-21 2020-09-01 小利兰·斯坦福大学董事会 Partial agonists of interleukin-2
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
CA3086199A1 (en) 2017-12-19 2019-06-27 Xencor, Inc. Engineered il-2 fc fusion proteins
JP7275049B2 (en) * 2017-12-27 2023-05-17 協和キリン株式会社 IL-2 variants
CN111886241A (en) 2018-01-09 2020-11-03 库尔生物制药有限公司 Multimeric T cell modulating polypeptides and methods of use thereof
EP3752178A1 (en) 2018-02-16 2020-12-23 Iltoo Pharma Use of interleukin 2 for treating sjögren's syndrome
KR20200136453A (en) 2018-03-28 2020-12-07 브리스톨-마이어스 스큅 컴퍼니 Interleukin-2/interleukin-2 receptor alpha fusion protein and method of use
WO2020007937A1 (en) 2018-07-03 2020-01-09 Iltoo Pharma Use of interleukin-2 for treating systemic sclerosis
WO2020035482A1 (en) 2018-08-13 2020-02-20 Iltoo Pharma Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
CN113383013B (en) 2018-12-21 2022-11-04 江苏恒瑞医药股份有限公司 Human interleukin 2 variant or derivative thereof
WO2020163782A2 (en) 2019-02-08 2020-08-13 The Uab Research Foundation Immunotherapy for the treatment and prevention of inflammatory bowel disease
EP3958887B1 (en) * 2019-04-23 2023-11-01 Institut National de la Santé et de la Recherche Médicale (INSERM) Medical uses for inducing or restoring immune tolerance
BR112021022682A2 (en) 2019-05-14 2022-02-22 Provention Bio Inc Methods and compositions for preventing type 1 diabetes
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
JP7483857B2 (en) 2019-07-26 2024-05-15 ビステラ, インコーポレイテッド Interleukin-2 agonists and uses thereof
CN114853874B (en) * 2019-09-10 2024-05-17 中国医学科学院北京协和医院 Long-acting interleukin-2 targeted to regulatory T cells and application thereof in treatment of autoimmune diseases
EP4073094A1 (en) 2019-12-12 2022-10-19 Iltoo Pharma Interleukin 2 chimeric constructs
EP4090674A4 (en) 2020-01-14 2024-01-24 Synthekine, Inc. Biased il2 muteins methods and compositions
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CA3169949A1 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
KR102219927B1 (en) 2020-05-20 2021-02-24 주식회사 카인사이언스 Use of a peptide as a therapeutic agent
WO2021252917A2 (en) 2020-06-11 2021-12-16 Provention Bio, Inc. Methods and compositions for preventing type 1 diabetes
KR102219928B1 (en) 2020-06-26 2021-02-24 주식회사 카인사이언스 Use of a peptide as a therapeutic agent
EP4211149A4 (en) 2020-09-09 2024-10-09 Cue Biopharma Inc Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof
US12024559B2 (en) 2020-10-23 2024-07-02 Asher Biotherapeutics, Inc. Fusions with CD8 antigen binding molecules for modulating immune cell function
IL302114A (en) 2020-10-29 2023-06-01 Bristol Myers Squibb Co Fusion proteins for the treatment of disease
CA3203977A1 (en) * 2020-12-04 2022-06-09 Visterra, Inc. Methods of using interleukin-2 agents
CN112843222B (en) * 2021-01-21 2023-01-31 暨南大学 Application of ANKRD22 protein in preparing product for treating or delaying autoimmune diseases
US20240368238A1 (en) 2021-07-30 2024-11-07 Dracoterpin Biomedicine Llc Human interleukin-2 variant and use thereof
CA3233644A1 (en) 2021-10-06 2023-04-13 David Klatzmann Interleukin 2 chimeric constructs with targeting specificy to inflamed tissues
WO2024056154A1 (en) 2022-09-12 2024-03-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Interleukin-2 for use in treating autism spectrum disorder
WO2024151515A2 (en) 2023-01-09 2024-07-18 Odyssey Therapeutics, Inc. Anti-tnfr2 antigen-binding proteins and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060128A1 (en) * 1998-05-15 1999-11-25 Bayer Corporation Il-2 selective agonists and antagonists
US6348192B1 (en) * 1999-05-11 2002-02-19 Bayer Corporation Interleukin-2 mutein expressed from mammalian cells
WO2003015697A2 (en) * 2001-08-13 2003-02-27 University Of Southern California Interleukin-2 mutants with reduced toxicity

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955807B1 (en) * 1998-05-15 2005-10-18 Bayer Pharmaceuticals Corporation IL-2 selective agonists and antagonists
US6689353B1 (en) 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
US20060057651A1 (en) * 2000-12-08 2006-03-16 Bowdish Katherine S Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
EP2354791A1 (en) * 2001-12-04 2011-08-10 Merck Patent GmbH Immunocytokines with modulated selectivity
US20060121029A1 (en) * 2002-08-30 2006-06-08 Hiroshi Shiku Method and composition for regulating the activity of regulatory t cells
CA2501677A1 (en) * 2002-10-22 2004-05-06 Waratah Pharmaceuticals, Inc. Treatment of diabetes
EP1715889A4 (en) * 2004-01-08 2008-03-05 Univ California Regulatory t cells suppress autoimmunity
US20060234205A1 (en) * 2004-03-05 2006-10-19 Chiron Corporation In vitro test system for predicting patient tolerability of therapeutic agents
DE202005001888U1 (en) * 2005-02-07 2005-07-28 Chiron Corp., Emeryville Antitumor composition comprises interleukin-2 and sodium dodecyl sulfate in the form of microaggregates
WO2009061853A2 (en) 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
DE102008023820A1 (en) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg An agent for the treatment and / or prophylaxis of an autoimmune disease and for the production of regulatory T cells

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060128A1 (en) * 1998-05-15 1999-11-25 Bayer Corporation Il-2 selective agonists and antagonists
US6348192B1 (en) * 1999-05-11 2002-02-19 Bayer Corporation Interleukin-2 mutein expressed from mammalian cells
WO2003015697A2 (en) * 2001-08-13 2003-02-27 University Of Southern California Interleukin-2 mutants with reduced toxicity

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANTONY PAUL ANDREW ET AL: "CD4+CD25+ T regulatory cells, immunotherapy of cancer, and interleukin-2", JOURNAL OF IMMUNOTHERAPY, LIPPINCOTT WILLIAMS & WILKINS, HAGERSTOWN, MD, US LNKD- DOI:10.1097/01.CJI.0000155049.26787.45, vol. 28, no. 2, 1 March 2005 (2005-03-01), pages 120 - 128, XP002457762, ISSN: 1524-9557 *
BURCHILL ET AL: "Interleukin-2 receptor signaling in regulatory T cell development and homeostasis", IMMUNOLOGY LETTERS, ELSEVIER BV, NL LNKD- DOI:10.1016/J.IMLET.2007.08.005, vol. 114, no. 1, 25 October 2007 (2007-10-25), pages 1 - 8, XP022314034, ISSN: 0165-2478 *
MALEK THOMAS R ET AL: "CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice: Implications for the nonredundant function of IL-2", IMMUNITY, vol. 17, no. 2, August 2002 (2002-08-01), pages 167 - 178, XP002579301, ISSN: 1074-7613 *
MATTHEWS L ET AL: "BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitro", CLINICAL IMMUNOLOGY, ACADEMIC PRESS, US LNKD- DOI:10.1016/J.CLIM.2004.07.009, vol. 113, no. 3, 1 December 2004 (2004-12-01), pages 248 - 255, XP004609296, ISSN: 1521-6616 *
NISHIMURA E ET AL: "Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory t cells", INTERNATIONAL IMMUNOLOGY, OXFORD UNIVERSITY PRESS, GB LNKD- DOI:10.1093/INTIMM/DXH122, vol. 16, no. 8, 5 July 2004 (2004-07-05), pages 1189 - 1201, XP003005849, ISSN: 0953-8178 *
TANG Q ET AL: "In Vitro-expanded Antigen-specific Regulatory T cells Suppress Autoimmune Diabetes", THE JOURNAL OF EXPERIMENTAL MEDICINE, ROCKEFELLER UNIVERSITY PRESS, UNITED STATES LNKD- DOI:10.1084/JEM.20040139, vol. 199, no. 11, 7 June 2004 (2004-06-07), pages 1455 - 1465, XP003005045, ISSN: 0022-1007 *
THORNTON ANGELA ET AL: "Activation requirements for the induction of CD4+CD25+ T cell suppressor function", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE LNKD- DOI:10.1002/EJI.200324455, vol. 34, no. 2, 1 February 2004 (2004-02-01), pages 366 - 376, XP002407890, ISSN: 0014-2980 *

Also Published As

Publication number Publication date
BRPI0912411A8 (en) 2019-05-14
KR101554056B1 (en) 2015-09-18
US10086046B2 (en) 2018-10-02
ATE544465T1 (en) 2012-02-15
KR20160092048A (en) 2016-08-03
KR20150079824A (en) 2015-07-08
CN102088996A (en) 2011-06-08
WO2009135615A8 (en) 2010-10-28
US20170165326A1 (en) 2017-06-15
UY31816A (en) 2010-01-05
JP2011519882A (en) 2011-07-14
US20170173117A1 (en) 2017-06-22
DK2288372T3 (en) 2012-04-02
RU2531936C2 (en) 2014-10-27
EP2288372B1 (en) 2012-02-08
AU2009244039A1 (en) 2009-11-12
KR101687506B1 (en) 2016-12-16
KR20110015576A (en) 2011-02-16
PT2288372E (en) 2012-03-06
AU2009244039B2 (en) 2014-04-17
WO2009135615A2 (en) 2009-11-12
RU2010149999A (en) 2012-06-20
JP5651583B2 (en) 2015-01-14
BRPI0912411B8 (en) 2021-05-25
PE20091967A1 (en) 2010-02-05
PL2288372T3 (en) 2012-07-31
CL2009001099A1 (en) 2011-03-11
UA102099C2 (en) 2013-06-10
CY1112469T1 (en) 2015-12-09
SI2288372T1 (en) 2012-05-31
BRPI0912411B1 (en) 2020-02-18
IL253790A0 (en) 2017-09-28
US20110150826A1 (en) 2011-06-23
ES2378957T3 (en) 2012-04-19
MX2010012214A (en) 2010-12-06
JP2015038084A (en) 2015-02-26
DE102008023820A1 (en) 2009-11-12
IL209128A (en) 2017-08-31
IL250435A0 (en) 2017-03-30
AR071756A1 (en) 2010-07-14
HRP20120296T1 (en) 2012-04-30
CN110935025A (en) 2020-03-31
US9616105B2 (en) 2017-04-11
US20150374788A1 (en) 2015-12-31
EP2288372A2 (en) 2011-03-02
TW201006926A (en) 2010-02-16
CA2723761C (en) 2019-01-22
CA2723761A1 (en) 2009-11-12
TWI510622B (en) 2015-12-01
ZA201008129B (en) 2012-02-29
BRPI0912411A2 (en) 2016-09-13
IL209128A0 (en) 2011-01-31

Similar Documents

Publication Publication Date Title
WO2009135615A3 (en) Means for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory t-cells
WO2012003377A3 (en) Methods of preparing chorion tissue and products derived therefrom
WO2012088290A3 (en) Tri-variable domain binding proteins and uses thereof
WO2012076293A9 (en) Formulations comprising polysiloxanes having nitrogen-containing groups
WO2010083347A3 (en) Peptidomimetic macrocycles
WO2011142858A3 (en) Chlorotoxin variants, conjugates, and methods for their use
MX2011009539A (en) Substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof.
MX2011007930A (en) Crystalline insulin-conjugates.
MX2014011134A (en) Carbamate compounds and of making and using same.
IL219107A0 (en) 2-amino--5,5-difluoro-5,6-dihydro-4h-oxazines as bace 1 and/or bace 2 inhibitors
TW201129938A (en) Personal mapping system
WO2011065982A3 (en) Polymorphisms associated with parkinson's disease
MY172372A (en) Compositions and methods for lowering triglycerides
MY161495A (en) Virus like particle compositions and methods of use
WO2012166626A8 (en) Reagents and methods for treating dental disease
WO2012173846A3 (en) Peptidomimetic macrocycles
WO2011035205A3 (en) Antibodies against candida, collections thereof and methods of use
WO2011109433A9 (en) Tissue for prosthetic implants and grafts, and methods associated therewith
WO2008066784A3 (en) Expression of foxp3 by cancer cells
WO2011006002A3 (en) Metal-coated nanostructures and related methods
WO2013183058A3 (en) Expanded device
WO2012012278A3 (en) Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
WO2011009890A3 (en) Use of azabicycloalkyl derivatives or pyrrolidine - 2 - one derivatives for the treatment or prevention of ataxia
WO2013023151A3 (en) Compositions and methods for treating celiac sprue disease
GB201102108D0 (en) Diagnostic method

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980126676.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09741834

Country of ref document: EP

Kind code of ref document: A2

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2723761

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2011507816

Country of ref document: JP

Ref document number: 2009244039

Country of ref document: AU

Ref document number: MX/A/2010/012214

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 8101/DELNP/2010

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2009741834

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 20107026580

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2009244039

Country of ref document: AU

Date of ref document: 20090428

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2010149999

Country of ref document: RU

Ref document number: A201014444

Country of ref document: UA

ENP Entry into the national phase

Ref document number: PI0912411

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20101104

WWE Wipo information: entry into national phase

Ref document number: 250435

Country of ref document: IL