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EA201401053A1 - Новые производные инданилоксидигидробензофуранилуксусной кислоты и их применение в качестве агонистов рецептора gpr40 - Google Patents

Новые производные инданилоксидигидробензофуранилуксусной кислоты и их применение в качестве агонистов рецептора gpr40

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Publication number
EA201401053A1
EA201401053A1 EA201401053A EA201401053A EA201401053A1 EA 201401053 A1 EA201401053 A1 EA 201401053A1 EA 201401053 A EA201401053 A EA 201401053A EA 201401053 A EA201401053 A EA 201401053A EA 201401053 A1 EA201401053 A1 EA 201401053A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indaniloxydyhydrobenzofuranyacic
agonists
new
application
acid derivatives
Prior art date
Application number
EA201401053A
Other languages
English (en)
Inventor
Маттиас Экхардт
Зара Фраттини
Дитер Хампрехт
Франк Химмельсбах
Эльке Лангкопф
Йан Лингард
Штефан Петерс
Хольгер Вагнер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48013980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201401053(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201401053A1 publication Critical patent/EA201401053A1/ru

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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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Abstract

В заявке описаны соединения общей формулы Iв которой группы R, Rи m являются такими, как определено в п.1 формулы изобретения, которые обладают ценными фармакологическими характеристиками и, в частности, связываются с рецептором GPR40 и модулируют его активность. Соединения являются подходящими для лечения и предупреждения заболеваний, на которые можно воздействовать с помощью этого рецептора, таких как метаболические заболевания, предпочтительно диабета типа 2.
EA201401053A 2012-03-26 2013-03-25 Новые производные инданилоксидигидробензофуранилуксусной кислоты и их применение в качестве агонистов рецептора gpr40 EA201401053A1 (ru)

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