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TR201819812T4 - Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim - Google Patents

Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim Download PDF

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Publication number
TR201819812T4
TR201819812T4 TR2018/19812T TR201819812T TR201819812T4 TR 201819812 T4 TR201819812 T4 TR 201819812T4 TR 2018/19812 T TR2018/19812 T TR 2018/19812T TR 201819812 T TR201819812 T TR 201819812T TR 201819812 T4 TR201819812 T4 TR 201819812T4
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TR
Turkey
Prior art keywords
antibody
caprin
pharmaceutical composition
cancer disease
seq
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TR2018/19812T
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English (en)
Inventor
Okano Fumiyoshi
Saito Takanori
Minamida Yoshitaka
Ido Takayoshi
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Toray Industries
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Publication of TR201819812T4 publication Critical patent/TR201819812T4/tr

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Geleneksel antikorlara kıyasla antitümör aktivitesi açısından daha üstün nitelikte olan bir CAPRIN-1-hedefleyici antikor sunulması ve bunun bir kanser hastalığı için terapötik ve/veya önleyici ajan olarak kullanımının sağlanması hedeflenmektedir. Bu buluş, kanser hücrelerinin yüzeyi üzerinde spesifik olarak eksprese edilen bir CAPRIN-1 polipeptidini hedef alan bir antikor ve bu antikorun bir kanser hastalığı için terapötik ve/veya önleyici ajan olarak kullanımını sunmaktadır. Bu buluş, SEKANS KOD NO.: 1, 2 ve 3 ile temsil edilen tamamlayıcılık belirleme bölgeleri içeren bir ağır zincir değişken bölgesi ve SEKANS KOD NO.: 4, 5 ve 6 ile temsil edilen tamamlayıcılık belirleme bölgeleri içeren bir hafif zincir değişken bölgesi bulunan ve bir CAPRIN-1 proteiniyle immünolojik reaktiviteye sahip olan bir antikor ya da onun bir fragmanını ve bir kanser hastalığının tedavisi ve/veya önlenmesi amacına yönelik olan ve bu antikoru ya da fragmanını bir etkin madde olarak içeren bir farmasötik bileşim sunmaktadır.
TR2018/19812T 2013-08-09 2014-08-08 Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim TR201819812T4 (tr)

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JP2013166164 2013-08-09

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TR201819812T4 true TR201819812T4 (tr) 2019-01-21

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US (1) US9862774B2 (tr)
EP (1) EP3031826B1 (tr)
JP (1) JP6447130B2 (tr)
KR (1) KR102255616B1 (tr)
CN (1) CN105452294B (tr)
AU (1) AU2014303375B2 (tr)
BR (1) BR112016001753B1 (tr)
CA (1) CA2918989C (tr)
DK (1) DK3031826T3 (tr)
ES (1) ES2704909T3 (tr)
HU (1) HUE042081T2 (tr)
MX (1) MX360671B (tr)
PL (1) PL3031826T3 (tr)
PT (1) PT3031826T (tr)
RU (1) RU2678138C2 (tr)
TR (1) TR201819812T4 (tr)
WO (1) WO2015020212A1 (tr)

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