[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MA33734B1 - N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase - Google Patents

N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase

Info

Publication number
MA33734B1
MA33734B1 MA34850A MA34850A MA33734B1 MA 33734 B1 MA33734 B1 MA 33734B1 MA 34850 A MA34850 A MA 34850A MA 34850 A MA34850 A MA 34850A MA 33734 B1 MA33734 B1 MA 33734B1
Authority
MA
Morocco
Prior art keywords
acetyl
coa carboxylase
pyrazolospirocetone
carboxylase inhibitors
inhibitors
Prior art date
Application number
MA34850A
Other languages
Arabic (ar)
English (en)
Inventor
Daniel Wei-Shung Kung
Scott William Bagley
David Andrew Griffith
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MA33734B1 publication Critical patent/MA33734B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un composé de formule (i) ou un sel pharmaceutiquement acceptable du composé, dans lequel r1, r2, r3 et r4 sont tels que présentement décrits; des compositions pharmaceutiques de celui-ci; et l'utilisation de celui-ci dans le traitement de maladies, affections ou troubles modulés par l'inhibition d'une ou des enzyme(s) acétyl-coa carboxylase(s) chez un animal.
MA34850A 2009-11-10 2012-05-10 N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase MA33734B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (fr) 2009-11-10 2010-10-29 Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase

Publications (1)

Publication Number Publication Date
MA33734B1 true MA33734B1 (fr) 2012-11-01

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34850A MA33734B1 (fr) 2009-11-10 2012-05-10 N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase

Country Status (39)

Country Link
US (4) US8288405B2 (fr)
EP (3) EP2947082A1 (fr)
JP (1) JP5114610B1 (fr)
KR (2) KR101550557B1 (fr)
CN (1) CN102695708B (fr)
AP (1) AP3283A (fr)
AR (1) AR078944A1 (fr)
AU (1) AU2010317501B2 (fr)
BR (1) BR112012011072A2 (fr)
CA (1) CA2778886C (fr)
CL (1) CL2012000999A1 (fr)
CO (1) CO6541569A2 (fr)
CR (1) CR20120190A (fr)
CU (1) CU24077B1 (fr)
DK (1) DK2499139T3 (fr)
DO (1) DOP2012000128A (fr)
EA (1) EA020153B1 (fr)
EC (1) ECSP12011880A (fr)
ES (1) ES2444543T3 (fr)
GE (1) GEP20146169B (fr)
HK (1) HK1173724A1 (fr)
HN (1) HN2012000973A (fr)
HR (1) HRP20140025T1 (fr)
IL (1) IL219373A (fr)
MA (1) MA33734B1 (fr)
MX (1) MX2012005429A (fr)
NI (1) NI201200089A (fr)
NZ (1) NZ599815A (fr)
PE (1) PE20121469A1 (fr)
PL (1) PL2499139T3 (fr)
PT (1) PT2499139E (fr)
RS (1) RS53156B (fr)
SI (1) SI2499139T1 (fr)
TN (1) TN2012000192A1 (fr)
TW (1) TWI394756B (fr)
UA (1) UA102336C2 (fr)
UY (1) UY33020A (fr)
WO (1) WO2011058474A1 (fr)
ZA (1) ZA201204231B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5435592B2 (ja) 2008-05-28 2014-03-05 ファイザー・インク ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
CA2766100C (fr) 2009-06-29 2018-05-22 Incyte Corporation Pyrimidinones comme inhibiteurs de pi3k
WO2011058474A1 (fr) 2009-11-10 2011-05-19 Pfizer Inc. Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase
WO2011075643A1 (fr) 2009-12-18 2011-06-23 Incyte Corporation Dérivés condensés d'hétéroaryles substitués à titre d'inhibiteurs de pi3k
EP2345643A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
WO2011130342A1 (fr) 2010-04-14 2011-10-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de ρi3κδ
WO2011163195A1 (fr) 2010-06-21 2011-12-29 Incyte Corporation Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k
US8859577B2 (en) 2010-09-30 2014-10-14 Pfizer Inc. N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
CN104774205A (zh) 2010-10-29 2015-07-15 辉瑞大药厂 N1/n2-内酰胺乙酰辅酶a羧化酶抑制剂
ES2764848T3 (es) 2010-12-20 2020-06-04 Incyte Holdings Corp N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (fr) 2011-03-25 2012-10-04 Incyte Corporation Dérivés de pyrimidine-4,6-diamine en tant qu'inhibiteurs de pi3k
PL2699576T3 (pl) * 2011-04-22 2016-05-31 Pfizer Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA
EP3888657A1 (fr) 2011-09-02 2021-10-06 Incyte Holdings Corporation Hétérocyclylamines en tant qu'inhibiteurs de pi3k
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
US9133166B2 (en) 2013-03-14 2015-09-15 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
RU2016106829A (ru) 2013-09-12 2017-10-17 Пфайзер Инк. Применение ингибиторов ацетил-СоА карбоксилазы для лечения обыкновенных угрей
EP3059225A4 (fr) 2013-10-17 2017-09-06 Shionogi & Co., Ltd. Nouveau dérivé d'alkylène
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
SG11201702108PA (en) 2014-09-16 2017-04-27 Celgene Quanticel Res Inc Histone demethylase inhibitors
US9896436B2 (en) 2014-09-16 2018-02-20 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
MX2017003463A (es) * 2014-09-17 2017-07-13 Celgene Quanticel Res Inc Inhibidores de histona desmetilasa.
EP3228731B1 (fr) 2014-11-10 2020-04-22 National University Corporation Yokohama National University Anode de génération d'oxygène
CN117736209A (zh) 2015-02-27 2024-03-22 因赛特控股公司 Pi3k抑制剂的盐及其制备方法
WO2016183063A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Formes cristallines d'un inhibiteur de pi3k
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CA3068623A1 (fr) 2017-06-30 2019-01-03 Quixgen, Inc. Nouveaux composes spirolactones
IL274820B2 (en) 2017-11-21 2024-11-01 Pfizer Inc Crystal structure of the 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4 ('-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid
WO2019178480A1 (fr) 2018-03-15 2019-09-19 Yale University Inhibiteurs du facteur inhibiteur de migration des macrophages contenant du pyrazole
MX2022014553A (es) 2020-05-21 2022-12-15 Shionogi & Co Composicion farmaceutica para tratar enfermedad de higado graso.
US10989621B1 (en) 2020-08-20 2021-04-27 Trinity Bay Equipment Holdings, LLC Online pipe integrity testing system and method
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
EP4434520A1 (fr) 2021-11-19 2024-09-25 Shionogi & Co., Ltd. Produit pharmaceutique pour le traitement d'une maladie cardiaque ou d'une maladie du muscle squelettique
CN115124542A (zh) * 2022-07-08 2022-09-30 河南师范大学 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US984083A (en) 1910-03-28 1911-02-14 William J Faber Floor-plane.
EP0901786B1 (fr) 1997-08-11 2007-06-13 Pfizer Products Inc. Dispersions solides pharmaceutiques à biodisponibilité accrue
CZ20032325A3 (cs) 2001-02-28 2004-02-18 Erck & Co., Inc. Acylované piperidinové deriváty
ES2246481T3 (es) 2002-02-27 2006-02-16 Pfizer Products Inc. Inhibidores de la acc.
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
JPWO2004092179A1 (ja) 2003-04-14 2006-07-06 日本曹達株式会社 スピロ誘導体、製造法および抗酸化薬
JP2005119987A (ja) 2003-10-15 2005-05-12 Ajinomoto Co Inc アシルスルホンアミド誘導体
WO2005113069A2 (fr) 2004-05-14 2005-12-01 Research Development Foundation Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2
AU2005247693A1 (en) 2004-05-25 2005-12-08 Pfizer Products Inc. Tetraazabenzo[E]azulene derivatives and analogs thereof
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
AU2006270145B2 (en) * 2005-07-19 2011-04-14 Msd K.K. Spirochromanone derivatives as acetyl coenzyme a carboxylase (ACC) inhibitors
EP1911753A1 (fr) * 2005-07-29 2008-04-16 Takeda Pharmaceutical Company Limited Composé spiro-cyclique
DE102006016566B4 (de) * 2005-09-22 2008-06-12 Beru Ag Zusammengesetzter Leiter, insbesondere für Glühkerzen für Dieselmotoren
US8071770B2 (en) 2005-11-18 2011-12-06 Merck Sharp & Dohme Corp. Spirohydantoin aryl CGRP receptor antagonists
CN101384568B (zh) 2006-02-15 2012-12-12 雅培制药有限公司 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
WO2008065508A1 (fr) * 2006-11-29 2008-06-05 Pfizer Products Inc. Inhibiteurs de la spirocétoneacétyl-coa carboxylase
PE20081559A1 (es) * 2007-01-12 2008-11-20 Merck & Co Inc DERIVADOS DE ESPIROCROMANONA SUSTITUIDOS COMO INHIBIDORES DE ACETIL CoA CARBOXILASA
US20100113418A1 (en) * 2007-02-20 2010-05-06 Takeda Pharmaceutical Company Limited Heterocyclic compound
EP2195321B1 (fr) * 2007-04-12 2016-10-19 Pfizer Inc. Derives de 3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde comme inhibiteurs de proteine kinase c
US20100211592A1 (en) * 2007-07-20 2010-08-19 Mark Jonathon Brownlee Email response time expectation system
US7981904B2 (en) * 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
JP5435592B2 (ja) * 2008-05-28 2014-03-05 ファイザー・インク ピラゾロスピロケトンアセチルＣｏＡカルボキシラーゼ阻害剤
CA2724603A1 (fr) * 2008-05-28 2009-12-03 Pfizer Inc. Inhibiteurs de la pyrazolospirocetone acetyl-coa carboxylase
EP2307422B1 (fr) 2008-07-04 2014-03-26 Msd K.K. Nouveaux acides spirochromanone carboxyliques
WO2010008521A1 (fr) * 2008-07-14 2010-01-21 Cropsolution, Inc. Modulateurs de l’acétyl-coenzyme a carboxylase et procédés d’utilisation associés
CA2972242A1 (fr) * 2008-09-18 2010-04-22 Auspex Pharmaceuticals, Inc. Inhibiteurs benzoquinoline du transporteur de monoamines vesiculaire 2
WO2011058474A1 (fr) * 2009-11-10 2011-05-19 Pfizer Inc. Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase
JP2013510191A (ja) 2009-11-10 2013-03-21 ファイザー・インク Ｎ−２ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害薬
US8859577B2 (en) * 2010-09-30 2014-10-14 Pfizer Inc. N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
PL2699576T3 (pl) * 2011-04-22 2016-05-31 Pfizer Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA

Also Published As

Publication number Publication date
DK2499139T3 (da) 2014-01-27
TW201127838A (en) 2011-08-16
BR112012011072A2 (pt) 2017-06-20
EP2947082A1 (fr) 2015-11-25
JP5114610B1 (ja) 2013-01-09
CN102695708B (zh) 2014-10-15
MX2012005429A (es) 2012-06-19
HK1173724A1 (en) 2013-05-24
AR078944A1 (es) 2011-12-14
US20130296319A1 (en) 2013-11-07
SI2499139T1 (sl) 2014-01-31
IL219373A (en) 2014-04-30
CN102695708A (zh) 2012-09-26
KR101550557B1 (ko) 2015-09-04
CU20120071A7 (es) 2013-05-31
ZA201204231B (en) 2013-02-27
NI201200089A (es) 2012-08-20
PL2499139T3 (pl) 2014-04-30
CU24077B1 (es) 2015-03-30
WO2011058474A8 (fr) 2012-04-26
US20130030181A1 (en) 2013-01-31
ES2444543T3 (es) 2014-02-25
CO6541569A2 (es) 2012-10-16
JP2013510192A (ja) 2013-03-21
RS53156B (en) 2014-06-30
EP2676958B1 (fr) 2015-07-01
CR20120190A (es) 2012-05-24
US20110111046A1 (en) 2011-05-12
DOP2012000128A (es) 2012-08-31
EP2499139A1 (fr) 2012-09-19
PT2499139E (pt) 2014-02-10
NZ599815A (en) 2013-04-26
PE20121469A1 (es) 2012-11-01
AU2010317501A1 (en) 2012-05-17
EA201290191A1 (ru) 2012-12-28
US8288405B2 (en) 2012-10-16
CA2778886A1 (fr) 2011-05-19
EP2499139B1 (fr) 2013-12-11
US8507681B2 (en) 2013-08-13
UY33020A (es) 2011-06-30
IL219373A0 (en) 2012-06-28
KR101478517B1 (ko) 2015-01-02
GEP20146169B (en) 2014-09-25
KR20140034919A (ko) 2014-03-20
CL2012000999A1 (es) 2012-07-20
US20140288111A1 (en) 2014-09-25
AU2010317501B2 (en) 2013-06-06
HRP20140025T1 (hr) 2014-02-14
HN2012000973A (es) 2015-03-02
AP3283A (en) 2015-05-31
US8802690B2 (en) 2014-08-12
US9139587B2 (en) 2015-09-22
ECSP12011880A (es) 2012-07-31
CA2778886C (fr) 2014-01-07
KR20120099460A (ko) 2012-09-10
TWI394756B (zh) 2013-05-01
EA020153B1 (ru) 2014-09-30
AP2012006269A0 (en) 2012-06-30
EP2676958A1 (fr) 2013-12-25
TN2012000192A1 (fr) 2013-12-12
UA102336C2 (uk) 2013-06-25
WO2011058474A1 (fr) 2011-05-19

Similar Documents

Publication Publication Date Title
MA33734B1 (fr) N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase
MA35061B1 (fr) Dérivés de pyrazolospirocétone pour une utilisation comme inhibiteurs d'acétyl-coa carboxylase
MA42295B1 (fr) Composés de la benzoxazépin oxazolidinone et procédé pour leur utilisation
MX2013004733A (es) Inhibidores de n1/n2-lactama acetil-coa carboxilasa.
MA34819B1 (fr) Dérivés bicyclo[3.2.1]octylamide et leurs utilisations
EA200801826A1 (ru) Дейтерированные производные катехоламина и лекарственные средства, содержащие указанные соединения
MA37400B1 (fr) Composés hétérocyclyle en tant qu'inhibiteurs de mek
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
MA32903B1 (fr) Inhibiteurs de proteine-kinases
MA34655B1 (fr) Dérivés de 2,3- dihydroimidazo[1,2-c]quinazoléine substitués par un aminoalcool utiles pour traiter des troubles hyperprolifératifs et des maladies associées à l'angiogenèse
MA37891A1 (fr) Alcoxypyrazoles comme activateurs de guanylate cyclase soluble
WO2007095050A3 (fr) N-hydroxyguanidines comme modulateurs de l'indolamine 2,3-dioxygénase
EA201000098A1 (ru) Производные хиназолинамида
BR112014006763A2 (pt) n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1
ATE538651T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
MA38810A1 (fr) Inhibiteurs de rorc2 méthodes d'utilisation associées
MA38315A1 (fr) Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales
MA33618B1 (fr) Agent thérapeutique destiné aux troubles de l'humeur
EA201000362A1 (ru) Производные 1,3-дигидроизоиндола
MA37691B1 (fr) 5-amino[1,4]thiazines comme inhibiteurs de bace1
EA200700909A1 (ru) Азаиндолкарбоксамиды
MA37763B1 (fr) Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1
MA46342A (fr) Dérivés de chromane, d'isochromane et de dihydroisobenzofurane en tant que modulateurs allostériques négatifs de mglur2, compositions et leur utilisation
MA33760B1 (fr) Dérivés spirolactames et leurs utilisations
EA201390398A1 (ru) Арилсульфонамиды для лечения заболеваний цнс