[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

UA102336C2 - N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ - Google Patents

N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ

Info

Publication number
UA102336C2
UA102336C2 UAA201205709A UAA201205709A UA102336C2 UA 102336 C2 UA102336 C2 UA 102336C2 UA A201205709 A UAA201205709 A UA A201205709A UA A201205709 A UAA201205709 A UA A201205709A UA 102336 C2 UA102336 C2 UA 102336C2
Authority
UA
Ukraine
Prior art keywords
heading
acetyl
coa carboxylase
pyrazolospiroketones
normal
Prior art date
Application number
UAA201205709A
Other languages
English (en)
Russian (ru)
Inventor
Скотт Вілліям Баґлі
Девід Ендрю Ґріффіт
Даніель Вей-Шунґ Кунґ
Original Assignee
Пфайзер Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Інк. filed Critical Пфайзер Інк.
Publication of UA102336C2 publication Critical patent/UA102336C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Винахід стосується сполуки формули (І) EMBED ISISServer (I) або фармацевтично прийнятної солі сполуки, де R1, R2, R3 і R4 є такими, як описано в даному документі; її фармацевтичних композицій; та їх застосування в лікуванні захворювань, станів або розладів, модульованих інгібуванням ферменту(ів) ацетил-СоА карбоксилази у тварин.
UAA201205709A 2009-11-10 2010-10-29 N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ UA102336C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (en) 2009-11-10 2010-10-29 N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Publications (1)

Publication Number Publication Date
UA102336C2 true UA102336C2 (uk) 2013-06-25

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201205709A UA102336C2 (uk) 2009-11-10 2010-10-29 N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ

Country Status (39)

Country Link
US (4) US8288405B2 (uk)
EP (3) EP2947082A1 (uk)
JP (1) JP5114610B1 (uk)
KR (2) KR101550557B1 (uk)
CN (1) CN102695708B (uk)
AP (1) AP3283A (uk)
AR (1) AR078944A1 (uk)
AU (1) AU2010317501B2 (uk)
BR (1) BR112012011072A2 (uk)
CA (1) CA2778886C (uk)
CL (1) CL2012000999A1 (uk)
CO (1) CO6541569A2 (uk)
CR (1) CR20120190A (uk)
CU (1) CU24077B1 (uk)
DK (1) DK2499139T3 (uk)
DO (1) DOP2012000128A (uk)
EA (1) EA020153B1 (uk)
EC (1) ECSP12011880A (uk)
ES (1) ES2444543T3 (uk)
GE (1) GEP20146169B (uk)
HK (1) HK1173724A1 (uk)
HN (1) HN2012000973A (uk)
HR (1) HRP20140025T1 (uk)
IL (1) IL219373A (uk)
MA (1) MA33734B1 (uk)
MX (1) MX2012005429A (uk)
NI (1) NI201200089A (uk)
NZ (1) NZ599815A (uk)
PE (1) PE20121469A1 (uk)
PL (1) PL2499139T3 (uk)
PT (1) PT2499139E (uk)
RS (1) RS53156B (uk)
SI (1) SI2499139T1 (uk)
TN (1) TN2012000192A1 (uk)
TW (1) TWI394756B (uk)
UA (1) UA102336C2 (uk)
UY (1) UY33020A (uk)
WO (1) WO2011058474A1 (uk)
ZA (1) ZA201204231B (uk)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5435592B2 (ja) 2008-05-28 2014-03-05 ファイザー・インク ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
MX2011013816A (es) 2009-06-29 2012-04-11 Incyte Corp Pirimidinonas como inhibidores de pi3k.
CU24077B1 (es) 2009-11-10 2015-03-30 Pfizer DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
EP2345643A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
US9193721B2 (en) 2010-04-14 2015-11-24 Incyte Holdings Corporation Fused derivatives as PI3Kδ inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
RS55224B1 (sr) 2010-09-30 2017-02-28 Pfizer N1-pirazolospiroketon acetil-coa karboksilaza inhibitori
RU2540337C2 (ru) 2010-10-29 2015-02-10 Пфайзер Инк. N1/N2-ЛАКТАМНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ
CA2822070C (en) 2010-12-20 2019-09-17 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
EA022375B1 (ru) * 2011-04-22 2015-12-30 Пфайзер Инк. ПРОИЗВОДНЫЕ ПИРАЗОЛОСПИРОКЕТОНОВ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ
ES2722524T3 (es) 2011-09-02 2019-08-13 Incyte Holdings Corp Heterociclaminas como inhibidores de pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
AU2014236711A1 (en) 2013-03-14 2015-09-17 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
MX2016002479A (es) 2013-09-12 2016-05-31 Pfizer Uso de inhibidores de acetil-coa carboxilasa para tratar acne vulgaris.
JPWO2015056782A1 (ja) 2013-10-17 2017-03-09 塩野義製薬株式会社 新規アルキレン誘導体
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
US9896436B2 (en) 2014-09-16 2018-02-20 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
AU2015317904A1 (en) 2014-09-16 2017-04-06 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
WO2016044138A1 (en) * 2014-09-17 2016-03-24 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
CA2966834C (en) 2014-11-10 2022-08-30 National University Corporation Yokohama National University Oxygen-generating anode
SG11201706917WA (en) 2015-02-27 2017-09-28 Incyte Corp Salts of pi3k inhibitor and processes for their preparation
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US11541046B2 (en) 2017-06-30 2023-01-03 Quixgen, Inc. Spirolactone compounds
IL313710A (en) 2017-11-21 2024-08-01 Pfizer Crystal structure of the 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4 ('-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid
US11465991B2 (en) 2018-03-15 2022-10-11 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
AU2021275292A1 (en) 2020-05-21 2022-12-15 Shionogi & Co., Ltd. Pharmaceutical for treating fatty liver diseases
US10989621B1 (en) 2020-08-20 2021-04-27 Trinity Bay Equipment Holdings, LLC Online pipe integrity testing system and method
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
EP4434520A1 (en) 2021-11-19 2024-09-25 Shionogi & Co., Ltd. Pharmaceutical for treating heart disease or skeletal muscle disease
CN115124542A (zh) * 2022-07-08 2022-09-30 河南师范大学 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US984083A (en) 1910-03-28 1911-02-14 William J Faber Floor-plane.
DE69837903T2 (de) 1997-08-11 2008-02-14 Pfizer Products Inc., Groton Feste pharmazeutische Dispersionen mit erhöhter Bioverfügbarkeit
GEP20053710B (en) 2001-02-28 2005-12-26 Merck & Co Inc Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists
ES2246481T3 (es) 2002-02-27 2006-02-16 Pfizer Products Inc. Inhibidores de la acc.
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
JPWO2004092179A1 (ja) 2003-04-14 2006-07-06 日本曹達株式会社 スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja) 2003-10-15 2005-05-12 Ajinomoto Co Inc アシルスルホンアミド誘導体
US20050267221A1 (en) 2004-05-14 2005-12-01 Research Development Foundation Use of curcumin and analogues thereof as inhibitors of ACC2
CN1950374A (zh) 2004-05-25 2007-04-18 辉瑞产品公司 四氮杂苯并[e]甘菊环衍生物及其类似物
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
WO2007011809A1 (en) * 2005-07-19 2007-01-25 Merck & Co., Inc. Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
CA2617042A1 (en) * 2005-07-29 2007-02-01 Takeda Pharmaceutical Company Limited Spiro-cyclic compound
DE102006016566B4 (de) * 2005-09-22 2008-06-12 Beru Ag Zusammengesetzter Leiter, insbesondere für Glühkerzen für Dieselmotoren
CA2629406A1 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin aryl cgrp receptor antagonists
US8735595B2 (en) 2006-02-15 2014-05-27 Abbvie Inc. Acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome
AU2007326950B2 (en) * 2006-11-29 2010-10-14 Pfizer Products Inc. Spiroketone acetyl-CoA carboxylase inhibitors
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
US20100113418A1 (en) 2007-02-20 2010-05-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
AU2008237660B2 (en) * 2007-04-12 2011-12-22 Pfizer Inc. 3-amido-pyrrolo [3, 4-C] pyrazole-5 (1H, 4H, 6H) carbaldehyde derivatives as inhibitors of protein kinase C
US20100211592A1 (en) * 2007-07-20 2010-08-19 Mark Jonathon Brownlee Email response time expectation system
US7981904B2 (en) * 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
JP5435592B2 (ja) * 2008-05-28 2014-03-05 ファイザー・インク ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
US20110009443A1 (en) * 2008-05-28 2011-01-13 Kevin Daniel Freeman-Cook Pyrazolospiroketone Acetyl-Coa Carboxylase Inhibitors
CA2729412A1 (en) 2008-07-04 2010-01-07 Banyu Pharmaceutical Co., Ltd. Novel spirochromanone carboxylic acids
US8110570B2 (en) * 2008-07-14 2012-02-07 Cropsolution, Inc. Modulators of acetyl-coenzyme A carboxylase and methods of use thereof
CA2736409C (en) * 2008-09-18 2017-07-11 Auspex Pharmaceutical, Inc. Benzoquinoline inhibitors of vesicular monoamine transporter 2
CA2778316A1 (en) 2009-11-10 2011-05-19 Pfizer Inc. N-2 pyrazolospiroketone acetyl-coa carboxylase inhibitors
CU24077B1 (es) * 2009-11-10 2015-03-30 Pfizer DERIVADOS DE N1-PIRAZOLOESPIROCETONA ÚTILES COMO INHIBIDORES DE ACETIL-CoA CARBOXILASA
RS55224B1 (sr) 2010-09-30 2017-02-28 Pfizer N1-pirazolospiroketon acetil-coa karboksilaza inhibitori
EA022375B1 (ru) * 2011-04-22 2015-12-30 Пфайзер Инк. ПРОИЗВОДНЫЕ ПИРАЗОЛОСПИРОКЕТОНОВ ДЛЯ ПРИМЕНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ АЦЕТИЛ-КоА-КАРБОКСИЛАЗ

Also Published As

Publication number Publication date
IL219373A (en) 2014-04-30
MA33734B1 (fr) 2012-11-01
KR101550557B1 (ko) 2015-09-04
PL2499139T3 (pl) 2014-04-30
IL219373A0 (en) 2012-06-28
US20130030181A1 (en) 2013-01-31
PE20121469A1 (es) 2012-11-01
EA201290191A1 (ru) 2012-12-28
DK2499139T3 (da) 2014-01-27
PT2499139E (pt) 2014-02-10
EP2499139A1 (en) 2012-09-19
EP2676958B1 (en) 2015-07-01
SI2499139T1 (sl) 2014-01-31
UY33020A (es) 2011-06-30
BR112012011072A2 (pt) 2017-06-20
WO2011058474A8 (en) 2012-04-26
ZA201204231B (en) 2013-02-27
AU2010317501A1 (en) 2012-05-17
EP2499139B1 (en) 2013-12-11
NZ599815A (en) 2013-04-26
CN102695708A (zh) 2012-09-26
AP2012006269A0 (en) 2012-06-30
CU20120071A7 (es) 2013-05-31
CA2778886C (en) 2014-01-07
KR20120099460A (ko) 2012-09-10
TWI394756B (zh) 2013-05-01
US20130296319A1 (en) 2013-11-07
MX2012005429A (es) 2012-06-19
US8507681B2 (en) 2013-08-13
US9139587B2 (en) 2015-09-22
EP2676958A1 (en) 2013-12-25
KR20140034919A (ko) 2014-03-20
HRP20140025T1 (hr) 2014-02-14
CO6541569A2 (es) 2012-10-16
TW201127838A (en) 2011-08-16
TN2012000192A1 (fr) 2013-12-12
HK1173724A1 (en) 2013-05-24
CN102695708B (zh) 2014-10-15
JP5114610B1 (ja) 2013-01-09
HN2012000973A (es) 2015-03-02
RS53156B (en) 2014-06-30
GEP20146169B (en) 2014-09-25
ECSP12011880A (es) 2012-07-31
US8802690B2 (en) 2014-08-12
CR20120190A (es) 2012-05-24
CL2012000999A1 (es) 2012-07-20
AR078944A1 (es) 2011-12-14
DOP2012000128A (es) 2012-08-31
NI201200089A (es) 2012-08-20
US8288405B2 (en) 2012-10-16
AU2010317501B2 (en) 2013-06-06
JP2013510192A (ja) 2013-03-21
EA020153B1 (ru) 2014-09-30
US20140288111A1 (en) 2014-09-25
CA2778886A1 (en) 2011-05-19
US20110111046A1 (en) 2011-05-12
CU24077B1 (es) 2015-03-30
KR101478517B1 (ko) 2015-01-02
EP2947082A1 (en) 2015-11-25
ES2444543T3 (es) 2014-02-25
WO2011058474A1 (en) 2011-05-19
AP3283A (en) 2015-05-31

Similar Documents

Publication Publication Date Title
UA102336C2 (uk) N1-ПІРАЗОЛСПІРОКЕТОНИ ЯК ІНГІБІТОРИ АЦЕТИЛ-СоА-КАРБОКСИЛАЗ
MX2013004733A (es) Inhibidores de n1/n2-lactama acetil-coa carboxilasa.
MY162167A (en) Substituted acetyl-coa carboxylase inhibitors
HK1133596A1 (en) Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
TW200744586A (en) Therapeutic compounds
JO2962B1 (en) Aminopronic derivatives substituted as niprilicin inhibitors
MY170326A (en) Imidazo [1,2-b] pyridazine derivativea as kinase inhibitors
AU2012258977A8 (en) Inhibitors of LRRK2 kinase activity
HRP20080493T3 (en) Substituted quinoline derivatives as mitotic kinesin inhibitors
JO3007B1 (ar) مركبات و تركيبات كمثبطات كيناز بروتين
UA105229C2 (uk) Фармацевтичний склад
UA103930C2 (uk) Сполуки та композиція для лікування паразитарних хвороб
MA32240B1 (fr) Inhibiteurs de désacétylases b à base d'hydroxamate
MY167898A (en) Co-crystals and salts of ccr3-inhibitors
TW200738651A (en) Cyclohexyl sulfonamide derivatives
MX2009011753A (es) Inhibidores de enzima de diacilglicerol o-aciltransferasa tipo 1.
MX2012002528A (es) Agente terapeutico para trastornos del estado de animo.
WO2007081808A3 (en) Compounds and derivatives for the treatment of medical conditions by modulating hormone-sensitive lipase activity
MY145122A (en) Phenylacetic acid derivatives as cox-2 inhibitors
TN2011000592A1 (en) Substituted aminopropionic derivatives as neprilysin inhibitors
UA109764C2 (uk) Похідні ізохінолінону, композиція на їх основі та застосування як інгібіторів рі3k