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WO2003011241A1 - Utilisation de creatinine et/ou de derives de la creatinine dans des preparations cosmetiques ou dermatologiques - Google Patents

Utilisation de creatinine et/ou de derives de la creatinine dans des preparations cosmetiques ou dermatologiques Download PDF

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Publication number
WO2003011241A1
WO2003011241A1 PCT/EP2002/008124 EP0208124W WO03011241A1 WO 2003011241 A1 WO2003011241 A1 WO 2003011241A1 EP 0208124 W EP0208124 W EP 0208124W WO 03011241 A1 WO03011241 A1 WO 03011241A1
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WO
WIPO (PCT)
Prior art keywords
skin
derivatives
prophylaxis
preparations
changes
Prior art date
Application number
PCT/EP2002/008124
Other languages
German (de)
English (en)
Other versions
WO2003011241A8 (fr
Inventor
Helga Biergiesser
Thomas Blatt
Inge Kruse
Melanie Schmidt
Uwe SCHÖNROCK
Franz STÄB
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Priority to EP02760258A priority Critical patent/EP1414401A1/fr
Priority to JP2003516473A priority patent/JP2004538299A/ja
Publication of WO2003011241A1 publication Critical patent/WO2003011241A1/fr
Publication of WO2003011241A8 publication Critical patent/WO2003011241A8/fr
Priority to US10/767,962 priority patent/US20040241197A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to the use of combinations of creatinine and / or creatinine derivatives with creatine and / or its derivatives in cosmetic or dermatological preparations for the treatment and prophylaxis of the symptoms of UV and / or ozone-induced skin damage as well as inflammatory and degenerative skin conditions.
  • Cosmetic skin care is understood primarily to strengthen or restore the skin's natural function as a barrier against environmental influences (e.g., dirt, chemicals, microorganisms) and against the loss of endogenous substances (e.g., water, natural fats, electrolytes).
  • environmental influences e.g., dirt, chemicals, microorganisms
  • endogenous substances e.g., water, natural fats, electrolytes
  • the aim of skin care is also to compensate for the daily loss of fat and water loss of the skin. This is especially important when the natural regeneration capacity is insufficient.
  • skin care products to protect against environmental influences, especially from the sun and wind, and delay the aging of the skin.
  • the chronological skin aging is caused eg by endogenous, genetically determined factors.
  • the epidermis and der is due to aging, for example, the following structural damage and dysfunction, which may also fall under the term "senile xerosis”: a) dryness, roughness and development of dryness wrinkles; b) itching; and c) reduced rehydration through sebaceous glands (eg after washing).
  • Exogenous factors such as UV light and chemical noxae can be cumulatively effective and e.g. accelerate or supplement endogenous aging processes.
  • exogenous factors occur, e.g. on the following structural damage and dysfunction in the skin that go beyond the extent and quality of the damage caused by chronological aging:
  • the present invention relates in particular to products for the care of naturally aged skin, as well as for the treatment of the consequential damages of photoageing, in particular of the phenomena listed under a) to g).
  • Products for the care of aged skin are known per se. They contain e.g. Retinoids (vitamin A acid and / or derivatives thereof) or vitamin A and / or its derivatives. Their effect on the structural damage, however, is limited in scope. In addition, there are significant difficulties in product development in stabilizing the active ingredients sufficiently against oxidative degradation. In addition, the use of vitamin A acid-containing products often causes severe erythematous skin irritation. Retinoids can therefore only be used in low concentrations.
  • the present invention relates to cosmetic preparations with effective protection against harmful oxidation processes in the skin, but also to protect cosmetic preparations themselves or to protect the ingredients of cosmetic preparations from harmful oxidation processes.
  • UVC range rays with a wavelength less than 290 nm
  • UVB range rays in the range between 290 nm and 320 nm, the so-called UVB range, cause erythema simple sunburn or even more or less severe burns.
  • UVA range it is important to have available filter substances, since its rays can cause reactions in photosensitive skin. It has been proven that UVA radiation leads to damage of the elastic and collagenous fibers of the connective tissue, which causes the skin to age prematurely, and that it is to be regarded as the cause of numerous phototoxic and photoallergic reactions. The damaging influence of UVB radiation can be amplified by UVA radiation.
  • UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products intervene in the skin metabolism.
  • such photochemical reaction products are free-radical compounds, for example hydroxy radicals.
  • Undefined radical photoproducts which are formed in the skin itself, can also show uncontrolled sequelae due to their high reactivity.
  • singlet oxygen a non-radical excited state of the oxygen molecule can occur on UV irradiation, as well as short-lived epoxides and many others. singlet For example, it is distinguished from the normally present triplet oxygen (radical ground state) by increased reactivity. However, there are also excited, reactive (radical) triplet states of the oxygen molecule.
  • UV radiation counts as ionizing radiation. There is thus the risk that ionic species may also be formed on exposure to UV radiation, which in turn may intervene oxidatively in the biochemical processes.
  • antioxidants and / or radical scavengers can be incorporated in the cosmetic or dermatological formulations.
  • vitamin E a substance with known antioxidant effect in sunscreen formulations, yet here again, the effect achieved far below the hoped for.
  • the object of the invention was therefore also to provide cosmetic, dermatological and pharmaceutical active ingredients and preparations as well as sunscreen formulations which are used for the prophylaxis and treatment of photosensitive skin, in particular photodermatoses, preferably PLD.
  • Mainly antioxidants are used as protective substances against spoilage of preparations containing them. Nevertheless, it is known that undesirable oxidation processes can also occur in human and animal skin. Such processes play an essential role in skin aging.
  • antioxidants and radical scavengers are known.
  • the object of the present invention was therefore to find ways that avoid the disadvantages of the prior art.
  • the effect of repairing the damage associated with endogenous, chronological and exogenous skin aging and the prophylaxis should be permanent, sustainable and without the risk of side effects.
  • Creatinine is included in meat extract and meatballs.
  • Creatine is formed in aqueous solution. In the organism it is formed by transamidation of L-arginine to glycine to guanidinoacetic acid and their subsequent methylation by means of S-adenosylmethionine (by guanidinoacetate methyltransferase). Creatine is thought to be an appetizing ingredient in beef and meat extract. Creatine supplementation increases physical performance.
  • Cosmetic or dermatological preparations according to the invention preferably comprise an active ingredient combination of 0.001-50% by weight, particularly preferably 0.01-15% by weight, very particularly preferably 0.1-8% by weight, of creatine and / or creatine derivatives with 0.001-50% by weight, particularly preferably 0.01-15% by weight, very particularly preferably 0.1-8% by weight of creatinine and / or creatinine derivatives, based on the total composition of the preparations. It is advantageous to choose the weight ratio of creatinine to creatine from the range of 50: 1 to 1:50, preferably from 10: 1 to 1:10, particularly preferably from 2: 1 to 1: 2.
  • Preferred derivative is the creatine phosphate, which has the following structure: and which is widespread in fresh muscle where it plays an important role as an energy-storing phosphate (Phosphagen).
  • Phosphagen an energy-storing phosphate
  • creatine phosphate with adenosine 5'-diphosphate under the influence of the enzyme creatine kinase, releases adenosine 5'-triphosphate (ATP) and creatine; in the resting muscle the reverse reaction takes place.
  • ATP adenosine 5'-triphosphate
  • JP2000 / 247866 describes skin cosmetics containing creatine and / or creatinine, which can be used as a cream or as a milky lotion, the preparations in question are said to have excellent skin-care properties.
  • this document could not pave the way for the present invention.
  • WO00 / 33787 describes the use of creatinine as an effective ingredient of deodorants. Even this document could not pave the way to the present invention.
  • EP-A 565 010 describes hair-growing and hair-dyeing preparations containing creatinine phosphate. Even this document could not pave the way to the present invention.
  • an effective way is surprisingly achieved Treatment, but also prophylaxis of deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive states of skin attachment of premature aging of the skin (eg wrinkles, age spots, telangiectasias) and / or skin appendages, of environmental (smoking, smog , reactive oxygen species, free radicals) and in particular light-induced negative changes of the skin and the skin appendages, of light-induced skin damage from pigmentation disorders, itching, dry skin conditions and horny layer barrier disorders, hair loss and for improved hair growth of inflammatory skin conditions and atopic eczema, seborrheic dermatitis, polymorphic Light dermatosis, psoriasis, vitiligo possible.
  • combination of active ingredients also surprisingly serves to soothe sensitive or irritated skin to stimulate the collagen, hyaluronic acid, elastin synthesis to stimulate intracellular DNA synthesis, especially in deficient or hypoactive skin conditions.
  • to increase the cell renewal and regeneration of the skin to increase the skin's own protective and repair mechanisms (for example for dysfunctional enzymes, DNA, lipids, proteins) for the pre- and post-treatment in topical application of laser and Abschleifnessen z.
  • As the reduction of skin wrinkles and scars serve to counteract the resulting skin irritation and promote the regeneration processes in the injured skin.
  • the active ingredient combination or cosmetic or topical dermatological preparations used according to the invention with an effective content of active ingredient combination used according to the invention for cosmetic or dermatological treatment or prophylaxis. desired skin conditions to use.
  • preparations containing the active compound combinations according to the invention can be used with customary antioxidants.
  • the antioxidants are selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urotanic acid) and derivatives thereof, peptides such as D, L-camosine, D-carnosine, L- Camosin and its derivatives (eg anserine), carotenoids, carotenes (eg ⁇ -carotene, ⁇ -carotene, lycopene) and their derivatives, lipoic acid and its derivatives (eg dihydrolipoic acid), rothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione , Cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl
  • ⁇ -hydroxyfatty acids eg citric acid, lactic acid, malic acid
  • humic acid eg citric acid, lactic acid, malic acid
  • bile acid bile extracts
  • bilirubin biliverdin
  • EDTA EDTA
  • EGTA EGTA and their derivatives
  • unsaturated fatty acids and their derivatives eg ⁇ -linolenic acid, linoleic acid, oleic acid
  • folic acid and its derivatives alaninediacetic acid, flavonoids, polyphenols, catechins, vitamin C and derivatives (eg ascorbyl palmitate, magnesium).
  • benzoic acid rutinic acid and its derivatives
  • the amount of antioxidants (one or more compounds) in the preparations is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular particular 1 - 10 wt .-%, based on the total weight of the preparation.
  • the prophylaxis or the cosmetic or dermatological treatment with the active ingredient combinations used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of the active ingredient combination used according to the invention is carried out in the usual way, in such a way that the active ingredient used according to the invention or the cosmetic or topical dermatological preparations having an effective content of active ingredient used according to the invention is applied to the affected skin areas.
  • the active ingredient combination used according to the invention can be incorporated into customary cosmetic and dermatological preparations which may be in various forms. So they can e.g. a solution, a water-in-oil (W / O) or oil-in-water (O / W) type emulsion, or a multiple emulsions, such as water-in-oil-in-water type (W / O / W) or oil-in-water-in-oil (O / W / O), a hydrodispersion or lipodispersion, a gel, a solid stick or even an aerosol.
  • W / O water-in-oil
  • O / W oil-in-water
  • O oil-in-water-in-oil
  • Emulsions according to the invention for the purposes of the present invention are advantageous and contain e.g. Fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers, as are commonly used for such a type of formulation.
  • Medicinal topical compositions according to the present invention usually contain one or more drugs in effective concentration.
  • drugs for the sake of simplicity, reference is made to the clear distinction between cosmetic and medical use and corresponding products to the statutory provisions of the Federal Republic of Germany (for example, Cosmetics Regulation, Food and Medicines Act).
  • cosmetic or topical dermatological compositions according to the present invention depending on their structure, for example, be used as skin protection cream, cleansing milk, sunscreen lotion, nutritional cream, day or night cream, etc. It may be possible and advantageous to use the compositions of the invention as a basis for pharmaceutical formulations use.
  • cosmetic and dermatological preparations which are in the form of a sunscreen agent are also advantageous.
  • these preferably additionally contain at least one UVA filter substance and / or at least one UVB filter substance and / or at least one inorganic pigment.
  • compositions according to the invention can advantageously contain substances which absorb UV radiation in the UVB range, the total amount of the filter substances being, for example, 0.1% by weight to 30% by weight, preferably 0.5% to 10% by weight, in particular 1% to 6 wt .-%, based on the total weight of the preparations.
  • the UVB filters may be oil-soluble or water-soluble.
  • oil-soluble substances are e.g. to call:
  • 4-aminobenzoic acid derivatives preferably (2- ethylhexyl) 4- (dimethylamino) benzoate, 4- (dimethylamino) benzoic acid amyl ester;
  • Esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
  • esters of salicylic acid preferably 2-ethylhexyl salicylate, salicylic acid
  • Esters of benzalmalonic acid preferably di (2-ethylhexyl) 4-methoxybenzalmalonate
  • Sulfonic acid derivatives of benzophenones preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
  • Sulfonic acid derivatives of the 3-benzylidene camphor e.g. 4- (2-oxo-3-bomylidene-methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfonic acid and its salts.
  • UVB filters which can be used according to the invention should of course not be limiting.
  • the invention also relates to the combination of a UVA film according to the invention ters with a UVB filter or a cosmetic or dermatological preparation according to the invention which also contains a UVB filter.
  • UVA filters in formulations according to the invention which are customarily contained in cosmetic and / or dermatological preparations.
  • Such filter substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1, 3-dione and 1-phenyl-3- ( 4'-isopropylphenyl) propane-1,3-dione.
  • preparations containing these combinations are the subject of the invention.
  • the same quantities of UVA filter substances which have been mentioned for UVB filter substances can be used.
  • Cosmetic and / or dermatological preparations according to the present invention may also contain inorganic pigments which are commonly used in cosmetics to protect the skin from UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as modifications in which the oxides are the active agents. Particular preference is given to pigments based on titanium dioxide. The amounts mentioned for the above combinations may be used.
  • the cosmetic and dermatological preparations according to the invention may contain cosmetic active substances, auxiliaries and / or additives such as are customarily used in such preparations, e.g. Antioxidants, preservatives, bactericides, perfumes, foaming inhibitors, colorants, pigments that have coloring properties, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.
  • cosmetic active substances e.g. Antioxidants, preservatives, bactericides, perfumes, foaming inhibitors, colorants, pigments that have coloring properties, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other conventional ingredients of a cosmetic or dermatological formulation such as alcohol
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion
  • solvent Water or aqueous solutions of oils, such as triglycerides of capric or caprylic acid, but preferably castor oil;
  • Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of from 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of from 3 to 30 carbon atoms. atoms.
  • ester oils can then advantageously be selected from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2- Hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and also synthetic, semisynthetic and natural mixtures of such esters, eg Jojoba oil.
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, in particular the triglycerol esters of saturated and / or unsaturated saturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 8 to 24, in particular 12 to 18 carbon atoms.
  • the fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm oil and the like.
  • any mixtures of such oil and wax components are also advantageous to use in the context of the present invention. It may also be advantageous, if appropriate, to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldodanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12-15 -alkyl benzoate, caprylic-capric acid triglyceride, dicaprylyl ether.
  • Particularly advantageous are mixtures of C 12-15 -alkyl benzoate and 2-Ethylhexylisostea- rat, mixtures of C 12-15 -alkyl benzoate and Isotridecylisononanoat and mixtures of C 12 .
  • hydrocarbons paraffin oil, squalane and squalene are to be used advantageously in the context of the present invention.
  • the oil phase can also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.
  • cyclomethicone octamethylcyclotetrasiloxane
  • silicone oils are also advantageous for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • the aqueous phase of the preparations according to the invention advantageously contains alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, di ethylene glycol monomethyl or monoethyl ether and analogous products, furthermore low C number alcohols, for example ethanol, isopropanol, 1,2-propanediol, glycerol, and in particular one or more thickening agents, which can be advantageously selected from the group silicon dioxide, aluminum silicates, Polysaccharides or their derivatives, for example
  • Gels used in the present invention usually contain low C number alcohols, e.g. Ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an above-mentioned oil in the presence of a thickener which is preferably silica or an aluminosilicate in oily-alcoholic gels, in aqueous-alcoholic or alcoholic gels, preferably a polyacrylate.
  • a thickener which is preferably silica or an aluminosilicate in oily-alcoholic gels, in aqueous-alcoholic or alcoholic gels, preferably a polyacrylate.
  • Fixed pins contain e.g. natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • Usual base materials which are suitable for use as cosmetic sticks in the context of the present invention are liquid oils (for example paraffin oils, castor oil, isopropyl myristate), semi-solid constituents (eg petrolatum, lanolin), solid constituents (eg beeswax, ceresin and microcrystalline Waxes or ozokerite) and high-melting waxes (eg carnauba wax, candelilla wax)
  • liquid oils for example paraffin oils, castor oil, isopropyl myristate
  • semi-solid constituents eg petrolatum, lanolin
  • solid constituents eg beeswax, ceresin and microcrystalline Waxes or ozokerite
  • high-melting waxes eg carnauba wax, candelilla wax
  • Suitable propellants for sprayable from aerosol containers cosmetic and / or dermatological preparations in the context of the present invention the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, compressed air is advantageous to use.
  • hydrocarbons propane, butane, isobutane
  • compressed air is advantageous to use.
  • propellants which would be useful in the practice of the present invention in the form of aerosol preparations, but which should be avoided due to adverse environmental effects or other concomitant conditions, especially fluorocarbons and chlorofluorocarbons (US Pat. CFC).
  • Cosmetic preparations for the purposes of the present invention may also be present as gels which, in addition to an effective content of the active ingredient according to the invention and solvents used for this purpose, preferably water, are also organic thickeners, e.g. Gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickeners, e.g. For example, aluminum silicates such as bentonites, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • the thickening agent is present in the gel e.g. in an amount of between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight.

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Abstract

Préparations cosmétiques ou dermatologiques présentant une teneur d'une combinaison de principes actifs de créatinine et de créatine.
PCT/EP2002/008124 2001-07-25 2002-07-22 Utilisation de creatinine et/ou de derives de la creatinine dans des preparations cosmetiques ou dermatologiques WO2003011241A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02760258A EP1414401A1 (fr) 2001-07-25 2002-07-22 Utilisation de creatinine et/ou de derives de la creatinine dans des preparations cosmetiques ou dermatologiques
JP2003516473A JP2004538299A (ja) 2001-07-25 2002-07-22 クレアチニンおよび／またはクレアチニン誘導体を化粧用および皮膚科学用調剤で用いる使用
US10/767,962 US20040241197A1 (en) 2001-07-25 2004-01-26 Cosmetic or dermatological preparations including creatinine or a derivative thereof and creatine or a derivative thereof and methods of applying the preparations to the skin

Applications Claiming Priority (2)

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DE10136076.2 2001-07-25
DE10136076A DE10136076A1 (de) 2001-07-25 2001-07-25 Verwendung von Kreatinin und/oder Kreatininderivaten in kosmetischen oder dermatologischen Zubereitungen

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064801A1 (fr) * 2003-01-17 2004-08-05 Beiersdorf Ag Preparations cosmetiques ou dermatologiques contenant de la creatine, de la creatinine et / ou leurs derives en combinaison avec des extraits de germe de graines de soja
WO2004089326A1 (fr) * 2003-04-10 2004-10-21 Beiersdorf Ag Preparations cosmetiques ou dermatologiques contenant une combinaison de creatinine, de creatine et de quinones biologiques
EP1535604A1 (fr) * 2003-11-26 2005-06-01 Beiersdorf AG Combinaison à base de créatine et/ou de créatinine, de phenoxyethanol et éventuallement de glycérine.
EP1535603A1 (fr) * 2003-11-26 2005-06-01 Beiersdorf AG Préparations cosmétique et dermatologique contenant de la créatine et/ou de la créatinine et des concentrations d'électrolytes d'au moins 50 mmol/l.
DE10355715A1 (de) * 2003-11-26 2005-06-16 Beiersdorf Ag Wirkstoffkombinationen Kreatin und/oder Kreatinderivaten und/oder Kreatinin und/oder Kreatininderivaten und einer wirksamen Menge an Retinoiden, insbesondere Retinol bzw. Retinylpalmitat und Zubereitungen, solche Wirkstoffkombinationen enthaltend
WO2009002913A1 (fr) * 2007-06-22 2008-12-31 Avicena Group, Inc. Utilisation de composés de créatine pour traiter une dermatite
WO2009046819A2 (fr) * 2007-10-01 2009-04-16 Beiersdorf Ag Procédé de réduction de symptômes cutanés de vieillissement
EP2123252A1 (fr) * 2003-02-28 2009-11-25 E-L Management Corp. Méthode visant a augmenter la croissance des cheveux
EP1535605B1 (fr) * 2003-11-26 2014-05-14 Beiersdorf AG Préparations cosmétiques contenant de la créatine et/ou des dérivés de la créatine et/ou de la créatinine et/ou des dérivés de la créatinine et un épaississant organique.

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10355717A1 (de) * 2003-11-26 2005-06-23 Beiersdorf Ag Kosmetische und dermatologische Emulsionen, enthaltend Kreatin und/oder Kreatinin mit gesteuerter Wasseraktivität
DE102004008440A1 (de) * 2004-02-19 2005-09-22 Stockhausen Gmbh Kosmetisches und/oder dermatologisches Mittel zur Steigerung des endogenen Lipidgehaltes der Haut

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63263060A (ja) * 1987-04-21 1988-10-31 Ajinomoto Co Inc 食品に煮干ダシの呈味を付与する方法
US5968544A (en) * 1996-05-31 1999-10-19 The Howard Foundation Compositions containing creatine
DE19841385A1 (de) * 1998-09-10 2000-03-16 Sueddeutsche Kalkstickstoff Verwendung von Kreatin und/oder Kreatin-derivaten als Feuchthaltemittel in kosmetischen Zubereitungen
JP2000247866A (ja) * 1998-12-28 2000-09-12 Lion Corp 皮膚外用剤
WO2000059519A2 (fr) * 1999-03-31 2000-10-12 Kapitz Carl Heinz Substance active et combinaison de substances actives pour l'homme et les animaux
DE19963628A1 (de) * 1999-12-29 2001-07-12 Knapp Gerhard Kolostralmilch von Ziegen und Schafen und deren Verwendung in Kosmetika, Pharmazeutika sowie in Nahrungs- und Nahrungsergänzungsmiteln
WO2002069740A1 (fr) * 2001-03-02 2002-09-12 The Howard Foundation Compositions contenant de la creatine et de la creatinine
WO2002076408A2 (fr) * 2001-03-24 2002-10-03 Wella Aktiengesellschaft Utilisation d'agents renfermant de la creatine, de la creatinine et/ou des derives de celles-ci afin de renforcer des fibres de keratine et d'ameliorer leur structure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647453A (en) * 1984-10-18 1987-03-03 Peritain, Ltd. Treatment for tissue degenerative inflammatory disease
US4590067A (en) * 1984-10-18 1986-05-20 Peritain, Ltd. Treatment for periodontal disease
US5091171B2 (en) * 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
IT1258069B (it) * 1992-04-10 1996-02-20 Composizione per uso topico avente attivita' di stimolo per la ricrescita, di rinvigorimento, di prevenzione dell'ingrigimento e di ripigmentazione naturale dei capelli
FR2786690A1 (fr) * 1998-12-08 2000-06-09 Oreal Composition cosmetique deodorante

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63263060A (ja) * 1987-04-21 1988-10-31 Ajinomoto Co Inc 食品に煮干ダシの呈味を付与する方法
US5968544A (en) * 1996-05-31 1999-10-19 The Howard Foundation Compositions containing creatine
DE19841385A1 (de) * 1998-09-10 2000-03-16 Sueddeutsche Kalkstickstoff Verwendung von Kreatin und/oder Kreatin-derivaten als Feuchthaltemittel in kosmetischen Zubereitungen
JP2000247866A (ja) * 1998-12-28 2000-09-12 Lion Corp 皮膚外用剤
WO2000059519A2 (fr) * 1999-03-31 2000-10-12 Kapitz Carl Heinz Substance active et combinaison de substances actives pour l'homme et les animaux
DE19963628A1 (de) * 1999-12-29 2001-07-12 Knapp Gerhard Kolostralmilch von Ziegen und Schafen und deren Verwendung in Kosmetika, Pharmazeutika sowie in Nahrungs- und Nahrungsergänzungsmiteln
WO2002069740A1 (fr) * 2001-03-02 2002-09-12 The Howard Foundation Compositions contenant de la creatine et de la creatinine
WO2002076408A2 (fr) * 2001-03-24 2002-10-03 Wella Aktiengesellschaft Utilisation d'agents renfermant de la creatine, de la creatinine et/ou des derives de celles-ci afin de renforcer des fibres de keratine et d'ameliorer leur structure

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURKE D G ET AL: "Analysis of creatine and creatinine in urine by capillary electrophoresis", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 732, no. 2, 24 September 1999 (1999-09-24), pages 479 - 485, XP004181090, ISSN: 0378-4347 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 069 (C - 569) 16 February 1989 (1989-02-16) *
PATENT ABSTRACTS OF JAPAN vol. 2000, no. 12 3 January 2001 (2001-01-03) *

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064801A1 (fr) * 2003-01-17 2004-08-05 Beiersdorf Ag Preparations cosmetiques ou dermatologiques contenant de la creatine, de la creatinine et / ou leurs derives en combinaison avec des extraits de germe de graines de soja
EP2123252A1 (fr) * 2003-02-28 2009-11-25 E-L Management Corp. Méthode visant a augmenter la croissance des cheveux
WO2004089326A1 (fr) * 2003-04-10 2004-10-21 Beiersdorf Ag Preparations cosmetiques ou dermatologiques contenant une combinaison de creatinine, de creatine et de quinones biologiques
EP1535605B1 (fr) * 2003-11-26 2014-05-14 Beiersdorf AG Préparations cosmétiques contenant de la créatine et/ou des dérivés de la créatine et/ou de la créatinine et/ou des dérivés de la créatinine et un épaississant organique.
DE10355715A1 (de) * 2003-11-26 2005-06-16 Beiersdorf Ag Wirkstoffkombinationen Kreatin und/oder Kreatinderivaten und/oder Kreatinin und/oder Kreatininderivaten und einer wirksamen Menge an Retinoiden, insbesondere Retinol bzw. Retinylpalmitat und Zubereitungen, solche Wirkstoffkombinationen enthaltend
EP1535603A1 (fr) * 2003-11-26 2005-06-01 Beiersdorf AG Préparations cosmétique et dermatologique contenant de la créatine et/ou de la créatinine et des concentrations d'électrolytes d'au moins 50 mmol/l.
EP1535604A1 (fr) * 2003-11-26 2005-06-01 Beiersdorf AG Combinaison à base de créatine et/ou de créatinine, de phenoxyethanol et éventuallement de glycérine.
EP2796136A1 (fr) * 2003-11-26 2014-10-29 Beiersdorf AG Préparations cosmétiques ayant une teneur de créatine et/ou des dérivés de créatine et des épaississants organiques
US10682534B2 (en) 2003-11-26 2020-06-16 Beiersdorf, Ag Cosmetic preparations containing creatine and/or creatinine and organic thickeners
US10888719B2 (en) 2003-11-26 2021-01-12 Beiersdorf Ag Active substance combination of creatine and/or creatinine and phenoxyethanol
WO2009002913A1 (fr) * 2007-06-22 2008-12-31 Avicena Group, Inc. Utilisation de composés de créatine pour traiter une dermatite
WO2009046819A2 (fr) * 2007-10-01 2009-04-16 Beiersdorf Ag Procédé de réduction de symptômes cutanés de vieillissement
WO2009046819A3 (fr) * 2007-10-01 2009-08-06 Beiersdorf Ag Procédé de réduction de symptômes cutanés de vieillissement

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WO2003011241A8 (fr) 2003-03-20
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DE10136076A1 (de) 2003-02-13

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