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EP1225866A4 - Method and compositions for treating pulmonary diseases - Google Patents

Method and compositions for treating pulmonary diseases

Info

Publication number
EP1225866A4
EP1225866A4 EP00975533A EP00975533A EP1225866A4 EP 1225866 A4 EP1225866 A4 EP 1225866A4 EP 00975533 A EP00975533 A EP 00975533A EP 00975533 A EP00975533 A EP 00975533A EP 1225866 A4 EP1225866 A4 EP 1225866A4
Authority
EP
European Patent Office
Prior art keywords
compositions
pulmonary diseases
treating pulmonary
treating
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00975533A
Other languages
German (de)
French (fr)
Other versions
EP1225866A2 (en
Inventor
Peter N Goodfellow
Richard Nieman
Theodore J Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1225866A2 publication Critical patent/EP1225866A2/en
Publication of EP1225866A4 publication Critical patent/EP1225866A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

This invention relates to treating pulmonary diseases such as chronic obstructive pulmonary disease or asthma by administering a phosphodiesterase 4 inhibitor in combination with anti-inflammatory corticosteroid.
EP00975533A 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases Withdrawn EP1225866A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16315899P 1999-11-02 1999-11-02
US163158P 1999-11-02
PCT/US2000/030113 WO2001032127A2 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
EP1225866A2 EP1225866A2 (en) 2002-07-31
EP1225866A4 true EP1225866A4 (en) 2004-04-21

Family

ID=22588737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00975533A Withdrawn EP1225866A4 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases

Country Status (29)

Country Link
EP (1) EP1225866A4 (en)
JP (1) JP2003513028A (en)
KR (1) KR20020057988A (en)
CN (1) CN1387404A (en)
AP (1) AP2002002496A0 (en)
AR (1) AR029189A1 (en)
AU (1) AU1357501A (en)
BG (1) BG106748A (en)
BR (1) BR0015270A (en)
CA (1) CA2388333A1 (en)
CO (1) CO5261512A1 (en)
CZ (1) CZ20021512A3 (en)
DZ (1) DZ3225A1 (en)
EA (1) EA200200518A1 (en)
EC (1) ECSP003747A (en)
HK (1) HK1049107A1 (en)
HU (1) HUP0203152A3 (en)
IL (1) IL149367A0 (en)
MA (1) MA26841A1 (en)
MX (1) MXPA02004350A (en)
NO (1) NO20022057L (en)
OA (1) OA12076A (en)
PE (1) PE20011005A1 (en)
PL (1) PL355261A1 (en)
SK (1) SK7592002A3 (en)
TR (1) TR200201211T2 (en)
TW (1) TWI242431B (en)
WO (1) WO2001032127A2 (en)
ZA (1) ZA200203435B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024489A2 (en) 2001-09-19 2003-03-27 Altana Pharma Ag Combination of a nsaid and a pde-4 inhibitor
US20040259863A1 (en) * 2001-10-31 2004-12-23 Hans-Michael Eggenweiler Type 4 phosphodiesterase inhibitors and uses thereof
UA82323C2 (en) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Novel combination of a glucocorticoid and pde-inhibitor for the treatment of respiratory diseases, allergic diseases, asthma and chronic obstructive pulmonary diseases
TW200410923A (en) * 2002-10-17 2004-07-01 Ono Pharmaceutical Co Therapeutic agent for chronic obstructive pulmonary disease
EP1616569A1 (en) * 2003-03-31 2006-01-18 Kyowa Hakko Kogyo Co., Ltd. Medicinal composition
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20070287689A1 (en) * 2004-10-13 2007-12-13 Kyowa Hakko Kogyo Co., Ltd. Therapeutic And/Or Preventive Agents For Chronic Skin Diseases
EP1948167A1 (en) * 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Compositions of phosphodiesterase type iv inhibitors
JP6017961B2 (en) 2010-01-05 2016-11-02 マイクロドース セラピューテクス，インコーポレイテッド Inhalation device and method
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000139A1 (en) * 1993-06-18 1995-01-05 Smithkline Beecham Corporation Compounds
DE4332041A1 (en) * 1993-09-21 1995-03-23 Rentschler Arzneimittel Use of pentoxifylline for the treatment of granulomatous and fibrotic pulmonary disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE44995A1 (en) * 1994-01-27 1995-12-18 Schering Corp MOMETASONE FUROATE FOR THE TREATMENT OF LUNG DISEASES AND RESPIRATORY TRACT
SE9801368D0 (en) * 1998-04-20 1998-04-20 Astra Ab New use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000139A1 (en) * 1993-06-18 1995-01-05 Smithkline Beecham Corporation Compounds
DE4332041A1 (en) * 1993-09-21 1995-03-23 Rentschler Arzneimittel Use of pentoxifylline for the treatment of granulomatous and fibrotic pulmonary disorders

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MURDOCH R ET AL: "The addition of SB 207499 (ARIFLO), a novel and selective PDE4 inhibitor, to oral prednisolone, is safe and well tolerated", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. SUPPL. 28, September 1998 (1998-09-01), European Respiratory Society Annual Congress;Geneva, Switzerland; September 19-23, 1998, pages 362S, XP009026674, ISSN: 0903-1936 *
NORMAN P: "PDE4 inhibitors 1999", EXPERT OPINION ON THERAPEUTIC PATENTS 1999 UNITED KINGDOM, vol. 9, no. 8, 1999, pages 1101 - 1118, XP001058161, ISSN: 1354-3776 *
SILVESTRE J ET AL: "SB-207499. Antiasthmatic/antiinflammatory phosphodiesterase IV inhibitor", DRUGS OF THE FUTURE 1998 SPAIN, vol. 23, no. 6, 1998, pages 607 - 615, XP000981875, ISSN: 0377-8282 *
TORPHY T J ET AL: "ARIFLO (SB 207499), A SECOND GENERATION PHOSPHODIESTERASE 4 INHIBITOR FOR THE TREATMENT OF ASTHMA AND COPD: FROM CONCEPT TO CLINIC", PULMONARY PHARMACOLOGY AND THERAPEUTICS, ACADEMIC PRESS, NEW YORK, NY, US, vol. 12, no. 2, 1999, pages 131 - 135, XP001155797, ISSN: 1094-5539 *

Also Published As

Publication number Publication date
PL355261A1 (en) 2004-04-05
NO20022057L (en) 2002-06-27
TR200201211T2 (en) 2002-08-21
NO20022057D0 (en) 2002-04-30
AP2002002496A0 (en) 2002-06-30
EP1225866A2 (en) 2002-07-31
HUP0203152A2 (en) 2003-01-28
CN1387404A (en) 2002-12-25
BG106748A (en) 2003-02-28
EA200200518A1 (en) 2002-10-31
BR0015270A (en) 2002-06-18
CA2388333A1 (en) 2001-05-10
ECSP003747A (en) 2002-05-23
TWI242431B (en) 2005-11-01
IL149367A0 (en) 2002-11-10
MXPA02004350A (en) 2002-11-07
AR029189A1 (en) 2003-06-18
JP2003513028A (en) 2003-04-08
CZ20021512A3 (en) 2003-04-16
DZ3225A1 (en) 2001-05-10
SK7592002A3 (en) 2002-11-06
HK1049107A1 (en) 2003-05-02
WO2001032127A3 (en) 2001-12-06
PE20011005A1 (en) 2001-09-28
AU1357501A (en) 2001-05-14
CO5261512A1 (en) 2003-03-31
KR20020057988A (en) 2002-07-12
WO2001032127A2 (en) 2001-05-10
OA12076A (en) 2006-05-04
HUP0203152A3 (en) 2004-06-28
ZA200203435B (en) 2003-06-25
MA26841A1 (en) 2004-12-20

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