WO1998047541B1 - Agents de contraste - Google Patents
Agents de contrasteInfo
- Publication number
- WO1998047541B1 WO1998047541B1 PCT/GB1998/001197 GB9801197W WO9847541B1 WO 1998047541 B1 WO1998047541 B1 WO 1998047541B1 GB 9801197 W GB9801197 W GB 9801197W WO 9847541 B1 WO9847541 B1 WO 9847541B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- matter
- vector
- formula
- subject
- Prior art date
Links
- 239000002872 contrast media Substances 0.000 title claims 6
- 239000000203 mixture Substances 0.000 claims abstract 19
- 230000001809 detectable Effects 0.000 claims abstract 6
- 230000033115 angiogenesis Effects 0.000 claims abstract 5
- 238000003384 imaging method Methods 0.000 claims abstract 2
- 125000005647 linker group Chemical group 0.000 claims abstract 2
- 125000000962 organic group Chemical group 0.000 claims abstract 2
- 241000894007 species Species 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 4
- 210000002889 Endothelial Cells Anatomy 0.000 claims 3
- -1 N-hydroxyamino Chemical group 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108010042918 Integrin alpha5beta1 Proteins 0.000 claims 2
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 claims 2
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 108010044426 integrins Proteins 0.000 claims 2
- 102000006495 integrins Human genes 0.000 claims 2
- 239000002184 metal Chemical group 0.000 claims 2
- 125000000143 2-carboxyethyl group Chemical group [H]OC(=O)C([H])([H])C([H])([H])* 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical class OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- GHGCFJGBPOQLPE-UHFFFAOYSA-N N-(6-aminohexyl)-2-[3-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-2H-imidazol-1-yl]acetamide Chemical compound C1=CN(CC(=O)NCCCCCCN)CN1CC(C=1C(=CC(Cl)=CC=1)Cl)OCC1=CC=C(Cl)C=C1 GHGCFJGBPOQLPE-UHFFFAOYSA-N 0.000 claims 1
- 108010043958 Peptoids Proteins 0.000 claims 1
- 108091007928 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- AXJDEHNQPMZKOS-UHFFFAOYSA-N acetylazanium;chloride Chemical compound [Cl-].CC([NH3+])=O AXJDEHNQPMZKOS-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001268 conjugating Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- NFPRBYPETYFMKO-UHFFFAOYSA-N hexan-1-amine Chemical group [CH2]CCCCCN NFPRBYPETYFMKO-UHFFFAOYSA-N 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- FUXJMHXHGDAHPD-UHFFFAOYSA-N pyrimidine-2-carboxamide Chemical compound NC(=O)C1=NC=CC=N1 FUXJMHXHGDAHPD-UHFFFAOYSA-N 0.000 claims 1
Abstract
L'invention porte sur une composition de la formule V - L - R dans laquelle V représente une fraction vectorielle ayant une affinité pour un récepteur de cellules endothéliales intervenant dans l'angiogenèse, L représente une fraction de liaison ou une liaison et R représente une fraction détectable. La caractéristique de cette invention est que V représente un groupe organique non peptidique ou est peptidique, et que R représente une espèce macromoléculaire ou particulaire générant une multitude d'étiquettes détectables dans l'imagerie in vivo.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK04007226T DK1442751T3 (da) | 1997-04-24 | 1998-04-24 | Diagnostisk billeddannelsesteknik |
JP54530798A JP4993419B2 (ja) | 1997-04-24 | 1998-04-24 | 造影剤 |
DE69824842T DE69824842T2 (de) | 1997-04-24 | 1998-04-24 | Kontrastmittel, die auf angiogenese-rezeptoren zielen |
AU70687/98A AU7068798A (en) | 1997-04-24 | 1998-04-24 | Contrast agents |
AT98917461T ATE270116T1 (de) | 1997-04-24 | 1998-04-24 | Kontrastmittel, die auf angiogenese-rezeptoren zielen |
EP98917461A EP0977600B1 (fr) | 1997-04-24 | 1998-04-24 | Agents de contraste qui ciblent les recepteurs de l'angiogenese |
US09/422,977 US6610269B1 (en) | 1997-04-24 | 1999-10-22 | Contrast agents |
US10/462,836 US7413727B2 (en) | 1997-04-24 | 2003-06-17 | Contrast agents |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9708265.5 | 1997-04-24 | ||
GBGB9708265.5A GB9708265D0 (en) | 1997-04-24 | 1997-04-24 | Contrast agents |
US4804497P | 1997-05-30 | 1997-05-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/422,977 Continuation US6610269B1 (en) | 1997-04-24 | 1999-10-22 | Contrast agents |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998047541A1 WO1998047541A1 (fr) | 1998-10-29 |
WO1998047541B1 true WO1998047541B1 (fr) | 1998-11-26 |
Family
ID=10811256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1998/001197 WO1998047541A1 (fr) | 1997-04-24 | 1998-04-24 | Agents de contraste |
Country Status (10)
Country | Link |
---|---|
US (2) | US6610269B1 (fr) |
EP (2) | EP1442751B1 (fr) |
JP (1) | JP4993419B2 (fr) |
AT (2) | ATE365054T1 (fr) |
AU (1) | AU7068798A (fr) |
DE (2) | DE69824842T2 (fr) |
DK (1) | DK1442751T3 (fr) |
ES (2) | ES2224379T3 (fr) |
GB (1) | GB9708265D0 (fr) |
WO (1) | WO1998047541A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9295737B2 (en) | 2002-03-01 | 2016-03-29 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US9408926B2 (en) | 2002-03-01 | 2016-08-09 | Bracco Suisse S.A. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
US6245318B1 (en) | 1997-05-27 | 2001-06-12 | Mallinckrodt Inc. | Selectively binding ultrasound contrast agents |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
EP1068224B1 (fr) | 1998-03-31 | 2005-05-11 | Bristol-Myers Squibb Pharma Company | Produits pharmaceutiques pour l'imagerie de troubles angiogenes |
DE19845798A1 (de) * | 1998-09-29 | 2000-04-13 | Schering Ag | Verwendung von Neoangiogenese-Markern für Diagnose und Therapie von Tumoren, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
US6284223B1 (en) * | 1998-10-15 | 2001-09-04 | Fluoroprobe, Inc. | Method for viewing tumor tissue located within a body cavity |
US6652836B2 (en) | 1998-10-15 | 2003-11-25 | Fluoroprobe, Inc. | Method for viewing tumor tissue located within a body cavity |
US6299860B1 (en) | 1998-10-15 | 2001-10-09 | Fluoro Probe, Inc. | Method for viewing diseased tissue located within a body cavity |
IL142958A0 (en) | 1998-12-18 | 2002-04-21 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
TR200101757T2 (tr) | 1998-12-18 | 2001-12-21 | Dupont Pharmaceuticais Company | Vitronektin reseptör antagonisti farmasötikler |
DE19924138A1 (de) | 1999-05-26 | 2000-11-30 | Henkel Kgaa | Lösbare Klebeverbindungen |
GB9922173D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
CA2387767A1 (fr) * | 1999-10-15 | 2001-04-26 | Henricus P. C. Hogenkamp | Conjugues de cobalamine utilises comme agents d'imagerie et therapeutiques |
DE19951599A1 (de) * | 1999-10-27 | 2001-05-23 | Henkel Kgaa | Verfahren zur adhesiven Trennung von Klebeverbunden |
AU2001227837A1 (en) * | 2000-01-12 | 2001-07-24 | Light Sciences Corporation | Novel treatment for eye disease |
US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
US6989139B2 (en) * | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
PT1272507E (pt) * | 2000-04-12 | 2005-11-30 | Amersham Health As | Derivados de peptidos para ligacao a integrina |
EP2279757A3 (fr) * | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Composés pour le ciblage de cellules endothéliales |
US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
AU2001275210B2 (en) | 2000-06-02 | 2006-09-28 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates |
AU7002501A (en) * | 2000-06-21 | 2002-01-02 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals for use in combination therapy |
DE10037884A1 (de) * | 2000-08-03 | 2002-02-21 | Henkel Kgaa | Verfahren zur beschleunigten Klebstoffaushärtung |
NO20004795D0 (no) | 2000-09-26 | 2000-09-26 | Nycomed Imaging As | Peptidbaserte forbindelser |
BRPI0210886B8 (pt) | 2001-07-10 | 2021-05-25 | Amersham Health As | composto, composição farmacêutica, uso de um composto, e, métodos de geração de imagens, de monitoração do efeito do tratamento de um corpo humano ou animal com uma droga para combater uma condição associada com câncer e de tratamento de câncer ou de uma doença relacionada em um corpo humano ou animal |
US7087212B2 (en) * | 2001-08-17 | 2006-08-08 | Mallinckrodt, Inc | Multicomponent assemblies having enhanced binding properties for diagnosis and therapy |
US20030100830A1 (en) * | 2001-11-27 | 2003-05-29 | Sheng-Ping Zhong | Implantable or insertable medical devices visible under magnetic resonance imaging |
US7666979B2 (en) | 2002-03-01 | 2010-02-23 | Bracco International B.V. | Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same |
US20050250700A1 (en) * | 2002-03-01 | 2005-11-10 | Sato Aaron K | KDR and VEGF/KDR binding peptides |
US7211240B2 (en) | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
US7985402B2 (en) * | 2002-03-01 | 2011-07-26 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
WO2004065621A1 (fr) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Peptides de liaison kdr et vegf/kdr et leur utilisation a des fins diagnostiques et therapeutiques |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
EP1369134A1 (fr) * | 2002-06-05 | 2003-12-10 | Bracco Imaging S.p.A. | Agents pour procédé d'imagerie magnétique |
JP2004138397A (ja) * | 2002-10-15 | 2004-05-13 | Kyowa Hakko Kogyo Co Ltd | 特定部位に集積する化合物のスクリーニング方法 |
AU2004217894B2 (en) | 2003-03-03 | 2010-07-15 | Bracco International B.V. | Peptides that specifically bind HGF receptor (cMet) and uses thereof |
JP2007521254A (ja) * | 2003-06-25 | 2007-08-02 | ゲルベ | 診断画像用化合物 |
FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
NO20034350D0 (no) * | 2003-09-29 | 2003-09-29 | Amersham Health As | Optisk avbilding av kolorektal kreft |
US9695251B2 (en) | 2003-10-31 | 2017-07-04 | The Regents Of The University Of California | Activatable cell penetrating peptides with quenched fluorophores |
US7431915B2 (en) * | 2003-10-31 | 2008-10-07 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
WO2011008992A2 (fr) * | 2009-07-15 | 2011-01-20 | The Regents Of The University Of California | Peptides dont labsorption par les cellules peut être régulée |
US7985401B2 (en) * | 2003-10-31 | 2011-07-26 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
US9050378B2 (en) * | 2003-12-10 | 2015-06-09 | Board Of Regents, The University Of Texas System | N2S2 chelate-targeting ligand conjugates |
NO20035681D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av lungekreft |
NO20035683D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av prostatakreft |
NO20035682D0 (no) * | 2003-12-18 | 2003-12-18 | Amersham Health As | Optisk avbildning av ösofagkreft og Barretts ösofag |
NO20035748D0 (no) * | 2003-12-19 | 2003-12-19 | Amersham Health As | Optisk avbildning av sårbar arteriosklerose |
US20070098631A2 (en) * | 2004-04-28 | 2007-05-03 | Guerbet | Diagnostic compounds comprising a scaffold coupled to a signal entity for medical imaging diagnostic |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
US20050281799A1 (en) | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
WO2006014567A2 (fr) * | 2004-07-08 | 2006-02-09 | Pneumrx, Inc. | Dispositif, procede et materiau pour le traitement d'epanchement pleural |
DE602004009169D1 (de) * | 2004-07-22 | 2007-11-08 | Bayer Schering Pharma Ag | Verwendung von Cyanin-farbstoffen zur Diagnose von Krankheiten, welche mit Angiogenese assoziert sind |
GB0421308D0 (en) * | 2004-09-24 | 2004-10-27 | Amersham Plc | Enzyme inhibitor imaging agents |
JP2008534617A (ja) * | 2005-04-01 | 2008-08-28 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | キレート剤としてのポリ(ペプチド):製造方法および用途 |
CA2606270A1 (fr) * | 2005-04-19 | 2006-10-26 | Massachusetts Institute Of Technology | Polymeres amphiphiles et leurs procedes d'utilisation |
WO2007030012A2 (fr) * | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Mise en image d'une matrice extracellulaire |
US20070140974A1 (en) * | 2005-12-15 | 2007-06-21 | General Electric Company | Targeted nanoparticles for magnetic resonance imaging |
EP1986682B1 (fr) * | 2006-02-06 | 2013-08-28 | The Burnham Institute for Medical Research | Procedes et compositions lies au ciblage de tumeurs et de plaies |
US8758723B2 (en) * | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
WO2008036763A2 (fr) * | 2006-09-20 | 2008-03-27 | Pneumrx, Inc. | Compositions adhesives pour tissu et methodes associees |
US10925977B2 (en) | 2006-10-05 | 2021-02-23 | Ceil>Point, LLC | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications |
WO2008136869A2 (fr) | 2006-12-06 | 2008-11-13 | Burnham Institute For Medical Research | Procédés et compositions relatives au ciblage de lésions, de tissu de régénération et de tumeurs |
JP2010514839A (ja) | 2007-01-03 | 2010-05-06 | バーナム インスティテュート フォー メディカル リサーチ | クロット結合化合物に関連する方法および組成物 |
DE102007036570A1 (de) | 2007-08-03 | 2009-02-19 | Siemens Ag | Screeningtest zur Erkennung von Prostataerkrankungen sowie Vorrichtung und Diagnosesubstanz zur Durchführung des Tests |
DE102007037008B4 (de) * | 2007-08-06 | 2015-09-10 | Siemens Aktiengesellschaft | Diagnosesubstanz zur Anwendung in einem Verfahren zur Bestimmung der Aggressivität eines Prostatatumors |
DE102007041836A1 (de) * | 2007-09-03 | 2009-03-05 | Siemens Ag | Verfahren zur Abbildung eines Prostatatumors und dafür geeignetes Kontrastmittel |
US20090074672A1 (en) * | 2007-09-17 | 2009-03-19 | Sri International | Tumor Boundary Imaging |
US8463365B2 (en) | 2007-09-19 | 2013-06-11 | Oncofluor, Inc. | Method for imaging and treating organs and tissues |
US20100143258A1 (en) * | 2008-12-05 | 2010-06-10 | General Electric Company | Tumor margin imaging agents |
WO2010075540A1 (fr) * | 2008-12-23 | 2010-07-01 | Burnham Institute For Medical Research | Procédés et compositions permettant un traitement à ciblage synaptique du cancer |
JP2012513589A (ja) | 2008-12-23 | 2012-06-14 | ジーイー・ヘルスケア・リミテッド | 骨髄イメージング剤としての99mTc−ペプチド系化合物の応用 |
US11235062B2 (en) * | 2009-03-06 | 2022-02-01 | Metaqor Llc | Dynamic bio-nanoparticle elements |
US11096901B2 (en) | 2009-03-06 | 2021-08-24 | Metaqor Llc | Dynamic bio-nanoparticle platforms |
JP2013507365A (ja) | 2009-10-07 | 2013-03-04 | サンフォード−バーナム メディカル リサーチ インスティテュート | 血餅結合脂質化合物に関する方法および組成物 |
WO2011049964A1 (fr) | 2009-10-19 | 2011-04-28 | Lab Scientific Group | Détection et quantification d'arn |
JP2013515008A (ja) | 2009-12-18 | 2013-05-02 | サンフォード−バーナム メディカル リサーチ インスティテュート | 凝血塊結合化合物に関連する方法および組成物 |
EP2515944B1 (fr) | 2009-12-23 | 2020-04-22 | Sanford-Burnham Medical Research Institute | Méthodes et compositions se rapportant à des composés se liant à l'annexine 1 |
EP2555802A1 (fr) | 2010-04-08 | 2013-02-13 | Sanford-Burnham Medical Research Institute | Méthodes et compositions pour une administration améliorée de composés |
WO2012136813A2 (fr) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents pour un diagnostic par radar médical |
EP2717909B1 (fr) | 2011-06-04 | 2017-12-06 | Rochester General Hospital Research Institute | Compositions et procédés associés à la protéine p6 de l'haemophilus influenzae |
US20140308342A1 (en) | 2011-11-11 | 2014-10-16 | Yale University | Reprogramming urokinase into an antibody-recruiting anticancer agent |
US10029017B2 (en) | 2013-01-29 | 2018-07-24 | The Regents Of The University Of California | Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug |
CA3128911C (fr) | 2013-01-30 | 2023-10-17 | Avelas Biosciences, Inc. | Distribution selective de molecules et procedes d'utilisation |
EP3164420A4 (fr) * | 2014-06-30 | 2018-05-23 | Tarveda Therapeutics, Inc. | Conjugués ciblés, particules et préparations associées |
ES2828954T3 (es) | 2014-09-17 | 2021-05-28 | Fluoguide As | Péptido de localización específica de uPAR para su uso en la formación peroperatoria de imágenes ópticas de cáncer invasivo |
US10385380B2 (en) | 2014-10-02 | 2019-08-20 | The Regents Of The University Of California | Personalized protease assay to measure protease activity in neoplasms |
EP3037820A1 (fr) * | 2014-12-27 | 2016-06-29 | Miltenyi Biotec GmbH | Procédé de détection de cellules et réactifs ayant un groupe fonctionnel d'étiquetage libérable |
US20180221513A1 (en) * | 2015-03-16 | 2018-08-09 | Northwestern University | Contrast-agent-labeled peptide amphiphile nanofibers |
US10596259B2 (en) | 2015-05-20 | 2020-03-24 | The Regents Of The University Of California | Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof |
US10548881B2 (en) | 2016-02-23 | 2020-02-04 | Tarveda Therapeutics, Inc. | HSP90 targeted conjugates and particles and formulations thereof |
WO2018022929A1 (fr) * | 2016-07-27 | 2018-02-01 | The Trustees Of Columbia University In The City Of New York | Composé pour radiothérapie. |
EP3412303A1 (fr) | 2017-06-08 | 2018-12-12 | Medizinische Universität Innsbruck | Pharmacocinétique améliorée et ciblage du récepteur cholecystokinin-2 (cck2r) pour le diagnostic et la thérapie |
WO2020198074A1 (fr) | 2019-03-22 | 2020-10-01 | Reflexion Pharmaceuticals, Inc. | Composés d-peptidiques pour facteur de croissance endothélial vasculaire (vegf) |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
MY106120A (en) * | 1988-12-05 | 1995-03-31 | Novartis Ag | Peptide derivatives. |
JPH04500823A (ja) * | 1989-07-20 | 1992-02-13 | ノバルティス・アクチエンゲゼルシャフト | ポリペプチド誘導体 |
US5183900A (en) | 1990-11-21 | 1993-02-02 | Galardy Richard E | Matrix metalloprotease inhibitors |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
US6004554A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
CN1173991C (zh) * | 1992-11-13 | 2004-11-03 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
US5512591A (en) * | 1993-02-18 | 1996-04-30 | President And Fellows Of Harvard College | Treatments for diseases characterized by neovascularization |
JP3670309B2 (ja) * | 1993-04-01 | 2005-07-13 | 第一製薬株式会社 | 二環性複素環化合物 |
US5480970A (en) | 1993-12-22 | 1996-01-02 | Resolution Pharmaceuticals | Metal chelators |
US5753230A (en) * | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
US6645933B1 (en) * | 1995-08-01 | 2003-11-11 | Helsinki University Licensing Ltd. Oy | Receptor ligand VEGF-C |
GB9502065D0 (en) * | 1995-02-02 | 1995-03-22 | Nycomed Imaging As | Contrast media |
US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
DE19522774A1 (de) * | 1995-06-27 | 1997-01-02 | Ifu Gmbh | Einrichtung zur spektroskopischen Untersuchung von Proben, die dem menschlichen Körper entnommen wurden |
NZ330868A (en) * | 1996-02-13 | 2000-01-28 | Zeneca Ltd | 4-phenoxy, phenylthio or phenylamino substituted quinazoline derivatives ane medicaments useful as VEGF inhibitors |
AU735900B2 (en) * | 1996-03-12 | 2001-07-19 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
JP2000508319A (ja) * | 1996-04-10 | 2000-07-04 | メルク エンド カンパニー インコーポレーテッド | αvβ3拮抗薬 |
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
WO1998018497A2 (fr) * | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Agents de contraste |
IL131655A0 (en) * | 1997-03-04 | 2001-01-28 | Bio Technology General Corp | Isolation of tissue specific ligands and their use for targeting pharmaceuticals to organs |
EP1056773A2 (fr) | 1998-02-11 | 2000-12-06 | Resolution Pharmaceuticals Inc. | Molecules ciblant l'angiogenese |
-
1997
- 1997-04-24 GB GBGB9708265.5A patent/GB9708265D0/en active Pending
-
1998
- 1998-04-24 AT AT04007226T patent/ATE365054T1/de not_active IP Right Cessation
- 1998-04-24 DK DK04007226T patent/DK1442751T3/da active
- 1998-04-24 EP EP04007226A patent/EP1442751B1/fr not_active Expired - Lifetime
- 1998-04-24 AT AT98917461T patent/ATE270116T1/de not_active IP Right Cessation
- 1998-04-24 EP EP98917461A patent/EP0977600B1/fr not_active Expired - Lifetime
- 1998-04-24 AU AU70687/98A patent/AU7068798A/en not_active Abandoned
- 1998-04-24 ES ES98917461T patent/ES2224379T3/es not_active Expired - Lifetime
- 1998-04-24 DE DE69824842T patent/DE69824842T2/de not_active Expired - Lifetime
- 1998-04-24 WO PCT/GB1998/001197 patent/WO1998047541A1/fr active IP Right Grant
- 1998-04-24 ES ES04007226T patent/ES2287599T3/es not_active Expired - Lifetime
- 1998-04-24 DE DE69837975T patent/DE69837975T2/de not_active Expired - Lifetime
- 1998-04-24 JP JP54530798A patent/JP4993419B2/ja not_active Expired - Fee Related
-
1999
- 1999-10-22 US US09/422,977 patent/US6610269B1/en not_active Expired - Fee Related
-
2003
- 2003-06-17 US US10/462,836 patent/US7413727B2/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9295737B2 (en) | 2002-03-01 | 2016-03-29 | Bracco Suisse Sa | Targeting vector-phospholipid conjugates |
US9381258B2 (en) | 2002-03-01 | 2016-07-05 | Bracco Suisse S.A. | Targeting vector-phospholipid conjugates |
US9408926B2 (en) | 2002-03-01 | 2016-08-09 | Bracco Suisse S.A. | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO1998047541B1 (fr) | Agents de contraste | |
JP7194161B2 (ja) | 前立腺特異的膜抗原(psma)の標識インヒビター、前立腺癌の治療のための画像化剤および薬剤としてのその使用 | |
Behr et al. | Reducing the renal uptake of radiolabeled antibody fragments and peptides for diagnosis and therapy: present status, future prospects and limitations | |
Bergmann et al. | Biodistribution and catabolism of 18F-labeled neurotensin (8–13) analogs | |
AU728712C (en) | Method for the detection and localization of malignant human tumours | |
JPH08502075A (ja) | 標識された単球走化性因子タンパク質材料およびその医学的使用 | |
CN108042811A (zh) | 用于治疗由psma表达细胞引起的疾病的共轭物 | |
JPH10502931A (ja) | ペプチド誘導の放射性核種キレート化剤 | |
CA2405469A1 (fr) | Composes a base de peptides | |
EA037512B1 (ru) | Улучшенные ингибиторы простатического специфического мембранного антигена (псма), меченные 18f, и их применение в качестве визуализирующих агентов при раке простаты | |
CN102159252B (zh) | 胰岛成像用分子探针前体及其使用 | |
de Roode et al. | Towards the magic radioactive bullet: improving targeted radionuclide therapy by reducing the renal retention of radioligands | |
WO2015119763A1 (fr) | Antagonistes de récepteur de peptide de libération de gastrine (grpr) marqués par al-f-18, marqués par al-f-19 et marqués par ga-68 pour l'imagerie du cancer de la prostate | |
CA2464002C (fr) | Compositions pacap et methodes d'imagerie et de therapie de tumeurs | |
US20230406847A1 (en) | Ligands of prostate specific membrane antigen (psma) containing heteroaromatic linker building blocks | |
AU7244894A (en) | Immunoreactive reagents employing monoamine oxidase | |
JP2022535463A (ja) | 放射性同位体をキレート化し、psma受容体を標的とする特異的分子で修飾された表面を有するポリマーナノ粒子を調製するプロセスおよびその使用 | |
EP1501554B1 (fr) | Derives benzothienyle de la somatostatine, selectifs pour certains recepteurs de la somatostatine | |
JP2002047210A (ja) | 尿路結石防止用組成物 | |
WO2018178923A1 (fr) | Agent d'imagerie | |
CN118619941A (zh) | 一种含氮杂环类化合物及其制备方法与用途 | |
Trump | Synthesis and metabolism of radiolabeled folate-chelate conjugates | |
Möllmann | Design of Molecular Ligands for (Nuclear) Imaging | |
AU2002342104A1 (en) | PACAP compositions and methods for tumor imaging and therapy |