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WO2012173846A3 - Peptidomimetic macrocycles - Google Patents

Peptidomimetic macrocycles Download PDF

Info

Publication number
WO2012173846A3
WO2012173846A3 PCT/US2012/041181 US2012041181W WO2012173846A3 WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3 US 2012041181 W US2012041181 W US 2012041181W WO 2012173846 A3 WO2012173846 A3 WO 2012173846A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptidomimetic macrocycles
macrocycles
disease
peptidomimetic
treatment
Prior art date
Application number
PCT/US2012/041181
Other languages
French (fr)
Other versions
WO2012173846A2 (en
Inventor
Huw M. Nash
Noriyuki Kawahata
Carl Elkin
Original Assignee
Aileron Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aileron Therapeutics, Inc. filed Critical Aileron Therapeutics, Inc.
Publication of WO2012173846A2 publication Critical patent/WO2012173846A2/en
Publication of WO2012173846A3 publication Critical patent/WO2012173846A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
PCT/US2012/041181 2011-06-06 2012-06-06 Peptidomimetic macrocycles WO2012173846A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161493979P 2011-06-06 2011-06-06
US61/493,979 2011-06-06
US201161494382P 2011-06-07 2011-06-07
US201161494377P 2011-06-07 2011-06-07
US61/494,377 2011-06-07
US61/494,382 2011-06-07

Publications (2)

Publication Number Publication Date
WO2012173846A2 WO2012173846A2 (en) 2012-12-20
WO2012173846A3 true WO2012173846A3 (en) 2013-03-21

Family

ID=47357671

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/041181 WO2012173846A2 (en) 2011-06-06 2012-06-06 Peptidomimetic macrocycles

Country Status (1)

Country Link
WO (1) WO2012173846A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105061577A (en) 2006-12-14 2015-11-18 爱勒让治疗公司 Bis-sulfhydryl macrocyclization systems
JP4997293B2 (en) 2007-02-23 2012-08-08 エイルロン セラピューティクス，インコーポレイテッド Triazole macrocycle
EP2142562B1 (en) 2007-03-28 2013-07-03 President and Fellows of Harvard College Stitched polypeptides
BRPI0918948A2 (en) 2008-09-22 2015-12-15 Aileron Therapeutics Inc peptidomimetic macrocycles
US9458202B2 (en) 2008-11-24 2016-10-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR20130099938A (en) 2010-08-13 2013-09-06 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles
BR112014009418A2 (en) 2011-10-18 2017-04-18 Aileron Therapeutics Inc peptidomimetic macrocycles
JP6450192B2 (en) 2012-02-15 2019-01-09 エイルロン セラピューティクス，インコーポレイテッド Triazole-bridged and thioether-bridged peptidomimetic macrocycles
ES2817877T3 (en) 2012-02-15 2021-04-08 Aileron Therapeutics Inc Peptidomimetic macrocycles
CA2887285A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
CN112245565A (en) 2014-09-24 2021-01-22 艾瑞朗医疗公司 Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
SG11201707750YA (en) 2015-03-20 2017-10-30 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20170056352A1 (en) 2015-08-25 2017-03-02 Rgenix, Inc. PHARMACEUTICALLY ACCEPTABLE SALTS OF beta-GUANIDINOPROPIONIC ACID WITH IMPROVED PROPERTIES AND USES THEREOF
CN108368161A (en) 2015-09-10 2018-08-03 艾瑞朗医疗公司 Peptidomimetic macrocyclic compound as MCL-1 conditioning agents
WO2018160178A1 (en) 2017-03-01 2018-09-07 Rgenix, Inc. Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof
JP2023505687A (en) 2019-12-11 2023-02-10 インスピルナ，インコーポレーテッド Cancer treatment method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080262200A1 (en) * 2007-02-23 2008-10-23 Aileron Therapeutics, Inc., A Delaware Corporation Triazole Macrocycle Systems
US20100184047A1 (en) * 2007-03-30 2010-07-22 Oncotherapy Science, Inc. Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JEYAPRAKASH ET AL.: "Structure of a survivin-borealin-INCENP core complex reveals how chromosomal passengers travel together.", CELL, vol. 131, 2007, pages 271 - 285 *

Also Published As

Publication number Publication date
WO2012173846A2 (en) 2012-12-20

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