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TR200400601T4 - Bir anti-tümöral etkiye sahip olan ikame edilmiş N-benzil-indol-3-il glioksilik asit türevleri - Google Patents

Bir anti-tümöral etkiye sahip olan ikame edilmiş N-benzil-indol-3-il glioksilik asit türevleri

Info

Publication number
TR200400601T4
TR200400601T4 TR2004/00601T TR200400601T TR200400601T4 TR 200400601 T4 TR200400601 T4 TR 200400601T4 TR 2004/00601 T TR2004/00601 T TR 2004/00601T TR 200400601 T TR200400601 T TR 200400601T TR 200400601 T4 TR200400601 T4 TR 200400601T4
Authority
TR
Turkey
Prior art keywords
compounds
indol
benzyl
substituted
acid derivatives
Prior art date
Application number
TR2004/00601T
Other languages
English (en)
Inventor
G�Nther Eckhard
Emig Peter
Reichert Dietmar
Le Baut Guillaume
Nickel Bernd
Bacher Gerald
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of TR200400601T4 publication Critical patent/TR200400601T4/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

Bulus, (I) formülünün yeni, ikame edilmis N-benzil-indol-3-il-glioksilik asit türevlerine ve bu türevlerin tümoral hastaliklarin tedavisinde kullanimina iliskindir. Bulus, ayni zamanda, mümkün oldugunda, bu bilesiklerin fizyolojik açidan kabul edilebilir asit ilave tuzlari ve N oksitlerine de iliskindir. Bulus, bundan baska, yukarida zikredilen formülün bilesiklerin en azindan birini ya da bilesiklerin tuzlari ya da N oksitlerini fizyolojik açidan kabul edilebilir inorganik ya da organik asitler ile ve istege göre, farmasötik açidan kullanilabilir tasiyici maddeler ve/veya seyreltme maddeleri ya da yardimci maddeler ile ihtiva eden farmasötik açidan kullanilabilir tasiyici maddeler ve/veya seyreltme maddeleri ya da yardimci maddeler ile ihtiva eden farmasötik bilesimlere de iliskindir. Bulus, ayni zamanda, bu formülün bilesikleri ya da bu bilesiklerin tuzlarinin en azindan birini, tabletler, drajeler, kapsüller, infüzyon ya da ampuller için çözeltiler, fitiller, plasterler, DEVAMI VAR
TR2004/00601T 1999-12-23 2000-12-19 Bir anti-tümöral etkiye sahip olan ikame edilmiş N-benzil-indol-3-il glioksilik asit türevleri TR200400601T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung

Publications (1)

Publication Number Publication Date
TR200400601T4 true TR200400601T4 (tr) 2004-04-21

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/00601T TR200400601T4 (tr) 1999-12-23 2000-12-19 Bir anti-tümöral etkiye sahip olan ikame edilmiş N-benzil-indol-3-il glioksilik asit türevleri

Country Status (31)

Country Link
US (1) US6432987B2 (tr)
EP (1) EP1240157B1 (tr)
JP (1) JP2003519137A (tr)
KR (1) KR100747425B1 (tr)
CN (1) CN1283637C (tr)
AR (1) AR027098A1 (tr)
AT (1) ATE259364T1 (tr)
AU (1) AU772745B2 (tr)
BG (1) BG106924A (tr)
BR (1) BR0016712A (tr)
CA (1) CA2395259A1 (tr)
CO (1) CO5251472A1 (tr)
CZ (1) CZ20022094A3 (tr)
DE (2) DE19962300A1 (tr)
DK (1) DK1240157T3 (tr)
ES (1) ES2215768T3 (tr)
HK (1) HK1054038B (tr)
HU (1) HUP0203716A3 (tr)
IL (1) IL150235A0 (tr)
MX (1) MXPA02006229A (tr)
NO (1) NO324750B1 (tr)
NZ (2) NZ533731A (tr)
PL (1) PL195014B1 (tr)
PT (1) PT1240157E (tr)
RU (1) RU2266280C2 (tr)
SK (1) SK8752002A3 (tr)
TR (1) TR200400601T4 (tr)
TW (1) TWI284128B (tr)
UA (1) UA75060C2 (tr)
WO (1) WO2001047913A2 (tr)
ZA (1) ZA200204896B (tr)

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DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
NZ543853A (en) * 2003-06-05 2009-09-25 Zentaris Gmbh Indole derivatives with apoptosis-inducing effect
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
MXPA06002853A (es) 2003-09-11 2006-06-14 Kemia Inc Inhibidores citoquina.
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
JP5096927B2 (ja) 2004-12-31 2012-12-12 レディ ユーエス セラピューティックス， インコーポレイテッド Ｃｅｔｐインヒビターとしての新規ベンジルアミン誘導体
JP5385605B2 (ja) * 2005-03-11 2014-01-08 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｐ結合カセットトランスポーターのモジュレーター
EP2049520A4 (en) * 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc indole compounds
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP2424521A4 (en) 2009-04-29 2015-03-04 Amarin Pharmaceuticals Ie Ltd PHARMACEUTICAL COMPOSITIONS COMPRISING EPA AND CARDIOVASCULAR AGENT AND METHODS OF USE
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CN103827105B (zh) 2011-08-18 2016-08-17 雷迪博士实验室有限公司 作为胆固醇酯转移蛋白(cetp)抑制剂的取代的杂环胺化合物
EP2760864B1 (en) 2011-09-27 2018-01-24 Dr. Reddy's Laboratories Ltd. 5-BENZYLAMINOMETHYL-6-AMINOPYRAZOLO[3,4-b]PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS

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EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
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Also Published As

Publication number Publication date
HUP0203716A2 (hu) 2003-03-28
PL355684A1 (en) 2004-05-17
MXPA02006229A (es) 2003-01-28
EP1240157A2 (de) 2002-09-18
BR0016712A (pt) 2002-09-03
DE19962300A1 (de) 2001-06-28
US6432987B2 (en) 2002-08-13
IL150235A0 (en) 2002-12-01
PT1240157E (pt) 2004-06-30
EP1240157B1 (de) 2004-02-11
HK1054038B (zh) 2007-04-13
NZ533731A (en) 2005-03-24
WO2001047913A2 (de) 2001-07-05
KR20020063245A (ko) 2002-08-01
BG106924A (bg) 2003-04-30
HUP0203716A3 (en) 2004-05-28
RU2002120462A (ru) 2004-01-10
NO324750B1 (no) 2007-12-03
DK1240157T3 (da) 2004-06-14
CN1283637C (zh) 2006-11-08
ZA200204896B (en) 2002-12-20
JP2003519137A (ja) 2003-06-17
CO5251472A1 (es) 2003-02-28
NO20023039D0 (no) 2002-06-21
ES2215768T3 (es) 2004-10-16
KR100747425B1 (ko) 2007-08-09
WO2001047913A3 (de) 2002-04-25
CA2395259A1 (en) 2001-07-05
CZ20022094A3 (cs) 2002-10-16
PL195014B1 (pl) 2007-07-31
NO20023039L (no) 2002-08-09
AU2011901A (en) 2001-07-09
AU772745B2 (en) 2004-05-06
AR027098A1 (es) 2003-03-12
US20010014690A1 (en) 2001-08-16
HK1054038A1 (en) 2003-11-14
NZ519977A (en) 2004-08-27
UA75060C2 (en) 2006-03-15
DE50005284D1 (de) 2004-03-18
RU2266280C2 (ru) 2005-12-20
ATE259364T1 (de) 2004-02-15
CN1420880A (zh) 2003-05-28
SK8752002A3 (en) 2003-01-09
TWI284128B (en) 2007-07-21

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