UY28484A1 - Compuestos para el tratamiento de trastornos neurodegenerativos - Google Patents
Compuestos para el tratamiento de trastornos neurodegenerativosInfo
- Publication number
- UY28484A1 UY28484A1 UY28484A UY28484A UY28484A1 UY 28484 A1 UY28484 A1 UY 28484A1 UY 28484 A UY28484 A UY 28484A UY 28484 A UY28484 A UY 28484A UY 28484 A1 UY28484 A1 UY 28484A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- treatment
- neurodegenerative disorders
- formula
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
La presente invención se relaciona con compuestos de Fórmula I en donde R3, R5, R7, U, X, Y y Z son como se definen. Los compuestos de Fórmula I presentn actividad inhibitoria de la producción de AB-péptidos. Esta invención también se relaciona con composiciones farmacéuticas y métodos para el tratamiento de enfermedades, por ejemplo, enfermedades neurodegenerativas como la enfermedad de Alzheimer, en un mamífero que comprende compuestos de Fórmula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49673503P | 2003-08-21 | 2003-08-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY28484A1 true UY28484A1 (es) | 2005-03-31 |
Family
ID=34272502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY28484A UY28484A1 (es) | 2003-08-21 | 2004-08-20 | Compuestos para el tratamiento de trastornos neurodegenerativos |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7253195B2 (es) |
| EP (1) | EP1658072A4 (es) |
| JP (1) | JP2007502828A (es) |
| AR (1) | AR045474A1 (es) |
| BR (1) | BRPI0413709A (es) |
| CA (1) | CA2534532A1 (es) |
| MX (1) | MXPA06001845A (es) |
| PA (1) | PA8609801A1 (es) |
| TW (1) | TW200526610A (es) |
| UY (1) | UY28484A1 (es) |
| WO (1) | WO2005020991A1 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0413709A (pt) * | 2003-08-21 | 2006-10-17 | Pfizer Prod Inc | compostos para o tratamento de distúrbios neurodegenerativos |
| US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
| DE602005007717D1 (de) * | 2004-03-23 | 2008-08-07 | Pfizer Prod Inc | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen |
| US7232820B2 (en) * | 2004-04-01 | 2007-06-19 | Pfizer Inc | Thiadiazole-amine compounds for the treatment of neurodegenerative disorders |
| AU2005295441B2 (en) * | 2004-10-18 | 2009-04-23 | Amgen, Inc. | Thiadiazole compounds and methods of use |
| WO2007034326A2 (en) * | 2005-09-22 | 2007-03-29 | Pfizer Products Inc. | Imidazole compounds for the treatment of neurological disorders |
| US8541406B2 (en) | 2006-02-07 | 2013-09-24 | Nv Remynd | Thiadiazole derivatives for the treatment of neurodegenerative diseases |
| GB0602335D0 (en) * | 2006-02-07 | 2006-03-15 | Remynd Nv | Thiadiazole Derivatives For The Treatment Of Neurodegenerative Diseases |
| GB0623258D0 (en) | 2006-11-22 | 2007-01-03 | Remynd Nv | Thiadiazole derivatives for the treatment of neuro-degenerative diseases |
| GB0704394D0 (en) * | 2007-03-07 | 2007-04-11 | Senexis Ltd | Compounds |
| JP2010533715A (ja) | 2007-07-17 | 2010-10-28 | アムジエン・インコーポレーテツド | 複素環系ｐｋｂ調節剤 |
| US7919504B2 (en) * | 2007-07-17 | 2011-04-05 | Amgen Inc. | Thiadiazole modulators of PKB |
| US8889670B2 (en) | 2009-02-18 | 2014-11-18 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds which modulate the CB2 receptor |
| US8299103B2 (en) * | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| JP2013517271A (ja) | 2010-01-15 | 2013-05-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| EP2595959B1 (en) | 2010-07-22 | 2015-11-04 | Boehringer Ingelheim International GmbH | Sulfonyl compounds which modulate the cb2 receptor |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| SG11201506135WA (en) * | 2013-02-05 | 2015-11-27 | Basf Se | Process for preparing a titanium-containing zeolitic material having an mww framework structure |
| EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
| SG11201705780PA (en) | 2015-02-03 | 2017-08-30 | Pfizer | Novel cyclopropabenzofuranyl pyridopyrazinediones |
| BR112019023851A2 (pt) | 2017-05-15 | 2020-08-18 | Cognition Therapeutics, Inc. | compostos, suas composições farmacêuticas e métodos para tratamento de doenças neurodegenerativas |
| EP4055011A1 (en) * | 2019-11-05 | 2022-09-14 | Dermira, Inc | Mrgprx2 antagonists and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69719385T2 (de) * | 1996-06-21 | 2003-12-18 | Pharmacia & Upjohn Co., Kalamazoo | Mmp-hemmende thiadiazolylamide |
| US6323315B1 (en) * | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| BRPI0413709A (pt) | 2003-08-21 | 2006-10-17 | Pfizer Prod Inc | compostos para o tratamento de distúrbios neurodegenerativos |
-
2004
- 2004-08-18 BR BRPI0413709-4A patent/BRPI0413709A/pt not_active IP Right Cessation
- 2004-08-18 JP JP2006524019A patent/JP2007502828A/ja not_active Withdrawn
- 2004-08-18 WO PCT/US2004/026854 patent/WO2005020991A1/en active Application Filing
- 2004-08-18 MX MXPA06001845A patent/MXPA06001845A/es active IP Right Grant
- 2004-08-18 EP EP04781522A patent/EP1658072A4/en not_active Withdrawn
- 2004-08-18 CA CA002534532A patent/CA2534532A1/en not_active Abandoned
- 2004-08-20 US US10/922,425 patent/US7253195B2/en not_active Expired - Fee Related
- 2004-08-20 PA PA20048609801A patent/PA8609801A1/es unknown
- 2004-08-20 TW TW093125231A patent/TW200526610A/zh unknown
- 2004-08-20 UY UY28484A patent/UY28484A1/es not_active Application Discontinuation
- 2004-08-23 AR ARP040103015A patent/AR045474A1/es unknown
-
2007
- 2007-07-17 US US11/778,773 patent/US7408068B2/en not_active Expired - Fee Related
-
2008
- 2008-06-18 US US12/141,212 patent/US20080249094A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1658072A1 (en) | 2006-05-24 |
| EP1658072A4 (en) | 2009-03-25 |
| US7253195B2 (en) | 2007-08-07 |
| BRPI0413709A (pt) | 2006-10-17 |
| US20080249094A1 (en) | 2008-10-09 |
| JP2007502828A (ja) | 2007-02-15 |
| CA2534532A1 (en) | 2005-03-10 |
| US7408068B2 (en) | 2008-08-05 |
| TW200526610A (en) | 2005-08-16 |
| WO2005020991A1 (en) | 2005-03-10 |
| AR045474A1 (es) | 2005-10-26 |
| US20070270426A1 (en) | 2007-11-22 |
| PA8609801A1 (es) | 2005-05-24 |
| US20050043372A1 (en) | 2005-02-24 |
| MXPA06001845A (es) | 2006-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20150608 |