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WO2009005151A1 - 新規脂質ペプチド並びにヒドロゲル - Google Patents

新規脂質ペプチド並びにヒドロゲル Download PDF

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Publication number
WO2009005151A1
WO2009005151A1 PCT/JP2008/062212 JP2008062212W WO2009005151A1 WO 2009005151 A1 WO2009005151 A1 WO 2009005151A1 JP 2008062212 W JP2008062212 W JP 2008062212W WO 2009005151 A1 WO2009005151 A1 WO 2009005151A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
hydrogel
lipid peptide
carbon atoms
disclosed
Prior art date
Application number
PCT/JP2008/062212
Other languages
English (en)
French (fr)
Inventor
Nobuhide Miyaji
Takehisa Iwama
Masahiro Gotoh
Tatsuo Maruyama
Daisuke Kohda
Original Assignee
Nissan Chemical Industries, Ltd.
Kyushu University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Industries, Ltd., Kyushu University filed Critical Nissan Chemical Industries, Ltd.
Priority to US12/452,473 priority Critical patent/US8916682B2/en
Priority to JP2009521681A priority patent/JP5441693B2/ja
Priority to EP08790893.5A priority patent/EP2172475B1/en
Priority to CN200880023439.9A priority patent/CN101809028B/zh
Publication of WO2009005151A1 publication Critical patent/WO2009005151A1/ja
Priority to US13/685,565 priority patent/US8816049B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

【課題】酸性からアルカリ性の液性範囲において極めて少量でヒドロゲルを形成できる脂質ペプチド並びに高い環境・生体適合性及び生分解性を有するヒドロゲルの提供。 【解決手段】式（１）： （式中、Ｒ1は炭素原子数９乃至２３の脂肪族基を表し、Ｒ2、Ｒ3、Ｒ4及びＲ5は、それぞれ独立して、水素原子、炭素原子数１乃至３の分枝鎖を有し得る炭素原子数１乃至７のアルキル基、フェニルメチル基、フェニルエチル基、又は－（ＣＨ2）ｎ－Ｘ基を表し、且つＲ2、Ｒ3、Ｒ4又はＲ5のうち少なくとも一つが－（ＣＨ2）ｎ－Ｘ基を表し、ｎは１乃至４の数を表し、Ｘはアミノ基、グアニジノ基、－ＣＯＮＨ2基、又は窒素原子を１乃至３個有し得る５員環若しくは６員環又は５員環と６員環から構成される縮合複素環を表し、ｍは１又は２を表す。）で表される脂質ペプチド及びそれからなるヒドロゲル。
PCT/JP2008/062212 2007-07-05 2008-07-04 新規脂質ペプチド並びにヒドロゲル WO2009005151A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/452,473 US8916682B2 (en) 2007-07-05 2008-07-04 Lipid peptide and hydrogel
JP2009521681A JP5441693B2 (ja) 2007-07-05 2008-07-04 新規脂質ペプチド並びにヒドロゲル
EP08790893.5A EP2172475B1 (en) 2007-07-05 2008-07-04 Lipid peptide for use as hydrogel
CN200880023439.9A CN101809028B (zh) 2007-07-05 2008-07-04 新型脂质肽和水凝胶
US13/685,565 US8816049B2 (en) 2007-07-05 2012-11-26 Lipid peptide and hydrogel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-177538 2007-07-05
JP2007177538 2007-07-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/452,473 A-371-Of-International US8916682B2 (en) 2007-07-05 2008-07-04 Lipid peptide and hydrogel
US13/685,565 Division US8816049B2 (en) 2007-07-05 2012-11-26 Lipid peptide and hydrogel

Publications (1)

Publication Number Publication Date
WO2009005151A1 true WO2009005151A1 (ja) 2009-01-08

Family

ID=40226189

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/062212 WO2009005151A1 (ja) 2007-07-05 2008-07-04 新規脂質ペプチド並びにヒドロゲル

Country Status (7)

Country Link
US (2) US8916682B2 (ja)
EP (2) EP2559697B1 (ja)
JP (1) JP5441693B2 (ja)
KR (1) KR101557796B1 (ja)
CN (1) CN101809028B (ja)
TW (1) TWI491617B (ja)
WO (1) WO2009005151A1 (ja)

Cited By (17)

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WO2010106981A1 (ja) 2009-03-16 2010-09-23 日産化学工業株式会社 低分子ゲル化剤からなるスプレー用基材
WO2010147158A1 (ja) * 2009-06-19 2010-12-23 日産化学工業株式会社 低分子ゲル化剤により化合物が内包されたゲル
WO2011027897A1 (ja) 2009-09-07 2011-03-10 日産化学工業株式会社 脂質ペプチド化合物の製造方法
WO2011052613A1 (ja) 2009-10-26 2011-05-05 日産化学工業株式会社 化粧料及び皮膚外用剤、並びに医療用機器
WO2012063947A1 (ja) 2010-11-12 2012-05-18 日産化学工業株式会社 脂質ペプチド型ゲル化剤と高分子化合物とを含有するゲルシート
WO2012133787A1 (ja) * 2011-03-31 2012-10-04 日産化学工業株式会社 化粧料の製造方法、化粧料用ゲルの調製方法及び化粧料原料に配合される高分子増粘剤の使用量を軽減する方法
WO2012144609A1 (ja) 2011-04-22 2012-10-26 日産化学工業株式会社 ヒドロゲル形成材料
WO2013094689A1 (ja) * 2011-12-21 2013-06-27 日産化学工業株式会社 水系リチウムイオン二次電池
WO2014003015A1 (ja) 2012-06-25 2014-01-03 日産化学工業株式会社 分散液及びヒドロゲル形成方法
WO2014054702A1 (ja) 2012-10-03 2014-04-10 日産化学工業株式会社 ヒドロゲル形成材料、プレミックス及びヒドロゲル形成方法
WO2014054699A1 (ja) 2012-10-03 2014-04-10 日産化学工業株式会社 ヒドロゲル形成材料
WO2015005219A1 (ja) 2013-07-09 2015-01-15 日産化学工業株式会社 分散液及びヒドロゲル形成方法
US20150367028A1 (en) * 2010-03-31 2015-12-24 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
US9925307B2 (en) 2010-03-31 2018-03-27 Agency For Science, Technology And Research Crosslinked peptide hydrogels
WO2020230697A1 (ja) * 2019-05-10 2020-11-19 国立大学法人九州大学 脂質ペプチド型ゲル化剤とポリアルキレンオキシドとを含有する高分子複合材料
US11452688B2 (en) 2015-01-28 2022-09-27 Kyushu University Transdermally absorbable base material containing lipid peptide compound

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WO2015099074A1 (ja) * 2013-12-25 2015-07-02 日産化学工業株式会社 脂質ペプチド型化合物を含有するスティック状基材
CN107735107A (zh) * 2015-06-24 2018-02-23 日产化学工业株式会社 含有脂质肽型化合物的棒状基材
CN106540339B (zh) * 2016-11-03 2019-04-09 东南大学 一种脂肽自组装凝胶及其制备方法和应用
AU2020274933A1 (en) * 2019-05-15 2021-09-30 Sekisui Chemical Co., Ltd. Cell culturing scaffolding material and cell culturing vessel
CN110204593A (zh) * 2019-05-17 2019-09-06 高邮市宇航化工机械厂 一种生物制药用多肽化合物的制备工艺
CN112587477A (zh) * 2020-12-24 2021-04-02 中科院过程工程研究所南京绿色制造产业创新研究院 一种棕榈酰肽水凝胶及其制备方法和用途

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WO2010106981A1 (ja) 2009-03-16 2010-09-23 日産化学工業株式会社 低分子ゲル化剤からなるスプレー用基材
TWI504737B (zh) * 2009-03-16 2015-10-21 Nissan Chemical Ind Ltd 低分子凝膠化劑所成之噴霧用基劑
CN102361951A (zh) * 2009-03-16 2012-02-22 日产化学工业株式会社 包含低分子胶凝剂的喷射用基材
JP5587290B2 (ja) * 2009-03-16 2014-09-10 日産化学工業株式会社 低分子ゲル化剤からなるスプレー用基材
US9333158B2 (en) 2009-03-16 2016-05-10 Nissan Chemical Industries, Ltd. Spray base material including low-molecular gelator
CN102361951B (zh) * 2009-03-16 2015-07-22 日产化学工业株式会社 包含低分子胶凝剂的喷射用基材
KR101736169B1 (ko) * 2009-03-16 2017-05-16 닛산 가가쿠 고교 가부시키 가이샤 저분자 겔화제로 이루어진 스프레이용 기재
JPWO2010106981A1 (ja) * 2009-03-16 2012-09-20 日産化学工業株式会社 低分子ゲル化剤からなるスプレー用基材
WO2010147158A1 (ja) * 2009-06-19 2010-12-23 日産化学工業株式会社 低分子ゲル化剤により化合物が内包されたゲル
JP5727932B2 (ja) * 2009-06-19 2015-06-03 日産化学工業株式会社 低分子ゲル化剤により化合物が内包されたゲル
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WO2011027897A1 (ja) 2009-09-07 2011-03-10 日産化学工業株式会社 脂質ペプチド化合物の製造方法
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EP2476691A4 (en) * 2009-09-07 2014-05-07 Nissan Chemical Ind Ltd METHOD FOR MANUFACTURING LIPID PEPTIDE COMPOUND
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US9561255B2 (en) 2009-10-26 2017-02-07 Nissan Chemical Industries, Ltd. Cosmetic, external skin preparation, and medical instrument
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US8999300B2 (en) 2009-10-26 2015-04-07 Nissan Chemical Industries Ltd. Cosmetic, external skin preparation, and medical instrument
JP5700222B2 (ja) * 2009-10-26 2015-04-15 日産化学工業株式会社 化粧料及び皮膚外用剤、並びに医療用機器
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JP2012213657A (ja) * 2009-10-26 2012-11-08 Nissan Chem Ind Ltd 医療用機器
US9687591B2 (en) 2010-03-31 2017-06-27 Agency For Science, Technology And Research Building stratified biomimetic tissues and organs using crosslinked ultrashort peptide hydrogel membranes
US10286110B2 (en) 2010-03-31 2019-05-14 Agency For Science, Technology And Research Crosslinked peptide hydrogels
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US10071183B2 (en) * 2010-03-31 2018-09-11 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
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US20150367028A1 (en) * 2010-03-31 2015-12-24 Agency For Science, Technology And Research Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US10293083B2 (en) 2010-03-31 2019-05-21 Agency For Science, Technology And Research Crosslinked peptide hydrogels
JP5904949B2 (ja) * 2010-11-12 2016-04-20 日産化学工業株式会社 脂質ペプチド型ゲル化剤と高分子化合物とを含有するゲルシート
KR101847385B1 (ko) 2010-11-12 2018-04-10 닛산 가가쿠 고교 가부시키 가이샤 지질 펩티드형 겔화제와 고분자 화합물을 함유하는 겔시트
US9480772B2 (en) 2010-11-12 2016-11-01 Nissan Chemical Industries, Ltd. Gel sheet containing lipid peptide gelator and polymeric compound
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