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TWI419889B - 吡唑并〔１，５-ａ〕嘧啶化合物 - Google Patents

吡唑并〔１，５-ａ〕嘧啶化合物 Download PDF

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Publication number
TWI419889B
TWI419889B TW96122242A TW96122242A TWI419889B TW I419889 B TWI419889 B TW I419889B TW 96122242 A TW96122242 A TW 96122242A TW 96122242 A TW96122242 A TW 96122242A TW I419889 B TWI419889 B TW I419889B
Authority
TW
Taiwan
Prior art keywords
group
chlorophenyl
pyrimidine
alkyl
pyrazolo
Prior art date
Application number
TW96122242A
Other languages
English (en)
Chinese (zh)
Other versions
TW200811177A (en
Inventor
Koichi Tanimoto
Mariko Oi
Yasunori Tsuboi
Yasunori Moritani
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Publication of TW200811177A publication Critical patent/TW200811177A/zh
Application granted granted Critical
Publication of TWI419889B publication Critical patent/TWI419889B/zh

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW96122242A 2006-07-05 2007-06-21 吡唑并〔１，５-ａ〕嘧啶化合物 TWI419889B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2006185036 2006-07-05
US81938806P 2006-07-10 2006-07-10
JP2007009706 2007-01-19
JP2007059332 2007-03-09
JP2007111340 2007-04-20

Publications (2)

Publication Number Publication Date
TW200811177A TW200811177A (en) 2008-03-01
TWI419889B true TWI419889B (zh) 2013-12-21

Family

ID=40145540

Family Applications (2)

Application Number Title Priority Date Filing Date
TW96122242A TWI419889B (zh) 2006-07-05 2007-06-21 吡唑并〔１，５-ａ〕嘧啶化合物
TW102126081A TW201345908A (zh) 2006-07-05 2007-06-21 吡唑并〔１，５-ａ〕嘧啶化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW102126081A TW201345908A (zh) 2006-07-05 2007-06-21 吡唑并〔１，５-ａ〕嘧啶化合物

Country Status (2)

Country Link
JP (1) JP4846665B2 (ja)
TW (2) TWI419889B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30090A1 (es) * 2006-01-16 2007-08-31 Syngenta Participations Ag Insecticidas novedosos
EP2350075B1 (en) 2008-09-22 2014-03-05 Array Biopharma, Inc. Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
KR101652189B1 (ko) 2008-10-22 2016-08-29 어레이 바이오파마 인크. ＴＲＫ 키나아제 억제제로서 치환된 피라졸로［１,５­ａ］ 피리미딘 화합물
CA2740792C (en) * 2008-10-31 2016-06-21 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
US8933084B2 (en) 2010-05-20 2015-01-13 Array Biopharma Inc. Macrocyclic compounds as Trk kinase inhibitors
CN103153999B (zh) * 2010-08-31 2016-06-01 株式会社爱茉莉太平洋 作为大麻素受体-1抑制剂的化合物
US8796305B2 (en) * 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
EP3699181B1 (en) 2014-11-16 2023-03-01 Array Biopharma, Inc. Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
CA2998469A1 (en) * 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same
EP3156405A1 (en) * 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
KR20180102544A (ko) 2015-10-26 2018-09-17 더 리전츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 Trk 억제제-내성 암에서의 점 돌연변이 및 이의 관련 방법
CA3019671C (en) 2016-04-04 2024-02-20 Loxo Oncology, Inc. Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
DK3458456T3 (da) 2016-05-18 2020-12-14 Array Biopharma Inc Fremstilling af (s)-n-(5-((r)-2-(2,5-difluorphenyl)pyrrolidin-1-yl)pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101993A1 (en) * 2002-06-04 2003-12-11 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
US20040157838A1 (en) * 2003-02-10 2004-08-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2007046548A1 (en) * 2005-10-21 2007-04-26 Mitsubishi Tanabe Pharma Corporation Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
DE102004008807A1 (de) * 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
WO2005103052A1 (en) * 2004-04-21 2005-11-03 Pfizer Products Inc. Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
JP4847275B2 (ja) * 2005-10-21 2011-12-28 田辺三菱製薬株式会社 ピラゾロ［１，５−ａ］ピリミジン化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003101993A1 (en) * 2002-06-04 2003-12-11 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
US20040157838A1 (en) * 2003-02-10 2004-08-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2007046548A1 (en) * 2005-10-21 2007-04-26 Mitsubishi Tanabe Pharma Corporation Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists

Also Published As

Publication number Publication date
JP2008285464A (ja) 2008-11-27
JP4846665B2 (ja) 2011-12-28
TW200811177A (en) 2008-03-01
TW201345908A (zh) 2013-11-16

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MM4A Annulment or lapse of patent due to non-payment of fees