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WO2001032127A3 - Method and compositions for treating pulmonary diseases - Google Patents

Method and compositions for treating pulmonary diseases Download PDF

Info

Publication number
WO2001032127A3
WO2001032127A3 PCT/US2000/030113 US0030113W WO0132127A3 WO 2001032127 A3 WO2001032127 A3 WO 2001032127A3 US 0030113 W US0030113 W US 0030113W WO 0132127 A3 WO0132127 A3 WO 0132127A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
pulmonary diseases
treating pulmonary
treating
diseases
Prior art date
Application number
PCT/US2000/030113
Other languages
French (fr)
Other versions
WO2001032127A2 (en
Inventor
Peter N Goodfellow
Richard Nieman
Theodore J Torphy
Original Assignee
Smithkline Beecham Corp
Peter N Goodfellow
Richard Nieman
Theodore J Torphy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IL14936700A priority Critical patent/IL149367A0/en
Priority to AU13575/01A priority patent/AU1357501A/en
Application filed by Smithkline Beecham Corp, Peter N Goodfellow, Richard Nieman, Theodore J Torphy filed Critical Smithkline Beecham Corp
Priority to JP2001534335A priority patent/JP2003513028A/en
Priority to KR1020027005609A priority patent/KR20020057988A/en
Priority to SK759-2002A priority patent/SK7592002A3/en
Priority to CA002388333A priority patent/CA2388333A1/en
Priority to PL00355261A priority patent/PL355261A1/en
Priority to EP00975533A priority patent/EP1225866A4/en
Priority to BR0015270-6A priority patent/BR0015270A/en
Priority to DZ003225A priority patent/DZ3225A1/en
Priority to APAP/P/2002/002496A priority patent/AP2002002496A0/en
Priority to HU0203152A priority patent/HUP0203152A3/en
Priority to EA200200518A priority patent/EA200200518A1/en
Priority to MXPA02004350A priority patent/MXPA02004350A/en
Publication of WO2001032127A2 publication Critical patent/WO2001032127A2/en
Publication of WO2001032127A3 publication Critical patent/WO2001032127A3/en
Priority to NO20022057A priority patent/NO20022057L/en
Priority to BG106748A priority patent/BG106748A/en
Priority to HK02109234.5A priority patent/HK1049107A1/en
Priority to US11/217,532 priority patent/US20060035877A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention relates to treating pulmonary diseases such as chronic obstructive pulmonary disease or asthma by administering a phosphodiesterase 4 inhibitor in combination with anti-inflammatory corticosteroid.
PCT/US2000/030113 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases WO2001032127A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
APAP/P/2002/002496A AP2002002496A0 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases.
DZ003225A DZ3225A1 (en) 1999-11-02 2000-11-01 METHOD AND COMPOSITIONS FOR THE TREATMENT OF LUNG DISEASES
HU0203152A HUP0203152A3 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
AU13575/01A AU1357501A (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
SK759-2002A SK7592002A3 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
CA002388333A CA2388333A1 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
PL00355261A PL355261A1 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
EP00975533A EP1225866A4 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
BR0015270-6A BR0015270A (en) 1999-11-02 2000-11-01 Method and compositions for treating lung diseases
IL14936700A IL149367A0 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
KR1020027005609A KR20020057988A (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases
JP2001534335A JP2003513028A (en) 1999-11-02 2000-11-01 Methods and compositions for treating lung disease
EA200200518A EA200200518A1 (en) 1999-11-02 2000-11-01 METHOD AND COMPOSITION FOR THE TREATMENT OF PULMONARY DISEASES
MXPA02004350A MXPA02004350A (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases.
NO20022057A NO20022057L (en) 1999-11-02 2002-04-30 Method and composition for treating pulmonary diseases
BG106748A BG106748A (en) 1999-11-02 2002-05-29 Method and compositions for treating pulmonary diseases
HK02109234.5A HK1049107A1 (en) 1999-11-02 2002-12-19 Method and compositions for treating pulmonary diseases
US11/217,532 US20060035877A1 (en) 1999-11-02 2005-09-01 Method and compositions for treating pulmonary diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16315899P 1999-11-02 1999-11-02
US60/163,158 1999-11-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10129311 A-371-Of-International 2002-05-02
US10/847,223 Continuation US20040214805A1 (en) 1999-11-02 2004-05-17 Method and compositions for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
WO2001032127A2 WO2001032127A2 (en) 2001-05-10
WO2001032127A3 true WO2001032127A3 (en) 2001-12-06

Family

ID=22588737

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/030113 WO2001032127A2 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases

Country Status (29)

Country Link
EP (1) EP1225866A4 (en)
JP (1) JP2003513028A (en)
KR (1) KR20020057988A (en)
CN (1) CN1387404A (en)
AP (1) AP2002002496A0 (en)
AR (1) AR029189A1 (en)
AU (1) AU1357501A (en)
BG (1) BG106748A (en)
BR (1) BR0015270A (en)
CA (1) CA2388333A1 (en)
CO (1) CO5261512A1 (en)
CZ (1) CZ20021512A3 (en)
DZ (1) DZ3225A1 (en)
EA (1) EA200200518A1 (en)
EC (1) ECSP003747A (en)
HK (1) HK1049107A1 (en)
HU (1) HUP0203152A3 (en)
IL (1) IL149367A0 (en)
MA (1) MA26841A1 (en)
MX (1) MXPA02004350A (en)
NO (1) NO20022057L (en)
OA (1) OA12076A (en)
PE (1) PE20011005A1 (en)
PL (1) PL355261A1 (en)
SK (1) SK7592002A3 (en)
TR (1) TR200201211T2 (en)
TW (1) TWI242431B (en)
WO (1) WO2001032127A2 (en)
ZA (1) ZA200203435B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024489A2 (en) 2001-09-19 2003-03-27 Altana Pharma Ag Combination of a nsaid and a pde-4 inhibitor
US20040259863A1 (en) * 2001-10-31 2004-12-23 Hans-Michael Eggenweiler Type 4 phosphodiesterase inhibitors and uses thereof
UA82323C2 (en) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Novel combination of a glucocorticoid and pde-inhibitor for the treatment of respiratory diseases, allergic diseases, asthma and chronic obstructive pulmonary diseases
TW200410923A (en) * 2002-10-17 2004-07-01 Ono Pharmaceutical Co Therapeutic agent for chronic obstructive pulmonary disease
EP1616569A1 (en) * 2003-03-31 2006-01-18 Kyowa Hakko Kogyo Co., Ltd. Medicinal composition
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20070287689A1 (en) * 2004-10-13 2007-12-13 Kyowa Hakko Kogyo Co., Ltd. Therapeutic And/Or Preventive Agents For Chronic Skin Diseases
EP1948167A1 (en) * 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Compositions of phosphodiesterase type iv inhibitors
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7174794A (en) * 1993-06-18 1995-01-17 Smithkline Beecham Corporation Compounds
DE4332041C2 (en) * 1993-09-21 1997-12-11 Rentschler Arzneimittel Use of pentoxifylline in certain lung diseases
PE44995A1 (en) * 1994-01-27 1995-12-18 Schering Corp MOMETASONE FUROATE FOR THE TREATMENT OF LUNG DISEASES AND RESPIRATORY TRACT
SE9801368D0 (en) * 1998-04-20 1998-04-20 Astra Ab New use

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BR. J. PHARMACOL., vol. 118, no. 5, 1996, pages 1201 - 1208 *
BR. J. PHARMACOL., vol. 119, no. 6, 1996, pages 1255 - 1261 *
DATABASE BIOSIS [online] DEPT. PHARMACOL., KING'S COLL. LONDON, (LONDON, UK); BANNER ET AL.: "The effect of selective phosphodiesterase inhibitors in comparison with other anti-asthma drugs on allergen-induced eosinophilia in Guinea-Pig airways", XP002938256, accession no. STN Database accession no. 1995:554394 *
DATABASE CA [online] DEPARTMENT OF PHARMACOLOGY, GIFU PHARMACEUTICAL UNIVERSITY, (GIFU, JAPAN); KIMATA ET AL.: "Pharmacological modulation of LPS-induced MIP-1 or production by peripheral blood mononuclear cells", XP002938253, accession no. STN Database accession no. 128:265772 *
DATABASE CA [online] DEPARTMENT OF PHARMACOLOGY, KING'S COLLEGE LONDON, (LONDON, ENGLAND); BANNER ET AL.: "The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti-asthma drugs on inflammatory cell activation", XP002938254, accession no. STN Database accession no. 126:14486 *
DATABASE CA [online] INFLAMMATION BIOLOGY, THERAPEUTICS, LTD. (SLOUGH, UK); GOZZARD ET AL.: "Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase Type 4 inhibitor CDP840 on antigen-induced airway responses in neonatally immunized rabbits", XP002938255, accession no. STN Database accession no. 125:132083 *
PHARMACOLOGY, vol. 56, no. 5, 1998, pages 230 - 236 *
PULMONERY PHARMACOLOGY, vol. 8, no. 1, 1995, pages 37 - 42 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method

Also Published As

Publication number Publication date
PL355261A1 (en) 2004-04-05
NO20022057L (en) 2002-06-27
TR200201211T2 (en) 2002-08-21
NO20022057D0 (en) 2002-04-30
AP2002002496A0 (en) 2002-06-30
EP1225866A2 (en) 2002-07-31
HUP0203152A2 (en) 2003-01-28
CN1387404A (en) 2002-12-25
BG106748A (en) 2003-02-28
EA200200518A1 (en) 2002-10-31
BR0015270A (en) 2002-06-18
CA2388333A1 (en) 2001-05-10
ECSP003747A (en) 2002-05-23
TWI242431B (en) 2005-11-01
IL149367A0 (en) 2002-11-10
MXPA02004350A (en) 2002-11-07
AR029189A1 (en) 2003-06-18
JP2003513028A (en) 2003-04-08
CZ20021512A3 (en) 2003-04-16
DZ3225A1 (en) 2001-05-10
SK7592002A3 (en) 2002-11-06
HK1049107A1 (en) 2003-05-02
PE20011005A1 (en) 2001-09-28
EP1225866A4 (en) 2004-04-21
AU1357501A (en) 2001-05-14
CO5261512A1 (en) 2003-03-31
KR20020057988A (en) 2002-07-12
WO2001032127A2 (en) 2001-05-10
OA12076A (en) 2006-05-04
HUP0203152A3 (en) 2004-06-28
ZA200203435B (en) 2003-06-25
MA26841A1 (en) 2004-12-20

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