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UY34704A - Ácidos indaniloxidihidrobenzofuranilacéticos como agonistas del receptor 40 acoplados a la proteina g (gpr40) - Google Patents

Ácidos indaniloxidihidrobenzofuranilacéticos como agonistas del receptor 40 acoplados a la proteina g (gpr40)

Info

Publication number
UY34704A
UY34704A UY0001034704A UY34704A UY34704A UY 34704 A UY34704 A UY 34704A UY 0001034704 A UY0001034704 A UY 0001034704A UY 34704 A UY34704 A UY 34704A UY 34704 A UY34704 A UY 34704A
Authority
UY
Uruguay
Prior art keywords
indaniloxidihydrobenzofuranilacetic
gpr40
protein
acids
coupled
Prior art date
Application number
UY0001034704A
Other languages
English (en)
Inventor
Frattini Sara
Langkopf Elke
Himmelsbach Frank
Eckhardt Matthias
Hamprecht Dieter
Wagner Holger
Lingard Iain
Peters Stefan
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34704(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY34704A publication Critical patent/UY34704A/es

Links

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/42—Oxazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se divulgan compuestos de fórmula general I,en donde los grupos R1, R2 y m se definen tal como en la reivindicación 1, que en particular se unen al receptor GPR40 y modulan su actividad. Los compuestos son apropiados para el tratamiento y prevención de enfermedades que pueden estar afectadas por este receptor, tal como enfermedades metabólicas, en particular diabetes tipo 2.
UY0001034704A 2012-03-26 2013-03-22 Ácidos indaniloxidihidrobenzofuranilacéticos como agonistas del receptor 40 acoplados a la proteina g (gpr40) UY34704A (es)

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MA20150065A1 (fr) 2015-02-27
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AP2014007903A0 (en) 2014-08-31
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CO7091175A2 (es) 2014-10-21
WO2013144098A1 (en) 2013-10-03
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KR20140139088A (ko) 2014-12-04
US8642585B2 (en) 2014-02-04
CA2868474A1 (en) 2013-10-03
JP6040486B2 (ja) 2016-12-07
SG11201405713UA (en) 2014-10-30
CN104321319A (zh) 2015-01-28
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EP2831064A1 (en) 2015-02-04
PE20142019A1 (es) 2014-12-18
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