SG11201504558TA - Methods for high throughput receptor:ligand identification - Google Patents
Methods for high throughput receptor:ligand identificationInfo
- Publication number
- SG11201504558TA SG11201504558TA SG11201504558TA SG11201504558TA SG11201504558TA SG 11201504558T A SG11201504558T A SG 11201504558TA SG 11201504558T A SG11201504558T A SG 11201504558TA SG 11201504558T A SG11201504558T A SG 11201504558TA SG 11201504558T A SG11201504558T A SG 11201504558TA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- high throughput
- ligand identification
- receptor
- throughput receptor
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261735791P | 2012-12-11 | 2012-12-11 | |
US201361833588P | 2013-06-11 | 2013-06-11 | |
PCT/US2013/073275 WO2014093118A1 (en) | 2012-12-11 | 2013-12-05 | Methods for high throughput receptor:ligand identification |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201504558TA true SG11201504558TA (en) | 2015-07-30 |
Family
ID=50934838
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201504558TA SG11201504558TA (en) | 2012-12-11 | 2013-12-05 | Methods for high throughput receptor:ligand identification |
SG10201808463RA SG10201808463RA (en) | 2012-12-11 | 2013-12-05 | Methods for high throughput receptor:ligand identification |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201808463RA SG10201808463RA (en) | 2012-12-11 | 2013-12-05 | Methods for high throughput receptor:ligand identification |
Country Status (12)
Country | Link |
---|---|
US (2) | US10048271B2 (en) |
EP (2) | EP3640375A3 (en) |
JP (2) | JP2016500255A (en) |
KR (1) | KR102208505B1 (en) |
CN (2) | CN105121715B (en) |
AU (2) | AU2013359907B2 (en) |
BR (1) | BR112015013557B1 (en) |
CA (1) | CA2894511C (en) |
HK (1) | HK1218144A1 (en) |
IL (2) | IL239096B (en) |
SG (2) | SG11201504558TA (en) |
WO (1) | WO2014093118A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG11201504558TA (en) | 2012-12-11 | 2015-07-30 | Einstein Coll Med | Methods for high throughput receptor:ligand identification |
AU2015288389B2 (en) | 2014-07-07 | 2021-05-13 | Astrego Diagnostics Ab | Phenotypic characterization and in situ genotyping of a library of genetically different cells |
AU2017266905B2 (en) * | 2016-05-18 | 2022-12-15 | Albert Einstein College Of Medicine, Inc. | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
AU2017268348A1 (en) | 2016-05-18 | 2018-10-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
JP7019171B2 (en) * | 2016-11-24 | 2022-02-15 | 国立研究開発法人物質・材料研究機構 | A method for measuring cell-cell interactions due to the binding of molecules existing on the cell surface |
WO2018111941A1 (en) * | 2016-12-12 | 2018-06-21 | 13.8, Inc. | Compositions of high affinity reagents and methods of use thereof |
EP4360647A3 (en) | 2016-12-22 | 2024-07-24 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
AU2018234628B2 (en) | 2017-03-15 | 2023-07-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
JP2020534352A (en) | 2017-09-07 | 2020-11-26 | キュー バイオファーマ,インコーポレーテッド | T cell regulatory multimeric polypeptide with conjugation site and how to use it |
CN111886241A (en) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | Multimeric T cell modulating polypeptides and methods of use thereof |
CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma Inc | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635363A (en) | 1995-02-28 | 1997-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for the detection, quantitation and purification of antigen-specific T cells |
US5869270A (en) | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
US6211342B1 (en) | 1996-07-18 | 2001-04-03 | Children's Hospital Medical Center | Multivalent MHC complex peptide fusion protein complex for stimulating specific T cell function |
US20050003431A1 (en) | 1996-08-16 | 2005-01-06 | Wucherpfennig Kai W. | Monovalent, multivalent, and multimeric MHC binding domain fusion proteins and conjugates, and uses therefor |
WO1998035981A1 (en) | 1997-02-13 | 1998-08-20 | The Regents Of The University Of California | Prevention and treatment of hepatocellular cancer |
US7098306B2 (en) | 1997-02-13 | 2006-08-29 | The Regents Of The University Of California | Method and compositions for treating hepatocellular cancer |
US6268411B1 (en) | 1997-09-11 | 2001-07-31 | The Johns Hopkins University | Use of multivalent chimeric peptide-loaded, MHC/ig molecules to detect, activate or suppress antigen-specific T cell-dependent immune responses |
US20030007978A1 (en) | 1997-09-16 | 2003-01-09 | Burrows Gregory G. | Recombinant MHC molecules useful for manipulation of antigen-specific T-cells |
US6696304B1 (en) * | 1999-02-24 | 2004-02-24 | Luminex Corporation | Particulate solid phase immobilized protein quantitation |
DE60044247D1 (en) | 1999-04-30 | 2010-06-02 | Inst Rech S Cliniques De Montr | HUMANE CD80 MUTANT AND COMPOSITIONS AND METHODS FOR THE PRODUCTION AND USE THEREOF |
US20020006664A1 (en) | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
CN1430728A (en) | 2000-05-25 | 2003-07-16 | 苏诺尔分子公司 | Modulation of T-cell receptor interactions |
US20020122820A1 (en) | 2001-01-16 | 2002-09-05 | Hildebrand William H. | Soluble MHC artificial antigen presenting cells |
US6800748B2 (en) * | 2001-01-25 | 2004-10-05 | Large Scale Biology Corporation | Cytoplasmic inhibition of gene expression and expression of a foreign protein in a monocot plant by a plant viral vector |
CA2440773A1 (en) | 2001-03-14 | 2002-09-19 | Dakocytomation Denmark A/S | Novel mhc molecule constructs, and methods of employing these constructs for diagnosis and therapy, and uses of mhc molecules |
US20030044847A1 (en) * | 2001-05-15 | 2003-03-06 | Sidney Pestka | Methods for anlyzing interactions between proteins in live and intact cells |
CN1533432A (en) | 2001-06-04 | 2004-09-29 | MLʵ���ҹ�������˾ | COmpositions and methods for high-level, large-scale production of recombinant proteins |
US20030017134A1 (en) | 2001-06-19 | 2003-01-23 | Technion Research And Development Foundation Ltd. | Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer |
EP1497426A2 (en) | 2001-06-22 | 2005-01-19 | Maxygen, Inc. | Co-stimulatory molecules |
WO2003006632A2 (en) | 2001-07-12 | 2003-01-23 | Canvac | Methods and compisitions for activation human t cells in vitro |
EP1478740A2 (en) | 2001-07-27 | 2004-11-24 | Human Genome Sciences, Inc. | Heteromultimeric tnf ligand family members |
EP2354791A1 (en) | 2001-12-04 | 2011-08-10 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
US8895020B2 (en) | 2002-04-19 | 2014-11-25 | Washington University | Single chain trimers and uses therefor |
US7432351B1 (en) * | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
EP1599502A1 (en) | 2003-02-27 | 2005-11-30 | TheraVision GmbH | A molecule which binds cd80 and cd86 |
AU2003901876A0 (en) | 2003-04-17 | 2003-05-08 | The Macfarlane Burnet Institute For Medical Research And Public Health | Viral vector |
US20050042641A1 (en) | 2003-05-27 | 2005-02-24 | Cold Spring Harbor Laboratory | In vivo high throughput selection of RNAi probes |
US7470513B2 (en) | 2003-11-10 | 2008-12-30 | Academia Sinica | Risk assessment for adverse drug reactions |
US20060234205A1 (en) | 2004-03-05 | 2006-10-19 | Chiron Corporation | In vitro test system for predicting patient tolerability of therapeutic agents |
DE102004014983A1 (en) | 2004-03-26 | 2005-10-20 | Univ Stuttgart | Recombinant polypeptides of the members of the TNF ligand family and their use |
AU2005247950B2 (en) | 2004-05-27 | 2012-02-02 | Receptor Logic, Inc. | Antibodies as T cell receptor mimics, methods of production and uses thereof |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
EP1945662A2 (en) * | 2005-11-10 | 2008-07-23 | Receptor Biologix, Inc. | Methods for production of receptor and ligand isoforms |
US8518697B2 (en) | 2006-04-04 | 2013-08-27 | Washington University | Single chain trimers and uses therefor |
ES2549128T3 (en) | 2006-05-19 | 2015-10-23 | Technion Research And Development Foundation Ltd. | Fusion proteins, uses thereof and processes to produce them |
EP1889851A1 (en) | 2006-08-18 | 2008-02-20 | Charite Universitätsmedizin-Berlin | PAX2 and PAX8 as targets for immunologic and molecular tumour treatment strategies |
US8992937B2 (en) | 2006-08-28 | 2015-03-31 | Washington University | Disulfide trap MHC class I molecules and uses therefor |
NZ601175A (en) | 2006-12-28 | 2012-12-21 | Int Inst Cancer Immunology Inc | Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same |
CN103736086A (en) | 2007-02-15 | 2014-04-23 | 曼康公司 | A method for enhancing t cell response |
EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
EP2615172A1 (en) * | 2007-04-27 | 2013-07-17 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
US8926961B2 (en) | 2007-10-03 | 2015-01-06 | Board Of Trustees Of The University Of Arkansas | HPV E6 protein T cell epitopes and uses thereof |
CN101418309B (en) | 2007-10-23 | 2011-05-04 | 中国农业科学院上海兽医研究所 | Cloning, expression and application of eimeria tenella protein disulfide isomerase gene |
DE102008023820A1 (en) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | An agent for the treatment and / or prophylaxis of an autoimmune disease and for the production of regulatory T cells |
TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
EP2337795A2 (en) | 2008-10-01 | 2011-06-29 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
EP2184070A1 (en) | 2008-11-07 | 2010-05-12 | Hla-G Technologies | HLA-G proteins and pharmaceutical uses thereof |
CN102348715B (en) | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | Extension recombinant polypeptide and the composition for including the extension recombinant polypeptide |
WO2010150233A2 (en) | 2009-06-25 | 2010-12-29 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Multimeric polypeptides of hla-g including at least two alpha3 domains and pharmaceutical uses thereof |
WO2011066342A2 (en) * | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
KR101740171B1 (en) * | 2009-11-24 | 2017-05-25 | 메디뮨 리미티드 | Targeted binding agents against b7-h1 |
EP2619229B1 (en) * | 2010-09-21 | 2016-04-06 | Altor BioScience Corporation | Multimeric il-15 soluble fusion molecules and methods of making and using same |
WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
WO2012127464A2 (en) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
PE20141212A1 (en) | 2011-06-22 | 2014-09-19 | Hoffmann La Roche | ELIMINATION OF TARGET CELLS BY VIRUS SPECIFIC CYTOTOXIC T CELLS USING COMPLEXES INCLUDING CLASS 1 MHC |
RU2657440C2 (en) | 2011-06-30 | 2018-06-13 | Джензим Корпорейшн | Inhibitors of t-cell activation |
WO2013030620A2 (en) | 2011-08-30 | 2013-03-07 | Jacobs University Bremen Ggmbh | Gene encoded for an mhc class i molecule, plasmid, expression system protein, multimer, reagent and kit for analyzing a t cell frequency |
US8956619B2 (en) | 2011-10-25 | 2015-02-17 | University Of Maryland, Baltimore County | Soluble CD80 as a therapeutic to reverse immune supression in cancer patients |
KR101764096B1 (en) * | 2011-11-28 | 2017-08-02 | 메르크 파텐트 게엠베하 | Anti-pd-l1 antibodies and uses thereof |
AU2013207669C1 (en) | 2012-01-13 | 2018-05-31 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
EP2809345A4 (en) | 2012-02-03 | 2015-11-25 | Univ Emory | Immunostimulatory compositions, particles, and uses related thereto |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
KR20150088881A (en) | 2012-11-30 | 2015-08-03 | 로슈 글리카트 아게 | Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class i comprising multi-function proteins |
SG11201504558TA (en) | 2012-12-11 | 2015-07-30 | Einstein Coll Med | Methods for high throughput receptor:ligand identification |
US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
EP2948475A2 (en) | 2013-01-23 | 2015-12-02 | AbbVie Inc. | Methods and compositions for modulating an immune response |
KR102121638B1 (en) | 2013-03-29 | 2020-06-10 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Wt1-antigen peptide conjugate vaccine |
GB201311475D0 (en) | 2013-06-27 | 2013-08-14 | Alligator Bioscience Ab | Polypeptides |
CN106132428B (en) | 2014-01-21 | 2021-08-06 | 阿尔伯特爱因斯坦医学院 | Cell platform for rapid and comprehensive T cell immune monitoring |
US20160152725A1 (en) | 2014-02-25 | 2016-06-02 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins specific for hla-a2-restricted wilms tumor 1 peptide |
CN106029699B (en) | 2014-02-26 | 2019-07-19 | 泰来有限公司 | WT1 antigenic polypeptide and antitumor agent containing the polypeptide |
CA2946398A1 (en) | 2014-04-24 | 2015-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Superagonists, partial agonists and antagonists of interleukin-2 |
CN113248624A (en) | 2014-06-18 | 2021-08-13 | 阿尔伯特爱因斯坦医学院 | SYNTAC polypeptides and uses thereof |
TWI687438B (en) | 2014-07-03 | 2020-03-11 | 英屬開曼群島商百濟神州生物科技有限公司 | Anti-pd-l1 antibodies and their use as therapeutics and diagnostics |
DK3172227T3 (en) | 2014-07-21 | 2019-12-02 | Delinia Inc | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases |
DK3180018T3 (en) | 2014-08-12 | 2019-10-28 | Massachusetts Inst Technology | Synergistic tumor treatment with IL-2 and integrin-binding Fc fusion protein |
US11111284B2 (en) | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
SI3186283T1 (en) | 2014-08-29 | 2020-04-30 | F. Hoffmann-La Roche Ag | Combination therapy of tumor-targeted il-2 variant immunocytokines and antibodies against human pd-l1 |
LT3283508T (en) | 2015-04-17 | 2021-07-12 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
AU2016303497A1 (en) | 2015-07-31 | 2018-03-01 | Tarveda Therapeutics, Inc. | Compositions and methods for immuno-oncology therapies |
CN106565836B (en) | 2015-10-10 | 2020-08-18 | 中国科学院广州生物医药与健康研究院 | High affinity soluble PDL-1 molecules |
JP2019516665A (en) | 2016-03-02 | 2019-06-20 | キュー バイオファーマ, インコーポレイテッド | T cell regulatory multimeric polypeptides and methods of use thereof |
CN109414498A (en) | 2016-03-03 | 2019-03-01 | Cue生物制药公司 | T cell modulability multimeric polypeptide and its application method |
JP7422480B2 (en) | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | Interleukin-2 mutant protein for regulatory T cell proliferation |
AU2017266905B2 (en) | 2016-05-18 | 2022-12-15 | Albert Einstein College Of Medicine, Inc. | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
WO2019051126A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof |
-
2013
- 2013-12-05 SG SG11201504558TA patent/SG11201504558TA/en unknown
- 2013-12-05 WO PCT/US2013/073275 patent/WO2014093118A1/en active Application Filing
- 2013-12-05 JP JP2015545835A patent/JP2016500255A/en not_active Ceased
- 2013-12-05 CN CN201380071758.8A patent/CN105121715B/en active Active
- 2013-12-05 AU AU2013359907A patent/AU2013359907B2/en not_active Ceased
- 2013-12-05 CA CA2894511A patent/CA2894511C/en active Active
- 2013-12-05 EP EP19197120.9A patent/EP3640375A3/en not_active Withdrawn
- 2013-12-05 BR BR112015013557-9A patent/BR112015013557B1/en not_active IP Right Cessation
- 2013-12-05 EP EP13862361.6A patent/EP2931949B1/en active Active
- 2013-12-05 US US14/649,176 patent/US10048271B2/en active Active
- 2013-12-05 SG SG10201808463RA patent/SG10201808463RA/en unknown
- 2013-12-05 CN CN201811139644.3A patent/CN109324190A/en active Pending
- 2013-12-05 KR KR1020157017981A patent/KR102208505B1/en active IP Right Grant
-
2015
- 2015-05-31 IL IL239096A patent/IL239096B/en active IP Right Grant
-
2016
- 2016-05-30 HK HK16106096.2A patent/HK1218144A1/en not_active IP Right Cessation
-
2018
- 2018-03-14 AU AU2018201812A patent/AU2018201812B2/en not_active Ceased
- 2018-07-25 US US16/044,608 patent/US11226339B2/en active Active
- 2018-11-05 IL IL262785A patent/IL262785B/en active IP Right Grant
-
2019
- 2019-11-05 JP JP2019200491A patent/JP7128792B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20150094674A (en) | 2015-08-19 |
JP2020043860A (en) | 2020-03-26 |
BR112015013557A2 (en) | 2020-01-14 |
CN105121715A (en) | 2015-12-02 |
US20160011204A1 (en) | 2016-01-14 |
IL262785B (en) | 2020-04-30 |
JP7128792B2 (en) | 2022-08-31 |
BR112015013557B1 (en) | 2021-12-14 |
EP3640375A3 (en) | 2020-07-29 |
KR102208505B1 (en) | 2021-01-27 |
AU2013359907B2 (en) | 2018-01-18 |
CA2894511C (en) | 2021-12-07 |
US11226339B2 (en) | 2022-01-18 |
AU2013359907A1 (en) | 2015-06-18 |
IL262785A (en) | 2018-12-31 |
EP2931949B1 (en) | 2019-09-18 |
JP2016500255A (en) | 2016-01-12 |
EP3640375A2 (en) | 2020-04-22 |
WO2014093118A1 (en) | 2014-06-19 |
US20200011875A1 (en) | 2020-01-09 |
US10048271B2 (en) | 2018-08-14 |
CN109324190A (en) | 2019-02-12 |
CN105121715B (en) | 2018-10-26 |
IL239096A0 (en) | 2015-07-30 |
EP2931949A1 (en) | 2015-10-21 |
EP2931949A4 (en) | 2016-07-27 |
IL239096B (en) | 2019-03-31 |
SG10201808463RA (en) | 2018-11-29 |
AU2018201812B2 (en) | 2020-09-10 |
CA2894511A1 (en) | 2014-06-19 |
AU2018201812A1 (en) | 2018-04-05 |
HK1218144A1 (en) | 2017-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL262785B (en) | Methods for high throughput receptor:ligand identification | |
IL239262A0 (en) | Methods for screening | |
HK1214504A1 (en) | Methods for treating anemia | |
EP2939260A4 (en) | Method for preparing samples for imaging | |
ZA201501833B (en) | Method for obtaining 1-kestone | |
ZA201409403B (en) | Process for reforming hydrocarbons | |
PL2914386T3 (en) | Device for sorting | |
EP2908119A4 (en) | Method for detecting nano-particles | |
PT3165483T (en) | Apparatus for sorting objects | |
IL237436A0 (en) | Method for screening cancer | |
EP2876447A4 (en) | Method for detecting cancer | |
EP2828639A4 (en) | Improved apparatus for detecting particles | |
EP2892042A4 (en) | Intellectual productivity analysis device, program | |
EP2876446A4 (en) | Method for detecting cancer | |
EP2837628A4 (en) | Method for preparing rivaroxaban intermediate | |
HK1201800A1 (en) | Method for forming packages | |
SG11201503816PA (en) | Alkylating process | |
EP2855433A4 (en) | Process for preparing dihalopyridines | |
EP2819995A4 (en) | Process for preparing 3-methylsulfonylpropionitrile | |
EP2888591A4 (en) | Method for improved cell identification | |
EP2849689A4 (en) | Modified pusher apparatus | |
EP2818476A4 (en) | Method for preparing 3-o-benzyl-1,2-o-isopropylidene- -l-furan idose | |
EP2835001A4 (en) | Identification for apparatuses | |
IL233626A (en) | Process for preparing chloroamines | |
EP2840305A4 (en) | Method for preparing reflector |